PANTHER Gene Information

Gene Symbol(s):

EIF2S3B

Organism:

Homo sapiens

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Gene Name:

Eukaryotic translation initiation factor 2 subunit 3B

Gene ID:

HGNC:43863

Protein ID:

Q2VIR3

Enhancers:

View enhancers for HUMAN|HGNC=43863|UniProtKB=Q2VIR3

Genetic Variant Annotation:

Annoq

Persistent Id:

PTN001897133

Alternate Ids:

CAA07331(EMBL-CDS)	DQ120619(EMBL)
F8W810(AltAccession)	IF2GL_HUMAN(UniProtKB-ID)
205830883(GI)	3.6.5.3(EC)
eIF-2gA(Synonym)	HGNC:43863(HGNC)
ENSG00000180574(Ensembl)	EIF2S3B{ECO:0000312\|HGNC:HGNC:43863}(Symbol)
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PANTHER Classification

PANTHER Family:	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER (PTHR42854)
PANTHER Subfamily:	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED (PTHR42854:SF14)
PANTHER GO-slim Molecular Function:	translation initiation factor activity tRNA binding
PANTHER GO-slim Biological Process:	protein-RNA complex assembly cytoplasmic translational initiation
PANTHER GO-slim Cellular Component:	cytosol protein-containing complex
PANTHER protein class:	translation initiation factor

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	GTP binding, translation initiation factor activity, membrane scission GTPase motor activity, tRNA binding
GO BP Complete:	formation of translation preinitiation complex
GO CC Complete:	eukaryotic translation initiation factor 2 complex

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
PANTR\|Ensembl=ENSPTRG00000050342.1\|UniProtKB=A0A2I3RF54	Pan troglodytes	O
PANTR\|Ensembl=ENSPTRG00000050860.1\|UniProtKB=A0A2I3RWK9	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000024609.2\|UniProtKB=G3SB85	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000040183.2\|UniProtKB=A0A1D5Q7H3	Macaca mulatta	O
MACMU\|Ensembl=ENSMMUG00000006979.4\|UniProtKB=F7DQV0	Macaca mulatta	O
MOUSE\|MGI=MGI=1349430\|UniProtKB=Q9Z0N2	Mus musculus	O
RAT\|RGD=2314438\|UniProtKB=C9WPN6	Rattus norvegicus	O
MOUSE\|MGI=MGI=1349431\|UniProtKB=Q9Z0N1	Mus musculus	O
RAT\|RGD=1561279\|UniProtKB=P81795	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000014337\|UniProtKB=Q2KHU8	Bos taurus	O
PIG\|Ensembl=ENSSSCG00005018186.1\|UniProtKB=A0A4X1T8G7	Sus scrofa	O
PIG\|Ensembl=ENSSSCG00000029857.5\|UniProtKB=A0A287APW7	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000018100.4\|UniProtKB=A0A3Q2HP26	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000017343.4\|UniProtKB=F6QF52	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000006477.6\|UniProtKB=M3W5Z5	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845030382.1\|UniProtKB=A0A8I3Q3Z7	Canis lupus familiaris	O
CANLF\|Ensembl=ENSCAFG00845020384.1\|UniProtKB=A0A8I3P243	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000007541.3\|UniProtKB=F7GAX1	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000011504.3\|UniProtKB=F6T5I9	Ornithorhynchus anatinus	O
CHICK\|Gene_ORFName=RCJMB04_1f8\|UniProtKB=Q5ZMS3	Gallus gallus	O
CHICK\|Ensembl=ENSGALG00010003077.1\|UniProtKB=F1NPF0	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000007288.4\|UniProtKB=G1KGH9	Anolis carolinensis	O
XENLA\|Gene=eif2s3.S\|UniProtKB=Q7ZY57	Xenopus laevis	O
XENLA\|Gene=eif2s3.L\|UniProtKB=A0A1L8HDJ0	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-986363\|UniProtKB=Q5I098	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000002716.2\|UniProtKB=H2LBW0	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-030131-5552\|UniProtKB=F1QGW6	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000003369.1\|UniProtKB=W5M6I0	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000004255.3\|UniProtKB=F6YFY0	Ciona intestinalis	O
BRAFL\|Gene=LOC118423650\|UniProtKB=A0A9J7LRM4	Branchiostoma floridae	O
BRAFL\|Gene=LOC118423649\|UniProtKB=A0A9J7LRH4	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC115918290\|UniProtKB=A0A7M7SSR2	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC582011\|UniProtKB=A0A7M7RCG1	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00021466\|UniProtKB=Q95XR0	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00026653\|UniProtKB=A8WX01	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00117807\|UniProtKB=A0A8R1YKE3	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0263740\|UniProtKB=Q24208	Drosophila melanogaster	O
TRICA\|EnsemblGenome=TC001103\|UniProtKB=D6WA55	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_231062\|UniProtKB=E9GN88	Daphnia pulex	O
HELRO\|EnsemblGenome=HelroG157135\|UniProtKB=T1EM70	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g187927\|UniProtKB=A7SBR9	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG37737\|UniProtKB=B3RYA1	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_32961\|UniProtKB=A9V2R8	Monosiga brevicollis	O
YEAST\|SGD=S000000827\|UniProtKB=P32481	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_ABR175W\|UniProtKB=Q75D48	Eremothecium gossypii	O
CANAL\|CGD=CAL0000197613\|UniProtKB=Q5AGF6	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_A03839g\|UniProtKB=Q6CHX3	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_04470\|UniProtKB=C8V8G5	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_4G07580\|UniProtKB=Q4WP05	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU02810\|UniProtKB=Q7SEK4	Neurospora crassa	O
SCLS1\|Gene_ORFName=SS1G_12843\|UniProtKB=A7F5G5	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_03512\|UniProtKB=Q0UXK2	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPBC17G9.09\|UniProtKB=Q09130	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_00466\|UniProtKB=B6JVQ1	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CND01480\|UniProtKB=Q5KIW8	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_10129\|UniProtKB=A0A0D1C8S1	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_06411\|UniProtKB=E3K7C5	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_33421\|UniProtKB=F4P6B1	Batrachochytrium dendrobatidis	O
ENTH1\|EnsemblGenome=CL6EHI_132880\|UniProtKB=C4MAU7	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0278967\|UniProtKB=Q54XD8	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_94221\|UniProtKB=F0ZGV2	Dictyostelium purpureum	O
LEIMA\|EnsemblGenome=LMJF_09_1090\|UniProtKB=Q4QHR6	Leishmania major	O
LEIMA\|EnsemblGenome=LMJF_09_1070\|UniProtKB=Q4QHR7	Leishmania major	O
TRYB2\|Gene_ORFName=Tb11.01.4830\|UniProtKB=Q382L1	Trypanosoma brucei	O
GIAIC\|EnsemblGenome=GL50803_12055\|UniProtKB=A8BFK6	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_2970\|UniProtKB=A8BD23	Giardia intestinalis	O
TRIV3\|Gene_ORFName=TVAG_423490\|UniProtKB=A2DTI7	Trichomonas vaginalis	O
PLAF7\|EnsemblGenome=PF3D7_1410600\|UniProtKB=Q8ILY9	Plasmodium falciparum	O
PARTE\|EnsemblGenome=GSPATT00014491001\|UniProtKB=A0D928	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00011016001\|UniProtKB=A0CVN1	Paramecium tetraurelia	O
THAPS\|EnsemblGenome=THAPS_7322\|UniProtKB=B5YNZ5	Thalassiosira pseudonana	O
PHYRM\|Gene=H3G8J5_PHYRM\|UniProtKB=H3G8J5	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_02g098450v5\|UniProtKB=A8I232	Chlamydomonas reinhardtii	O
AMBTC\|EnsemblGenome=AMTR_s00059p00168200\|UniProtKB=U5CWC1	Amborella trichopoda	O
AMBTC\|EnsemblGenome=AMTR_s00006p00256440\|UniProtKB=W1PDL6	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_88G00550\|UniProtKB=A0A0K9NKE5	Zostera marina	O
ZOSMR\|Gene_ORFName=ZOSMA_88G00520\|UniProtKB=A0A0K9NKU2	Zostera marina	O
MUSAM\|EnsemblGenome=Ma11_g10760\|UniProtKB=A0A804L6H4	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma08_g14760\|UniProtKB=A0A804K6M8	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_032152mg\|UniProtKB=K3ZZW7	Setaria italica	O
SETIT\|EnsemblGenome=SETIT_026330mg\|UniProtKB=K3ZIC8	Setaria italica	O
SETIT\|EnsemblGenome=SETIT_013695mg\|UniProtKB=K3YHH7	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3002G341800\|UniProtKB=C5XBM7	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb324510\|UniProtKB=A0A1D6IGS0	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb107110\|UniProtKB=B6TNU0	Zea mays	O
ORYSJ\|EnsemblGenome=Os12g0176800\|UniProtKB=Q2QWZ1	Oryza sativa	O
ORYSJ\|EnsemblGenome=Os12g0607100\|UniProtKB=Q2QME5	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_5g09350v3\|UniProtKB=A0A0Q3P1F7	Brachypodium distachyon	O
BRADI\|EnsemblGenome=BRADI_2g56414v3\|UniProtKB=A0A2K2DG59	Brachypodium distachyon	O
BRADI\|EnsemblGenome=BRADI_4g02587v3\|UniProtKB=I1IGR7	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.1HG0077420\|UniProtKB=F2CW97	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS5D02G083100\|UniProtKB=A0A3B6MKF5	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1A02G336000\|UniProtKB=A0A3B5Y477	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1D02G419100\|UniProtKB=A0A3B6A2S7	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1B02G441500\|UniProtKB=A0A3B5Z4N7	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1A02G411300\|UniProtKB=A0A3B5Y7X2	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1B02G349300\|UniProtKB=W5F459	Triticum aestivum	O
NELNU\|Gene=LOC104588303\|UniProtKB=A0A1U7Z1J7	Nelumbo nucifera	O
NELNU\|Gene=LOC104610645\|UniProtKB=A0A1U8B479	Nelumbo nucifera	O
SPIOL\|Gene=LOC110777638\|UniProtKB=A0A9R0HW73	Spinacia oleracea	O
SPIOL\|Gene=LOC110788947\|UniProtKB=A0A9R0IH72	Spinacia oleracea	O
HELAN\|Gene_ORFName=HannXRQ_Chr11g0349361\|UniProtKB=A0A251TEG3	Helianthus annuus	O
HELAN\|Gene_ORFName=HanXRQr2_Chr01g0036151\|UniProtKB=A0A9K3P479	Helianthus annuus	O
HELAN\|Gene_ORFName=HanXRQr2_Chr11g0513811\|UniProtKB=A0A9K3HSF1	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr11g0504451\|UniProtKB=A0A251TBS4	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C100031290\|UniProtKB=A0A9R1WKN7	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a005929mg\|UniProtKB=A0A022RVH3	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_02356\|UniProtKB=A0A1U8HGG1	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400011315\|UniProtKB=M1AST3	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc01g066690.3\|UniProtKB=A0A3Q7EFX0	Solanum lycopersicum	O
TOBAC\|Gene=LOC107828677\|UniProtKB=A0A1S4DDW7	Nicotiana tabacum	O
TOBAC\|Gene=LOC107768991\|UniProtKB=A0A1S3XUU6	Nicotiana tabacum	O
CAPAN\|EnsemblGenome=T459_01486\|UniProtKB=A0A1U8H259	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400008801\|UniProtKB=M1AH31	Solanum tuberosum	O
TOBAC\|Gene=LOC107818198\|UniProtKB=A0A1S4CET9	Nicotiana tabacum	O
TOBAC\|Gene=LOC107791447\|UniProtKB=A0A1S3ZX41	Nicotiana tabacum	O
CAPAN\|EnsemblGenome=T459_31374\|UniProtKB=A0A2G2YB84	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400023536\|UniProtKB=M1C613	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc05g054310.3\|UniProtKB=A0A3Q7GME0	Solanum lycopersicum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400004704\|UniProtKB=M1A0I0	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc12g099470.2\|UniProtKB=A0A3Q7JFK3	Solanum lycopersicum	O
TOBAC\|Gene=LOC107770261\|UniProtKB=A0A1S3XYL4	Nicotiana tabacum	O
TOBAC\|Gene=LOC107766896\|UniProtKB=A0A1S3XMV0	Nicotiana tabacum	O
TOBAC\|Gene=LOC107825776\|UniProtKB=A0A1S4D4H2	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi13g00732\|UniProtKB=D7UBU1	Vitis vinifera	O
VITVI\|EnsemblGenome=Vitvi10g01338\|UniProtKB=A5AKA8	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_H03938\|UniProtKB=A0A059B562	Eucalyptus grandis	O
GOSHI\|Gene=LOC107944498\|UniProtKB=A0A1U8N400	Gossypium hirsutum	O
GOSHI\|Gene=LOC107936138\|UniProtKB=A0A1U8MBT8	Gossypium hirsutum	O
GOSHI\|Gene=LOC107891860\|UniProtKB=A0A1U8I7U2	Gossypium hirsutum	O
EUCGR\|EnsemblGenome=EUGRSUZ_B01599\|UniProtKB=A0A059D2H3	Eucalyptus grandis	O
BRANA\|Gene_ORFName=DARMORV10_A10P02590.1\|UniProtKB=A0A078DKS3	Brassica napus	O
BRACM\|EnsemblGenome=Bra015292\|UniProtKB=M4DFL9	Brassica campestris	O
BRANA\|Gene_ORFName=DARMORV10_A08P37080.1\|UniProtKB=A0A078FT64	Brassica napus	O
BRACM\|EnsemblGenome=Bra030556\|UniProtKB=M4EP36	Brassica campestris	O
BRANA\|Gene_ORFName=DARMORV10_A09P68000.1\|UniProtKB=A0A078H530	Brassica napus	O
BRANA\|Gene_ORFName=DARMORV10_C08P52440.1\|UniProtKB=A0A078FAL8	Brassica napus	O
BRACM\|EnsemblGenome=Bra032525\|UniProtKB=M4EUP3	Brassica campestris	O
ARATH\|TAIR=locus=2141857\|UniProtKB=F4JQU1	Arabidopsis thaliana	O
ARATH\|TAIR=locus=2053972\|UniProtKB=F4IRF5	Arabidopsis thaliana	O
ARATH\|TAIR=locus=2020260\|UniProtKB=O64490	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107891861\|UniProtKB=A0A1U8I220	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_021231\|UniProtKB=A0A061EPF4	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g039945mg\|UniProtKB=A0A067FWF8	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_003G104900v3\|UniProtKB=B9H043	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_001G129100v3\|UniProtKB=B9GLM1	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_01G138000\|UniProtKB=A0A2C9WN85	Manihot esculenta	O
SOYBN\|EnsemblGenome=GLYMA_15G255900\|UniProtKB=C6TAN4	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_08G171500\|UniProtKB=I1KU39	Glycine max	O
MEDTR\|EnsemblGenome=MTR_2g075870\|UniProtKB=G7ITF1	Medicago truncatula	O
MEDTR\|EnsemblGenome=MTR_2g069440\|UniProtKB=G7IJ99	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr12_11050\|UniProtKB=A0A2I4F261	Juglans regia	O
JUGRE\|EnsemblGenome=Jr07_18480\|UniProtKB=A0A2I4HND1	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_5G266830\|UniProtKB=A0A0A0KMB1	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_5G215200\|UniProtKB=A0A251PDF8	Prunus persica	O
PRUPE\|EnsemblGenome=PRUPE_1G133900\|UniProtKB=M5XFJ6	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_180798\|UniProtKB=D8SLJ2	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_172686\|UniProtKB=D8RMF8	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c11_18690\|UniProtKB=A0A7I4AEQ4	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c7_5020\|UniProtKB=A9TD58	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0005s0129\|UniProtKB=A0A2R6XQV5	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_002060240\|UniProtKB=A0A1Y1I2V6	Klebsormidium nitens	O
NITMS\|EnsemblGenome=Nmar_0072\|UniProtKB=A9A111	Nitrosopumilus maritimus	O
KORCO\|EnsemblGenome=Kcr_1022\|UniProtKB=B1L5N9	Korarchaeum cryptofilum	O
SACS2\|EnsemblGenome=SSO0412\|UniProtKB=Q980A5	Sulfolobus solfataricus	O
PYRAE\|EnsemblGenome=PAE0064\|UniProtKB=Q8ZZV4	Pyrobaculum aerophilum	O
METAC\|EnsemblGenome=MA_3690\|UniProtKB=Q8TJT7	Methanosarcina acetivorans	O
METJA\|EnsemblGenome=MJ_1261\|UniProtKB=Q58657	Methanocaldococcus jannaschii	O
HALSA\|EnsemblGenome=VNG_2056G\|UniProtKB=Q9HNK9	Halobacterium salinarum	O
THEKO\|EnsemblGenome=TK1946\|UniProtKB=Q5JDL3	Thermococcus kodakaraensis	O
CHLAA\|EnsemblGenome=Caur_0243\|UniProtKB=A9WCA3	Chloroflexus aurantiacus	O
THEYD\|EnsemblGenome=THEYE_A0071\|UniProtKB=B5YHA3	Thermodesulfovibrio yellowstonii	O
GEOSL\|EnsemblGenome=GSU0102\|UniProtKB=Q74GZ1	Geobacter sulfurreducens	O
HAEIN\|EnsemblGenome=HI_0709\|UniProtKB=P43927	Haemophilus influenzae	O
SHEON\|Gene_OrderedLocusName=SO_0106\|UniProtKB=Q8EKI7	Shewanella oneidensis	O
PSEAE\|EnsemblGenome=PA4807\|UniProtKB=Q9HV02	Pseudomonas aeruginosa	O
SALTY\|EnsemblGenome=STM3682\|UniProtKB=Q8ZL70	Salmonella typhimurium	O
ECOLI\|EnsemblGenome=BAE77703\|UniProtKB=P14081	Escherichia coli	O