PANTHER Gene Information

Gene Symbol(s):

nfatc2a

Organism:

Danio rerio

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Gene Name:

Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1

Gene ID:

ZDB-GENE-120913-4

Protein ID:

E7F9Z5

Persistent Id:

PTN002288497

Alternate Ids:

100333254(GeneID)	ENSDART00000164711(Ensembl_TRS)
ENSDARP00000138593(Ensembl_PRO)	ZDB-GENE-120913-4(ZFIN)
CABZ01054024(EMBL)	E7F9Z5(Synonym)
528518647(GI)	ENSDARG00000100927(Ensembl)
E7F9Z5_DANRE(UniProtKB-ID)	XP_003201273(refSeq)
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PANTHER Classification

PANTHER Family:	NFAT (PTHR12533)
PANTHER Subfamily:	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2 (PTHR12533:SF4)
PANTHER GO-slim Molecular Function:	DNA-binding transcription factor activity, RNA polymerase II-specific transcription factor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding
PANTHER GO-slim Biological Process:	regulation of transcription by RNA polymerase II calcineurin-mediated signaling cytokine production
PANTHER GO-slim Cellular Component:	transcription regulator complex
PANTHER protein class:	Rel homology transcription factor

Pathway Categories:

T cell activation

Nuclear factor of activated T cells

Inflammation mediated by chemokine and cytokine signaling pathway

Nuclear factor of activated T cells

Gonadotropin-releasing hormone receptor pathway

NFAT

CCKR signaling map

NFAT1

B cell activation

Nuclear factor of activated T cells

Wnt signaling pathway

Nuclear factor of activated T-cells

Axon guidance mediated by netrin

Nuclear factor of activated T-cells

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	DNA binding, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, transcription factor binding, DNA-binding transcription factor activity, RNA polymerase II-specific
GO BP Complete:	calcineurin-NFAT signaling cascade, nervous system development, regulation of DNA-templated transcription, cytokine production, anatomical structure morphogenesis, epithelium development, regulation of transcription by RNA polymerase II
GO CC Complete:	nucleus, transcription regulator complex, cytoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=7776\|UniProtKB=Q13469	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000013628.6\|UniProtKB=H2R4F5	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000024518.2\|UniProtKB=A0A2I2Z5M1	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000012657.4\|UniProtKB=A0A1D5QLW3	Macaca mulatta	LDO
MOUSE\|MGI=MGI=102463\|UniProtKB=Q60591	Mus musculus	LDO
RAT\|RGD=1307690\|UniProtKB=D4A0I8	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000018270.6\|UniProtKB=F1MGR9	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000007477.6\|UniProtKB=A5GFS6	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000018997.4\|UniProtKB=A0A3Q2GY86	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000000947.6\|UniProtKB=A0A337SIS5	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845026966.1\|UniProtKB=A0A8I3PTE6	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000016363.4\|UniProtKB=A0A5F8GT26	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000008671.3\|UniProtKB=A0A6I8NPB1	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010014143.1\|UniProtKB=E1C473	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000013075.4\|UniProtKB=A0A803TMM2	Anolis carolinensis	LDO
XENLA\|Gene=nfatc2.S\|UniProtKB=A0A8J0U0C0	Xenopus laevis	O
XENLA\|Gene=nfatc2.L\|UniProtKB=A0A8J1LSR4	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-492278\|UniProtKB=A0A8J0QIL1	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000023353.1\|UniProtKB=A0A3B3HBY2	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000016173.2\|UniProtKB=H2MND3	Oryzias latipes	LDO
LEPOC\|Ensembl=ENSLOCG00000002372.1\|UniProtKB=W5M323	lepisosteus oculatus	LDO
BRAFL\|Gene=LOC118418168\|UniProtKB=A0A9J7LBQ8	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC590859\|UniProtKB=A0A7M7LTI6	Strongylocentrotus purpuratus	O
DROME\|FlyBase=FBgn0030505\|UniProtKB=A8JUV3	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP013287\|UniProtKB=A0A453YYJ4	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC014708\|UniProtKB=D6WNZ3	Tribolium castaneum	O
IXOSC\|EnsemblGenome=ISCW023728\|UniProtKB=B7QHC8	Ixodes scapularis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g243338\|UniProtKB=A7S787	Nematostella vectensis	O