PANTHER Gene Information   
Gene Symbol(s): p38a
Organism: Drosophila melanogaster
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Gene Name: Mitogen-activated protein kinase p38a
Gene ID: FBgn0015765
Protein ID: O62618
Persistent Id: PTN000622506
Alternate Ids:
MAP kinase 14A {ECO:0000312|FlyBase:FBgn0015765}(Synonym) FBpp0289799(Ensembl_PRO)
Q9TXB4(AltAccession) MK38A_DROME(UniProtKB-ID)
42866(GeneID) AF035547(EMBL)
FBgn0015765(FlyBase) AAB97138(EMBL-CDS)
p38a{ECO:0000303|PubMed:9584193,ECO:0000312|FlyBase:FBgn0015765}(Symbol) FBtr0084580(Ensembl_TRS)
NP_732959(refSeq) 24649559(GI)
FBgn0015765(Ensembl) 2.7.11.24(EC)
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PANTHER Classification
PANTHER Family: MITOGEN-ACTIVATED PROTEIN KINASE (PTHR24055)
PANTHER Subfamily: MITOGEN-ACTIVATED PROTEIN KINASE P38A-RELATED (PTHR24055:SF158)  
PANTHER GO-slim Molecular Function: protein serine/threonine kinase activity
PANTHER GO-slim Biological Process: intracellular signal transduction
PANTHER GO-slim Cellular Component: cytoplasm
nucleus
PANTHER protein class: non-receptor serine/threonine protein kinase
Pathway Categories: Parkinson disease
   p38 mitogen activated protein kinase
FGF signaling pathway
   p38 mitogen activated protein kinase
Ras Pathway
   p38 mitogen activated protein kinase
Interferon-gamma signaling pathway
   Serine kinase
p53 pathway feedback loops 2
   p38 mitogen activated protein kinase
EGF receptor signaling pathway
   p38 mitogen activated protein kinase
Oxidative stress response
   p38 mitogen activated protein kinase
Parkinson disease
   Stress-activated protein kinase
TGF-beta signaling pathway
   p38 mitogen activated protein kinase
Alzheimer disease-amyloid secretase pathway
   Mitogen activated protein kinase
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: ATP binding, MAP kinase activity, protein serine/threonine kinase activity
GO BP Complete: p38MAPK cascade, determination of adult lifespan, paracrine signaling, response to osmotic stress, response to starvation, response to hydrogen peroxide, mucosal immune response, protein phosphorylation, defense response to bacterium, negative regulation of antimicrobial humoral response, regulation of cellular response to oxidative stress, MAPK cascade, response to oxidative stress, heart morphogenesis, response to heat, immune response, positive regulation of cell size, cellular response to arsenic-containing substance, cellular response to cadmium ion, defense response to fungus, cellular response to reactive oxygen species, intracellular signal transduction, regulation of adult chitin-containing cuticle pigmentation
GO CC Complete: nucleus, cytoplasm
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Cellular Senescence, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, VEGFA-VEGFR2 Pathway, Signaling by VEGF, Toll Like Receptor 3 (TLR3) Cascade, MAPK family signaling cascades, Oxidative Stress Induced Senescence, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by Interleukins, Platelet activation, signaling and aggregation, MAP kinase activation, Platelet sensitization by LDL, Hemostasis, RAF/MAP kinase cascade, Signalling to ERKs, Cellular responses to stimuli, Negative regulation of MAPK pathway, Innate Immune System, MAPK1/MAPK3 signaling, Nuclear Events (kinase and transcription factor activation), Signalling to RAS, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 9 (TLR9) Cascade, DSCAM interactions, Interleukin-17 signaling, Toll Like Receptor TLR1:TLR2 Cascade, Immune System, Developmental Biology, activated TAK1 mediates p38 MAPK activation, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, Activation of the AP-1 family of transcription factors, Signaling by NTRK1 (TRKA), Toll-like Receptor Cascades, Toll Like Receptor TLR6:TLR2 Cascade, Platelet homeostasis, Toll Like Receptor 10 (TLR10) Cascade, Signaling by NTRKs, Cellular responses to stress, MyD88-independent TLR4 cascade , ERK/MAPK targets, Toll Like Receptor 7/8 (TLR7/8) Cascade, Netrin-1 signaling, ADP signalling through P2Y purinoceptor 1, TRIF(TICAM1)-mediated TLR4 signaling , Myogenesis, Signal amplification, MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Axon guidance, Nervous system development, p38MAPK events, Cytokine Signaling in Immune system, MAPK targets/ Nuclear events mediated by MAP kinases, NOD1/2 Signaling Pathway, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, Toll Like Receptor 4 (TLR4) Cascade, Neutrophil degranulation, Toll Like Receptor 2 (TLR2) Cascade

Orthologs