PANTHER Gene Information

Gene Symbol(s):

RHEB

Organism:

Macaca mulatta

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Gene Name:

GTP-binding protein Rheb

Gene ID:

ENSMMUG00000051076.1

Protein ID:

F7H5C5

Persistent Id:

PTN009079547

Alternate Ids:

383408111(GI)	JU320547(EMBL)
F7H5C5_MACMU(UniProtKB-ID)	NM_001261182(refSeq)
AFI37915(EMBL-CDS)	715378(GeneID)
ENSMMUP00000079430(Ensembl_PRO)	F7H5C5(Synonym)
ENSMMUT00000082593(Ensembl_TRS)	ENSMMUG00000051076(Ensembl)
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PANTHER Classification

PANTHER Family:	RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY (PTHR24070)
PANTHER Subfamily:	GTP-BINDING PROTEIN RHEB (PTHR24070:SF264)
PANTHER GO-slim Molecular Function:	GTPase activity carbohydrate derivative binding anion binding nucleotide binding
PANTHER GO-slim Biological Process:	small GTPase-mediated signal transduction
PANTHER GO-slim Cellular Component:	plasma membrane
PANTHER protein class:	small GTPase

Pathway Categories:

p53 pathway by glucose deprivation

Ras homolog enriched in brain 2

CCKR signaling map

RHEB-GTP

CCKR signaling map

RHEB-GDP

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	magnesium ion binding, GTP binding, protein kinase binding, protein serine/threonine kinase activator activity, GTPase activity, protein kinase activator activity, GDP binding
GO BP Complete:	oligodendrocyte differentiation, positive regulation of TORC1 signaling, cellular response to nutrient levels, signal transduction, small GTPase-mediated signal transduction, regulation of type B pancreatic cell development, positive regulation of TOR signaling, negative regulation of cold-induced thermogenesis, regulation of TOR signaling, positive regulation of oligodendrocyte differentiation
GO CC Complete:	postsynaptic density, membrane, spliceosomal complex, endomembrane system, Golgi membrane, synapse, lysosomal membrane, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=10011\|UniProtKB=Q15382	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000046866.1\|UniProtKB=K7C1E5	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000014675.3\|UniProtKB=G3RFE9	Gorilla gorilla gorilla	LDO
MOUSE\|MGI=MGI=97912\|UniProtKB=Q921J2	Mus musculus	LDO
RAT\|RGD=621840\|UniProtKB=Q62639	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000053552.1\|UniProtKB=A0A3Q1LSR3	Bos taurus	O
BOVIN\|Gene=RHEB\|UniProtKB=Q56JV3	Bos taurus	LDO
BOVIN\|Ensembl=ENSBTAG00000031861.4\|UniProtKB=F2Z4I1	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000035428.2\|UniProtKB=A0A287A0E5	Sus scrofa	O
PIG\|Ensembl=ENSSSCG00000016434.5\|UniProtKB=F2Z5R2	Sus scrofa	LDO
FELCA\|Ensembl=ENSFCAG00000012862.6\|UniProtKB=M3WHR6	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845011138.1\|UniProtKB=A0A8I3NTN6	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000048800.1\|UniProtKB=A0A5F8HB55	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000048639.1\|UniProtKB=A0A6I8NCC2	Ornithorhynchus anatinus	LDO
XENLA\|Gene=LOC108719819\|UniProtKB=A0A1L8FQH6	Xenopus laevis	O
XENLA\|Gene=rheb.L\|UniProtKB=Q7ZYE5	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-492096\|UniProtKB=B7ZST5	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000001566.2\|UniProtKB=A0A3B3I0P2	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-000510-1\|UniProtKB=Q08CD8	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000007682.1\|UniProtKB=W5MLR9	lepisosteus oculatus	O
ORYLA\|Ensembl=ENSORLG00000025819.1\|UniProtKB=A0A3B3I1B9	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000003681.2\|UniProtKB=H2LF54	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-040426-1690\|UniProtKB=Q6PC18	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000010004.1\|UniProtKB=W5MV23	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000002194.3\|UniProtKB=F6S569	Ciona intestinalis	LDO
BRAFL\|Gene_ORFName=BRAFLDRAFT_120734\|UniProtKB=C3YXK2	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC592590\|UniProtKB=A0A7M7REY8	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00020833\|UniProtKB=U4PQV1	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00024842\|UniProtKB=A8WR73	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00277005\|UniProtKB=A0A8R1YUY4	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00010038\|UniProtKB=P34443	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00031567\|UniProtKB=A8XAD0	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00282717\|UniProtKB=A0A2A6BR52	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0041191\|UniProtKB=Q9VND8	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP001902\|UniProtKB=Q7PYE6	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC014613\|UniProtKB=D6WMY2	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC014205\|UniProtKB=D6W709	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_198166\|UniProtKB=E9GRL7	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW018020\|UniProtKB=B7PF10	Ixodes scapularis	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g236736\|UniProtKB=A7RY50	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG53571\|UniProtKB=B3RPK3	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_36472\|UniProtKB=A9UVE7	Monosiga brevicollis	LDO
YEAST\|SGD=S000000622\|UniProtKB=P25378	Saccharomyces cerevisiae	LDO
CANAL\|CGD=CAL0000173935\|UniProtKB=Q5ANA9	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_E30943g\|UniProtKB=Q6C400	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_08868\|UniProtKB=Q5AS62	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_5G05480\|UniProtKB=E9R5S0	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU01042\|UniProtKB=F5HE08	Neurospora crassa	O
NEUCR\|EnsemblGenome=NCU01444\|UniProtKB=Q1K4R5	Neurospora crassa	LDO
PHANO\|EnsemblGenome=SNOG_09429\|UniProtKB=Q0UFN5	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPBC428.16c\|UniProtKB=O94363	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_02605\|UniProtKB=B6K0P7	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNB03660\|UniProtKB=Q5KLY1	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_05654\|UniProtKB=A0A0D1DR30	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_12906\|UniProtKB=E3KSN6	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_84861\|UniProtKB=F4NVR2	Batrachochytrium dendrobatidis	LDO
DICDI\|dictyBase=DDB_G0278717\|UniProtKB=Q54YI4	Dictyostelium discoideum	O
DICDI\|dictyBase=DDB_G0273099\|UniProtKB=Q556U0	Dictyostelium discoideum	O
DICDI\|dictyBase=DDB_G0279305\|UniProtKB=Q54WZ4	Dictyostelium discoideum	O
DICDI\|dictyBase=DDB_G0278217\|UniProtKB=Q54YJ0	Dictyostelium discoideum	O
DICDI\|dictyBase=DDB_G0278403\|UniProtKB=Q54Y59	Dictyostelium discoideum	O
DICDI\|dictyBase=DDB_G0278389\|UniProtKB=Q54Y66	Dictyostelium discoideum	O
DICDI\|dictyBase=DDB_G0292318\|UniProtKB=Q54DD9	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_93001\|UniProtKB=F1A0K5	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_148955\|UniProtKB=F0ZCF5	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_82710\|UniProtKB=F0ZXC4	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_55232\|UniProtKB=F0ZL00	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_80316\|UniProtKB=F0ZQ50	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_84962\|UniProtKB=F1A497	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0277041\|UniProtKB=Q550Q4	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_147775\|UniProtKB=F0Z9D6	Dictyostelium purpureum	LDO
PARTE\|EnsemblGenome=GSPATT00005802001\|UniProtKB=A0BVI9	Paramecium tetraurelia	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_40580\|UniProtKB=B8C1N9	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3G694_PHYRM\|UniProtKB=H3G694	Phytophthora ramorum	LDO