PANTHER Gene Information

Gene Symbol(s):

pyrE

Organism:

Mycobacterium tuberculosis

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Gene Name:

Orotate phosphoribosyltransferase

Gene ID:

Rv0382c

Protein ID:

P9WHK9

Persistent Id:

PTN002319186

Alternate Ids:

P0A5U0(AltAccession)	WP_003401894(refSeq)
395137078(GI)	PYRE_MYCTU(UniProtKB-ID)
pyrE{ECO:0000255\|HAMAP-Rule:MF_01208}(Symbol)	PYRE(Synonym)
CCP43112(EMBL-CDS)	2.4.2.10 {ECO:0000255\|HAMAP-Rule:MF_01208}(EC)
AL123456(EMBL)	45424348(GeneID)
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PANTHER Classification

PANTHER Family:	OROTATE PHOSPHORIBOSYLTRANSFERASE (PTHR19278)
PANTHER Subfamily:	URIDINE 5'-MONOPHOSPHATE SYNTHASE (PTHR19278:SF9)
PANTHER GO-slim Molecular Function:	pentosyltransferase activity
PANTHER GO-slim Biological Process:	organonitrogen compound biosynthetic process pyrimidine nucleotide metabolic process ribonucleotide biosynthetic process pyrimidine nucleobase metabolic process ribonucleoside monophosphate metabolic process
PANTHER GO-slim Cellular Component:
PANTHER protein class:	transferase

Pathway Categories:

De novo pyrimidine ribonucleotides biosythesis

Orotate phosphoribosyltransferase

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	magnesium ion binding, glycosyltransferase activity, orotate phosphoribosyltransferase activity
GO BP Complete:	UMP biosynthetic process, pyrimidine nucleotide biosynthetic process, 'de novo' UMP biosynthetic process, pyrimidine nucleobase biosynthetic process
GO CC Complete:	-

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=12563\|UniProtKB=P11172	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000015312.5\|UniProtKB=H2QN92	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000014137.3\|UniProtKB=G3RTQ7	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000032009.3\|UniProtKB=F7H6L5	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1298388\|UniProtKB=P13439	Mus musculus	LDO
RAT\|RGD=1311908\|UniProtKB=Q4QQS7	Rattus norvegicus	LDO
BOVIN\|Gene=UMPS\|UniProtKB=P31754	Bos taurus	LDO
BOVIN\|Ensembl=ENSBTAG00000013727.6\|UniProtKB=A0A140T887	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000011864.5\|UniProtKB=A0A5G2RBV3	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000009708.4\|UniProtKB=A0A9L0R509	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000006800.6\|UniProtKB=M3W6I6	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845026912.1\|UniProtKB=A0A8I3Q010	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000018353.4\|UniProtKB=F6PQI2	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000045479.1\|UniProtKB=A0A6I8NL84	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010019985.1\|UniProtKB=A0A8V0ZCP5	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000000507.4\|UniProtKB=H9G3U6	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000010326.3\|UniProtKB=G1KK10	Anolis carolinensis	LDO
XENLA\|Gene=umps.L\|UniProtKB=Q640C3	Xenopus laevis	LDO
XENTR\|Ensembl=ENSXETG00000048614\|UniProtKB=A0A803J9F1	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000020552.2\|UniProtKB=H2N1Z7	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-040426-785\|UniProtKB=B8JLL1	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000005441.1\|UniProtKB=W5MDU9	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000009202.3\|UniProtKB=F6WNN3	Ciona intestinalis	LDO
STRPU\|EnsemblGenome=LOC115918764\|UniProtKB=A0A7M7P379	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC580407\|UniProtKB=A0A7M7T0U5	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00011559\|UniProtKB=G5EDZ2	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00042643\|UniProtKB=A8WKZ4	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00101705\|UniProtKB=A0A454Y590	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00099445\|UniProtKB=A0A2A6CAB4	Pristionchus pacificus	LDO
CAEEL\|WormBase=WBGene00020036\|UniProtKB=O61790	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00033092\|UniProtKB=A8XEI9	Caenorhabditis briggsae	O
DROME\|FlyBase=FBgn0003257\|UniProtKB=Q01637	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP004175\|UniProtKB=Q7QB57	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC007436\|UniProtKB=D1ZZL8	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_305287\|UniProtKB=E9GRD4	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW004439\|UniProtKB=B7PGC4	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG185115\|UniProtKB=T1FME8	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g81583\|UniProtKB=A7RH78	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG51535\|UniProtKB=B3RJP1	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_32885\|UniProtKB=A9V2A7	Monosiga brevicollis	LDO
EMENI\|EnsemblGenome=ANIA_00919\|UniProtKB=Q5BEW1	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_1G15830\|UniProtKB=Q4WRM1	Neosartorya fumigata	LDO
DICDI\|dictyBase=DDB_G0280041\|UniProtKB=P09556	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_29684\|UniProtKB=F0ZE03	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_16_0550\|UniProtKB=Q4QEW5	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb927.5.3810\|UniProtKB=Q57U85	Trypanosoma brucei	LDO
CHLRE\|EnsemblGenome=CHLRE_01g048950v5\|UniProtKB=A0A2K3E7W9	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00036p00222560\|UniProtKB=U5CZ43	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_203G00340\|UniProtKB=A0A0K9PNV6	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma08_g30030\|UniProtKB=A0A804KCE1	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_001296mg\|UniProtKB=K3XHC5	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3003G427300\|UniProtKB=C5XHW8	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb140930\|UniProtKB=C0P3M5	Zea mays	O
ORYSJ\|EnsemblGenome=Os01g0951400\|UniProtKB=Q8RZA1	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_2g60926v3\|UniProtKB=A0A0Q3JGS3	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0321170\|UniProtKB=F2D3N8	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS3B02G547500\|UniProtKB=A0A3B6FXP6	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3D02G493700\|UniProtKB=A0A3B6H6A6	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G547300\|UniProtKB=A0A3B6FY60	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3D02G492900\|UniProtKB=A0A3B6H3D2	Triticum aestivum	O
SORBI\|EnsemblGenome=SORBI_3001G327500\|UniProtKB=A0A1Z5S912	Sorghum bicolor	O
SORBI\|EnsemblGenome=SORBI_3003G427200\|UniProtKB=A0A1B6Q869	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb140940\|UniProtKB=A0A804N7I2	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os01g0951200\|UniProtKB=Q9LDN2	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_2g60932v3\|UniProtKB=I1HV95	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0321260\|UniProtKB=F2E520	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS3B02G547900\|UniProtKB=W5CPX1	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3D02G494000\|UniProtKB=A0A3B6H1U9	Triticum aestivum	LDO
NELNU\|Gene=LOC104608808\|UniProtKB=A0A1U8BAN3	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110800090\|UniProtKB=A0A9R0J472	Spinacia oleracea	O
SPIOL\|Gene=LOC110793754\|UniProtKB=A0A9R0IRX5	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr13g0592601\|UniProtKB=A0A251STP6	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr01g0012121\|UniProtKB=A0A251VLP1	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C500285860\|UniProtKB=A0A9R1VN23	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a005736mg\|UniProtKB=A0A022RTB9	Erythranthe guttata	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a005467mg\|UniProtKB=A0A022RET2	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_28572\|UniProtKB=A0A1U8EL35	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400019620\|UniProtKB=M1BQD4	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc11g068830.2\|UniProtKB=A0A3Q7J0E0	Solanum lycopersicum	LDO
TOBAC\|Gene=PYR5-6\|UniProtKB=Q42942	Nicotiana tabacum	LDO
TOBAC\|Gene=LOC107765924\|UniProtKB=A0A1S3XKB9	Nicotiana tabacum	LDO
TOBAC\|Gene=LOC107794649\|UniProtKB=A0A1S4A7T6	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi13g01485\|UniProtKB=F6HVE9	Vitis vinifera	LDO
BRANA\|Gene_ORFName=DARMORV10_C04P38050.1\|UniProtKB=A0A078FLR3	Brassica napus	O
BRACM\|EnsemblGenome=Bra014814\|UniProtKB=M4DE93	Brassica campestris	O
BRANA\|Gene_ORFName=DARMORV10_C06P22180.1\|UniProtKB=A0A078F7E9	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra003186\|UniProtKB=M4CG53	Brassica campestris	LDO
ARATH\|TAIR=locus=504955714\|UniProtKB=Q42586	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107920502\|UniProtKB=A0A1U8KXF7	Gossypium hirsutum	O
GOSHI\|Gene=LOC107903544\|UniProtKB=A0A1U8J468	Gossypium hirsutum	O
GOSHI\|Gene=LOC107895284\|UniProtKB=A0A1U8II60	Gossypium hirsutum	O
GOSHI\|Gene=LOC107952158\|UniProtKB=A0A1U8NVE8	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_031360\|UniProtKB=A0A061F719	Theobroma cacao	LDO
POPTR\|EnsemblGenome=POPTR_001G026300v3\|UniProtKB=A0A2K2BRD9	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_003G198500v3\|UniProtKB=A0A2K2B9U7	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_11G004200\|UniProtKB=A0A2C9UX46	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_1617220\|UniProtKB=B9RE05	Ricinus communis	O
RICCO\|Gene_ORFName=RCOM_1452740\|UniProtKB=B9RGC1	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_11G154200\|UniProtKB=I1LLC6	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_3g017580\|UniProtKB=A0A072V4E2	Medicago truncatula	O
MEDTR\|EnsemblGenome=MTR_1g025060\|UniProtKB=G7I763	Medicago truncatula	LDO
SOYBN\|EnsemblGenome=GLYMA_15G237000\|UniProtKB=K7MDG9	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_13G198700\|UniProtKB=K7M0S3	Glycine max	O
MEDTR\|EnsemblGenome=MTR_8g038390\|UniProtKB=Q1RU71	Medicago truncatula	O
JUGRE\|Gene=LOC108990755\|UniProtKB=A0A6P9EAE4	Juglans regia	O
JUGRE\|EnsemblGenome=Jr05_01240\|UniProtKB=A0A2I4EF11	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_5G456730\|UniProtKB=A0A0A0KNB1	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_2G032600\|UniProtKB=M5XC97	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_236575\|UniProtKB=D8TAS2	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_429593\|UniProtKB=D8T6P3	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_448325\|UniProtKB=D8T6I1	Selaginella moellendorffii	LDO
SELML\|EnsemblGenome=SELMODRAFT_269777\|UniProtKB=D8T6P1	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c13_16830\|UniProtKB=A0A2K1JM90	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c3_16990\|UniProtKB=A9RSH8	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0052s0107\|UniProtKB=A0A2R6WWU9	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_004200020\|UniProtKB=A0A1Y1II01	Klebsormidium nitens	LDO
NITMS\|EnsemblGenome=Nmar_0289\|UniProtKB=A9A401	Nitrosopumilus maritimus	LDO
KORCO\|EnsemblGenome=Kcr_0155\|UniProtKB=B1L386	Korarchaeum cryptofilum	LDO
SACS2\|EnsemblGenome=SSO0615\|UniProtKB=Q9UX09	Sulfolobus solfataricus	LDO
PYRAE\|EnsemblGenome=PAE3264\|UniProtKB=Q8ZTG3	Pyrobaculum aerophilum	LDO
METAC\|EnsemblGenome=MA_2520\|UniProtKB=P58863	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_0919\|UniProtKB=P58862	Methanosarcina acetivorans	O
METJA\|EnsemblGenome=MJ_1646\|UniProtKB=Q59040	Methanocaldococcus jannaschii	O
HALSA\|EnsemblGenome=VNG_0448G\|UniProtKB=Q9HS16	Halobacterium salinarum	O
METAC\|EnsemblGenome=MA_3307\|UniProtKB=P58859	Methanosarcina acetivorans	LDO
METJA\|EnsemblGenome=MJ_1109\|UniProtKB=Q58509	Methanocaldococcus jannaschii	LDO
HALSA\|EnsemblGenome=VNG_2118G\|UniProtKB=Q9HNG2	Halobacterium salinarum	LDO
THEKO\|EnsemblGenome=TK2138\|UniProtKB=Q5JHF4	Thermococcus kodakaraensis	LDO
CHLAA\|EnsemblGenome=Caur_3926\|UniProtKB=A9WDI4	Chloroflexus aurantiacus	LDO
STRCO\|Gene_OrderedLocusName=SCO3650\|UniProtKB=Q9X8R7	Streptomyces coelicolor	LDO
CLOBH\|Gene_OrderedLocusName=CBO3235\|UniProtKB=A5I6W5	Clostridium botulinum	LDO
STRR6\|EnsemblGenome=spr0614\|UniProtKB=Q8DQL5	Streptococcus pneumoniae	LDO
STAA8\|EnsemblGenome=SAOUHSC_01172\|UniProtKB=Q2FZ70	Staphylococcus aureus	LDO
LISMO\|EnsemblGenome=CAC99909\|UniProtKB=Q8Y668	Listeria monocytogenes	LDO
BACSU\|EnsemblGenome=BSU_15560\|UniProtKB=P25972	Bacillus subtilis	LDO
BACCR\|EnsemblGenome=BC_3882\|UniProtKB=Q819S7	Bacillus cereus	LDO
THEMA\|EnsemblGenome=TM_0331\|UniProtKB=Q9WYG6	Thermotoga maritima	LDO
DEIRA\|EnsemblGenome=DR_0447\|UniProtKB=Q9RX68	Deinococcus radiodurans	LDO
GLOVI\|Gene=pyrE\|UniProtKB=Q7NLP2	Gloeobacter violaceus	LDO
SYNY3\|EnsemblGenome=BAA10077\|UniProtKB=Q55574	Synechocystis	LDO
LEPIN\|EnsemblGenome=LA_2988\|UniProtKB=Q8F1Z0	Leptospira interrogans	LDO
BACTN\|EnsemblGenome=BT_3731\|UniProtKB=Q8A1D5	Bacteroides thetaiotaomicron	LDO
RHOBA\|EnsemblGenome=RB328\|UniProtKB=Q7UYX5	Rhodopirellula baltica	LDO
AQUAE\|EnsemblGenome=aq_1907\|UniProtKB=O67742	Aquifex aeolicus	LDO
THEYD\|EnsemblGenome=THEYE_A1932\|UniProtKB=B5YI91	Thermodesulfovibrio yellowstonii	LDO
DICTD\|EnsemblGenome=Dtur_0923\|UniProtKB=B8E176	Dictyoglomus turgidum	LDO
FUSNN\|EnsemblGenome=FN0427\|UniProtKB=P58856	Fusobacterium nucleatum	LDO
HELPY\|EnsemblGenome=HP_1257\|UniProtKB=P56162	Helicobacter pylori	LDO
GEOSL\|EnsemblGenome=GSU1637\|UniProtKB=Q74CN6	Geobacter sulfurreducens	LDO
BRADU\|EnsemblGenome=BAC53399\|UniProtKB=Q89BL4	Bradyrhizobium diazoefficiens	LDO
COXBU\|EnsemblGenome=CBU_0296\|UniProtKB=Q45918	Coxiella burnetii	LDO