PANTHER Gene Information

Gene Symbol(s):

CRYAB

Organism:

Monodelphis domestica

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Tree

Gene Name:

Crystallin alpha B

Gene ID:

ENSMODG00000014453.3

Protein ID:

F7ATA8

Persistent Id:

PTN009180256

Alternate Ids:

F7ATA8(Synonym)	F7ATA8_MONDO(UniProtKB-ID)
100026448(GeneID)	ENSMODP00000018065(Ensembl_PRO)
126326656(GI)	ENSMODG00000014453(Ensembl)
ENSMODT00000018397(Ensembl_TRS)	XM_001371207(refSeq)
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PANTHER Classification

PANTHER Family:	HEAT SHOCK PROTEIN HSP-12.2-RELATED (PTHR45640)
PANTHER Subfamily:	ALPHA-CRYSTALLIN B CHAIN (PTHR45640:SF5)
PANTHER GO-slim Molecular Function:	unfolded protein binding
PANTHER GO-slim Biological Process:	protein folding negative regulation of apoptotic process response to heat
PANTHER GO-slim Cellular Component:	nucleus cytoplasm
PANTHER protein class:	chaperone

Pathway Categories:

Angiogenesis

Heat-Shock Protein 27

VEGF signaling pathway

Heat-Shock Protein 27

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	identical protein binding, protein homodimerization activity, metal ion binding, structural molecule activity, unfolded protein binding, structural constituent of eye lens, amyloid-beta binding, protein-containing complex binding
GO BP Complete:	apoptotic process involved in morphogenesis, tubulin complex assembly, regulation of programmed cell death, response to hydrogen peroxide, lens development in camera-type eye, protein refolding, muscle organ development, negative regulation of gene expression, response to heat, cellular response to gamma radiation, negative regulation of amyloid fibril formation, response to hypoxia, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, camera-type eye development, negative regulation of protein-containing complex assembly, negative regulation of intracellular transport, protein stabilization
GO CC Complete:	nucleus, Z disc, contractile muscle fiber, cytoplasm, mitochondrion, cytosol, protein-containing complex, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=2389\|UniProtKB=P02511	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000004274.4\|UniProtKB=A0A2J8L0C8	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000005167.3\|UniProtKB=G3QR27	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000022133.4\|UniProtKB=F7H3G0	Macaca mulatta	LDO
MOUSE\|MGI=MGI=88516\|UniProtKB=P23927	Mus musculus	LDO
RAT\|RGD=2414\|UniProtKB=P23928	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000000434\|UniProtKB=P02510	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000036724\|UniProtKB=Q7M2W6	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000012507.3\|UniProtKB=F6SYI2	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000028550.4\|UniProtKB=M3WT79	Felis catus	LDO
ORNAN\|Ensembl=ENSOANG00000006525.2\|UniProtKB=F6YB30	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010025192\|UniProtKB=Q05713	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000006473.3\|UniProtKB=H9GBH5	Anolis carolinensis	LDO
XENLA\|Gene=cryab.S\|UniProtKB=A0A8J0TEF4	Xenopus laevis	O
XENLA\|Gene=cryab.L\|UniProtKB=A0A8J0T2B8	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-971379\|UniProtKB=A0A7D9N0F3	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000005891.2\|UniProtKB=H2LMY6	Oryzias latipes	LDO
DANRE\|Gene=cryabb\|UniProtKB=A0A8M9Q8E3	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-991119-2\|UniProtKB=Q9PUR2	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000001451.1\|UniProtKB=W5LZU6	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000024613.1\|UniProtKB=H2XSW8	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000019613.1\|UniProtKB=H2XKW8	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000000618.3\|UniProtKB=F6RRK4	Ciona intestinalis	O
BRAFL\|Gene_ORFName=BRAFLDRAFT_130907\|UniProtKB=C3XVH9	Branchiostoma floridae	O
BRAFL\|Gene_ORFName=BRAFLDRAFT_126126\|UniProtKB=C3Y475	Branchiostoma floridae	O
BRAFL\|Gene=LOC118409934\|UniProtKB=A0A9J7KNQ7	Branchiostoma floridae	O
BRAFL\|Gene_ORFName=BRAFLDRAFT_130908\|UniProtKB=C3XVI4	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC115924178\|UniProtKB=A0A7M7HD42	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC578820\|UniProtKB=A0A7M7HNT4	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00002023\|UniProtKB=Q17849	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG14817\|UniProtKB=A8XKR5	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00099140\|UniProtKB=A0A2A6CU40	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0031037\|UniProtKB=Q8IQW5	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP000941\|UniProtKB=F5HJ02	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC001152\|UniProtKB=D6WAG3	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_93031\|UniProtKB=E9GYA8	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_208978\|UniProtKB=E9G4S2	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW017709\|UniProtKB=B7PIN1	Ixodes scapularis	O
CAEEL\|WormBase=WBGene00002024\|UniProtKB=B0M0L8	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00027569\|UniProtKB=A8WYZ1	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00118281\|UniProtKB=A0A2A6CZW0	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00002012\|UniProtKB=Q20164	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00040365\|UniProtKB=A8Y0T6	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00011906\|UniProtKB=G5EE65	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00025335\|UniProtKB=G2J682	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00002013\|UniProtKB=G5EE36	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00040366\|UniProtKB=A8Y0T5	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00002011\|UniProtKB=P34328	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG16680\|UniProtKB=A8XPB0	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00092798\|UniProtKB=A0A2A6BDS7	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00099715\|UniProtKB=A0A454Y2J6	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00099747\|UniProtKB=A0A2A6B890	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00115342\|UniProtKB=A0A454XMT5	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00109633\|UniProtKB=A0A454Y2J4	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00273476\|UniProtKB=A0A2A6B9B6	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00280026\|UniProtKB=A0A2A6CK21	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00202553\|UniProtKB=A0A2A6CK15	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00278388\|UniProtKB=A0A2A6BIP9	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00008592\|UniProtKB=Q19228	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00002015\|UniProtKB=P34696	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00008591\|UniProtKB=Q19227	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00002016\|UniProtKB=P06582	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00027245\|UniProtKB=A8WY16	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00027233\|UniProtKB=A8WY04	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00027247\|UniProtKB=A8WY18	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00038447\|UniProtKB=A8XV09	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00038449\|UniProtKB=A8XV11	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00002021\|UniProtKB=Q20660	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00032413\|UniProtKB=A8XDE7	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00002018\|UniProtKB=P06581	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00002019\|UniProtKB=P02513	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG19187\|UniProtKB=A8XV12	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG04605\|UniProtKB=A8WY15	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00027246\|UniProtKB=A8WY17	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00027234\|UniProtKB=A8WY05	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00038448\|UniProtKB=A8XV10	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00004798\|UniProtKB=Q20363	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00037808\|UniProtKB=A8XSJ6	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00101796\|UniProtKB=A0A2A6CLS3	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00275012\|UniProtKB=A0A2A6BPU4	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00101797\|UniProtKB=A0A2A6CBU4	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00277138\|UniProtKB=A0A2A6CB04	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00277146\|UniProtKB=A0A2A6CB77	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00279705\|UniProtKB=A0A2A6CNX4	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00091037\|UniProtKB=A0A2A6BWN2	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00277142\|UniProtKB=A0A2A6CB26	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00014233\|UniProtKB=G5EF99	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG09876\|UniProtKB=A8X9V6	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00090334\|UniProtKB=A0A2A6BQP7	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00021943\|UniProtKB=A0A1I6CMC9	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG23899\|UniProtKB=A8WJJ4	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00202996\|UniProtKB=A0A2A6CMD9	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00103567\|UniProtKB=A0A2A6CRP1	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00305079\|UniProtKB=A0A8R1V3B6	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0001227\|UniProtKB=P05812	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0001225\|UniProtKB=P02517	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0001226\|UniProtKB=P02518	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0001223\|UniProtKB=P02515	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0001229\|UniProtKB=P22979	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0035817\|UniProtKB=Q9VSA9	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0032181\|UniProtKB=Q9VL41	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0035982\|UniProtKB=Q9VSX2	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0001224\|UniProtKB=P02516	Drosophila melanogaster	O
TRICA\|EnsemblGenome=TC005529\|UniProtKB=D6WXQ7	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC006793\|UniProtKB=D6WV46	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC003541\|UniProtKB=D6WHH1	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC005528\|UniProtKB=D6WXQ8	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC005338\|UniProtKB=D6WV45	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC005527\|UniProtKB=D6WXR0	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC006592\|UniProtKB=D6WXQ9	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC006593\|UniProtKB=D6WXR1	Tribolium castaneum	O
DROME\|FlyBase=FBgn0011296\|UniProtKB=P82147	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP005547\|UniProtKB=Q7Q724	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP007161\|UniProtKB=Q7PT52	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP007160\|UniProtKB=Q7QIZ9	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP005548\|UniProtKB=Q7Q723	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP007158\|UniProtKB=Q7PCM8	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP007162\|UniProtKB=Q7PT53	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC014644\|UniProtKB=D6WNC2	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC010105\|UniProtKB=D6WSJ5	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_312502\|UniProtKB=E9FZ86	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_235846\|UniProtKB=E9FZ72	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_103650\|UniProtKB=E9GJS6	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_303433\|UniProtKB=E9GGM6	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_303432\|UniProtKB=E9GGM5	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_312488\|UniProtKB=E9FZ71	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_312487\|UniProtKB=E9FZ70	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW024922\|UniProtKB=B7QM70	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW024717\|UniProtKB=B7Q645	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW003290\|UniProtKB=B7PCG5	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW023576\|UniProtKB=B7QH66	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW002513\|UniProtKB=B7P7W0	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW024834\|UniProtKB=B7QGM9	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW024062\|UniProtKB=B7P6K1	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW024054\|UniProtKB=B7P624	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW001763\|UniProtKB=B7P7F8	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW001762\|UniProtKB=B7P7F7	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW007791\|UniProtKB=B7PWF4	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW007793\|UniProtKB=B7PWF5	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW015266\|UniProtKB=B7QNN7	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW023475\|UniProtKB=B7QJZ5	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW020672\|UniProtKB=B7Q2C4	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG190314\|UniProtKB=T1FRW3	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG194746\|UniProtKB=T1FWD2	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG125965\|UniProtKB=T1EH79	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG191861\|UniProtKB=T1FTD2	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG160608\|UniProtKB=T1EQH5	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG163906\|UniProtKB=T1EUL7	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG191122\|UniProtKB=T1FSM2	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG191185\|UniProtKB=T1FSQ1	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG190058\|UniProtKB=T1FRM8	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG188325\|UniProtKB=T1FPV8	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG194315\|UniProtKB=T1FVX2	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG169784\|UniProtKB=T1F2B5	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG180213\|UniProtKB=T1FFK9	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG106514\|UniProtKB=T1EE30	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g143610\|UniProtKB=A7T2X7	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g129111\|UniProtKB=A7SRS3	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g143593\|UniProtKB=A7T2X8	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g86804\|UniProtKB=A7RMQ6	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g127462\|UniProtKB=A7SQF6	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g105643\|UniProtKB=A7S5R0	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g129113\|UniProtKB=A7SRS2	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g244569\|UniProtKB=A7SDV3	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g160645\|UniProtKB=A7RMQ7	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g127508\|UniProtKB=A7SQF7	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g239200\|UniProtKB=A7RLT4	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g127482\|UniProtKB=A7SQF4	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g127468\|UniProtKB=A7SQF5	Nematostella vectensis	O