PANTHER Gene Information   
Gene Symbol(s): AGO2
Organism: Drosophila melanogaster
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Gene Name: Protein argonaute-2
Gene ID: FBgn0087035
Protein ID: Q9VUQ5
Persistent Id: PTN000527463
Alternate Ids:
DQ228766(EMBL) AAF49619(EMBL-CDS)
Q2Q3Y3(AltAccession) 23093414(GI)
FBgn0087035(FlyBase) 39683(GeneID)
FBgn0087035(Ensembl) AGO2_DROME(UniProtKB-ID)
AGO2(Synonym)
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PANTHER Classification
PANTHER Family: EUKARYOTIC TRANSLATION INITIATION FACTOR 2C (PTHR22891)
PANTHER Subfamily: PROTEIN ARGONAUTE-2 (PTHR22891:SF66)  
PANTHER GO-slim Molecular Function: RNA endonuclease activity
single-stranded RNA binding
PANTHER GO-slim Biological Process: regulatory ncRNA-mediated post-transcriptional gene silencing
PANTHER GO-slim Cellular Component: ribonucleoprotein complex
cytoplasmic ribonucleoprotein granule
nucleus
PANTHER protein class: translation initiation factor
Pathway Categories: No pathway information available
GO MF Complete: miRNA binding, RNA binding, protein binding, endoribonuclease activity, cleaving siRNA-paired mRNA, single-stranded RNA binding, siRNA binding, RNA endonuclease activity, producing 5'-phosphomonoesters, RNA endonuclease activity
GO BP Complete: siRNA-mediated heterochromatin formation, regulatory ncRNA-mediated post-transcriptional gene silencing, miRNA-mediated post-transcriptional gene silencing, syncytial nuclear migration, pole cell formation, segment polarity determination, dosage compensation by hyperactivation of X chromosome, cellularization, cellular response to virus, RNAi-mediated antiviral immunity against RNA virus, siRNA-mediated pericentric heterochromatin formation, RNAi-mediated antiviral immune response, defense response to virus, piRNA processing, siRNA processing, RISC complex assembly, negative regulation of viral genome replication, siRNA-mediated gene silencing by mRNA destabilization, piRNA-mediated gene silencing by mRNA destabilization
GO CC Complete: nucleus, cytoplasmic ribonucleoprotein granule, cytoplasm, cytosol, RISC-loading complex, neuronal ribonucleoprotein granule, RISC complex
Reactome Pathways: Post-transcriptional silencing by small RNAs, Transcriptional regulation by small RNAs, Small interfering RNA (siRNA) biogenesis, Gene expression (Transcription), Gene Silencing by RNA, MicroRNA (miRNA) biogenesis