PANTHER Gene Information

Gene Symbol(s):

Ubc4

Organism:

Drosophila melanogaster

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Gene Name:

Ubiquitin-conjugating enzyme E2-22 kDa

Gene ID:

FBgn0015321

Protein ID:

P52486

Persistent Id:

PTN000629656

Alternate Ids:

Ubiquitin carrier protein(Synonym)	CAA72184(EMBL-CDS)
UBCD4_DROME(UniProtKB-ID)	FBpp0076124(Ensembl_PRO)
FBgn0015321(Ensembl)	P91633(AltAccession)
2.3.2.23(EC)	665410168(GI)
Ubc4{ECO:0000312\|FlyBase:FBgn0015321}(Symbol)	NM_001300085(refSeq)
FBtr0345603(Ensembl_TRS)	39133(GeneID)
FBgn0015321(FlyBase)	X92838(EMBL)
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PANTHER Classification

PANTHER Family:	UBIQUITIN-CONJUGATING ENZYME E2 (PTHR24068)
PANTHER Subfamily:	E2 UBIQUITIN-CONJUGATING ENZYME (PTHR24068:SF147)
PANTHER GO-slim Molecular Function:	ubiquitin conjugating enzyme activity
PANTHER GO-slim Biological Process:	protein polyubiquitination
PANTHER GO-slim Cellular Component:	nucleus
PANTHER protein class:	ubiquitin-protein ligase

Pathway Categories:

Ubiquitin proteasome pathway

Ubiquitin protein ligase E3

Ubiquitin proteasome pathway

Ubiquitin-conjugating enzyme E2

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	ubiquitin-protein transferase activity, ubiquitin protein ligase binding, ubiquitin conjugating enzyme activity, proteasome binding
GO BP Complete:	positive regulation of peptidoglycan recognition protein signaling pathway, protein polyubiquitination
GO CC Complete:	nucleus

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Class I MHC mediated antigen processing & presentation, Protein ubiquitination, Antigen processing: Ubiquitination & Proteasome degradation, Immune System, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Metabolism of proteins, Adaptive Immune System, Post-translational protein modification

Orthologs

ID	Organism	Type
RAT\|RGD=1311626\|UniProtKB=A0A8I6A356	Rattus norvegicus	LDO
CANLF\|Ensembl=ENSCAFG00845004479.1\|UniProtKB=A0A8I3MSC8	Canis lupus familiaris	LDO
HUMAN\|HGNC=4914\|UniProtKB=P61086	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000050230.1\|UniProtKB=G2HEI6	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000003261.3\|UniProtKB=G3QL63	Gorilla gorilla gorilla	LDO
MOUSE\|MGI=MGI=1858216\|UniProtKB=P61087	Mus musculus	LDO
RAT\|RGD=1311626\|UniProtKB=A0A8I6A356	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000020175\|UniProtKB=P61085	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000033602.3\|UniProtKB=A0A287AUE4	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000014586.4\|UniProtKB=A0A5F5PTZ6	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000033193.3\|UniProtKB=A0A2I2UNS7	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845004479.1\|UniProtKB=A0A8I3MSC8	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000020556.3\|UniProtKB=F7AQ16	Monodelphis domestica	LDO
CHICK\|Ensembl=ENSGALG00010016295.1\|UniProtKB=A0A8V0Z1W7	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000011290.4\|UniProtKB=A0A803STM1	Anolis carolinensis	LDO
ORYLA\|Ensembl=ENSORLG00000004403.2\|UniProtKB=H2LHQ9	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-980605-9\|UniProtKB=Q5PR60	Danio rerio	O
ORYLA\|Ensembl=ENSORLG00000005661.2\|UniProtKB=A0A3B3HWJ8	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-050320-48\|UniProtKB=Q5BLA9	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000012989.1\|UniProtKB=W5N5T9	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000002344.3\|UniProtKB=F6PJV8	Ciona intestinalis	LDO
BRAFL\|Gene_ORFName=BRAFLDRAFT_126583\|UniProtKB=C3ZUG9	Branchiostoma floridae	LDO
CAEEL\|WormBase=WBGene00006716\|UniProtKB=P52484	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00035728\|UniProtKB=A8XM81	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00219376\|UniProtKB=H8W3X5	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00006715\|UniProtKB=Q9TZ69	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00035871\|UniProtKB=A8XMM5	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00091292\|UniProtKB=A0A454Y036	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00275876\|UniProtKB=A0A2A6BA02	Pristionchus pacificus	LDO
ANOGA\|EnsemblGenome=AGAP004889\|UniProtKB=A0A1S4GMG1	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC003444\|UniProtKB=D6WGK1	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_305966\|UniProtKB=E9GU18	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW018508\|UniProtKB=B7PN10	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG185754\|UniProtKB=T1FN90	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g235155\|UniProtKB=A7S9Q6	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG24883\|UniProtKB=B3RXP9	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_39004\|UniProtKB=A9VBK9	Monosiga brevicollis	LDO
YEAST\|SGD=S000002584\|UniProtKB=P21734	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_ADR169C\|UniProtKB=Q759V3	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000174534\|UniProtKB=A0A1D8PQD4	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_F02563g\|UniProtKB=Q6C353	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_02212\|UniProtKB=Q5BB68	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_5G07040\|UniProtKB=Q4WU34	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU01225\|UniProtKB=Q1K827	Neurospora crassa	LDO
SCLS1\|Gene_ORFName=SS1G_11962\|UniProtKB=A7F3W6	Sclerotinia sclerotiorum	O
SCLS1\|EnsemblGenome=SS1G_07048\|UniProtKB=A7ENZ9	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_09070\|UniProtKB=Q0UGP4	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPBC2D10.20\|UniProtKB=O74810	Schizosaccharomyces pombe	LDO
CRYNJ\|EnsemblGenome=CNC05160\|UniProtKB=Q5KJW2	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_00525\|UniProtKB=A0A0D1D151	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_14526\|UniProtKB=E3KU36	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_91378\|UniProtKB=F4PAN9	Batrachochytrium dendrobatidis	LDO
PLAF7\|EnsemblGenome=PF3D7_1356300\|UniProtKB=Q8IDD9	Plasmodium falciparum	LDO
PARTE\|EnsemblGenome=GSPATT00000305001\|UniProtKB=Q6BG08	Paramecium tetraurelia	LDO
PARTE\|EnsemblGenome=GSPATT00022887001\|UniProtKB=A0E347	Paramecium tetraurelia	LDO
PARTE\|EnsemblGenome=GSPATT00003626001\|UniProtKB=A0E646	Paramecium tetraurelia	LDO
PARTE\|EnsemblGenome=GSPATT00020981001\|UniProtKB=A0DWC2	Paramecium tetraurelia	LDO
THAPS\|EnsemblGenome=THAPS_10985\|UniProtKB=B5YM29	Thalassiosira pseudonana	LDO
CHLRE\|EnsemblGenome=CHLRE_01g046850v5\|UniProtKB=A0A2K3E7S5	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00016p00186510\|UniProtKB=W1PGM7	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_27G00420\|UniProtKB=A0A0K9PFJ7	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma08_g00590\|UniProtKB=A0A804K1E3	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma02_g02090\|UniProtKB=A0A804HYD0	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_004105mg\|UniProtKB=K3XQC2	Setaria italica	O
SETIT\|EnsemblGenome=SETIT_002998mg\|UniProtKB=K3XM75	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3003G410200\|UniProtKB=C5XGY6	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb363890\|UniProtKB=A0A1D6G555	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os01g0925800\|UniProtKB=Q8S1Y5	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_2g59350v3\|UniProtKB=I1HUS1	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0311810\|UniProtKB=A0A287ME54	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS3A02G439400\|UniProtKB=A0A3B6EQ39	Triticum aestivum	LDO
WHEAT\|EnsemblGenome=TraesCS3D02G432200\|UniProtKB=A0A3B6H0V6	Triticum aestivum	LDO
WHEAT\|EnsemblGenome=TraesCS3B02G473300\|UniProtKB=W5D2H3	Triticum aestivum	LDO
NELNU\|Gene=LOC104592793\|UniProtKB=A0A1U7ZGJ0	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110786022\|UniProtKB=A0A9R0IBJ8	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr08g0320281\|UniProtKB=A0A251U1M7	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr06g0254211\|UniProtKB=A0A251UIS0	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr16g0724151\|UniProtKB=A0A251RWW0	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr09g0412631\|UniProtKB=A0A251U0E9	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C400189980\|UniProtKB=A0A9R1VV91	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a014267mg\|UniProtKB=A0A022QYC5	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_17913\|UniProtKB=A0A1U8H457	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400027041\|UniProtKB=Q2V986	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc06g072570.3\|UniProtKB=A0A3Q7H275	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107810677\|UniProtKB=A0A1S4BPZ4	Nicotiana tabacum	O
TOBAC\|Gene=LOC107794380\|UniProtKB=A0A1S4A703	Nicotiana tabacum	O
TOBAC\|Gene=LOC107803861\|UniProtKB=W0KML3	Nicotiana tabacum	LDO
VITVI\|EnsemblGenome=Vitvi17g00056\|UniProtKB=F6GT08	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_K02668\|UniProtKB=A0A059A5G9	Eucalyptus grandis	LDO
BRANA\|Gene_ORFName=DARMORV10_C03P19460.1\|UniProtKB=A0A078I6Q2	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra022755\|UniProtKB=M4E1V5	Brassica campestris	LDO
ARATH\|TAIR=locus=2157428\|UniProtKB=Q9FI61	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107923158\|UniProtKB=A0A1U8L2F8	Gossypium hirsutum	O
GOSHI\|Gene=LOC107946874\|UniProtKB=A0A1U8NCW2	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_014720\|UniProtKB=A0A061FYJ2	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g029412mg\|UniProtKB=A0A067E0V4	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_012G104100v3\|UniProtKB=B9I3X3	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_015G103400v3\|UniProtKB=A9P939	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_06G124300\|UniProtKB=A0A2C9VQD2	Manihot esculenta	O
MANES\|EnsemblGenome=MANES_14G047100\|UniProtKB=A0A2C9UJU0	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_1504700\|UniProtKB=B9RA92	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_04G199200\|UniProtKB=A0A0R4J375	Glycine max	LDO
SOYBN\|EnsemblGenome=GLYMA_06G166300\|UniProtKB=A0A0R0JMD5	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_3g098780\|UniProtKB=G7J3B4	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr09_00290\|UniProtKB=A0A2I4DUZ5	Juglans regia	O
JUGRE\|EnsemblGenome=Jr02_00360\|UniProtKB=A0A2I4FJC9	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_1G000740\|UniProtKB=A0A0A0LTY2	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_5G145200\|UniProtKB=A0A251P8H5	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_95808\|UniProtKB=D8RKQ5	Selaginella moellendorffii	LDO
SELML\|EnsemblGenome=SELMODRAFT_186167\|UniProtKB=D8T7K5	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c24_12210\|UniProtKB=A0A2K1IGH0	Physcomitrella patens	LDO