PANTHER Gene Information

Gene Symbol(s):

ER[b]2

Organism:

Danio rerio

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Gene Name:

Esr2a protein

Gene ID:

ZDB-GENE-030116-2

Protein ID:

Q7ZU32

Persistent Id:

PTN000639452

Alternate Ids:

Q7ZU32_DANRE(UniProtKB-ID)	317734(GeneID)
82209527(GI)	NP_851297(refSeq)
AAI65404(EMBL-CDS)	ENSDARG00000016454(Ensembl)
Q7ZU32(Synonym)	BC044349(EMBL)
ENSDARP00000017514(Ensembl_PRO)	ENSDART00000131069(Ensembl_TRS)
ZDB-GENE-030116-2(ZFIN)
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PANTHER Classification

PANTHER Family:	KNIRPS-RELATED PROTEIN-RELATED (PTHR48092)
PANTHER Subfamily:	ESR2A PROTEIN (PTHR48092:SF28)
PANTHER GO-slim Molecular Function:	RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific signaling receptor activity
PANTHER GO-slim Biological Process:	regulation of transcription by RNA polymerase II
PANTHER GO-slim Cellular Component:	chromatin nucleus
PANTHER protein class:	C4 zinc finger nuclear receptor

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	zinc ion binding, estrogen response element binding, nuclear estrogen receptor activity, lipid binding, sequence-specific DNA binding, steroid binding, estradiol binding, DNA binding, DNA-binding transcription factor activity, nuclear receptor activity, metal ion binding, steroid hormone binding, nuclear steroid receptor activity
GO BP Complete:	cellular response to estradiol stimulus, response to estrogen, regulation of DNA-templated transcription, estrogen receptor signaling pathway, regulation of transcription by RNA polymerase II
GO CC Complete:	nucleus, chromatin

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

PIP3 activates AKT signaling, Signaling by Nuclear Receptors, Extra-nuclear estrogen signaling, ESR-mediated signaling, Intracellular signaling by second messengers, Negative regulation of the PI3K/AKT network, Signal Transduction, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Orthologs

ID	Organism	Type
HUMAN\|HGNC=3468\|UniProtKB=Q92731	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000006432.7\|UniProtKB=H2Q8G2	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000003030.3\|UniProtKB=G3QKK5	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000022839.4\|UniProtKB=F6UFZ0	Macaca mulatta	O
MACMU\|Gene=ESR2\|UniProtKB=Q9TTE5	Macaca mulatta	O
MOUSE\|MGI=MGI=109392\|UniProtKB=O08537	Mus musculus	O
RAT\|RGD=2582\|UniProtKB=Q62986	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000004498\|UniProtKB=Q9XSB5	Bos taurus	O
PIG\|Gene=ESR2\|UniProtKB=Q9XSW2	Sus scrofa	O
PIG\|Ensembl=ENSSSCG00000005109.4\|UniProtKB=F1SRR6	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000024947.3\|UniProtKB=F6S2G4	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000009636.6\|UniProtKB=A0A337S6Q3	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845001856.1\|UniProtKB=A0A8I3RRT3	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000009240.4\|UniProtKB=F7EDQ2	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000009109.4\|UniProtKB=F7F1J6	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010017591.1\|UniProtKB=A0A8V0Z9A0	Gallus gallus	O
CHICK\|Gene=ESR2\|UniProtKB=Q9PTU5	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000015814.4\|UniProtKB=G1KRR5	Anolis carolinensis	O
XENLA\|Gene=esr2.L\|UniProtKB=B2NIY4	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-486256\|UniProtKB=Q25C13	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000017721.2\|UniProtKB=H2MTS4	Oryzias latipes	LDO
LEPOC\|Ensembl=ENSLOCG00000010280.1\|UniProtKB=W5MW66	lepisosteus oculatus	O
BRAFL\|Gene=LOC118427878\|UniProtKB=A0A9J7M3F2	Branchiostoma floridae	O
BRAFL\|Gene=LOC118426196\|UniProtKB=A0A9J7N4D2	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC579264\|UniProtKB=A0A7M7T545	Strongylocentrotus purpuratus	O
PRIPA\|EnsemblGenome=WBGene00203376\|UniProtKB=A0A2A6BM67	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0000560\|UniProtKB=P15370	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0001320\|UniProtKB=P10734	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0001323\|UniProtKB=P13054	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP028221\|UniProtKB=A0A1S4HD49	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP010438\|UniProtKB=A0A1S4H3Z4	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC003413\|UniProtKB=B3GVU9	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_290668\|UniProtKB=E9GU00	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_290673\|UniProtKB=E9GTZ8	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW008631\|UniProtKB=B7PZN4	Ixodes scapularis	O
DROME\|FlyBase=FBgn0035849\|UniProtKB=Q8WS79	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP001743\|UniProtKB=Q7PUY0	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC009140\|UniProtKB=A0A139WFK8	Tribolium castaneum	O
DAPPU\|Gene_ORFName=DAPPUDRAFT_46682\|UniProtKB=E9G6R8	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW021172\|UniProtKB=B7Q7W9	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG79507\|UniProtKB=T1G3P5	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG106750\|UniProtKB=T1EE46	helobdella robusta	O
NEMVE\|Gene_ORFName=NEMVEDRAFT_v1g134436\|UniProtKB=A7SVT5	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g93844\|UniProtKB=A7RUL3	Nematostella vectensis	O