PANTHER Gene Information   
Gene Symbol(s): wg
Organism: Drosophila melanogaster
View Gene in Tree
Tree Reduced Tree  
Tree Reduced Tree
Gene Name: Protein wingless
Gene ID: FBgn0284084
Protein ID: P09615
Persistent Id: PTN000246685
Alternate Ids:
WNTG_DROME(UniProtKB-ID) AY128458(EMBL)
455944(GI) Q8MQP9(AltAccession)
AAA28646(EMBL-CDS) FBgn0284084(Ensembl)
dWnt-1(Synonym) wg(Symbol)
34009(GeneID) FBgn0284084(FlyBase)
Show All

PANTHER Classification
PANTHER Family: WNT RELATED (PTHR12027)
PANTHER Subfamily: PROTO-ONCOGENE WNT-1 (PTHR12027:SF91)  
PANTHER GO-slim Molecular Function: cytokine activity
G protein-coupled receptor binding
PANTHER GO-slim Biological Process: cell fate commitment
canonical Wnt signaling pathway
neuron differentiation
PANTHER GO-slim Cellular Component: extracellular space
PANTHER protein class: intercellular signal molecule
Pathway Categories: Alzheimer disease-presenilin pathway
   Wingless-type MMTV integration site family member
Angiogenesis
   Wingless-type MMTV integration site family member
Cadherin signaling pathway
   Wingless-type MMTV integration site family member
Wnt signaling pathway
   Wingless-type MMTV integration site family member

GO MF Complete: extracellular matrix binding, frizzled binding, protein binding, glycosaminoglycan binding, heparan sulfate proteoglycan binding, cytokine activity, signaling receptor binding, morphogen activity
GO BP Complete: epithelial cell proliferation involved in Malpighian tubule morphogenesis, Malpighian tubule bud morphogenesis, larval lymph gland hemopoiesis, dorsal/ventral pattern formation, imaginal disc, cell elongation involved in imaginal disc-derived wing morphogenesis, mesoderm development, epidermis development, negative regulation of cell fate specification, positive regulation of programmed cell death, imaginal disc-derived wing margin morphogenesis, branching morphogenesis of an epithelial tube, synaptic assembly at neuromuscular junction, compound eye morphogenesis, follicle cell of egg chamber development, positive regulation of imaginal disc growth, Wnt signaling pathway, neuroblast development, pericardial nephrocyte differentiation, spiracle morphogenesis, open tracheal system, wing cell fate specification, neuron differentiation, synapse organization, epithelial cell type specification, open tracheal system, posterior Malpighian tubule development, negative regulation of hemocyte differentiation, proboscis development, ventral midline development, long-term memory, heart formation, positive regulation of stem cell proliferation, positive regulation of compound eye retinal cell programmed cell death, mesoderm morphogenesis, negative regulation of DNA endoreduplication, branch fusion, open tracheal system, genital disc anterior/posterior pattern formation, determination of genital disc primordium, dorsal closure, wing disc development, positive regulation of cell population proliferation, genital disc sexually dimorphic development, imaginal disc-derived wing morphogenesis, regulation of stem cell proliferation, ectoderm development, heart development, lymph gland development, labial disc development, canonical Wnt signaling pathway, chitin-based larval cuticle pattern formation, Malpighian tubule tip cell differentiation, segment polarity determination, imaginal disc development, histoblast morphogenesis, lymph gland crystal cell differentiation, digestive tract morphogenesis, hindgut morphogenesis, tissue regeneration, anterior/posterior pattern specification, imaginal disc, larval visceral muscle development, regulation of compound eye pigmentation, positive regulation of crystal cell differentiation, cell fate commitment, cardioblast differentiation
GO CC Complete: extracellular space, early endosome, terminal bouton, membrane raft, late endosome, endoplasmic reticulum, multivesicular body, extracellular region, plasma membrane, cell surface
Reactome Pathways: Signaling by WNT, TCF dependent signaling in response to WNT, PCP/CE pathway, WG ligand bound to FZ receptors, Signal Transduction, Wingless pathway, Assembly of receptor complex, WNT ligand biogenesis and trafficking, Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM, Disassembly of the destruction complex and recruitment of AXIN to the membrane, Phosphorylation of ARR, Drosophila signaling pathways, Beta-catenin independent WNT signaling