PANTHER Gene Information   
Gene Symbol(s): Skp2
Organism: Mus musculus
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Gene Name: S-phase kinase-associated protein 2
Gene ID: MGI:1351663
Protein ID: Q9Z0Z3
Persistent Id: PTN002546527
Alternate Ids:
Cyclin-A/CDK2-associated protein p45(Synonym) 27401(GeneID)
BAC31819(EMBL-CDS) AK032979(EMBL)
13097468(GI) ENSMUSG00000054115(Ensembl)
Q99J53(AltAccession) MGI:1351663(MGI)
SKP2_MOUSE(UniProtKB-ID) Skp2(Symbol)
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PANTHER Classification
PANTHER Family: F-BOX/TPR REPEAT PROTEIN POF3 (PTHR16134)
PANTHER Subfamily: S-PHASE KINASE-ASSOCIATED PROTEIN 2 (PTHR16134:SF32)  
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process: G2/M transition of mitotic cell cycle
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
regulation of cell cycle
PANTHER GO-slim Cellular Component: SCF ubiquitin ligase complex
nucleus
cytosol
PANTHER protein class: ubiquitin-protein ligase
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: identical protein binding, protein binding, ubiquitin-like ligase-substrate adaptor activity
GO BP Complete: protein K48-linked ubiquitination, protein polyubiquitination, positive regulation of double-strand break repair via homologous recombination, regulation of apoptotic process, ubiquitin-dependent protein catabolic process, positive regulation of smooth muscle cell proliferation, positive regulation of protein polyubiquitination, proteasome-mediated ubiquitin-dependent protein catabolic process, G2/M transition of mitotic cell cycle, innate immune response, G1/S transition of mitotic cell cycle, positive regulation of intracellular estrogen receptor signaling pathway, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, defense response to virus, protein K63-linked ubiquitination, regulation of cell cycle
GO CC Complete: nucleus, cytosol, SCF ubiquitin ligase complex, nucleolus, nucleoplasm
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Immune System, Cellular responses to stimuli, Deubiquitination, KEAP1-NFE2L2 pathway, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Generic Transcription Pathway, Regulation of RUNX2 expression and activity, DNA Replication, G1/S Transition, Gene expression (Transcription), Cyclin D associated events in G1, Cell Cycle, Mitotic, APC/C-mediated degradation of cell cycle proteins, G1 Phase, SCF(Skp2)-mediated degradation of p27/p21, Ub-specific processing proteases, Switching of origins to a post-replicative state, Orc1 removal from chromatin, Regulation of BACH1 activity, Cellular response to chemical stress, Neddylation, Cyclin A:Cdk2-associated events at S phase entry, Synthesis of DNA, Transcriptional regulation by RUNX2, Regulation of mitotic cell cycle, S Phase, Mitotic G1 phase and G1/S transition, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Cyclin E associated events during G1/S transition , Adaptive Immune System, Cell Cycle, Cellular responses to stress, Metabolism of proteins, Post-translational protein modification, RNA Polymerase II Transcription

Orthologs