PANTHER Gene Information

Gene Symbol(s):

CRYAA

Organism:

Felis catus

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Tree

Gene Name:

Alpha-crystallin A chain

Gene ID:

ENSFCAG00000000224

Protein ID:

P68282

Persistent Id:

PTN001692902

Alternate Ids:

P02473(AltAccession)	CRYAA_FELCA(UniProtKB-ID)
410969863(GI)	XM_003991362(refSeq)
ENSFCAG00000000224(Ensembl)	CRYAA(Symbol)
ENSFCAT00000000224(Ensembl_TRS)	CRYAA(Synonym)
ENSFCAP00000000208(Ensembl_PRO)	101083874(GeneID)
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PANTHER Classification

PANTHER Family:	HEAT SHOCK PROTEIN HSP-12.2-RELATED (PTHR45640)
PANTHER Subfamily:	ALPHA-CRYSTALLIN A CHAIN (PTHR45640:SF14)
PANTHER GO-slim Molecular Function:	unfolded protein binding
PANTHER GO-slim Biological Process:	protein folding lens development in camera-type eye negative regulation of apoptotic process response to heat
PANTHER GO-slim Cellular Component:	nucleus cytoplasm
PANTHER protein class:	chaperone

Pathway Categories:

Angiogenesis

Heat-Shock Protein 27

VEGF signaling pathway

Heat-Shock Protein 27

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	identical protein binding, metal ion binding, structural molecule activity, unfolded protein binding, structural constituent of eye lens
GO BP Complete:	response to heat, negative regulation of apoptotic process, negative regulation of intracellular transport, lens development in camera-type eye, visual perception, protein refolding, protein stabilization
GO CC Complete:	nucleus, cytoplasm, cytosol, protein-containing complex, nucleoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=2388\|UniProtKB=P02489	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000013953.4\|UniProtKB=A0A2I3RKP9	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000010345.3\|UniProtKB=G3R496	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000020271\|UniProtKB=P02488	Macaca mulatta	LDO
MOUSE\|MGI=MGI=88515\|UniProtKB=P24622	Mus musculus	LDO
RAT\|RGD=2413\|UniProtKB=P24623	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000003134\|UniProtKB=P02470	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000038816\|UniProtKB=P02475	Sus scrofa	LDO
HORSE\|Gene=CRYAA\|UniProtKB=P02478	Equus caballus	LDO
CANLF\|Ensembl=ENSCAFG00000010584\|UniProtKB=P68280	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000021030.3\|UniProtKB=F6QYV3	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000006464.3\|UniProtKB=A0A6I8N4J0	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010011889.1\|UniProtKB=A0A8V0YJR9	Gallus gallus	LDO
CHICK\|Gene=CRYAA\|UniProtKB=P02504	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000017837.4\|UniProtKB=G1KUE8	Anolis carolinensis	LDO
XENLA\|Gene=LOC108707790\|UniProtKB=A0A8J0UD72	Xenopus laevis	O
XENLA\|Gene=cryaa.S\|UniProtKB=Q9W6T3	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-5940571\|UniProtKB=F7DB35	Xenopus tropicalis	LDO
ORYLA\|Gene=cryaa\|UniProtKB=O73919	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000020678.2\|UniProtKB=H2N2D4	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-020508-1\|UniProtKB=Q8UUZ6	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000001257.1\|UniProtKB=W5LZ71	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000024613.1\|UniProtKB=H2XSW8	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000019613.1\|UniProtKB=H2XKW8	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000000618.3\|UniProtKB=F6RRK4	Ciona intestinalis	O
BRAFL\|Gene_ORFName=BRAFLDRAFT_130907\|UniProtKB=C3XVH9	Branchiostoma floridae	O
BRAFL\|Gene_ORFName=BRAFLDRAFT_126126\|UniProtKB=C3Y475	Branchiostoma floridae	O
BRAFL\|Gene=LOC118409934\|UniProtKB=A0A9J7KNQ7	Branchiostoma floridae	O
BRAFL\|Gene_ORFName=BRAFLDRAFT_130908\|UniProtKB=C3XVI4	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC115924178\|UniProtKB=A0A7M7HD42	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC578820\|UniProtKB=A0A7M7HNT4	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00002023\|UniProtKB=Q17849	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG14817\|UniProtKB=A8XKR5	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00099140\|UniProtKB=A0A2A6CU40	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0031037\|UniProtKB=Q8IQW5	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP000941\|UniProtKB=F5HJ02	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC001152\|UniProtKB=D6WAG3	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_93031\|UniProtKB=E9GYA8	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_208978\|UniProtKB=E9G4S2	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW017709\|UniProtKB=B7PIN1	Ixodes scapularis	O
CAEEL\|WormBase=WBGene00002024\|UniProtKB=B0M0L8	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00027569\|UniProtKB=A8WYZ1	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00118281\|UniProtKB=A0A2A6CZW0	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00002012\|UniProtKB=Q20164	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00040365\|UniProtKB=A8Y0T6	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00011906\|UniProtKB=G5EE65	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00025335\|UniProtKB=G2J682	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00002013\|UniProtKB=G5EE36	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00040366\|UniProtKB=A8Y0T5	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00002011\|UniProtKB=P34328	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG16680\|UniProtKB=A8XPB0	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00092798\|UniProtKB=A0A2A6BDS7	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00099715\|UniProtKB=A0A454Y2J6	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00099747\|UniProtKB=A0A2A6B890	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00115342\|UniProtKB=A0A454XMT5	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00109633\|UniProtKB=A0A454Y2J4	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00273476\|UniProtKB=A0A2A6B9B6	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00280026\|UniProtKB=A0A2A6CK21	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00202553\|UniProtKB=A0A2A6CK15	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00278388\|UniProtKB=A0A2A6BIP9	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00008592\|UniProtKB=Q19228	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00002015\|UniProtKB=P34696	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00008591\|UniProtKB=Q19227	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00002016\|UniProtKB=P06582	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00027245\|UniProtKB=A8WY16	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00027233\|UniProtKB=A8WY04	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00027247\|UniProtKB=A8WY18	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00038447\|UniProtKB=A8XV09	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00038449\|UniProtKB=A8XV11	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00002021\|UniProtKB=Q20660	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00032413\|UniProtKB=A8XDE7	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00002018\|UniProtKB=P06581	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00002019\|UniProtKB=P02513	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG19187\|UniProtKB=A8XV12	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG04605\|UniProtKB=A8WY15	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00027246\|UniProtKB=A8WY17	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00027234\|UniProtKB=A8WY05	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00038448\|UniProtKB=A8XV10	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00004798\|UniProtKB=Q20363	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00037808\|UniProtKB=A8XSJ6	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00101796\|UniProtKB=A0A2A6CLS3	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00275012\|UniProtKB=A0A2A6BPU4	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00101797\|UniProtKB=A0A2A6CBU4	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00277138\|UniProtKB=A0A2A6CB04	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00277146\|UniProtKB=A0A2A6CB77	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00279705\|UniProtKB=A0A2A6CNX4	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00091037\|UniProtKB=A0A2A6BWN2	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00277142\|UniProtKB=A0A2A6CB26	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00014233\|UniProtKB=G5EF99	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG09876\|UniProtKB=A8X9V6	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00090334\|UniProtKB=A0A2A6BQP7	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00021943\|UniProtKB=A0A1I6CMC9	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG23899\|UniProtKB=A8WJJ4	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00202996\|UniProtKB=A0A2A6CMD9	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00103567\|UniProtKB=A0A2A6CRP1	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00305079\|UniProtKB=A0A8R1V3B6	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0001227\|UniProtKB=P05812	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0001225\|UniProtKB=P02517	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0001226\|UniProtKB=P02518	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0001223\|UniProtKB=P02515	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0001229\|UniProtKB=P22979	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0035817\|UniProtKB=Q9VSA9	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0032181\|UniProtKB=Q9VL41	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0035982\|UniProtKB=Q9VSX2	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0001224\|UniProtKB=P02516	Drosophila melanogaster	O
TRICA\|EnsemblGenome=TC005529\|UniProtKB=D6WXQ7	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC006793\|UniProtKB=D6WV46	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC003541\|UniProtKB=D6WHH1	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC005528\|UniProtKB=D6WXQ8	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC005338\|UniProtKB=D6WV45	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC005527\|UniProtKB=D6WXR0	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC006592\|UniProtKB=D6WXQ9	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC006593\|UniProtKB=D6WXR1	Tribolium castaneum	O
DROME\|FlyBase=FBgn0011296\|UniProtKB=P82147	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP005547\|UniProtKB=Q7Q724	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP007161\|UniProtKB=Q7PT52	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP007160\|UniProtKB=Q7QIZ9	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP005548\|UniProtKB=Q7Q723	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP007158\|UniProtKB=Q7PCM8	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP007162\|UniProtKB=Q7PT53	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC014644\|UniProtKB=D6WNC2	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC010105\|UniProtKB=D6WSJ5	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_312502\|UniProtKB=E9FZ86	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_235846\|UniProtKB=E9FZ72	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_103650\|UniProtKB=E9GJS6	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_303433\|UniProtKB=E9GGM6	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_303432\|UniProtKB=E9GGM5	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_312488\|UniProtKB=E9FZ71	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_312487\|UniProtKB=E9FZ70	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW024922\|UniProtKB=B7QM70	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW024717\|UniProtKB=B7Q645	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW003290\|UniProtKB=B7PCG5	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW023576\|UniProtKB=B7QH66	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW002513\|UniProtKB=B7P7W0	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW024834\|UniProtKB=B7QGM9	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW024062\|UniProtKB=B7P6K1	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW024054\|UniProtKB=B7P624	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW001763\|UniProtKB=B7P7F8	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW001762\|UniProtKB=B7P7F7	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW007791\|UniProtKB=B7PWF4	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW007793\|UniProtKB=B7PWF5	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW015266\|UniProtKB=B7QNN7	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW023475\|UniProtKB=B7QJZ5	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW020672\|UniProtKB=B7Q2C4	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG190314\|UniProtKB=T1FRW3	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG194746\|UniProtKB=T1FWD2	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG125965\|UniProtKB=T1EH79	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG191861\|UniProtKB=T1FTD2	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG160608\|UniProtKB=T1EQH5	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG163906\|UniProtKB=T1EUL7	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG191122\|UniProtKB=T1FSM2	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG191185\|UniProtKB=T1FSQ1	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG190058\|UniProtKB=T1FRM8	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG188325\|UniProtKB=T1FPV8	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG194315\|UniProtKB=T1FVX2	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG169784\|UniProtKB=T1F2B5	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG180213\|UniProtKB=T1FFK9	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG106514\|UniProtKB=T1EE30	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g143610\|UniProtKB=A7T2X7	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g129111\|UniProtKB=A7SRS3	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g143593\|UniProtKB=A7T2X8	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g86804\|UniProtKB=A7RMQ6	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g127462\|UniProtKB=A7SQF6	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g105643\|UniProtKB=A7S5R0	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g129113\|UniProtKB=A7SRS2	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g244569\|UniProtKB=A7SDV3	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g160645\|UniProtKB=A7RMQ7	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g127508\|UniProtKB=A7SQF7	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g239200\|UniProtKB=A7RLT4	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g127482\|UniProtKB=A7SQF4	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g127468\|UniProtKB=A7SQF5	Nematostella vectensis	O