PANTHER Gene Information

Gene Symbol(s):

MARK4

Organism:

Felis catus

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Gene Name:

non-specific serine_threonine protein kinase

Gene ID:

ENSFCAG00000002671.6

Protein ID:

A0A2I2UQW3

Persistent Id:

PTN001966528

Alternate Ids:

AANG04000747(EMBL)	A0A2I2UQW3(Synonym)
ENSFCAP00000034909(Ensembl_PRO)	ENSFCAG00000002671(Ensembl)
ENSFCAT00000042520(Ensembl_TRS)	A0A2I2UQW3_FELCA(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	MAP/MICROTUBULE AFFINITY-REGULATING KINASE (PTHR24346)
PANTHER Subfamily:	MAP_MICROTUBULE AFFINITY-REGULATING KINASE 4 (PTHR24346:SF28)
PANTHER GO-slim Molecular Function:	protein serine/threonine kinase activity
PANTHER GO-slim Biological Process:	microtubule cytoskeleton organization intracellular signal transduction
PANTHER GO-slim Cellular Component:	cytoplasm
PANTHER protein class:	non-receptor serine/threonine protein kinase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	ribosomal protein S6 kinase activity, DNA-dependent protein kinase activity, ATP binding, histone H2AT120 kinase activity, AMP-activated protein kinase activity, histone H3S57 kinase activity, histone H4S1 kinase activity, histone H3S28 kinase activity, histone H3T45 kinase activity, histone H2AXS139 kinase activity, protein serine kinase activity, cytoskeletal anchor activity, histone H3S10 kinase activity, histone H2BS14 kinase activity, histone H2AS1 kinase activity, eukaryotic translation initiation factor 2alpha kinase activity, gamma-tubulin binding, protein serine/threonine kinase activity, 3-phosphoinositide-dependent protein kinase activity, microtubule binding, tau-protein kinase activity, histone H2AS121 kinase activity, histone H3T3 kinase activity, histone H2BS36 kinase activity, Rho-dependent protein serine/threonine kinase activity, histone H3T11 kinase activity, histone H3T6 kinase activity
GO BP Complete:	positive regulation of protein localization to centrosome, chromatin remodeling, microtubule bundle formation, cilium organization, nervous system development, positive regulation of cell cycle, microtubule cytoskeleton organization, positive regulation of cilium assembly, positive regulation of NLRP3 inflammasome complex assembly, regulation of centrosome cycle, intracellular signal transduction
GO CC Complete:	dendrite, centrosome, microtubule cytoskeleton, microtubule organizing center, cytoplasm, ciliary basal body, cytosol, gamma-tubulin complex, midbody, neuron projection

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=13538\|UniProtKB=Q96L34	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000011145.6\|UniProtKB=H2QL36	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000008801.3\|UniProtKB=G3R0C3	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000018672.4\|UniProtKB=F6ZYA3	Macaca mulatta	LDO
MOUSE\|MGI=MGI=3644439\|UniProtKB=J3QK59	Mus musculus	O
MOUSE\|MGI=MGI=3645601\|UniProtKB=J3KMT3	Mus musculus	O
MOUSE\|MGI=MGI=3642760\|UniProtKB=Q3UT86	Mus musculus	O
MOUSE\|MGI=MGI=3782698\|UniProtKB=A0A140LJ87	Mus musculus	O
MOUSE\|MGI=MGI=3648211\|UniProtKB=A0A087WRH8	Mus musculus	O
MOUSE\|MGI=MGI=3642587\|UniProtKB=Q3UTA8	Mus musculus	O
MOUSE\|MGI=MGI=3649012\|UniProtKB=A0A140LI04	Mus musculus	O
RAT\|RGD=41085852\|UniProtKB=A0A8I5Y7S3	Rattus norvegicus	O
RAT\|RGD=11442890\|UniProtKB=A0A8I5ZN46	Rattus norvegicus	O
RAT\|RGD=41360929\|UniProtKB=A0A8I6AAX5	Rattus norvegicus	O
RAT\|RGD=15003712\|UniProtKB=F1LTP9	Rattus norvegicus	O
RAT\|RGD=1564651\|UniProtKB=A0A8I6GDY5	Rattus norvegicus	O
MOUSE\|MGI=MGI=1920955\|UniProtKB=Q8CIP4	Mus musculus	LDO
RAT\|RGD=1591792\|UniProtKB=D4A6T9	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000002682.6\|UniProtKB=A0A3Q1MUZ6	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000022538.4\|UniProtKB=A0A287BEB6	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000000359.4\|UniProtKB=A0A9L0SRR3	Equus caballus	LDO
CANLF\|Ensembl=ENSCAFG00845005692.1\|UniProtKB=A0A8I3N0J6	Canis lupus familiaris	LDO
ORNAN\|Ensembl=ENSOANG00000041059.1\|UniProtKB=A0A6I8NLW9	Ornithorhynchus anatinus	LDO
ANOCA\|Ensembl=ENSACAG00000042341.1\|UniProtKB=A0A803TAK0	Anolis carolinensis	LDO
XENLA\|Gene=mark4.S\|UniProtKB=A0A8J0TNT4	Xenopus laevis	O
XENLA\|Gene=mark4.L\|UniProtKB=A0A8J0TH98	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-6042140\|UniProtKB=A0A8J0SLL0	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000000445.2\|UniProtKB=A0A3B3H4B3	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000001611.2\|UniProtKB=A0A3B3H6D2	Oryzias latipes	LDO
DANRE\|Gene=mark4a\|UniProtKB=A0A8M2BCS1	Danio rerio	LDO
DANRE\|Gene=si=dkey-31m14.7\|UniProtKB=A0A8M2B3S3	Danio rerio	LDO
DANRE\|ZFIN=ZDB-GENE-100330-2\|UniProtKB=R4GEN1	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000014735.1\|UniProtKB=W5NBY7	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000008201.3\|UniProtKB=F6PJL4	Ciona intestinalis	O
BRAFL\|Gene=LOC118411561\|UniProtKB=A0A9J7MJW1	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC100890266\|UniProtKB=A0A7M7SYA1	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100889556\|UniProtKB=A0A7M7P9P4	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC592325\|UniProtKB=A0A7M7HGN9	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00003916\|UniProtKB=Q9TW45	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG04756\|UniProtKB=A8WYE4	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00277629\|UniProtKB=A0A2A6BEG1	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00102456\|UniProtKB=A0A2A6BZY9	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00280367\|UniProtKB=A0A2A6C102	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0026064\|UniProtKB=Q9VGP9	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0026063\|UniProtKB=Q9VGQ0	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0260934\|UniProtKB=A1ZBL9	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP010341\|UniProtKB=A0A1S4H3R9	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP029469\|UniProtKB=A0A453YZQ5	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC032576\|UniProtKB=A0A139WKC9	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_313175\|UniProtKB=E9G331	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW014579\|UniProtKB=B7QKV7	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG192553\|UniProtKB=T1FU26	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG62924\|UniProtKB=T1FX78	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG84170\|UniProtKB=T1G5F9	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG71411\|UniProtKB=T1G0L1	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG66187\|UniProtKB=T1FYI3	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG86903\|UniProtKB=T1G6J0	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG83409\|UniProtKB=T1G552	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g139527\|UniProtKB=A7SZV3	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG27001\|UniProtKB=B3S0C9	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_34468\|UniProtKB=A9VBY4	Monosiga brevicollis	O
CANAL\|CGD=CAL0000177153\|UniProtKB=A0A1D8PRN8	Candida albicans	O
ASPFU\|EnsemblGenome=AFUA_1G11080\|UniProtKB=Q4WSZ7	Neosartorya fumigata	O
SCHJY\|EnsemblGenome=SJAG_02838\|UniProtKB=B6K1B3	Schizosaccharomyces japonicus	O
ASPFU\|EnsemblGenome=AFUA_1G11930\|UniProtKB=E9RDZ3	Neosartorya fumigata	O
SCHJY\|EnsemblGenome=SJAG_04469\|UniProtKB=B6K6W9	Schizosaccharomyces japonicus	O
SCHJY\|EnsemblGenome=SJAG_03602\|UniProtKB=B6K4P0	Schizosaccharomyces japonicus	O
BATDJ\|Gene_ORFName=BATDEDRAFT_10042\|UniProtKB=F4NZ62	Batrachochytrium dendrobatidis	O
ENTH1\|EnsemblGenome=CL6EHI_073490\|UniProtKB=C4LXL3	Entamoeba histolytica	O
ENTH1\|Gene_ORFName=EHI_025300\|UniProtKB=A0A8U0WP54	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0280133\|UniProtKB=Q54VU4	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_151676\|UniProtKB=F0ZJH1	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0292304\|UniProtKB=Q54DF2	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_51418\|UniProtKB=F1A3P4	Dictyostelium purpureum	O
GIAIC\|EnsemblGenome=GL50803_9487\|UniProtKB=A8B530	Giardia intestinalis	O
PLAF7\|EnsemblGenome=PF3D7_1441300\|UniProtKB=Q8IL57	Plasmodium falciparum	O
PARTE\|EnsemblGenome=GSPATT00031618001\|UniProtKB=A0BS70	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00002297001\|UniProtKB=A0DGK1	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00020040001\|UniProtKB=A0DTJ2	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00018964001\|UniProtKB=A0DP01	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00030300001\|UniProtKB=A0BM97	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00004376001\|UniProtKB=A0BCL5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00018952001\|UniProtKB=A0DNY9	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00026401001\|UniProtKB=A0EFI7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00024498001\|UniProtKB=A0E900	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00024481001\|UniProtKB=A0E8Y3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00017966001\|UniProtKB=A0DKR9	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00028068001\|UniProtKB=A0BER8	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00022278001\|UniProtKB=A0E1E2	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00009964001\|UniProtKB=A0CSC5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00025088001\|UniProtKB=A0EAN7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00029968001\|UniProtKB=A0BLB9	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00014139001\|UniProtKB=A0D805	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00019068001\|UniProtKB=A0DPB9	Paramecium tetraurelia	O
PHYRM\|Gene=H3H0P0_PHYRM\|UniProtKB=H3H0P0	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_07g329850v5\|UniProtKB=A0A2K3DJR9	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_09g403850v5\|UniProtKB=A0A2K3DCM7	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_13g568050v5\|UniProtKB=A0A2K3CZG1	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_16g685389v5\|UniProtKB=A0A2K3CW32	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_02g076000v5\|UniProtKB=A0A2K3E058	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_01g036000v5\|UniProtKB=A0A2K3E716	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_06g251050v5\|UniProtKB=A0A2K3DLY4	Chlamydomonas reinhardtii	O
HELAN\|Gene_ORFName=HanXRQr2_Chr05g0231561\|UniProtKB=A0A9K3J1W2	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C500236580\|UniProtKB=A0A9R1XB86	Lactuca sativa	O
KLENI\|Gene_ORFName=KFL_000330150\|UniProtKB=A0A1Y1HQV7	Klebsormidium nitens	O
LACSA\|Gene_ORFName=LSAT_V11C400212270\|UniProtKB=A0A9R1XHY6	Lactuca sativa	O
KLENI\|Gene_ORFName=KFL_000980330\|UniProtKB=A0A0U9HJG2	Klebsormidium nitens	O
KLENI\|Gene_ORFName=KFL_007820030\|UniProtKB=A0A1Y1IQA2	Klebsormidium nitens	O
KLENI\|Gene_ORFName=KFL_001250250\|UniProtKB=A0A1Y1I3Z9	Klebsormidium nitens	O
KLENI\|Gene_ORFName=KFL_000970360\|UniProtKB=A0A0U9HJE6	Klebsormidium nitens	O
MUSAM\|EnsemblGenome=Ma01_g02460\|UniProtKB=A0A804HPI0	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma00_g00400\|UniProtKB=A0A804HLY2	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma10_g08280\|UniProtKB=A0A804KTZ1	Musa acuminata subsp. malaccensis	O
MAIZE\|EnsemblGenome=Zm00001eb013270\|UniProtKB=Q6RXY1	Zea mays	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0320770\|UniProtKB=A0A8I7BB45	Hordeum vulgare subsp. vulgare	O
SETIT\|EnsemblGenome=SETIT_019716mg\|UniProtKB=K3YZK6	Setaria italica	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.1HG0060110\|UniProtKB=A0A8I6X3U9	Hordeum vulgare subsp. vulgare	O
MAIZE\|EnsemblGenome=Zm00001eb293240\|UniProtKB=A0A804Q4X7	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb353700\|UniProtKB=A0A804QSJ7	Zea mays	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0286490\|UniProtKB=A0A8I6XFN7	Hordeum vulgare subsp. vulgare	O
SPIOL\|Gene=LOC110800356\|UniProtKB=A0A9R0J5M8	Spinacia oleracea	O
HELAN\|Gene_ORFName=HanXRQr2_Chr07g0308661\|UniProtKB=A0A9K3ING8	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C900467660\|UniProtKB=A0A9R1UGU9	Lactuca sativa	O
PHYPA\|EnsemblGenome=Pp3c3_5570\|UniProtKB=A0A7I4DGQ5	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0038s0082\|UniProtKB=A0A2R6X3U9	Marchantia polymorpha	O
MARPO\|EnsemblGenome=MARPO_0160s0010\|UniProtKB=A0A2R6W3Y3	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_008220030\|UniProtKB=A0A1Y1INE1	Klebsormidium nitens	O
STRCO\|Gene_OrderedLocusName=SCO4820\|UniProtKB=Q9K3K0	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO4817\|UniProtKB=Q9K3K3	Streptomyces coelicolor	O
DEIRA\|EnsemblGenome=DR_1213\|UniProtKB=Q9RV17	Deinococcus radiodurans	O
RHOBA\|EnsemblGenome=RB12694\|UniProtKB=Q7UI82	Rhodopirellula baltica	O
AQUAE\|EnsemblGenome=aq_576\|UniProtKB=O66844	Aquifex aeolicus	O