PANTHER Gene Information

Gene Symbol(s):

RTEL1

Organism:

Gorilla gorilla gorilla

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Gene Name:

Regulator of telomere elongation helicase 1

Gene ID:

ENSGGOG00000004784.3

Protein ID:

G3RRM2

Persistent Id:

PTN002607496

Alternate Ids:

ENSGGOT00000027733(Ensembl_TRS)	ENSGGOP00000018446(Ensembl_PRO)
CABD030117745(EMBL)	G3RRM2(Synonym)
426392493(GI)	ENSGGOG00000004784(Ensembl)
G3RRM2_GORGO(UniProtKB-ID)	XP_004062584(refSeq)
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PANTHER Classification

PANTHER Family:	DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER (PTHR11472)
PANTHER Subfamily:	REGULATOR OF TELOMERE ELONGATION HELICASE 1 (PTHR11472:SF62)
PANTHER GO-slim Molecular Function:	ATP binding enzyme binding DNA helicase activity
PANTHER GO-slim Biological Process:	negative regulation of DNA recombination DNA duplex unwinding regulation of cellular component biogenesis telomere maintenance regulation of telomere maintenance regulation of double-strand break repair via homologous recombination negative regulation of cellular component organization
PANTHER GO-slim Cellular Component:	nucleus
PANTHER protein class:	DNA helicase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	ATP hydrolysis activity, double-stranded DNA helicase activity, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, helicase activity, four-way junction helicase activity, forked DNA-dependent helicase activity, cohesin loader activity, DNA binding, ATP binding, DNA helicase activity, DNA clamp loader activity, DNA polymerase binding, ATP-dependent H2AZ histone chaperone activity, metal ion binding, ATP-dependent H3-H4 histone complex chaperone activity, 4 iron, 4 sulfur cluster binding, single-stranded 3'-5' DNA helicase activity, chromatin extrusion motor activity, hydrolase activity, isomerase activity
GO BP Complete:	negative regulation of t-circle formation, DNA repair, telomeric loop disassembly, DNA replication, positive regulation of telomere capping, DNA recombination, telomere maintenance, positive regulation of telomere maintenance via telomere lengthening, negative regulation of DNA recombination, chromatin remodeling, DNA duplex unwinding, regulation of double-strand break repair via homologous recombination, chromatin looping
GO CC Complete:	nucleus, nuclear membrane, nuclear speck, nucleoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=15888\|UniProtKB=Q9NZ71	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000052107.1\|UniProtKB=H2R359	Pan troglodytes	LDO
MACMU\|Ensembl=ENSMMUG00000000167.4\|UniProtKB=F7HLR9	Macaca mulatta	LDO
MOUSE\|MGI=MGI=2139369\|UniProtKB=Q0VGM9	Mus musculus	LDO
RAT\|RGD=1306721\|UniProtKB=Q5RJZ1	Rattus norvegicus	LDO
BOVIN\|Gene=RTEL1\|UniProtKB=A4K436	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000021096.6\|UniProtKB=F1N079	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000039160.3\|UniProtKB=A0A287B3D4	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000021707.4\|UniProtKB=A0A9L0R4H3	Equus caballus	LDO
CANLF\|Ensembl=ENSCAFG00845017564.1\|UniProtKB=A0A8I3NU99	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000017003.4\|UniProtKB=F6QF76	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000004935.4\|UniProtKB=F7E2C2	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010024973.1\|UniProtKB=A0A8V0ZVY2	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000011739.4\|UniProtKB=A0A803SW31	Anolis carolinensis	LDO
XENLA\|Gene=rtel1.L\|UniProtKB=A0A8J0TVL1	Xenopus laevis	LDO
XENTR\|Gene=rtel1\|UniProtKB=A0A8J1IWY9	Xenopus tropicalis	LDO
DANRE\|ZFIN=ZDB-GENE-050306-11\|UniProtKB=P0C928	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000001700.1\|UniProtKB=W5M0Q7	lepisosteus oculatus	LDO
BRAFL\|Gene=LOC118409403\|UniProtKB=A0A9J7HVW0	Branchiostoma floridae	LDO
CAEEL\|WormBase=WBGene00009124\|UniProtKB=Q93575	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00025337\|UniProtKB=A8WS58	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00113329\|UniProtKB=A0A8R1UHC1	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0029798\|UniProtKB=Q9W484	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP000634\|UniProtKB=Q7QEI1	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC007666\|UniProtKB=D2A2D4	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_128417\|UniProtKB=E9GJP0	Daphnia pulex	LDO
HELRO\|EnsemblGenome=HelroG79366\|UniProtKB=T1G3N2	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g168196\|UniProtKB=A7SA32	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG27892\|UniProtKB=B3S2Q7	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_27129\|UniProtKB=A9V4D9	Monosiga brevicollis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_22849\|UniProtKB=F4NVZ2	Batrachochytrium dendrobatidis	LDO
TRIV3\|Gene_ORFName=TVAG_065670\|UniProtKB=A2ELX1	Trichomonas vaginalis	O
PARTE\|EnsemblGenome=GSPATT00024345001\|UniProtKB=A0E8J9	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00015995001\|UniProtKB=A0DDN7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00019494001\|UniProtKB=A0DRX3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00010733001\|UniProtKB=A0CUR5	Paramecium tetraurelia	O
LEIMA\|EnsemblGenome=LMJF_29_2660\|UniProtKB=E9AEC8	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb927.3.3090\|UniProtKB=Q57ZK3	Trypanosoma brucei	LDO
GIAIC\|EnsemblGenome=GL50803_92673\|UniProtKB=A8BI67	Giardia intestinalis	LDO
TRIV3\|Gene_ORFName=TVAG_013790\|UniProtKB=A2DDD4	Trichomonas vaginalis	LDO
PLAF7\|EnsemblGenome=PF3D7_1408400\|UniProtKB=Q8IM12	Plasmodium falciparum	LDO
PARTE\|EnsemblGenome=GSPATT00016196001\|UniProtKB=A0DE87	Paramecium tetraurelia	LDO
PARTE\|EnsemblGenome=GSPATT00012558001\|UniProtKB=A0D1W6	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00010742001\|UniProtKB=A0CUS4	Paramecium tetraurelia	LDO
PARTE\|EnsemblGenome=GSPATT00016216001\|UniProtKB=A0DEC3	Paramecium tetraurelia	O
THAPS\|EnsemblGenome=THAPSDRAFT_32522\|UniProtKB=B8BYI1	Thalassiosira pseudonana	LDO
CHLRE\|EnsemblGenome=CHLRE_02g089608v5\|UniProtKB=A0A2K3E158	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00078p00189390\|UniProtKB=W1PA87	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_178G00010\|UniProtKB=A0A0K9PRE6	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma03_g21420\|UniProtKB=A0A804IEP8	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_000155mg\|UniProtKB=K3XE38	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3003G205100\|UniProtKB=A0A1B6Q4E8	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb161030\|UniProtKB=A0A804NHJ1	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os01g0592900\|UniProtKB=A0A0P0V4R0	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_2g42410v3\|UniProtKB=A0A2K2DDF0	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0268950\|UniProtKB=A0A8I6X658	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS3D02G215000\|UniProtKB=A0A3B6GRF6	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G242700\|UniProtKB=A0A3B6FMQ1	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3A02G212600\|UniProtKB=A0A3B6EHR9	Triticum aestivum	LDO
NELNU\|Gene_ORFName=HUJ06_002949\|UniProtKB=A0A1U7ZAV4	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110787765\|UniProtKB=A0A9R0IEY2	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr09g0415401\|UniProtKB=A0A251U073	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C400198010\|UniProtKB=A0A9R1XN59	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a017765mg\|UniProtKB=A0A022Q2W7	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_10875\|UniProtKB=A0A2G3A3E8	Capsicum annuum	LDO
SOLLC\|EnsemblGenome=Solyc03g120200.2\|UniProtKB=A0A3Q7GK99	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107794086\|UniProtKB=A0A1S4A631	Nicotiana tabacum	O
TOBAC\|Gene=LOC107778074\|UniProtKB=A0A1S3YNQ8	Nicotiana tabacum	LDO
VITVI\|Gene_OrderedLocusName=VIT_09s0002g04670\|UniProtKB=F6HYG0	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_F03013\|UniProtKB=A0A059BTJ8	Eucalyptus grandis	LDO
BRANA\|Gene_ORFName=DARMORV10_C06P54320.1\|UniProtKB=A0A078J498	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra035203\|UniProtKB=M4F2A5	Brassica campestris	O
BRACM\|EnsemblGenome=Bra003540\|UniProtKB=M4CH57	Brassica campestris	LDO
ARATH\|TAIR=locus=2016209\|UniProtKB=F4HQE2	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107937350\|UniProtKB=A0A1U8MFT9	Gossypium hirsutum	O
GOSHI\|Gene=LOC107924100\|UniProtKB=A0A1U8L924	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_028696\|UniProtKB=A0A061GBH2	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g001656mg\|UniProtKB=A0A067EJX3	Citrus sinensis	LDO
POPTR\|Gene_ORFName=POPTR_001G180200\|UniProtKB=A0A3N7EFU5	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_11G047500\|UniProtKB=A0A2C9UYK0	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_0980890\|UniProtKB=B9SQD1	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_13G359400\|UniProtKB=K7M3U8	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_2g102150\|UniProtKB=G7II45	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr07_30250\|UniProtKB=A0A2I4DXZ7	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_7G446720\|UniProtKB=A0A0A0K6J7	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_3G071000\|UniProtKB=A0A251PWK2	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_77246\|UniProtKB=D8QTS9	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_94786\|UniProtKB=D8RJV6	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c18_12550\|UniProtKB=A0A2K1J0U8	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0076s0066\|UniProtKB=A0A2R6WLU8	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_000430260\|UniProtKB=A0A1Y1HMY1	Klebsormidium nitens	LDO
KORCO\|EnsemblGenome=Kcr_1439\|UniProtKB=B1L6V6	Korarchaeum cryptofilum	O
KORCO\|EnsemblGenome=Kcr_1088\|UniProtKB=B1L5V5	Korarchaeum cryptofilum	LDO
SACS2\|EnsemblGenome=SSO0313\|UniProtKB=Q980I2	Sulfolobus solfataricus	LDO
PYRAE\|EnsemblGenome=PAE3526\|UniProtKB=Q8ZSY2	Pyrobaculum aerophilum	O
PYRAE\|EnsemblGenome=PAE2991\|UniProtKB=Q8ZU14	Pyrobaculum aerophilum	LDO
METAC\|EnsemblGenome=MA_2096\|UniProtKB=Q8TP28	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_0335\|UniProtKB=Q8TTU0	Methanosarcina acetivorans	LDO
METJA\|EnsemblGenome=MJ_0942\|UniProtKB=Q58352	Methanocaldococcus jannaschii	LDO
HALSA\|EnsemblGenome=VNG_1383G\|UniProtKB=Q9HQ08	Halobacterium salinarum	O
HALSA\|EnsemblGenome=VNG_2476C\|UniProtKB=Q9HMM1	Halobacterium salinarum	O
HALSA\|EnsemblGenome=VNG_2441G\|UniProtKB=Q9HMP9	Halobacterium salinarum	LDO
THEKO\|EnsemblGenome=TK0784\|UniProtKB=Q5JH96	Thermococcus kodakaraensis	LDO
CHLAA\|EnsemblGenome=Caur_1621\|UniProtKB=A9WBN2	Chloroflexus aurantiacus	LDO
STRCO\|Gene_OrderedLocusName=SCO5802\|UniProtKB=O69978	Streptomyces coelicolor	LDO
MYCTU\|Gene_OrderedLocusName=Rv1329c\|UniProtKB=P9WMR5	Mycobacterium tuberculosis	LDO
LISMO\|Gene=dinG\|UniProtKB=Q8Y604	Listeria monocytogenes	LDO
BACSU\|EnsemblGenome=BSU_22150\|UniProtKB=P50831	Bacillus subtilis	O
BACCR\|EnsemblGenome=BC_1565\|UniProtKB=Q81FL6	Bacillus cereus	O
BACSU\|EnsemblGenome=BSU_22400\|UniProtKB=P54394	Bacillus subtilis	LDO
GLOVI\|Gene=Q7NKM8_GLOVI\|UniProtKB=Q7NKM8	Gloeobacter violaceus	O
SYNY3\|Gene=P72618_SYNY3\|UniProtKB=P72618	Synechocystis	O
GLOVI\|Gene=Q7NN01_GLOVI\|UniProtKB=Q7NN01	Gloeobacter violaceus	LDO
LEPIN\|EnsemblGenome=LA_1875\|UniProtKB=Q8F513	Leptospira interrogans	LDO
RHOBA\|EnsemblGenome=RB8062\|UniProtKB=Q7UG83	Rhodopirellula baltica	LDO
AQUAE\|EnsemblGenome=aq_358\|UniProtKB=O66684	Aquifex aeolicus	LDO
FUSNN\|EnsemblGenome=FN0743\|UniProtKB=Q8RFF8	Fusobacterium nucleatum	LDO
NEIMB\|EnsemblGenome=NMB0287\|UniProtKB=Q9K181	Neisseria meningitidis serogroup b	O
SHEON\|Gene_OrderedLocusName=SO_1819\|UniProtKB=Q8EFZ5	Shewanella oneidensis	O
VIBCH\|EnsemblGenome=VC_1855\|UniProtKB=Q9KQZ2	Vibrio cholerae	O
XANCP\|EnsemblGenome=XCC3950\|UniProtKB=Q8P3W9	Xanthomonas campestris	O
PSEAE\|EnsemblGenome=PA1045\|UniProtKB=Q9I4S9	Pseudomonas aeruginosa	O
SALTY\|EnsemblGenome=STM0821\|UniProtKB=Q8ZQN7	Salmonella typhimurium	O
YERPE\|Gene_OrderedLocusName=YPO1206\|UniProtKB=A0A2S9PKW4	Yersinia pestis	O
ECOLI\|EnsemblGenome=BAA35465\|UniProtKB=P27296	Escherichia coli	O
GEOSL\|EnsemblGenome=GSU0363\|UniProtKB=Q74G84	Geobacter sulfurreducens	LDO
HAEIN\|EnsemblGenome=HI_0387\|UniProtKB=P44680	Haemophilus influenzae	LDO
SHEON\|Gene_OrderedLocusName=SO_2081\|UniProtKB=Q8EFA4	Shewanella oneidensis	LDO
VIBCH\|EnsemblGenome=VC_1990\|UniProtKB=Q9KQK8	Vibrio cholerae	LDO
XANCP\|EnsemblGenome=XCC2930\|UniProtKB=Q8P6N7	Xanthomonas campestris	LDO
SALTY\|EnsemblGenome=STM1821\|UniProtKB=Q7CQD9	Salmonella typhimurium	LDO
YERPE\|Gene_OrderedLocusName=YPO2071\|UniProtKB=A0A3N4B3X5	Yersinia pestis	LDO
ECOLI\|EnsemblGenome=BAA15617\|UniProtKB=P76257	Escherichia coli	LDO