PANTHER Gene Information

Gene Symbol(s):

RTEL1

Organism:

Gorilla gorilla gorilla

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Gene Name:

Regulator of telomere elongation helicase 1

Gene ID:

ENSGGOG00000042405.1

Protein ID:

A0A2I2YK90

Persistent Id:

PTN004263389

Alternate Ids:

A0A2I2YK90_GORGO(UniProtKB-ID)	ENSGGOP00000035362(Ensembl_PRO)
CABD030032771(EMBL)	A0A2I2YK90(Synonym)
ENSGGOG00000042405(Ensembl)	ENSGGOT00000050763(Ensembl_TRS)
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PANTHER Classification

PANTHER Family:	DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER (PTHR11472)
PANTHER Subfamily:	REGULATOR OF TELOMERE ELONGATION HELICASE 1 (PTHR11472:SF61)
PANTHER GO-slim Molecular Function:	ATP binding enzyme binding DNA helicase activity
PANTHER GO-slim Biological Process:	negative regulation of DNA recombination DNA duplex unwinding regulation of cellular component biogenesis telomere maintenance regulation of telomere maintenance regulation of double-strand break repair via homologous recombination negative regulation of cellular component organization
PANTHER GO-slim Cellular Component:	nucleus
PANTHER protein class:	DNA helicase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	ATP hydrolysis activity, double-stranded DNA helicase activity, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, helicase activity, four-way junction helicase activity, forked DNA-dependent helicase activity, cohesin loader activity, DNA binding, ATP binding, DNA helicase activity, DNA clamp loader activity, DNA polymerase binding, ATP-dependent H2AZ histone chaperone activity, metal ion binding, ATP-dependent H3-H4 histone complex chaperone activity, 4 iron, 4 sulfur cluster binding, single-stranded 3'-5' DNA helicase activity, chromatin extrusion motor activity, hydrolase activity, isomerase activity
GO BP Complete:	negative regulation of t-circle formation, DNA repair, telomeric loop disassembly, chromatin remodeling, DNA replication, DNA duplex unwinding, DNA recombination, telomere maintenance, regulation of double-strand break repair via homologous recombination, chromatin looping, negative regulation of DNA recombination
GO CC Complete:	nucleus

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
PANTR\|Ensembl=ENSPTRG00000048787.1\|UniProtKB=A0A2I3TE43	Pan troglodytes	LDO
MACMU\|Ensembl=ENSMMUG00000000167.4\|UniProtKB=F7HLR9	Macaca mulatta	O
MOUSE\|MGI=MGI=2139369\|UniProtKB=Q0VGM9	Mus musculus	O
RAT\|RGD=1306721\|UniProtKB=Q5RJZ1	Rattus norvegicus	O
BOVIN\|Gene=RTEL1\|UniProtKB=A4K436	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000021096.6\|UniProtKB=F1N079	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000039160.3\|UniProtKB=A0A287B3D4	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000021707.4\|UniProtKB=A0A9L0R4H3	Equus caballus	O
CANLF\|Ensembl=ENSCAFG00845017564.1\|UniProtKB=A0A8I3NU99	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000017003.4\|UniProtKB=F6QF76	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000004935.4\|UniProtKB=F7E2C2	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010024973.1\|UniProtKB=A0A8V0ZVY2	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000011739.4\|UniProtKB=A0A803SW31	Anolis carolinensis	O
XENLA\|Gene=rtel1.L\|UniProtKB=A0A8J0TVL1	Xenopus laevis	O
XENTR\|Gene=rtel1\|UniProtKB=A0A8J1IWY9	Xenopus tropicalis	O
DANRE\|ZFIN=ZDB-GENE-050306-11\|UniProtKB=P0C928	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000001700.1\|UniProtKB=W5M0Q7	lepisosteus oculatus	O
BRAFL\|Gene=LOC118409403\|UniProtKB=A0A9J7HVW0	Branchiostoma floridae	O
CAEEL\|WormBase=WBGene00009124\|UniProtKB=Q93575	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00025337\|UniProtKB=A8WS58	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00113329\|UniProtKB=A0A8R1UHC1	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0029798\|UniProtKB=Q9W484	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP000634\|UniProtKB=Q7QEI1	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC007666\|UniProtKB=D2A2D4	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_128417\|UniProtKB=E9GJP0	Daphnia pulex	O
HELRO\|EnsemblGenome=HelroG79366\|UniProtKB=T1G3N2	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g168196\|UniProtKB=A7SA32	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG27892\|UniProtKB=B3S2Q7	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_27129\|UniProtKB=A9V4D9	Monosiga brevicollis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_22849\|UniProtKB=F4NVZ2	Batrachochytrium dendrobatidis	O
TRIV3\|Gene_ORFName=TVAG_065670\|UniProtKB=A2ELX1	Trichomonas vaginalis	O
PARTE\|EnsemblGenome=GSPATT00024345001\|UniProtKB=A0E8J9	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00015995001\|UniProtKB=A0DDN7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00019494001\|UniProtKB=A0DRX3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00010733001\|UniProtKB=A0CUR5	Paramecium tetraurelia	O
LEIMA\|EnsemblGenome=LMJF_29_2660\|UniProtKB=E9AEC8	Leishmania major	O
TRYB2\|Gene_ORFName=Tb927.3.3090\|UniProtKB=Q57ZK3	Trypanosoma brucei	O
GIAIC\|EnsemblGenome=GL50803_92673\|UniProtKB=A8BI67	Giardia intestinalis	O
TRIV3\|Gene_ORFName=TVAG_013790\|UniProtKB=A2DDD4	Trichomonas vaginalis	O
PLAF7\|EnsemblGenome=PF3D7_1408400\|UniProtKB=Q8IM12	Plasmodium falciparum	O
PARTE\|EnsemblGenome=GSPATT00016196001\|UniProtKB=A0DE87	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00012558001\|UniProtKB=A0D1W6	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00010742001\|UniProtKB=A0CUS4	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00016216001\|UniProtKB=A0DEC3	Paramecium tetraurelia	O
THAPS\|EnsemblGenome=THAPSDRAFT_32522\|UniProtKB=B8BYI1	Thalassiosira pseudonana	O
CHLRE\|EnsemblGenome=CHLRE_02g089608v5\|UniProtKB=A0A2K3E158	Chlamydomonas reinhardtii	O
AMBTC\|EnsemblGenome=AMTR_s00078p00189390\|UniProtKB=W1PA87	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_178G00010\|UniProtKB=A0A0K9PRE6	Zostera marina	O
MUSAM\|EnsemblGenome=Ma03_g21420\|UniProtKB=A0A804IEP8	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_000155mg\|UniProtKB=K3XE38	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3003G205100\|UniProtKB=A0A1B6Q4E8	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb161030\|UniProtKB=A0A804NHJ1	Zea mays	O
ORYSJ\|EnsemblGenome=Os01g0592900\|UniProtKB=A0A0P0V4R0	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_2g42410v3\|UniProtKB=A0A2K2DDF0	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0268950\|UniProtKB=A0A8I6X658	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS3D02G215000\|UniProtKB=A0A3B6GRF6	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G242700\|UniProtKB=A0A3B6FMQ1	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3A02G212600\|UniProtKB=A0A3B6EHR9	Triticum aestivum	O
NELNU\|Gene_ORFName=HUJ06_002949\|UniProtKB=A0A1U7ZAV4	Nelumbo nucifera	O
SPIOL\|Gene=LOC110787765\|UniProtKB=A0A9R0IEY2	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr09g0415401\|UniProtKB=A0A251U073	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C400198010\|UniProtKB=A0A9R1XN59	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a017765mg\|UniProtKB=A0A022Q2W7	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_10875\|UniProtKB=A0A2G3A3E8	Capsicum annuum	O
SOLLC\|EnsemblGenome=Solyc03g120200.2\|UniProtKB=A0A3Q7GK99	Solanum lycopersicum	O
TOBAC\|Gene=LOC107794086\|UniProtKB=A0A1S4A631	Nicotiana tabacum	O
TOBAC\|Gene=LOC107778074\|UniProtKB=A0A1S3YNQ8	Nicotiana tabacum	O
VITVI\|Gene_OrderedLocusName=VIT_09s0002g04670\|UniProtKB=F6HYG0	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_F03013\|UniProtKB=A0A059BTJ8	Eucalyptus grandis	O
BRANA\|Gene_ORFName=DARMORV10_C06P54320.1\|UniProtKB=A0A078J498	Brassica napus	O
BRACM\|EnsemblGenome=Bra035203\|UniProtKB=M4F2A5	Brassica campestris	O
BRACM\|EnsemblGenome=Bra003540\|UniProtKB=M4CH57	Brassica campestris	O
ARATH\|TAIR=locus=2016209\|UniProtKB=F4HQE2	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107937350\|UniProtKB=A0A1U8MFT9	Gossypium hirsutum	O
GOSHI\|Gene=LOC107924100\|UniProtKB=A0A1U8L924	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_028696\|UniProtKB=A0A061GBH2	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g001656mg\|UniProtKB=A0A067EJX3	Citrus sinensis	O
POPTR\|Gene_ORFName=POPTR_001G180200\|UniProtKB=A0A3N7EFU5	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_11G047500\|UniProtKB=A0A2C9UYK0	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_0980890\|UniProtKB=B9SQD1	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_13G359400\|UniProtKB=K7M3U8	Glycine max	O
MEDTR\|EnsemblGenome=MTR_2g102150\|UniProtKB=G7II45	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr07_30250\|UniProtKB=A0A2I4DXZ7	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_7G446720\|UniProtKB=A0A0A0K6J7	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_3G071000\|UniProtKB=A0A251PWK2	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_77246\|UniProtKB=D8QTS9	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_94786\|UniProtKB=D8RJV6	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c18_12550\|UniProtKB=A0A2K1J0U8	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0076s0066\|UniProtKB=A0A2R6WLU8	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_000430260\|UniProtKB=A0A1Y1HMY1	Klebsormidium nitens	O
KORCO\|EnsemblGenome=Kcr_1439\|UniProtKB=B1L6V6	Korarchaeum cryptofilum	O
KORCO\|EnsemblGenome=Kcr_1088\|UniProtKB=B1L5V5	Korarchaeum cryptofilum	O
SACS2\|EnsemblGenome=SSO0313\|UniProtKB=Q980I2	Sulfolobus solfataricus	O
PYRAE\|EnsemblGenome=PAE3526\|UniProtKB=Q8ZSY2	Pyrobaculum aerophilum	O
PYRAE\|EnsemblGenome=PAE2991\|UniProtKB=Q8ZU14	Pyrobaculum aerophilum	O
METAC\|EnsemblGenome=MA_2096\|UniProtKB=Q8TP28	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_0335\|UniProtKB=Q8TTU0	Methanosarcina acetivorans	O
METJA\|EnsemblGenome=MJ_0942\|UniProtKB=Q58352	Methanocaldococcus jannaschii	O
HALSA\|EnsemblGenome=VNG_1383G\|UniProtKB=Q9HQ08	Halobacterium salinarum	O
HALSA\|EnsemblGenome=VNG_2476C\|UniProtKB=Q9HMM1	Halobacterium salinarum	O
HALSA\|EnsemblGenome=VNG_2441G\|UniProtKB=Q9HMP9	Halobacterium salinarum	O
THEKO\|EnsemblGenome=TK0784\|UniProtKB=Q5JH96	Thermococcus kodakaraensis	O
CHLAA\|EnsemblGenome=Caur_1621\|UniProtKB=A9WBN2	Chloroflexus aurantiacus	O
STRCO\|Gene_OrderedLocusName=SCO5802\|UniProtKB=O69978	Streptomyces coelicolor	O
MYCTU\|Gene_OrderedLocusName=Rv1329c\|UniProtKB=P9WMR5	Mycobacterium tuberculosis	O
LISMO\|Gene=dinG\|UniProtKB=Q8Y604	Listeria monocytogenes	O
BACSU\|EnsemblGenome=BSU_22150\|UniProtKB=P50831	Bacillus subtilis	O
BACCR\|EnsemblGenome=BC_1565\|UniProtKB=Q81FL6	Bacillus cereus	O
BACSU\|EnsemblGenome=BSU_22400\|UniProtKB=P54394	Bacillus subtilis	O
GLOVI\|Gene=Q7NKM8_GLOVI\|UniProtKB=Q7NKM8	Gloeobacter violaceus	O
SYNY3\|Gene=P72618_SYNY3\|UniProtKB=P72618	Synechocystis	O
GLOVI\|Gene=Q7NN01_GLOVI\|UniProtKB=Q7NN01	Gloeobacter violaceus	O
LEPIN\|EnsemblGenome=LA_1875\|UniProtKB=Q8F513	Leptospira interrogans	O
RHOBA\|EnsemblGenome=RB8062\|UniProtKB=Q7UG83	Rhodopirellula baltica	O
AQUAE\|EnsemblGenome=aq_358\|UniProtKB=O66684	Aquifex aeolicus	O
FUSNN\|EnsemblGenome=FN0743\|UniProtKB=Q8RFF8	Fusobacterium nucleatum	O
NEIMB\|EnsemblGenome=NMB0287\|UniProtKB=Q9K181	Neisseria meningitidis serogroup b	O
SHEON\|Gene_OrderedLocusName=SO_1819\|UniProtKB=Q8EFZ5	Shewanella oneidensis	O
VIBCH\|EnsemblGenome=VC_1855\|UniProtKB=Q9KQZ2	Vibrio cholerae	O
XANCP\|EnsemblGenome=XCC3950\|UniProtKB=Q8P3W9	Xanthomonas campestris	O
PSEAE\|EnsemblGenome=PA1045\|UniProtKB=Q9I4S9	Pseudomonas aeruginosa	O
SALTY\|EnsemblGenome=STM0821\|UniProtKB=Q8ZQN7	Salmonella typhimurium	O
YERPE\|Gene_OrderedLocusName=YPO1206\|UniProtKB=A0A2S9PKW4	Yersinia pestis	O
ECOLI\|EnsemblGenome=BAA35465\|UniProtKB=P27296	Escherichia coli	O
GEOSL\|EnsemblGenome=GSU0363\|UniProtKB=Q74G84	Geobacter sulfurreducens	O
HAEIN\|EnsemblGenome=HI_0387\|UniProtKB=P44680	Haemophilus influenzae	O
SHEON\|Gene_OrderedLocusName=SO_2081\|UniProtKB=Q8EFA4	Shewanella oneidensis	O
VIBCH\|EnsemblGenome=VC_1990\|UniProtKB=Q9KQK8	Vibrio cholerae	O
XANCP\|EnsemblGenome=XCC2930\|UniProtKB=Q8P6N7	Xanthomonas campestris	O
SALTY\|EnsemblGenome=STM1821\|UniProtKB=Q7CQD9	Salmonella typhimurium	O
YERPE\|Gene_OrderedLocusName=YPO2071\|UniProtKB=A0A3N4B3X5	Yersinia pestis	O
ECOLI\|EnsemblGenome=BAA15617\|UniProtKB=P76257	Escherichia coli	O