PANTHER Gene Information

Gene Symbol(s):

TIE1

Organism:

Macaca mulatta

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Gene Name:

receptor protein-tyrosine kinase

Gene ID:

ENSMMUG00000010660.4

Protein ID:

G7MGE5

Persistent Id:

PTN000699010

Alternate Ids:

G7MGE5(Synonym)	AFH28328(EMBL-CDS)
ENSMMUP00000013971(Ensembl_PRO)	ENSMMUT00000014912(Ensembl_TRS)
ENSMMUG00000010660(Ensembl)	702208(GeneID)
XM_015137399(refSeq)	966917053(GI)
JU471524(EMBL)	G7MGE5_MACMU(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	TYROSINE-PROTEIN KINASE RECEPTOR (PTHR24416)
PANTHER Subfamily:	TYROSINE-PROTEIN KINASE RECEPTOR TIE-1 (PTHR24416:SF341)
PANTHER GO-slim Molecular Function:	transmembrane receptor protein tyrosine kinase activity
PANTHER GO-slim Biological Process:	multicellular organism development regulation of angiogenesis positive regulation of multicellular organismal process positive regulation of kinase activity transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of developmental process
PANTHER GO-slim Cellular Component:	plasma membrane receptor complex
PANTHER protein class:	transmembrane signal receptor

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	placental growth factor receptor activity, stem cell factor receptor activity, brain-derived neurotrophic factor receptor activity, macrophage colony-stimulating factor receptor activity, protein tyrosine kinase collagen receptor activity, insulin-like growth factor receptor activity, vascular endothelial growth factor receptor activity, protein kinase activity, boss receptor activity, GPI-linked ephrin receptor activity, epidermal growth factor receptor activity, transmembrane-ephrin receptor activity, hepatocyte growth factor receptor activity, platelet-derived growth factor beta-receptor activity, fibroblast growth factor receptor activity, platelet-derived growth factor alpha-receptor activity, ATP binding, protein tyrosine kinase activity, insulin receptor activity, transmembrane receptor protein tyrosine kinase activity, kinase activity
GO BP Complete:	negative regulation of angiogenesis, multicellular organism development, insulin receptor signaling pathway, epidermal growth factor receptor signaling pathway, fibroblast growth factor receptor signaling pathway, regulation of extracellular matrix assembly, plasma membrane fusion, positive regulation of angiogenesis, response to retinoic acid, blood vessel development, in utero embryonic development, Kit signaling pathway, vascular endothelial growth factor receptor-1 signaling pathway, aortic valve morphogenesis, platelet-derived growth factor receptor-alpha signaling pathway, macrophage colony-stimulating factor signaling pathway, platelet-derived growth factor receptor-beta signaling pathway, vascular endothelial growth factor signaling pathway, insulin-like growth factor receptor signaling pathway, cell surface receptor protein tyrosine kinase signaling pathway, collagen-activated tyrosine kinase receptor signaling pathway, lymphatic endothelial cell differentiation, branching involved in lymph vessel morphogenesis, hepatocyte growth factor receptor signaling pathway, tissue remodeling, brain-derived neurotrophic factor receptor signaling pathway, ephrin receptor signaling pathway, regulation of endothelial cell proliferation, negative regulation of cell migration
GO CC Complete:	membrane, receptor complex, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=11809\|UniProtKB=P35590	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000000631.6\|UniProtKB=H2PYU7	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000008745.3\|UniProtKB=G3R075	Gorilla gorilla gorilla	LDO
MOUSE\|MGI=MGI=99906\|UniProtKB=Q06806	Mus musculus	LDO
RAT\|RGD=621642\|UniProtKB=B5DFD6	Rattus norvegicus	LDO
BOVIN\|Gene=TIE1\|UniProtKB=Q06805	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000003777.5\|UniProtKB=A0A3Q1M0U5	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000003950.5\|UniProtKB=F1SFD1	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000006177.3\|UniProtKB=F7E396	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000015111.6\|UniProtKB=M3WLY6	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845019831.1\|UniProtKB=A0A8I3S459	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000011374.4\|UniProtKB=F6SPK9	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000008211.4\|UniProtKB=A0A6I8N8C2	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010022659.1\|UniProtKB=A0A8V0ZWV8	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000013254.4\|UniProtKB=G1KNK3	Anolis carolinensis	LDO
XENLA\|Gene=tie1.L\|UniProtKB=A0A1L8GM27	Xenopus laevis	O
XENLA\|Gene=LOC108715544\|UniProtKB=A0A8J1KM96	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-922217\|UniProtKB=A0A6I8S349	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000010699.2\|UniProtKB=H2M4P5	Oryzias latipes	LDO
LEPOC\|Ensembl=ENSLOCG00000006350.1\|UniProtKB=W5MH08	lepisosteus oculatus	LDO
BRAFL\|Gene=LOC118432243\|UniProtKB=A0A9J7NDK0	Branchiostoma floridae	O
BRAFL\|Gene=LOC118431533\|UniProtKB=A0A9J7MCD0	Branchiostoma floridae	O
BRAFL\|Gene=LOC118410884\|UniProtKB=A0A9J7MIL3	Branchiostoma floridae	O
BRAFL\|Gene=LOC118431526\|UniProtKB=A0A9J7NCD2	Branchiostoma floridae	O
BRAFL\|Gene=LOC118416664\|UniProtKB=A0A9J7MSZ6	Branchiostoma floridae	O
BRAFL\|Gene=LOC118431263\|UniProtKB=A0A9J7NCM0	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=GeneID_592402\|UniProtKB=A0A7M7PIL3	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00020966\|UniProtKB=Q23136	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG05171\|UniProtKB=A8WZA7	Caenorhabditis briggsae	O
DROME\|FlyBase=FBgn0011829\|UniProtKB=Q7KT06	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP008899\|UniProtKB=A0A1S4H0B3	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC012783\|UniProtKB=D6X0D7	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_40778\|UniProtKB=E9FTN9	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW003506\|UniProtKB=B7PIC9	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG133652\|UniProtKB=T1EI21	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g134557\|UniProtKB=A7SVX1	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g210816\|UniProtKB=A7SE14	Nematostella vectensis	O
NEMVE\|Gene_ORFName=NEMVEDRAFT_v1g150265\|UniProtKB=A7T8I7	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g1620\|UniProtKB=A7SZN9	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g117565\|UniProtKB=A7SGK0	Nematostella vectensis	O
NEMVE\|Gene_ORFName=NEMVEDRAFT_v1g120496\|UniProtKB=A7SJE2	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g41034\|UniProtKB=A7SQ51	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g1840\|UniProtKB=A7T537	Nematostella vectensis	O
MONBE\|EnsemblGenome=MONBRDRAFT_38493\|UniProtKB=A9V865	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_34608\|UniProtKB=A9VCU7	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_27123\|UniProtKB=A9V4D1	Monosiga brevicollis	O