PANTHER Gene Information

Gene Symbol(s):

DmelCG8199

Organism:

Drosophila melanogaster

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Gene Name:

2-oxoisovalerate dehydrogenase subunit alpha

Gene ID:

FBgn0037709

Protein ID:

Q9VHB8

Persistent Id:

PTN000162319

Alternate Ids:

FBgn0037709(Ensembl)	21355903(GI)
AE014297(EMBL)	AAK92966(EMBL-CDS)
FBtr0082067(Ensembl_TRS)	Q9VHB8(Synonym)
FBgn0037709(FlyBase)	FBpp0081545(Ensembl_PRO)
Q9VHB8_DROME(UniProtKB-ID)	41149(GeneID)
NP_649905(refSeq)
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PANTHER Classification

PANTHER Family:	2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL (PTHR43380)
PANTHER Subfamily:	2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL (PTHR43380:SF1)
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:	amino acid catabolic process branched-chain amino acid metabolic process
PANTHER GO-slim Cellular Component:
PANTHER protein class:	dehydrogenase

Pathway Categories:

Pyruvate metabolism

Pyruvate Dehydrogenase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, branched-chain alpha-keto acid dehydrogenase activity
GO BP Complete:	branched-chain amino acid catabolic process
GO CC Complete:	oxoglutarate dehydrogenase complex, branched-chain alpha-ketoacid dehydrogenase complex

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Metabolism, Branched-chain amino acid catabolism, Glyoxylate metabolism and glycine degradation, Metabolism of amino acids and derivatives

Orthologs

ID	Organism	Type
HUMAN\|HGNC=986\|UniProtKB=P12694	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000011025.6\|UniProtKB=H2QGE1	Pan troglodytes	O
PANTR\|Gene=BCKDHA\|UniProtKB=A5A6H9	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000013033.3\|UniProtKB=A0A2I2Z3I0	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000014346.4\|UniProtKB=H9YW21	Macaca mulatta	LDO
MOUSE\|MGI=MGI=107701\|UniProtKB=P50136	Mus musculus	LDO
RAT\|RGD=2196\|UniProtKB=P11960	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000016037.6\|UniProtKB=F1N5F2	Bos taurus	O
BOVIN\|Gene=BCKDHA\|UniProtKB=P11178	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000028794.4\|UniProtKB=F1RHA0	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000012246.4\|UniProtKB=F6REC8	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000005438.5\|UniProtKB=M3W423	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845002258.1\|UniProtKB=A0A8I3MNY7	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000008538.4\|UniProtKB=F7DH17	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000008790.4\|UniProtKB=F7G384	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010008284.1\|UniProtKB=A0A8V0XT23	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000003703.3\|UniProtKB=A0A803SVL6	Anolis carolinensis	LDO
XENLA\|Gene=bckdha.L\|UniProtKB=A0A1L8F8Z5	Xenopus laevis	LDO
XENLA\|Gene=bckdha.S\|UniProtKB=A0A8J0TR14	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-1007472\|UniProtKB=A0A8J0SRZ7	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000002156.2\|UniProtKB=H2L9X9	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-050522-376\|UniProtKB=Q4VBU0	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000014217.1\|UniProtKB=W5NA50	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000008058.3\|UniProtKB=F7BCV4	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118420682\|UniProtKB=A0A9J7LJ67	Branchiostoma floridae	O
BRAFL\|Gene=LOC118413846\|UniProtKB=A0A9J7L174	Branchiostoma floridae	O
BRAFL\|Gene=LOC118409090\|UniProtKB=A0A9J7HUL5	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC583728\|UniProtKB=A0A7M7T580	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00012713\|UniProtKB=O45924	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG00460\|UniProtKB=H8WGW8	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00035912\|UniProtKB=A8XMR6	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00107454\|UniProtKB=A0A2A6C9L1	Pristionchus pacificus	LDO
ANOGA\|EnsemblGenome=AGAP003136\|UniProtKB=Q7PQR1	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC004386\|UniProtKB=D6X542	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_301077\|UniProtKB=E9G7A7	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW018615\|UniProtKB=B7PL04	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW018614\|UniProtKB=B7PL03	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG187239\|UniProtKB=T1FP82	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g183894\|UniProtKB=A7RZV6	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG63370\|UniProtKB=B3S5B4	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_38974\|UniProtKB=A9VBA8	Monosiga brevicollis	LDO
YARLI\|EnsemblGenome=YALI0_D08690g\|UniProtKB=Q6C9S7	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_01726\|UniProtKB=Q5BCK4	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_6G08830\|UniProtKB=Q4WMT0	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU09864\|UniProtKB=Q7S5Z0	Neurospora crassa	LDO
SCLS1\|EnsemblGenome=SS1G_02218\|UniProtKB=A7EA86	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_06188\|UniProtKB=Q0UPX6	Phaeosphaeria nodorum	LDO
CRYNJ\|EnsemblGenome=CNE02620\|UniProtKB=Q5KGR5	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_10735\|UniProtKB=A0A0D1CIW9	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_08556\|UniProtKB=E3KGE5	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_9167\|UniProtKB=F4NVJ5	Batrachochytrium dendrobatidis	LDO
DICDI\|dictyBase=DDB_G0286335\|UniProtKB=Q54M22	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_49625\|UniProtKB=F0ZUJ1	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_21_1430\|UniProtKB=Q4QC52	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb10.70.7550\|UniProtKB=Q38CH4	Trypanosoma brucei	LDO
PLAF7\|EnsemblGenome=PF3D7_1312600\|UniProtKB=Q8IEJ6	Plasmodium falciparum	LDO
PARTE\|EnsemblGenome=GSPATT00031734001\|UniProtKB=A0BSI5	Paramecium tetraurelia	LDO
PARTE\|EnsemblGenome=GSPATT00014995001\|UniProtKB=A0DAM1	Paramecium tetraurelia	O
THAPS\|EnsemblGenome=THAPSDRAFT_795\|UniProtKB=B8CEA6	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3G9H1_PHYRM\|UniProtKB=H3G9H1	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_12g539900v5\|UniProtKB=A0A2K3D6Z2	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00017p00255800\|UniProtKB=W1PFP5	Amborella trichopoda	LDO
MUSAM\|EnsemblGenome=Ma03_g19820\|UniProtKB=A0A804IE27	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_009977mg\|UniProtKB=K3Y6Y6	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3008G062200\|UniProtKB=A0A1B6PCB8	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb409040\|UniProtKB=B4F923	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os12g0183100\|UniProtKB=Q2QWT8	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_4g40870v3\|UniProtKB=I1ITU2	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.5HG0453670\|UniProtKB=A0A8I6XM96	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS4B02G071500\|UniProtKB=A0A3B6IM92	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS5A02G120000\|UniProtKB=A0A3B6KF66	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS5D02G126700\|UniProtKB=A0A3B6MM57	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS5B02G121400\|UniProtKB=A0A3B6LIT7	Triticum aestivum	LDO
NELNU\|Gene=LOC104606714\|UniProtKB=A0A1U8AR52	Nelumbo nucifera	O
NELNU\|Gene=LOC104599555\|UniProtKB=A0A1U8Q4E7	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110782031\|UniProtKB=A0A9R0I376	Spinacia oleracea	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a005821mg\|UniProtKB=A0A022QUX4	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_12242\|UniProtKB=A0A1U8GLM7	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400024860\|UniProtKB=M1CBI2	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc04g063350.3\|UniProtKB=A0A3Q7G6H2	Solanum lycopersicum	O
TOBAC\|Gene=LOC107786009\|UniProtKB=A0A1S3ZEQ7	Nicotiana tabacum	O
TOBAC\|Gene=LOC107805669\|UniProtKB=A0A1S4B8Q2	Nicotiana tabacum	O
CAPAN\|EnsemblGenome=T459_16819\|UniProtKB=A0A2G2Z9T2	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400013029\|UniProtKB=M1AZW6	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc06g059840.3\|UniProtKB=A0A3Q7HQ59	Solanum lycopersicum	O
TOBAC\|Gene=LOC107819511\|UniProtKB=A0A1S4CIW1	Nicotiana tabacum	O
TOBAC\|Gene=LOC107793791\|UniProtKB=A0A1S4A566	Nicotiana tabacum	O
CAPAN\|EnsemblGenome=T459_16820\|UniProtKB=A0A2G2Z9U7	Capsicum annuum	LDO
SOLLC\|EnsemblGenome=Solyc06g059850.2\|UniProtKB=A0A3Q7GX16	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107769784\|UniProtKB=A0A1S3XX57	Nicotiana tabacum	LDO
TOBAC\|Gene=LOC107768963\|UniProtKB=A0A1S3XUK4	Nicotiana tabacum	LDO
VITVI\|EnsemblGenome=Vitvi18g01174\|UniProtKB=E0CQJ8	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_F02765\|UniProtKB=A0A059BT26	Eucalyptus grandis	LDO
BRANA\|Gene_ORFName=DARMORV10_C05P20280.1\|UniProtKB=A0A078JJI9	Brassica napus	O
BRANA\|Gene_ORFName=DARMORV10_A06P17460.1\|UniProtKB=A0A078IK13	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra016423\|UniProtKB=A0A397YIF0	Brassica campestris	O
BRACM\|EnsemblGenome=Bra017912\|UniProtKB=M4DN25	Brassica campestris	LDO
ARATH\|TAIR=locus=2027072\|UniProtKB=Q9LPL5	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107951462\|UniProtKB=A0A1U8NSQ6	Gossypium hirsutum	O
GOSHI\|Gene=LOC107910399\|UniProtKB=A0A1U8JY88	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_035302\|UniProtKB=A0A061FHF3	Theobroma cacao	O
GOSHI\|Gene=LOC107914135\|UniProtKB=A0A1U8KBS2	Gossypium hirsutum	O
GOSHI\|Gene=LOC107957713\|UniProtKB=A0A1U8PC54	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_035303\|UniProtKB=A0A061FII1	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g011937mg\|UniProtKB=A0A067H721	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_002G074900v3\|UniProtKB=B9GTQ0	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_005G185400v3\|UniProtKB=B9H7L5	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_02G172400\|UniProtKB=A0A2C9WHE2	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_0559760\|UniProtKB=B9S2P3	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_04G243000\|UniProtKB=I1JYZ2	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_06G120300\|UniProtKB=I1KAH2	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_8g075470\|UniProtKB=G7LC20	Medicago truncatula	O
MEDTR\|EnsemblGenome=MTR_3g088845\|UniProtKB=A0A072V066	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr06_02700\|UniProtKB=A0A2I4DLM7	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_6G395130\|UniProtKB=A0A0A0KIX5	Cucumis sativus	LDO
SPIOL\|Gene=LOC110800751\|UniProtKB=A0A9R0K8X4	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr05g0235171\|UniProtKB=A0A251UTC6	Helianthus annuus	O
HELAN\|Gene_ORFName=HannXRQ_Chr08g0232391\|UniProtKB=A0A251U7H9	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr05g0235181\|UniProtKB=A0A251UUR3	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr01g0028591\|UniProtKB=A0A251VPR3	Helianthus annuus	O
HELAN\|Gene_ORFName=HanXRQr2_Chr08g0349561\|UniProtKB=A0A9K3IGD8	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr01g0028641\|UniProtKB=A0A251VQX2	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C100004530\|UniProtKB=A0A9R1WMM7	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a005724mg\|UniProtKB=A0A022Q4Y7	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_28991\|UniProtKB=A0A2G2Y480	Capsicum annuum	O
CAPAN\|EnsemblGenome=T459_28990\|UniProtKB=A0A2G2Y491	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG402023446\|UniProtKB=M1C5I5	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc05g056480.3\|UniProtKB=A0A3Q7GR48	Solanum lycopersicum	O
TOBAC\|Gene=LOC107771953\|UniProtKB=A0A1S3Y434	Nicotiana tabacum	O
TOBAC\|Gene=LOC107818320\|UniProtKB=A0A1S4CF75	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi04g01711\|UniProtKB=D7U4C7	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_I00194\|UniProtKB=A0A059ALC2	Eucalyptus grandis	O
BRACM\|EnsemblGenome=Bra006017\|UniProtKB=M4CP79	Brassica campestris	O
ARATH\|TAIR=locus=2184702\|UniProtKB=Q84JL2	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107959621\|UniProtKB=A0A1U8PJ32	Gossypium hirsutum	O
GOSHI\|Gene=LOC107935806\|UniProtKB=A0A1U8MAP7	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_001513\|UniProtKB=A0A061DIX9	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g016909mg\|UniProtKB=A0A067EIK1	Citrus sinensis	O
POPTR\|Gene_ORFName=POPTR_005G064000\|UniProtKB=A0A3N7EWG0	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_12G156700\|UniProtKB=A0A2C9UWZ6	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_1187670\|UniProtKB=B9RRD6	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_04G212100\|UniProtKB=K7KLG0	Glycine max	O
MEDTR\|EnsemblGenome=MTR_3g096390\|UniProtKB=G7JBL9	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr10_10450\|UniProtKB=A0A2I4GLG0	Juglans regia	O
JUGRE\|EnsemblGenome=Jr01_14210\|UniProtKB=A0A2I4F7E8	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_6G483270\|UniProtKB=A0A0A0KF52	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_4G272100\|UniProtKB=M5WVC4	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_150961\|UniProtKB=D8RY23	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_169956\|UniProtKB=D8RBK5	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c7_4810\|UniProtKB=A9TD44	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0006s0123\|UniProtKB=A0A2R6XPQ0	Marchantia polymorpha	O
MARPO\|EnsemblGenome=MARPO_0027s0073\|UniProtKB=A0A2R6XA23	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_004520050\|UniProtKB=A0A1Y1IKR8	Klebsormidium nitens	LDO