PANTHER Gene Information

Gene Symbol(s):

CRB2

Organism:

Equus caballus

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Tree

Gene Name:

Crumbs cell polarity complex component 2

Gene ID:

ENSECAG00000021531.4

Protein ID:

F6Q1L5

Persistent Id:

PTN002513788

Alternate Ids:

ENSECAP00000018960(Ensembl_PRO)	ENSECAG00000021531(Ensembl)
ENSECAT00000022914(Ensembl_TRS)	F6Q1L5_HORSE(UniProtKB-ID)
F6Q1L5(Synonym)
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PANTHER Classification

PANTHER Family:	EGF-LIKE DOMAIN-CONTAINING PROTEIN (PTHR24033)
PANTHER Subfamily:	SUSHI, NIDOGEN AND EGF LIKE DOMAINS 1 (PTHR24033:SF234)
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:
PANTHER protein class:

Pathway Categories:

Alzheimer disease-presenilin pathway

Notch extracellular fragment

Notch signaling pathway

Notch intracellular tethered fragment

Alzheimer disease-presenilin pathway

Notch N-terminal fragment

Alzheimer disease-presenilin pathway

Notch transmembrane fragment

Alzheimer disease-presenilin pathway

Notch fragment

Alzheimer disease-presenilin pathway

Notch C-terminal fragment

Notch signaling pathway

Notch intracellular soluble fragment

Alzheimer disease-presenilin pathway

Notch

Angiogenesis

Notch Receptor

Notch signaling pathway

Notch

Notch signaling pathway

Serrate and Notch extracellular fragment

Notch signaling pathway

Notch transmembrane domain fragment

Alzheimer disease-presenilin pathway

Notch intracellular domain

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	aspartic-type endopeptidase inhibitor activity, calcium ion binding, protein-containing complex binding
GO BP Complete:	regulation of gastrulation, ingression involved in gastrulation with mouth forming second, retinal cone cell development, positive regulation of epithelial to mesenchymal transition, retina homeostasis, positive regulation of BMP signaling pathway, maintenance of epithelial cell apical/basal polarity, somitogenesis, photoreceptor cell maintenance, establishment of cell polarity, circulatory system development, mesoderm formation, notochord formation
GO CC Complete:	apicolateral plasma membrane, subapical complex, apical part of cell, cytoplasm, membrane, cell junction, protein-containing complex, apical plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
GORGO\|Ensembl=ENSGGOG00000002332.3\|UniProtKB=G3QIT2	Gorilla gorilla gorilla	LDO
CANLF\|Ensembl=ENSCAFG00845005453.1\|UniProtKB=A0A8I3MTK6	Canis lupus familiaris	LDO
CHICK\|Ensembl=ENSGALG00010025389.1\|UniProtKB=A0A8V1A524	Gallus gallus	LDO
XENLA\|Gene=notch4.S\|UniProtKB=A0A8J1LNN4	Xenopus laevis	LDO
DANRE\|Gene=notch1b\|UniProtKB=A0A8M2BFY6	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000017043.1\|UniProtKB=W5NKA3	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000024809.1\|UniProtKB=H2XTR0	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000007101.3\|UniProtKB=F6VLU0	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000004569.3\|UniProtKB=F6XCC4	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000004361.3\|UniProtKB=F6S5M6	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000006949.3\|UniProtKB=F6VN18	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000006420.3\|UniProtKB=F6PQG2	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000004617.3\|UniProtKB=F6Q0H1	Ciona intestinalis	LDO
BRAFL\|Gene_ORFName=BRAFLDRAFT_105530\|UniProtKB=C3ZJX0	Branchiostoma floridae	O
BRAFL\|Gene=LOC118432296\|UniProtKB=A0A9J7MEG9	Branchiostoma floridae	O
BRAFL\|Gene=LOC118421835\|UniProtKB=A0A9J7LNV7	Branchiostoma floridae	O
BRAFL\|Gene=LOC118413717\|UniProtKB=A0A9J7L0U5	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC576643\|UniProtKB=A0A7M7LVH7	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115925497\|UniProtKB=A0A7M7P340	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115923851\|UniProtKB=A0A7M7SYP0	Strongylocentrotus purpuratus	LDO
STRPU\|EnsemblGenome=GeneID_373315\|UniProtKB=P49013	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC575307\|UniProtKB=A0A7M7PSF2	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100891127\|UniProtKB=A0A7M7HEE2	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105437803\|UniProtKB=A0A7M7P5X1	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105445537\|UniProtKB=A0A7M7SW05	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC754732\|UniProtKB=A0A7M7PCH4	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100891837\|UniProtKB=A0A7M7T5Y9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100888963\|UniProtKB=A0A7M7P9M6	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC594451\|UniProtKB=A0A7M7PVE8	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100889823\|UniProtKB=A0A7M7PQ27	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC755030\|UniProtKB=A0A7M7T4U8	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00004963\|UniProtKB=Q9TVY6	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG15356\|UniProtKB=A8XM10	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00018547\|UniProtKB=Q20531	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG20700\|UniProtKB=A8XYE8	Caenorhabditis briggsae	LDO
CAEBR\|Gene_ORFName=CBG05891\|UniProtKB=A8X1E4	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00097142\|UniProtKB=A0A2A6CAY4	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00098476\|UniProtKB=A0A2A6BT74	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00109296\|UniProtKB=A0A2A6CVC7	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00103845\|UniProtKB=A0A2A6C4U2	Pristionchus pacificus	LDO
PRIPA\|EnsemblGenome=WBGene00281316\|UniProtKB=A0A2A6CV68	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00098612\|UniProtKB=A0A2A6CKS2	Pristionchus pacificus	O
TRICA\|EnsemblGenome=TC000871\|UniProtKB=D6W8V9	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_247827\|UniProtKB=E9GSY7	Daphnia pulex	O
DROME\|FlyBase=FBgn0053196\|UniProtKB=M9PB30	Drosophila melanogaster	O
TRICA\|EnsemblGenome=TC011986\|UniProtKB=A0A139WBH2	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC010461\|UniProtKB=D6WKS5	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC004393\|UniProtKB=A0A139WAL3	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_113314\|UniProtKB=E9HEP8	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_319716\|UniProtKB=E9GMK8	Daphnia pulex	O
DAPPU\|Gene_ORFName=DAPPUDRAFT_61886\|UniProtKB=E9HEQ0	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW008751\|UniProtKB=B7PYC7	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG86708\|UniProtKB=T1G6F9	helobdella robusta	LDO
HELRO\|EnsemblGenome=HelroG75318\|UniProtKB=T1G236	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g41069\|UniProtKB=A7SQB0	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g888\|UniProtKB=A7T2U3	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g219789\|UniProtKB=A7SZ24	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g125559\|UniProtKB=A7SNZ8	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g130363\|UniProtKB=A7SSU4	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g747\|UniProtKB=A7SZ25	Nematostella vectensis	O
NEMVE\|Gene_ORFName=NEMVEDRAFT_v1g150279\|UniProtKB=A8DUV0	Nematostella vectensis	O
NEMVE\|Gene_ORFName=NEMVEDRAFT_v1g139276\|UniProtKB=A7SZN2	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g87211\|UniProtKB=A7RMX3	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g192003\|UniProtKB=A7SPB2	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g51468\|UniProtKB=A7SNQ2	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g548\|UniProtKB=A7RQW9	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g50817\|UniProtKB=A7S429	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g342\|UniProtKB=A7SL31	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g52068\|UniProtKB=A7SJC3	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG26462\|UniProtKB=B3RZW2	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG33213\|UniProtKB=B3SCC4	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG34361\|UniProtKB=B3SE65	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG21402\|UniProtKB=B3RPA9	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG22166\|UniProtKB=B3RS24	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG12692\|UniProtKB=B3RNJ5	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG25138\|UniProtKB=B3RWU9	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG33810\|UniProtKB=B3SDB5	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG26631\|UniProtKB=B3RZ31	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG57304\|UniProtKB=B3RZ27	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG57597\|UniProtKB=B3RZW3	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG64387\|UniProtKB=B3SC77	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG21526\|UniProtKB=B3RNJ4	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_32603\|UniProtKB=A9V0L5	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_12732\|UniProtKB=A9VD54	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_36207\|UniProtKB=A9UTS1	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_38323\|UniProtKB=A9V702	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_35451\|UniProtKB=A9UP58	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_29619\|UniProtKB=A9VBM5	Monosiga brevicollis	O
DICDI\|dictyBase=DDB_G0271042\|UniProtKB=Q55C92	Dictyostelium discoideum	O
DICDI\|dictyBase=DDB_G0275659\|UniProtKB=Q869K4	Dictyostelium discoideum	O
DICDI\|Gene_ORFName=DDB_G0285745\|UniProtKB=Q54N64	Dictyostelium discoideum	O
DICDI\|dictyBase=DDB_G0285585\|UniProtKB=Q54N02	Dictyostelium discoideum	O
GIAIC\|EnsemblGenome=GL50803_114626\|UniProtKB=A8BWG3	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_91099\|UniProtKB=A8BTA8	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_113531\|UniProtKB=A8BEA6	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_113836\|UniProtKB=A8BXP3	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_137727\|UniProtKB=A8BNN0	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_14573\|UniProtKB=A8BMN6	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_6372\|UniProtKB=A8BT87	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_112633\|UniProtKB=A8BVF8	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_95162\|UniProtKB=A8BZA2	Giardia intestinalis	O
GIAIC\|Gene_ORFName=GL50803_0060030\|UniProtKB=A0A644F7H1	Giardia intestinalis	O
GIAIC\|Gene_ORFName=GL50803_006509\|UniProtKB=A0A644F1Q0	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_114210\|UniProtKB=A8BQI2	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_113213\|UniProtKB=A8BYX4	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_16322\|UniProtKB=A8BIQ0	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_114991\|UniProtKB=A8B938	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_16936\|UniProtKB=A8B2J5	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_94003\|UniProtKB=A8BST4	Giardia intestinalis	O
THAPS\|EnsemblGenome=THAPSDRAFT_24894\|UniProtKB=B8CCM9	Thalassiosira pseudonana	O
PHYRM\|Gene=H3GUG4_PHYRM\|UniProtKB=H3GUG4	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_16g668700v5\|UniProtKB=A0A2K3CUE0	Chlamydomonas reinhardtii	O