PANTHER Gene Information

Gene Symbol(s):

Phlpp

Organism:

Drosophila melanogaster

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Gene Name:

Protein phosphatase PHLPP-like protein

Gene ID:

FBgn0032749

Protein ID:

Q9VJ07

Persistent Id:

PTN002391894

Alternate Ids:

FBgn0032749(Ensembl)	24585117(GI)
FBtr0336844(Ensembl_TRS)	AAF53751(EMBL-CDS)
Phlpp(Symbol)	AE014134(EMBL)
FBpp0307805(Ensembl_PRO)	dPHLPP(Synonym)
3.1.3.16(EC)	NP_001260558(refSeq)
35178(GeneID)	PHLPP_DROME(UniProtKB-ID)
FBgn0032749(FlyBase)
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PANTHER Classification

PANTHER Family:	LEUCINE-RICH REPEAT-CONTAINING (PTHR45752)
PANTHER Subfamily:	LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 4 (PTHR45752:SF187)
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:
PANTHER protein class:	scaffold/adaptor protein

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	protein serine/threonine phosphatase activity, protein binding
GO BP Complete:	protein dephosphorylation, regulation of apoptotic process, intracellular signal transduction
GO CC Complete:	-

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Negative regulation of the PI3K/AKT network, TP53 Regulates Transcription of Caspase Activators and Caspases, Generic Transcription Pathway, Signal Transduction, Transcriptional Regulation by TP53, Intracellular signaling by second messengers, RNA Polymerase II Transcription, Gene expression (Transcription), PIP3 activates AKT signaling, TP53 Regulates Transcription of Cell Death Genes

Orthologs

ID	Organism	Type
MOUSE\|MGI=MGI=1915557\|UniProtKB=A6H6A4	Mus musculus	LDO
RAT\|RGD=2323202\|UniProtKB=F1M0Y2	Rattus norvegicus	LDO
FELCA\|Ensembl=ENSFCAG00000004402.6\|UniProtKB=M3W242	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845021060.1\|UniProtKB=A0A8I3PLV8	Canis lupus familiaris	LDO
ORNAN\|Ensembl=ENSOANG00000022336.3\|UniProtKB=F6TD55	Ornithorhynchus anatinus	LDO
LEPOC\|Ensembl=ENSLOCG00000007153.1\|UniProtKB=W5MJU9	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000012555.2\|UniProtKB=F7AAW0	Ciona intestinalis	LDO
PANTR\|Ensembl=ENSPTRG00000051323.1\|UniProtKB=H2RFM8	Pan troglodytes	O
MOUSE\|MGI=MGI=3045299\|UniProtKB=Q8C0R9	Mus musculus	O
RAT\|RGD=1562785\|UniProtKB=D4AD14	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000001571.6\|UniProtKB=E1BPT0	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000029092.4\|UniProtKB=A0A287A597	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000014527.4\|UniProtKB=F7C2M4	Equus caballus	O
MONDO\|Ensembl=ENSMODG00000007537.3\|UniProtKB=A0A5F8GRB1	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000010621.3\|UniProtKB=F7DPB1	Monodelphis domestica	O
HUMAN\|HGNC=16982\|UniProtKB=Q9Y4C4	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000019969.6\|UniProtKB=K7CSF7	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000002862.3\|UniProtKB=G3QK50	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000016708.4\|UniProtKB=F6VEH3	Macaca mulatta	O
MOUSE\|MGI=MGI=1098644\|UniProtKB=Q3V1N1	Mus musculus	O
RAT\|RGD=1308812\|UniProtKB=A0A8I5ZRZ8	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000015913.6\|UniProtKB=A0A3Q1MVM6	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000035366.3\|UniProtKB=A0A287AK26	Sus scrofa	O
CANLF\|Ensembl=ENSCAFG00845013064.1\|UniProtKB=A0A8I3NEN2	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000019027.4\|UniProtKB=F7BLK0	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000037192.1\|UniProtKB=A0A6I8MYR2	Ornithorhynchus anatinus	O
ORYLA\|Ensembl=ENSORLG00000022182.1\|UniProtKB=A0A3B3H658	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-080917-20\|UniProtKB=F1QVP4	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000012154.1\|UniProtKB=W5N2T9	lepisosteus oculatus	O
TRICA\|EnsemblGenome=TC030752\|UniProtKB=D6WLS2	Tribolium castaneum	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g247673\|UniProtKB=A7SVP7	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG51723\|UniProtKB=B3RKQ5	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_33530\|UniProtKB=A9V5X2	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_32857\|UniProtKB=A9V242	Monosiga brevicollis	LDO
EREGS\|EnsemblGenome=AGOS_AAL162C\|UniProtKB=Q75F93	Eremothecium gossypii	LDO
PUCGT\|EnsemblGenome=PGTG_00032\|UniProtKB=E3JPZ3	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_12331\|UniProtKB=F4P668	Batrachochytrium dendrobatidis	LDO
ENTH1\|EnsemblGenome=EHI_081720\|UniProtKB=C4M699	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_087420\|UniProtKB=C4LXT5	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_024640\|UniProtKB=C4M0K6	Entamoeba histolytica	LDO
DICDI\|dictyBase=DDB_G0294094\|UniProtKB=Q54AX5	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_36946\|UniProtKB=F0ZRY2	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_160203\|UniProtKB=F1A5X2	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_34_0640\|UniProtKB=Q4Q3E3	Leishmania major	LDO
TRIV3\|Gene_ORFName=TVAG_093970\|UniProtKB=A2DBL9	Trichomonas vaginalis	LDO
TRIV3\|Gene_ORFName=TVAG_093780\|UniProtKB=A2DBK1	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_201970\|UniProtKB=A2DWL8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_442260\|UniProtKB=A2F1W9	Trichomonas vaginalis	LDO
TRIV3\|Gene_ORFName=TVAG_028660\|UniProtKB=A2E0B3	Trichomonas vaginalis	O
PARTE\|EnsemblGenome=GSPATT00037265001\|UniProtKB=A0CCG3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00015320001\|UniProtKB=A0DBK7	Paramecium tetraurelia	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_1268\|UniProtKB=B8BQF6	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_7450\|UniProtKB=B8C6J7	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3H5A3_PHYRM\|UniProtKB=H3H5A3	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_02g115508v5\|UniProtKB=A0A2K3E396	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_10g466150v5\|UniProtKB=A0A2K3DCA3	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_06g248900v5\|UniProtKB=A0A2K3DLT6	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_02g107700v5\|UniProtKB=A0A2K3E2R0	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_03g205697v5\|UniProtKB=A0A2K3DZT4	Chlamydomonas reinhardtii	LDO
CHLRE\|EnsemblGenome=CHLRE_06g311750v5\|UniProtKB=A0A2K3DRQ9	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_02g093850v5\|UniProtKB=A0A2K3E1G8	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_16g685600v5\|UniProtKB=A0A2K3CUR7	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_17g697000v5\|UniProtKB=A0A2K3CNM6	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_16g684800v5\|UniProtKB=A0A2K3CUT1	Chlamydomonas reinhardtii	O
AMBTC\|EnsemblGenome=AMTR_s00110p00083560\|UniProtKB=W1NYZ9	Amborella trichopoda	LDO
MUSAM\|EnsemblGenome=Ma05_g07170\|UniProtKB=A0A804J1V4	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_036233mg\|UniProtKB=K4ABH6	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3001G231500\|UniProtKB=C5WZI5	Sorghum bicolor	O
ORYSJ\|Gene_OrderedLocusName=LOC_Os10g31790\|UniProtKB=Q7XDQ7	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_3g27860v3\|UniProtKB=I1I4E3	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.1HG0039370\|UniProtKB=F2DS26	Hordeum vulgare subsp. vulgare	O
NELNU\|Gene=LOC104597302\|UniProtKB=A0A1U8A5I9	Nelumbo nucifera	O
HELAN\|EnsemblGenome=HanXRQr2_Chr07g0287421\|UniProtKB=A0A251ULE9	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C800434480\|UniProtKB=A0A9R1UTX5	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a010971mg\|UniProtKB=A0A022S0Y7	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_16035\|UniProtKB=A0A2G2Z7J9	Capsicum annuum	O
CAPAN\|EnsemblGenome=T459_16043\|UniProtKB=A0A2G2Z7W0	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400020546\|UniProtKB=M1BU62	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc06g007250.3\|UniProtKB=A0A3Q7GQS4	Solanum lycopersicum	O
TOBAC\|Gene=LOC107829767\|UniProtKB=A0A1S4DH76	Nicotiana tabacum	O
TOBAC\|Gene=LOC107793856\|UniProtKB=A0A1S4A542	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi06g00691\|UniProtKB=D7SJT3	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_B02227\|UniProtKB=A0A059D5C7	Eucalyptus grandis	O
BRANA\|Gene_ORFName=DARMORV10_A04P22790.1\|UniProtKB=A0A078GYN4	Brassica napus	O
BRACM\|EnsemblGenome=Bra021606\|UniProtKB=M4DYL0	Brassica campestris	O
ARATH\|TAIR=locus=6530298186\|UniProtKB=P0C895	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107927102\|UniProtKB=A0A1U8LG10	Gossypium hirsutum	O
GOSHI\|Gene=LOC107887517\|UniProtKB=A0A1U8HMJ7	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_042197\|UniProtKB=A0A061GYH6	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g017986mg\|UniProtKB=A0A067FU48	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_001G280500v3\|UniProtKB=B9GGR4	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_18G144200\|UniProtKB=A0A2C9U535	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_1093190\|UniProtKB=B9SKU7	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_11G166200\|UniProtKB=A0A0R0HI53	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_18G059000\|UniProtKB=K7MQ74	Glycine max	O
MEDTR\|EnsemblGenome=MTR_3g465570\|UniProtKB=A0A072UX66	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr14_08540\|UniProtKB=A0A2I4FA20	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_6G181600\|UniProtKB=A0A0A0KBL0	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_6G052000\|UniProtKB=M5WBC5	Prunus persica	O
ZOSMR\|Gene_ORFName=ZOSMA_19G00560\|UniProtKB=A0A0K9PNC6	Zostera marina	LDO
SETIT\|EnsemblGenome=SETIT_009199mg\|UniProtKB=K3Y4R1	Setaria italica	O
SETIT\|EnsemblGenome=SETIT_012295mg\|UniProtKB=K3YDJ0	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3007G071950\|UniProtKB=A0A1Z5R9D1	Sorghum bicolor	O
SETIT\|EnsemblGenome=SETIT_037087mg\|UniProtKB=K4ADY0	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3001G459500\|UniProtKB=C5WTM6	Sorghum bicolor	LDO
ORYSJ\|EnsemblGenome=Os03g0212200\|UniProtKB=B9F655	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_1g70250v3\|UniProtKB=A0A0Q3HJ89	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.4HG0397280\|UniProtKB=F2DGA5	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS4A02G055400\|UniProtKB=A0A3B6HNG8	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1A02G350800\|UniProtKB=A0A3B5Y4Q4	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS4B02G249200\|UniProtKB=A0A3B6IVK6	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1B02G365000\|UniProtKB=A0A3B5Z280	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1D02G353700\|UniProtKB=A0A3B5ZZS2	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS4D02G249500\|UniProtKB=A0A3B6JKA7	Triticum aestivum	LDO
NELNU\|Gene=LOC104597983\|UniProtKB=A0A1U8A985	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110789868\|UniProtKB=A0A9R0IJ45	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr02g0061941\|UniProtKB=A0A251VEV4	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C100006320\|UniProtKB=A0A9R1WJ53	Lactuca sativa	O
HELAN\|EnsemblGenome=HanXRQr2_Chr01g0006121\|UniProtKB=A0A251VKC4	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr09g0408441\|UniProtKB=A0A251SG90	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C400200690\|UniProtKB=A0A9R1VWE9	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a012122mg\|UniProtKB=A0A022PSK7	Erythranthe guttata	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a018225mg\|UniProtKB=A0A022QM55	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_10374\|UniProtKB=A0A1U8FVZ3	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG401024548\|UniProtKB=M1CA27	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc03g115410.3\|UniProtKB=A0A3Q7FS08	Solanum lycopersicum	O
TOBAC\|Gene=LOC107808836\|UniProtKB=A0A1S4BJ26	Nicotiana tabacum	O
TOBAC\|Gene=LOC107806366\|UniProtKB=A0A1S4BB02	Nicotiana tabacum	O
CAPAN\|EnsemblGenome=T459_23713\|UniProtKB=A0A2G2YT36	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400005395\|UniProtKB=M1A3C3	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc12g040320.2\|UniProtKB=A0A3Q7J8T8	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107781648\|UniProtKB=A0A1S3Z0F9	Nicotiana tabacum	O
TOBAC\|Gene=LOC107815989\|UniProtKB=A0A1S4C7L3	Nicotiana tabacum	LDO
VITVI\|EnsemblGenome=Vitvi18g02375\|UniProtKB=F6GW07	Vitis vinifera	O
VITVI\|EnsemblGenome=Vitvi17g00680\|UniProtKB=D7SI42	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_K02503\|UniProtKB=A0A059A5D2	Eucalyptus grandis	LDO
BRANA\|Gene_ORFName=DARMORV10_C02P03310.1\|UniProtKB=A0A078FMD9	Brassica napus	O
BRANA\|Gene_ORFName=GSBRNA2T00071671001\|UniProtKB=A0A078HQ96	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra005960\|UniProtKB=M4CP22	Brassica campestris	O
BRACM\|EnsemblGenome=Bra028680\|UniProtKB=M4EIR5	Brassica campestris	LDO
ARATH\|TAIR=locus=2142773\|UniProtKB=Q8RWI2	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107951243\|UniProtKB=A0A1U8NUN9	Gossypium hirsutum	O
GOSHI\|Gene=LOC107931496\|UniProtKB=A0A1U8M034	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_014164\|UniProtKB=A0A061FWT2	Theobroma cacao	LDO
POPTR\|EnsemblGenome=POPTR_015G048800v3\|UniProtKB=B9IE13	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_06G087000\|UniProtKB=A0A2C9VP61	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_1470450\|UniProtKB=B9RLR8	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_04G164100\|UniProtKB=I1JWQ3	Glycine max	LDO
SOYBN\|EnsemblGenome=GLYMA_06G201600\|UniProtKB=I1KCZ0	Glycine max	LDO
JUGRE\|EnsemblGenome=Jr02_06530\|UniProtKB=A0A2I4EML2	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_1G012140\|UniProtKB=A0A0A0LPH7	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_5G201600\|UniProtKB=A0A251PB47	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_83151\|UniProtKB=D8R217	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_420321\|UniProtKB=D8SBM1	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_438024\|UniProtKB=D8QST9	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c6_19101\|UniProtKB=A0A2K1KG99	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c15_14980\|UniProtKB=A0A2K1JD88	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c19_5770\|UniProtKB=A9TS86	Physcomitrella patens	LDO
KLENI\|Gene_ORFName=KFL_001760070\|UniProtKB=A0A1Y1I7L7	Klebsormidium nitens	LDO