PANTHER Gene Information

Gene Symbol(s):

REXO5

Organism:

Homo sapiens

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Gene Name:

RNA exonuclease 5

Gene ID:

HGNC:24661

Protein ID:

Q96IC2

Enhancers:

View enhancers for HUMAN|HGNC=24661|UniProtKB=Q96IC2

Genetic Variant Annotation:

Annoq

Persistent Id:

PTN002291996

Alternate Ids:

AL162035(EMBL)	81691(GeneID)
ENSG00000005189(Ensembl)	74760869(GI)
HGNC:24661(HGNC)	CAB66697(EMBL-CDS)
REXO5{ECO:0000312\|HGNC:HGNC:24661}(Symbol)	Exonuclease NEF-sp(Synonym)
B2RB19(AltAccession)	3.1.-.-(EC)
REXO5_HUMAN(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED (PTHR12801)
PANTHER Subfamily:	RNA EXONUCLEASE 5 (PTHR12801:SF82)
PANTHER GO-slim Molecular Function:	exonuclease activity
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:	nucleus
PANTHER protein class:	exoribonuclease

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	RNA binding, exonuclease activity
GO BP Complete:	rRNA 3'-end processing
GO CC Complete:	nucleus, extracellular exosome, nucleolus

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
PANTR\|Ensembl=ENSPTRG00000007851.6\|UniProtKB=G2HG75	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000004539.3\|UniProtKB=G3RM81	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000016748.4\|UniProtKB=F7AIV4	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1919402\|UniProtKB=D3YW29	Mus musculus	LDO
RAT\|RGD=1305412\|UniProtKB=A1A5R7	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000006449\|UniProtKB=Q2T9U5	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000007855.5\|UniProtKB=A0A287A111	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000018769.4\|UniProtKB=A0A9L0RHP6	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000015160.6\|UniProtKB=M3WM25	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845007224.1\|UniProtKB=A0A8I3N036	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000007059.4\|UniProtKB=A0A5F8G601	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000014291.3\|UniProtKB=F6Q5D5	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010017993.1\|UniProtKB=A0A8V0Z4K9	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000009744.4\|UniProtKB=H9GFL6	Anolis carolinensis	LDO
XENLA\|Gene=rexo5.S\|UniProtKB=A0A1L8EQK4	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-980884\|UniProtKB=A0A6I8Q8M0	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000009738.2\|UniProtKB=H2M1D1	Oryzias latipes	LDO
BRAFL\|Gene=LOC118427907\|UniProtKB=A0A9J7M5K7	Branchiostoma floridae	LDO
CAEEL\|WormBase=WBGene00015462\|UniProtKB=O16312	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00038387\|UniProtKB=G2J6Z5	Caenorhabditis briggsae	LDO
DROME\|FlyBase=FBgn0286051\|UniProtKB=Q9VRX7	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP005406\|UniProtKB=Q7Q7B0	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC003027\|UniProtKB=D6WG53	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_326896\|UniProtKB=E9H939	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_227396\|UniProtKB=E9H6J0	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW000182\|UniProtKB=B7P3V4	Ixodes scapularis	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g100526\|UniProtKB=A7S141	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG20882\|UniProtKB=B3RN63	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG28004\|UniProtKB=B3S1E2	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG63711\|UniProtKB=B3RR26	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_10314\|UniProtKB=A9V5V0	Monosiga brevicollis	O
YEAST\|SGD=S000004097\|UniProtKB=Q12090	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_AGR052C\|UniProtKB=Q750A5	Eremothecium gossypii	O
CANAL\|CGD=CAL0000199313\|UniProtKB=Q5AL29	Candida albicans	O
YEAST\|SGD=S000003508\|UniProtKB=P53331	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_AGL332W\|UniProtKB=Q751M9	Eremothecium gossypii	O
CANAL\|CGD=CAL0000194430\|UniProtKB=Q5AAW5	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_B07689g\|UniProtKB=Q6CFE7	Yarrowia lipolytica	O
YARLI\|EnsemblGenome=YALI0_B15400g\|UniProtKB=Q6CEI3	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_05013\|UniProtKB=Q5B367	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_3G12310\|UniProtKB=Q4WYA1	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU08945\|UniProtKB=Q1K6R8	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_10273\|UniProtKB=A7EY58	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_10708\|UniProtKB=Q0UC06	Phaeosphaeria nodorum	O
EMENI\|EnsemblGenome=ANIA_07566\|UniProtKB=Q5AVW4	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_2G14950\|UniProtKB=Q4X025	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU02961\|UniProtKB=Q7SH08	Neurospora crassa	O
SCLS1\|Gene_ORFName=SS1G_07883\|UniProtKB=A7ERC9	Sclerotinia sclerotiorum	O
PHANO\|Gene_ORFName=SNOG_07576\|UniProtKB=Q0UKY8	Phaeosphaeria nodorum	O
PHANO\|EnsemblGenome=SNOG_16531\|UniProtKB=Q0TVD3	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPAC1782.08c\|UniProtKB=Q9P7H2	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_00081\|UniProtKB=B6JUY2	Schizosaccharomyces japonicus	O
SCHPO\|PomBase=SPAC637.09\|UniProtKB=O94443	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_02993\|UniProtKB=B6K314	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CNC00500\|UniProtKB=Q5KL74	Cryptococcus neoformans	O
CRYNJ\|EnsemblGenome=CNN02200\|UniProtKB=Q5K6U9	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_03695\|UniProtKB=A0A0D1DX14	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_10578\|UniProtKB=E3KIS5	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_87676\|UniProtKB=F4P0H5	Batrachochytrium dendrobatidis	O
DICDI\|dictyBase=DDB_G0281327\|UniProtKB=Q54U94	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_159911\|UniProtKB=F1A595	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0291590\|UniProtKB=Q54EC1	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_54227\|UniProtKB=F0ZG40	Dictyostelium purpureum	O
LEIMA\|EnsemblGenome=LMJF_10_0270\|UniProtKB=Q4QHI9	Leishmania major	O
TRYB2\|Gene_ORFName=Tb927.8.3710\|UniProtKB=Q580Z1	Trypanosoma brucei	O
GIAIC\|EnsemblGenome=GL50803_5823\|UniProtKB=A8BIN6	Giardia intestinalis	O
PLAF7\|Gene_ORFName=PF3D7_1337300\|UniProtKB=A0A5K1K8K9	Plasmodium falciparum	O
THAPS\|EnsemblGenome=THAPSDRAFT_2991\|UniProtKB=B8BVX8	Thalassiosira pseudonana	O
PHYRM\|Gene=H3GSG9_PHYRM\|UniProtKB=H3GSG9	Phytophthora ramorum	O
PHYRM\|Gene=H3GPY8_PHYRM\|UniProtKB=H3GPY8	Phytophthora ramorum	O
PHYRM\|Gene=H3H3X4_PHYRM\|UniProtKB=H3H3X4	Phytophthora ramorum	O
PHYRM\|Gene=H3GZJ8_PHYRM\|UniProtKB=H3GZJ8	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_01g036600v5\|UniProtKB=A0A2K3E734	Chlamydomonas reinhardtii	O
AMBTC\|EnsemblGenome=AMTR_s00131p00040500\|UniProtKB=W1NXJ3	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_2G02090\|UniProtKB=A0A0K9PB69	Zostera marina	O
MUSAM\|EnsemblGenome=Ma09_g29740\|UniProtKB=A0A804KQ65	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_010407mg\|UniProtKB=K3Y866	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3006G243100\|UniProtKB=A0A1Z5RFB3	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb110230\|UniProtKB=A0A804MTE7	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb068290\|UniProtKB=A0A1D6DW13	Zea mays	O
ORYSJ\|EnsemblGenome=Os04g0650600\|UniProtKB=Q0J9I1	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_5g24250v3\|UniProtKB=A0A2K2CJ08	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.2HG0204270\|UniProtKB=A0A8I7B8A0	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS2B02G538900\|UniProtKB=A0A3B6CEU0	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2D02G512200\|UniProtKB=A0A3B6DLN4	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2A02G510900\|UniProtKB=A0A3B6B7Z0	Triticum aestivum	O
NELNU\|Gene=LOC104588125\|UniProtKB=A0A1U7YUZ6	Nelumbo nucifera	O
NELNU\|Gene=LOC104607051\|UniProtKB=A0A1U8B432	Nelumbo nucifera	O
SPIOL\|Gene=LOC110778473\|UniProtKB=A0A9R0HXM1	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr12g0552621\|UniProtKB=A0A251TE73	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C300135010\|UniProtKB=A0A9R1VYA1	Lactuca sativa	O
LACSA\|Gene_ORFName=LSAT_V11C300135040\|UniProtKB=A0A9R1W1Y1	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a008812mg\|UniProtKB=A0A022RWX4	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_25983\|UniProtKB=A0A2G2YM85	Capsicum annuum	O
CAPAN\|EnsemblGenome=T459_25984\|UniProtKB=A0A2G2YMC1	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400010461\|UniProtKB=M1AP79	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc10g084160.2\|UniProtKB=A0A3Q7IN57	Solanum lycopersicum	O
TOBAC\|Gene=LOC107789081\|UniProtKB=A0A1S3ZPQ6	Nicotiana tabacum	O
TOBAC\|Gene=LOC107798545\|UniProtKB=A0A1S4AKU4	Nicotiana tabacum	O
TOBAC\|Gene=LOC107816016\|UniProtKB=A0A1S4C7Q2	Nicotiana tabacum	O
EUCGR\|EnsemblGenome=EUGRSUZ_I00803\|UniProtKB=A0A059ALY5	Eucalyptus grandis	O
BRANA\|Gene_ORFName=GSBRNA2T00007275001\|UniProtKB=A0A078IU89	Brassica napus	O
ARATH\|TAIR=locus=2169717\|UniProtKB=Q9FFG1	Arabidopsis thaliana	O
BRANA\|Gene_ORFName=DARMORV10_C01P30070.1\|UniProtKB=A0A078JCU8	Brassica napus	O
BRACM\|EnsemblGenome=Bra029995\|UniProtKB=M4EMH5	Brassica campestris	O
BRANA\|Gene_ORFName=DARMORV10_C08P25210.1\|UniProtKB=A0A078FZI1	Brassica napus	O
BRANA\|Gene_ORFName=DARMORV10_A09P43220.1\|UniProtKB=A0A078GVW0	Brassica napus	O
BRACM\|EnsemblGenome=Bra036055\|UniProtKB=M4F4Q5	Brassica campestris	O
ARATH\|TAIR=locus=2083153\|UniProtKB=Q9SN09	Arabidopsis thaliana	O
ARATH\|TAIR=locus=2155563\|UniProtKB=Q8RXK2	Arabidopsis thaliana	O
ARATH\|TAIR=locus=2083163\|UniProtKB=A3KPE8	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107891333\|UniProtKB=A0A1U8I765	Gossypium hirsutum	O
GOSHI\|Gene=LOC107913580\|UniProtKB=A0A1U8K5A8	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_000687\|UniProtKB=A0A061DH86	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g010743mg\|UniProtKB=A0A067GH79	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_007G048000v3\|UniProtKB=A0A2K1ZPE2	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_12G151100\|UniProtKB=A0A2C9UWY5	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_1153050\|UniProtKB=B9SFZ8	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_10G069900\|UniProtKB=A0A0R0HZA8	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_17G167900\|UniProtKB=A0A0R0FML0	Glycine max	O
MEDTR\|EnsemblGenome=MTR_1g023955\|UniProtKB=A0A072VF22	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr12_00780\|UniProtKB=A0A2I4E2U9	Juglans regia	O
JUGRE\|EnsemblGenome=Jr12_00790\|UniProtKB=A0A2I4GU16	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_6G491630\|UniProtKB=A0A0A0KLE2	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_6G230000\|UniProtKB=A0A251NUE1	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_420963\|UniProtKB=D8SDP5	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_410683\|UniProtKB=D8RFI4	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c18_20990\|UniProtKB=A0A2K1J1U4	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0033s0099\|UniProtKB=A0A2R6X6H7	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_002080110\|UniProtKB=A0A1Y1I1P1	Klebsormidium nitens	O
CHLRE\|EnsemblGenome=CHLRE_14g610663v5\|UniProtKB=A0A2K3CX82	Chlamydomonas reinhardtii	O
AMBTC\|EnsemblGenome=AMTR_s00186p00018880\|UniProtKB=W1PCI0	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_117G00200\|UniProtKB=A0A0K9Q3X3	Zostera marina	O
ZOSMR\|Gene_ORFName=ZOSMA_34G00820\|UniProtKB=A0A0K9P970	Zostera marina	O
MUSAM\|EnsemblGenome=Ma03_g18390\|UniProtKB=A0A804IDJ0	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_009934mg\|UniProtKB=K3Y6U3	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3008G063300\|UniProtKB=A0A1B6PBP4	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb409200\|UniProtKB=C4J3C8	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb138630\|UniProtKB=A0A804N6F3	Zea mays	O
ORYSJ\|EnsemblGenome=Os12g0188900\|UniProtKB=A0A0P0Y7W0	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_4g40790v3\|UniProtKB=A0A0Q3HEQ7	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0292850\|UniProtKB=A0A8I6Y1R1	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS3A02G320700\|UniProtKB=A0A3B6EJG4	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3D02G310600\|UniProtKB=A0A3B6H066	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G345100\|UniProtKB=A0A077RV03	Triticum aestivum	O
NELNU\|Gene=LOC104606737\|UniProtKB=A0A1U8AV44	Nelumbo nucifera	O
SPIOL\|Gene=LOC110782046\|UniProtKB=A0A9R0I373	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr02g0072811\|UniProtKB=A0A251RX73	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr15g0704911\|UniProtKB=A0A251S9Z9	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C900506660\|UniProtKB=A0A9R1UIS8	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a002280mg\|UniProtKB=A0A022R118	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_12327\|UniProtKB=A0A1U8GES2	Capsicum annuum	O
SOLLC\|EnsemblGenome=Solyc04g064560.3\|UniProtKB=A0A3Q7G3A2	Solanum lycopersicum	O
TOBAC\|Gene=LOC107796462\|UniProtKB=A0A1S4AE31	Nicotiana tabacum	O
TOBAC\|Gene=LOC107815163\|UniProtKB=A0A1S4C513	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi18g01211\|UniProtKB=F6H092	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_F02755\|UniProtKB=A0A059BTD7	Eucalyptus grandis	O
BRACM\|EnsemblGenome=Bra009860\|UniProtKB=M4D062	Brassica campestris	O
BRACM\|EnsemblGenome=Bra020513\|UniProtKB=M4DVG9	Brassica campestris	O
ARATH\|TAIR=locus=2145244\|UniProtKB=Q8L7M4	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107952030\|UniProtKB=A0A1U8NXF9	Gossypium hirsutum	O
GOSHI\|Gene=LOC107910416\|UniProtKB=A0A1U8JU16	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_035363\|UniProtKB=A0A061FIQ9	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g008340mg\|UniProtKB=A0A067GY04	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_005G186600v3\|UniProtKB=A0A2K2AIQ5	Populus trichocarpa	O
RICCO\|Gene_ORFName=RCOM_0559410\|UniProtKB=B9S2M9	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_14G119200\|UniProtKB=A0A0R0GCQ1	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_13G037300\|UniProtKB=I1LXA9	Glycine max	O
MEDTR\|EnsemblGenome=MTR_1g029410\|UniProtKB=A0A072VFB2	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr06_02540\|UniProtKB=A0A2I4DYX4	Juglans regia	O
JUGRE\|EnsemblGenome=Jr06_02530\|UniProtKB=A0A2I4DYW6	Juglans regia	O
PRUPE\|EnsemblGenome=PRUPE_8G016300\|UniProtKB=M5W069	Prunus persica	O
PHYPA\|EnsemblGenome=Pp3c1_5030\|UniProtKB=A0A2K1L6X6	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c7_16700\|UniProtKB=A0A2K1KBY1	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0062s0093\|UniProtKB=A0A2R6WS50	Marchantia polymorpha	O
MARPO\|EnsemblGenome=MARPO_0062s0092\|UniProtKB=A0A2R6WS43	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_003920140\|UniProtKB=A0A1Y1IAJ6	Klebsormidium nitens	O