PANTHER Gene Information

Gene Symbol(s):

MME

Organism:

Canis lupus familiaris

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Gene Name:

Membrane metalloendopeptidase

Gene ID:

ENSCAFG00845020957.1

Protein ID:

F5C3N2

Persistent Id:

PTN000199954

Alternate Ids:

ENSCAFP00845028984(Ensembl_PRO)	ENSCAFT00845037015(Ensembl_TRS)
XP_005634648(refSeq)	477120(GeneID)
F5C3N2_CANLF(UniProtKB-ID)	545539412(GI)
JF451103(EMBL)	ENSCAFG00845020957(Ensembl)
F5C3N2(Synonym)	AEB96248(EMBL-CDS)
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PANTHER Classification

PANTHER Family:	ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED (PTHR11733)
PANTHER Subfamily:	NEPRILYSIN (PTHR11733:SF114)
PANTHER GO-slim Molecular Function:	metalloendopeptidase activity
PANTHER GO-slim Biological Process:	protein processing
PANTHER GO-slim Cellular Component:	plasma membrane
PANTHER protein class:	metalloprotease

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	phosphatidylserine binding, zinc ion binding, protein homodimerization activity, peptide binding, metalloendopeptidase activity, cardiolipin binding, exopeptidase activity
GO BP Complete:	replicative senescence, positive regulation of long-term synaptic potentiation, neuropeptide processing, learning or memory, hormone catabolic process, creatinine metabolic process, cellular response to UV-B, amyloid-beta clearance, cellular response to UV-A, kidney development, peptide metabolic process, bradykinin catabolic process, proteolysis, substance P catabolic process, amyloid-beta clearance by cellular catabolic process, sensory perception of pain, protein processing, cellular response to cytokine stimulus, positive regulation of neurogenesis, amyloid-beta metabolic process
GO CC Complete:	dendrite, early endosome, trans-Golgi network, brush border, cytoplasm, synaptic vesicle, membrane raft, neuronal cell body, synapse, plasma membrane, axon, neuron projection terminus

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Innate Immune System, Metabolism of proteins, Immune System, Metabolism of Angiotensinogen to Angiotensins, Cardiac conduction, Neutrophil degranulation, Physiological factors, Muscle contraction, Peptide hormone metabolism

Orthologs

ID	Organism	Type
HUMAN\|HGNC=7154\|UniProtKB=P08473	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000015550.6\|UniProtKB=K7CJF2	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000013260.3\|UniProtKB=G3SA97	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000006662.4\|UniProtKB=F7H3Y6	Macaca mulatta	LDO
MOUSE\|MGI=MGI=97004\|UniProtKB=Q61391	Mus musculus	LDO
RAT\|RGD=3098\|UniProtKB=P07861	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000002075.5\|UniProtKB=E1BPL8	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000011723.6\|UniProtKB=A0A8W4FP09	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000009138.4\|UniProtKB=F7B8E7	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000004615.6\|UniProtKB=A0A337SXF4	Felis catus	LDO
MONDO\|Ensembl=ENSMODG00000015805.4\|UniProtKB=F7FEB8	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000009510.3\|UniProtKB=F6UPD1	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010001385.1\|UniProtKB=A0A8V0XAX6	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000003903.4\|UniProtKB=A0A803U1T5	Anolis carolinensis	LDO
XENLA\|Gene=mme.L\|UniProtKB=A0A8J1KSV4	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-1011098\|UniProtKB=A0A6I8PTH1	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000005790.2\|UniProtKB=A0A3B3HI63	Oryzias latipes	LDO
LEPOC\|Ensembl=ENSLOCG00000002202.1\|UniProtKB=W5M2J5	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000017942.1\|UniProtKB=H2XQ28	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118405049\|UniProtKB=A0A9J7HLG4	Branchiostoma floridae	O
BRAFL\|Gene=LOC118405047\|UniProtKB=A0A9J7HIW7	Branchiostoma floridae	O
BRAFL\|Gene=LOC118430801\|UniProtKB=A0A9J7MAC0	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC580325\|UniProtKB=A0A7M7NXK5	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC755783\|UniProtKB=A0A7M7NY20	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC578052\|UniProtKB=A0A7M7MXI0	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC580975\|UniProtKB=A0A7M7SZB7	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC583486\|UniProtKB=A0A7M7N0E0	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC594281\|UniProtKB=A0A7M7HMZ7	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00018278\|UniProtKB=H2KZE5	Caenorhabditis elegans	O
DROME\|FlyBase=FBgn0032613\|UniProtKB=Q9VJH0	Drosophila melanogaster	O
CAEEL\|WormBase=WBGene00017393\|UniProtKB=Q09946	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG02411\|UniProtKB=A8WUD7	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00017842\|UniProtKB=A0A5S9MNU9	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00039561\|UniProtKB=A8XY73	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00279259\|UniProtKB=A0A2A6CM30	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00104229\|UniProtKB=A0A2A6CVL4	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0039277\|UniProtKB=Q9VBX6	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP029586\|UniProtKB=A0A453Z012	Anopheles gambiae	O
IXOSC\|EnsemblGenome=ISCW006299\|UniProtKB=B7PM32	Ixodes scapularis	O
DROME\|FlyBase=FBgn0031678\|UniProtKB=Q9VMU6	Drosophila melanogaster	O
IXOSC\|EnsemblGenome=ISCW001618\|UniProtKB=B7P6U3	Ixodes scapularis	O
DROME\|FlyBase=FBgn0032442\|UniProtKB=Q9VK72	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0032585\|UniProtKB=Q9VJK5	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0259716\|UniProtKB=Q9VME2	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0029769\|UniProtKB=Q9W4B8	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0031808\|UniProtKB=Q9VME3	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0031081\|UniProtKB=Q9W5Y0	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP007796\|UniProtKB=A0A1S4GX10	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC015284\|UniProtKB=D2A4X8	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC015285\|UniProtKB=D2A4X7	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC015207\|UniProtKB=D2A597	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_300917\|UniProtKB=E9HFF5	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW014756\|UniProtKB=B7QM96	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG110566\|UniProtKB=T1EF32	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g229362\|UniProtKB=A7S4D9	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG37639\|UniProtKB=B3RTH7	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG63323\|UniProtKB=B3RZU7	Trichoplax adhaerens	O
EMENI\|EnsemblGenome=ANIA_03091\|UniProtKB=C8VIN1	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_3G12420\|UniProtKB=Q4WYB2	Neosartorya fumigata	O
SCLS1\|EnsemblGenome=SS1G_05697\|UniProtKB=A7EK51	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_15353\|UniProtKB=Q0TYS9	Phaeosphaeria nodorum	O
CRYNJ\|EnsemblGenome=CNB04230\|UniProtKB=Q5KLS5	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_02693\|UniProtKB=A0A0D1C704	Ustilago maydis	O
THAPS\|EnsemblGenome=THAPSDRAFT_269863\|UniProtKB=B8LCF9	Thalassiosira pseudonana	O
PHYRM\|Gene=H3GEF2_PHYRM\|UniProtKB=H3GEF2	Phytophthora ramorum	O
PHYRM\|Gene=H3HBZ9_PHYRM\|UniProtKB=H3HBZ9	Phytophthora ramorum	O
PHYRM\|Gene=H3H7F1_PHYRM\|UniProtKB=H3H7F1	Phytophthora ramorum	O
KLENI\|Gene_ORFName=KFL_000670270\|UniProtKB=A0A1Y1HUV6	Klebsormidium nitens	O
METAC\|EnsemblGenome=MA_2001\|UniProtKB=Q8TPB2	Methanosarcina acetivorans	O
MYCTU\|Gene_OrderedLocusName=Rv0198c\|UniProtKB=I6X8R2	Mycobacterium tuberculosis	O
STRR6\|EnsemblGenome=spr1491\|UniProtKB=Q8DNW9	Streptococcus pneumoniae	O
BACTN\|EnsemblGenome=BT_3811\|UniProtKB=Q8A156	Bacteroides thetaiotaomicron	O
SHEON\|Gene_OrderedLocusName=SO_0429\|UniProtKB=Q8EJN4	Shewanella oneidensis	O
SHEON\|Gene_OrderedLocusName=SO_3844\|UniProtKB=Q8EAQ3	Shewanella oneidensis	O
RHOBA\|EnsemblGenome=RB9029\|UniProtKB=Q7UM68	Rhodopirellula baltica	O
SHEON\|Gene_OrderedLocusName=SO_0491\|UniProtKB=Q8EJH4	Shewanella oneidensis	O
XANCP\|EnsemblGenome=XCC3671\|UniProtKB=Q8P4N6	Xanthomonas campestris	O
XANCP\|EnsemblGenome=XCC2710\|UniProtKB=Q8P7A3	Xanthomonas campestris	O
XANCP\|EnsemblGenome=XCC2035\|UniProtKB=Q8P931	Xanthomonas campestris	O
XANCP\|EnsemblGenome=XCC2575\|UniProtKB=Q8P7N6	Xanthomonas campestris	O
XANCP\|EnsemblGenome=XCC2574\|UniProtKB=Q8P7N7	Xanthomonas campestris	O