PANTHER Gene Information

Gene Symbol(s):

pnpla6

Organism:

Danio rerio

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Gene Name:

Neuropathy target esterase isoform X1

Gene ID:

pnpla6

Protein ID:

A0A8M2B6R2

Persistent Id:

PTN001022633

Alternate Ids:

560986(GeneID)	A0A8M2B6R2(Synonym)
XM_005160052(refSeq)	A0A8M2B6R2_DANRE(UniProtKB-ID)
528468915(GI)
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PANTHER Classification

PANTHER Family:	NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER (PTHR14226)
PANTHER Subfamily:	PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 6 (PTHR14226:SF26)
PANTHER GO-slim Molecular Function:	lysophospholipase activity
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:	endoplasmic reticulum
PANTHER protein class:	esterase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	lysophospholipase activity, carboxylic ester hydrolase activity, hydrolase activity
GO BP Complete:	negative regulation of BMP signaling pathway, anterior/posterior axis specification, phosphatidylcholine metabolic process, axonogenesis, lipid metabolic process, lipid catabolic process, neuron development
GO CC Complete:	endoplasmic reticulum membrane, membrane, endoplasmic reticulum

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=16268\|UniProtKB=Q8IY17	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000010393.6\|UniProtKB=A0A2I3RQP5	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000011946.3\|UniProtKB=G3QXS8	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000011392.4\|UniProtKB=A0A5F7ZVU5	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1354723\|UniProtKB=Q3TRM4	Mus musculus	LDO
RAT\|RGD=1564611\|UniProtKB=M0R715	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000032137.4\|UniProtKB=E1BMJ5	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000013572.5\|UniProtKB=A0A286ZW95	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000012712.4\|UniProtKB=A0A5K1UAF9	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000008288.6\|UniProtKB=A0A5F5Y625	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845025938.1\|UniProtKB=A0A8I3PYI6	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000015066.4\|UniProtKB=A0A5F8GAF8	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000008685.4\|UniProtKB=A0A6I8PKL7	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010003585.1\|UniProtKB=A0A8V0XA08	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000016134.4\|UniProtKB=G1KSE9	Anolis carolinensis	LDO
XENLA\|Gene=pnpla7.L\|UniProtKB=A0A8J1MMR1	Xenopus laevis	LDO
XENTR\|Gene=pnpla7\|UniProtKB=A0A8J1JEX7	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000018435.2\|UniProtKB=A0A3B3H762	Oryzias latipes	LDO
LEPOC\|Ensembl=ENSLOCG00000008681.1\|UniProtKB=W5MQC5	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000006539.3\|UniProtKB=F6RNR5	Ciona intestinalis	O
BRAFL\|Gene=LOC118408629\|UniProtKB=A0A9J7HTM1	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC105443374\|UniProtKB=A0A7M7PPZ1	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00010915\|UniProtKB=Q21534	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG00653\|UniProtKB=A8WND0	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00022718\|UniProtKB=Q02331	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG06931\|UniProtKB=A8X3E1	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00203954\|UniProtKB=A0A8R1YNZ1	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00276325\|UniProtKB=A0A8R1YTX5	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0003656\|UniProtKB=Q9U969	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP000467\|UniProtKB=A0A3F2YXS0	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC001035\|UniProtKB=A0A139WN47	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_325592\|UniProtKB=E9H575	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_119345\|UniProtKB=E9HY95	Daphnia pulex	O
HELRO\|EnsemblGenome=HelroG67348\|UniProtKB=T1FZ00	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g115565\|UniProtKB=A7SEQ9	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG10294\|UniProtKB=B3RP00	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_16206\|UniProtKB=A9UVY6	Monosiga brevicollis	O
YEAST\|SGD=S000004524\|UniProtKB=Q04958	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_AER124W\|UniProtKB=Q756Z0	Eremothecium gossypii	O
CANAL\|CGD=CAL0000194621\|UniProtKB=Q5A368	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_B11044g\|UniProtKB=Q6CF18	Yarrowia lipolytica	O
EMENI\|Gene_ORFName=AN2481\|UniProtKB=Q5BAE9	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_4G03000\|UniProtKB=Q4WA15	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU08276\|UniProtKB=Q7S8J1	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_13049\|UniProtKB=A7F621	Sclerotinia sclerotiorum	O
PHANO\|Gene_ORFName=SNOG_08222\|UniProtKB=Q0UJ42	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPCC4B3.04c\|UniProtKB=Q9USJ4	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_04110\|UniProtKB=B6K5Y4	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CND04180\|UniProtKB=P0CP36	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_01230\|UniProtKB=Q4PF83	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_08318\|UniProtKB=E3KE05	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_9648\|UniProtKB=F4NXA8	Batrachochytrium dendrobatidis	O
DICDI\|dictyBase=DDB_G0288005\|UniProtKB=Q54JJ8	Dictyostelium discoideum	O
DICDI\|dictyBase=DDB_G0274499\|UniProtKB=B0G109	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_33288\|UniProtKB=F0ZKK3	Dictyostelium purpureum	O
THAPS\|EnsemblGenome=THAPSDRAFT_22809\|UniProtKB=B8C393	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_2537\|UniProtKB=B8BUM9	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPS_23441\|UniProtKB=B5YMT6	Thalassiosira pseudonana	O
CHLRE\|EnsemblGenome=CHLRE_09g388763v5\|UniProtKB=A0A2K3DDY6	Chlamydomonas reinhardtii	O
THAPS\|EnsemblGenome=THAPSDRAFT_25263\|UniProtKB=B8CE60	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_263945\|UniProtKB=B8CAS6	Thalassiosira pseudonana	O
PHYRM\|Gene=H3GBN6_PHYRM\|UniProtKB=H3GBN6	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_10g417750v5\|UniProtKB=A0A2K3D8Y0	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_06g262400v5\|UniProtKB=A0A2K3DMS3	Chlamydomonas reinhardtii	O
CHLAA\|EnsemblGenome=Caur_3286\|UniProtKB=A9WJ15	Chloroflexus aurantiacus	O
STRCO\|Gene_OrderedLocusName=SCO5322\|UniProtKB=Q9XAG3	Streptomyces coelicolor	O
MYCTU\|Gene_OrderedLocusName=Rv1062\|UniProtKB=O53410	Mycobacterium tuberculosis	O
LEPIN\|EnsemblGenome=LB_252\|UniProtKB=Q8EXG0	Leptospira interrogans	O
BRADU\|Gene=Q89L64_BRADU\|UniProtKB=Q89L64	Bradyrhizobium diazoefficiens	O
YERPE\|Gene_OrderedLocusName=YPO1689\|UniProtKB=A0A380PKV8	Yersinia pestis	O
BRADU\|Gene=Q89RJ6_BRADU\|UniProtKB=Q89RJ6	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89UD0_BRADU\|UniProtKB=Q89UD0	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89EP5_BRADU\|UniProtKB=Q89EP5	Bradyrhizobium diazoefficiens	O
SHEON\|Gene_OrderedLocusName=SO_3155\|UniProtKB=Q8ECI7	Shewanella oneidensis	O
PSEAE\|EnsemblGenome=PA3241\|UniProtKB=Q9HYZ9	Pseudomonas aeruginosa	O
MYCTU\|Gene_OrderedLocusName=Rv3091\|UniProtKB=I6YB49	Mycobacterium tuberculosis	O
MYCTU\|Gene_OrderedLocusName=Rv2037c\|UniProtKB=L0TB61	Mycobacterium tuberculosis	O
CLOBH\|Gene_OrderedLocusName=CBO1487\|UniProtKB=A5I1W5	Clostridium botulinum	O
BACSU\|EnsemblGenome=BSU_24510\|UniProtKB=P54513	Bacillus subtilis	O
BACCR\|EnsemblGenome=BC_1989\|UniProtKB=Q813P5	Bacillus cereus	O
SYNY3\|Gene=Q55151_SYNY3\|UniProtKB=Q55151	Synechocystis	O
BACTN\|EnsemblGenome=BT_0774\|UniProtKB=Q8A9P1	Bacteroides thetaiotaomicron	O
RHOBA\|EnsemblGenome=RB971\|UniProtKB=Q7UY00	Rhodopirellula baltica	O
AQUAE\|EnsemblGenome=aq_1386\|UniProtKB=O67393	Aquifex aeolicus	O
GEOSL\|EnsemblGenome=GSU2584\|UniProtKB=Q74A07	Geobacter sulfurreducens	O
GEOSL\|EnsemblGenome=GSU0310\|UniProtKB=Q74GD6	Geobacter sulfurreducens	O
BRADU\|Gene=Q89G72_BRADU\|UniProtKB=Q89G72	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89K16_BRADU\|UniProtKB=Q89K16	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89C34_BRADU\|UniProtKB=Q89C34	Bradyrhizobium diazoefficiens	O
MYCTU\|Gene_OrderedLocusName=Rv3479\|UniProtKB=O06342	Mycobacterium tuberculosis	O
BACTN\|EnsemblGenome=BT_0896\|UniProtKB=Q8A9B9	Bacteroides thetaiotaomicron	O
SHEON\|Gene_OrderedLocusName=SO_0428\|UniProtKB=Q8EJN5	Shewanella oneidensis	O
VIBCH\|EnsemblGenome=VC_0603\|UniProtKB=Q9KUB9	Vibrio cholerae	O
PSEAE\|EnsemblGenome=PA3339\|UniProtKB=Q9HYQ6	Pseudomonas aeruginosa	O
BACCR\|EnsemblGenome=BC_2704\|UniProtKB=Q81CP6	Bacillus cereus	O
BACCR\|EnsemblGenome=BC_0759\|UniProtKB=Q81HP5	Bacillus cereus	O
BACTN\|EnsemblGenome=BT_1782\|UniProtKB=Q8A6U4	Bacteroides thetaiotaomicron	O
FUSNN\|EnsemblGenome=FN0508\|UniProtKB=Q8R6A1	Fusobacterium nucleatum	O
SHEON\|Gene_OrderedLocusName=SO_4525\|UniProtKB=Q8E8X5	Shewanella oneidensis	O
VIBCH\|EnsemblGenome=VC_2009\|UniProtKB=Q9KQI9	Vibrio cholerae	O
SALTY\|EnsemblGenome=STM4563\|UniProtKB=Q8ZJW2	Salmonella typhimurium	O
YERPE\|Gene_OrderedLocusName=YPO0433\|UniProtKB=A0A2S9PL72	Yersinia pestis	O
ECOLI\|EnsemblGenome=BAE78366\|UniProtKB=P39407	Escherichia coli	O
BACSU\|EnsemblGenome=BSU_15040\|UniProtKB=O34731	Bacillus subtilis	O
BACCR\|EnsemblGenome=BC_3927\|UniProtKB=Q819P2	Bacillus cereus	O
LEPIN\|EnsemblGenome=LA_2832\|UniProtKB=Q8F2D9	Leptospira interrogans	O
LEPIN\|EnsemblGenome=LA_2175\|UniProtKB=Q8F470	Leptospira interrogans	O
BACTN\|EnsemblGenome=BT_0303\|UniProtKB=Q8AB09	Bacteroides thetaiotaomicron	O
BACTN\|EnsemblGenome=BT_1016\|UniProtKB=Q8A901	Bacteroides thetaiotaomicron	O
FUSNN\|EnsemblGenome=FN1704\|UniProtKB=Q8R6F6	Fusobacterium nucleatum	O
NEIMB\|EnsemblGenome=NMB2139\|UniProtKB=Q9JXB2	Neisseria meningitidis serogroup b	O
BRADU\|Gene=Q89IT4_BRADU\|UniProtKB=Q89IT4	Bradyrhizobium diazoefficiens	O
SHEON\|Gene_OrderedLocusName=SO_2836\|UniProtKB=Q8EDC6	Shewanella oneidensis	O
XANCP\|EnsemblGenome=XCC0159\|UniProtKB=Q8PE24	Xanthomonas campestris	O
PSEAE\|EnsemblGenome=PA1640\|UniProtKB=Q9I385	Pseudomonas aeruginosa	O
SALTY\|EnsemblGenome=STM1754\|UniProtKB=Q8ZP44	Salmonella typhimurium	O
ECOLI\|EnsemblGenome=BAA36102\|UniProtKB=P0AFR0	Escherichia coli	O