PANTHER Gene Information

Gene Symbol(s):

fadB2

Organism:

Mycobacterium tuberculosis

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Gene Name:

3-hydroxybutyryl-CoA dehydrogenase

Gene ID:

Rv0468

Protein ID:

P9WNP7

Persistent Id:

PTN002455241

Alternate Ids:

886288(GeneID)	FADB2(Synonym)
FADB2_MYCTU(UniProtKB-ID)	NC_000962(refSeq)
1.1.1.157 {ECO:0000269\|PubMed:20378648}(EC)	O53753(AltAccession)
CCP43201(EMBL-CDS)	444893947(GI)
fadB2(Symbol)	AL123456(EMBL)
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PANTHER Classification

PANTHER Family:	3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN (PTHR48075)
PANTHER Subfamily:	3-HYDROXYBUTYRYL-COA DEHYDROGENASE (PTHR48075:SF9)
PANTHER GO-slim Molecular Function:	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
PANTHER GO-slim Biological Process:	fatty acid beta-oxidation
PANTHER GO-slim Cellular Component:
PANTHER protein class:	dehydrogenase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, oxidoreductase activity, 3-hydroxybutyryl-CoA dehydrogenase activity, NAD+ binding
GO BP Complete:	butyrate metabolic process, fatty acid beta-oxidation, catabolic process, response to host immune response, fatty acid elongation, fatty acid metabolic process
GO CC Complete:	peptidoglycan-based cell wall, cytosol, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=18246\|UniProtKB=Q9Y2S2	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000005684.7\|UniProtKB=H2Q793	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000011053.3\|UniProtKB=G3R639	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000004560.4\|UniProtKB=F6S480	Macaca mulatta	O
MOUSE\|MGI=MGI=1915881\|UniProtKB=Q99KP3	Mus musculus	O
RAT\|RGD=631427\|UniProtKB=Q811X6	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000011726\|UniProtKB=Q8SPX7	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000009268.4\|UniProtKB=A0A287B6X3	Sus scrofa	O
PIG\|Gene=CRYL1\|UniProtKB=Q8SQ26	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000005884.4\|UniProtKB=F7B232	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000007299.6\|UniProtKB=M3W7G9	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845023166.1\|UniProtKB=A0A8I3PDK8	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000008139.4\|UniProtKB=A0A5F8H2J9	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000009024.3\|UniProtKB=F7ETW8	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010005554.1\|UniProtKB=A0A8V0XPP8	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000002246.4\|UniProtKB=G1KAH7	Anolis carolinensis	O
XENLA\|Gene=cryl1.L\|UniProtKB=A1L2W4	Xenopus laevis	O
XENLA\|Gene=cryl1.S\|UniProtKB=A0A8J0UKX1	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-945577\|UniProtKB=B1H3F7	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000013055.2\|UniProtKB=H2MCS4	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-060810-7\|UniProtKB=Q0V973	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000010863.1\|UniProtKB=W5MY58	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000003368.4\|UniProtKB=F7BA03	Ciona intestinalis	O
BRAFL\|Gene_ORFName=BRAFLDRAFT_125244\|UniProtKB=C3YH50	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC577306\|UniProtKB=A0A7M7PLK4	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115928294\|UniProtKB=A0A7M7PIM2	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC589657\|UniProtKB=A0A7M7PGS8	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00022130\|UniProtKB=C0VXV5	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG04121\|UniProtKB=A8WW93	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00203981\|UniProtKB=A0A2A6CEA9	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0033949\|UniProtKB=Q5U1B0	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0286508\|UniProtKB=Q9VXI1	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP013544\|UniProtKB=F5HIY0	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC015170\|UniProtKB=D2A5H7	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_306692\|UniProtKB=E9GXZ8	Daphnia pulex	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g168735\|UniProtKB=A7SBT1	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g150101\|UniProtKB=A7T8E7	Nematostella vectensis	O
MONBE\|EnsemblGenome=MONBRDRAFT_2035\|UniProtKB=A9UPC3	Monosiga brevicollis	O
EMENI\|EnsemblGenome=ANIA_06215\|UniProtKB=Q5AZR5	Emericella nidulans	O
PHANO\|EnsemblGenome=SNOG_02795\|UniProtKB=Q0UZL9	Phaeosphaeria nodorum	O
EMENI\|EnsemblGenome=ANIA_07238\|UniProtKB=Q5AWU2	Emericella nidulans	O
LEIMA\|EnsemblGenome=LMJF_17_0630\|UniProtKB=Q4QED1	Leishmania major	O
GOSHI\|Gene=LOC107944024\|UniProtKB=A0A1U8N2K8	Gossypium hirsutum	O
SACS2\|EnsemblGenome=SSO0647\|UniProtKB=Q7LXQ8	Sulfolobus solfataricus	O
BRAFL\|Gene=LOC118429263\|UniProtKB=A0A9J7M744	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC100892111\|UniProtKB=A0A7M7GMN9	Strongylocentrotus purpuratus	O
IXOSC\|EnsemblGenome=ISCW024382\|UniProtKB=B7PL78	Ixodes scapularis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g206892\|UniProtKB=A7S4Z9	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG59820\|UniProtKB=B3S6I8	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_6371\|UniProtKB=A9UTN2	Monosiga brevicollis	O
YARLI\|EnsemblGenome=YALI0_C08811g\|UniProtKB=Q6CCJ7	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_10471\|UniProtKB=C8V6H1	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_5G10070\|UniProtKB=Q4WUX9	Neosartorya fumigata	O
EMENI\|EnsemblGenome=ANIA_08921\|UniProtKB=Q5AS09	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_3G03860\|UniProtKB=Q4WF09	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU04393\|UniProtKB=Q7RZ80	Neurospora crassa	O
NEUCR\|EnsemblGenome=NCU16336\|UniProtKB=V5IQ26	Neurospora crassa	O
NEUCR\|EnsemblGenome=NCU08058\|UniProtKB=Q7SGM5	Neurospora crassa	O
PHANO\|EnsemblGenome=SNOG_16509\|UniProtKB=Q0TVF5	Phaeosphaeria nodorum	O
EMENI\|EnsemblGenome=ANIA_07008\|UniProtKB=C8VC90	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_4G04410\|UniProtKB=Q4W9M5	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU09553\|UniProtKB=Q7S2A8	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_00672\|UniProtKB=A7E5U7	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_08110\|UniProtKB=Q0UJF4	Phaeosphaeria nodorum	O
CRYNJ\|EnsemblGenome=CNG04300\|UniProtKB=Q5KDE2	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_02105\|UniProtKB=A0A0D1E020	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_18721\|UniProtKB=E3L7R4	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_29410\|UniProtKB=F4NV39	Batrachochytrium dendrobatidis	O
DICDI\|dictyBase=DDB_G0280465\|UniProtKB=Q54VB8	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_81401\|UniProtKB=F0ZTD3	Dictyostelium purpureum	O
PARTE\|EnsemblGenome=GSPATT00024383001\|UniProtKB=A0E8N7	Paramecium tetraurelia	O
PHYRM\|Gene=H3H347_PHYRM\|UniProtKB=H3H347	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_12g534350v5\|UniProtKB=A0A2K3D509	Chlamydomonas reinhardtii	O
AMBTC\|EnsemblGenome=AMTR_s00183p00017230\|UniProtKB=U5D5K2	Amborella trichopoda	O
MUSAM\|EnsemblGenome=Ma09_g18840\|UniProtKB=A0A804KL69	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_002398mg\|UniProtKB=K3XKH5	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3003G324000\|UniProtKB=C5XME6	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb369580\|UniProtKB=B4F890	Zea mays	O
ORYSJ\|EnsemblGenome=Os01g0796400\|UniProtKB=Q8S1G9	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_2g52350v3\|UniProtKB=I1HSG4	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0294830\|UniProtKB=F2D6Y9	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS3A02G327700\|UniProtKB=A0A3B6EM95	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G357200\|UniProtKB=A0A3B6FVA8	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3D02G321200\|UniProtKB=A0A3B6H0K6	Triticum aestivum	O
NELNU\|Gene=LOC104608192\|UniProtKB=A0A1U8AW50	Nelumbo nucifera	O
SPIOL\|Gene=LOC110783618\|UniProtKB=A0A9R0I6Q1	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr10g0449611\|UniProtKB=A0A251TME3	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C500275180\|UniProtKB=A0A9R1VLR5	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a011315mg\|UniProtKB=A0A022RY93	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_20623\|UniProtKB=A0A2G2Z5C2	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400012409\|UniProtKB=M1AX71	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc07g063010.3\|UniProtKB=A0A3Q7HEP7	Solanum lycopersicum	O
TOBAC\|Gene=LOC107821763\|UniProtKB=A0A1S4CRG7	Nicotiana tabacum	O
TOBAC\|Gene=LOC107806817\|UniProtKB=A0A1S4BCE8	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi19g00202\|UniProtKB=E0CSH4	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_F03304\|UniProtKB=A0A059BUU3	Eucalyptus grandis	O
BRACM\|EnsemblGenome=Bra027263\|UniProtKB=M4EEQ1	Brassica campestris	O
ARATH\|TAIR=locus=2087120\|UniProtKB=Q9LDF5	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107952096\|UniProtKB=A0A1U8NXQ4	Gossypium hirsutum	O
GOSHI\|Gene=LOC107916679\|UniProtKB=A0A1U8KGF9	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_031591\|UniProtKB=A0A061F847	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g022434mg\|UniProtKB=A0A067FGE9	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_001G398600v3\|UniProtKB=A0A2K2CB23	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_03G107000\|UniProtKB=A0A2C9W6B1	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_0589820\|UniProtKB=B9SQH3	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_06G238900\|UniProtKB=A0A0R0JSV2	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_06G254700\|UniProtKB=B0M194	Glycine max	O
MEDTR\|EnsemblGenome=MTR_8g058775\|UniProtKB=G7LDR5	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr02_22050\|UniProtKB=A0A2I4H3P2	Juglans regia	O
JUGRE\|EnsemblGenome=Jr02_22030\|UniProtKB=A0A2I4H3L6	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_3G234000\|UniProtKB=A0A0A0L6N5	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_4G177500\|UniProtKB=M5WGP6	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_171538\|UniProtKB=D8RH87	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_89801\|UniProtKB=D8RAU9	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c22_7880\|UniProtKB=A9RJ32	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0058s0041\|UniProtKB=A0A2R6WTR5	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_002610050\|UniProtKB=A0A1Y1I928	Klebsormidium nitens	O
NITMS\|EnsemblGenome=Nmar_1028\|UniProtKB=A9A3J2	Nitrosopumilus maritimus	O
KORCO\|EnsemblGenome=Kcr_0114\|UniProtKB=B1L7P7	Korarchaeum cryptofilum	O
SACS2\|EnsemblGenome=SSO2996\|UniProtKB=Q97UK9	Sulfolobus solfataricus	O
SACS2\|EnsemblGenome=SSO2871\|UniProtKB=Q97UX0	Sulfolobus solfataricus	O
SACS2\|EnsemblGenome=SSO2514\|UniProtKB=Q97VU5	Sulfolobus solfataricus	O
PYRAE\|EnsemblGenome=PAE1383\|UniProtKB=Q8ZXA0	Pyrobaculum aerophilum	O
HALSA\|EnsemblGenome=VNG_1313G\|UniProtKB=Q9HQ61	Halobacterium salinarum	O
HALSA\|EnsemblGenome=VNG_0681G\|UniProtKB=Q9HRI4	Halobacterium salinarum	O
STRCO\|Gene_OrderedLocusName=SCO1591\|UniProtKB=O88051	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO6475\|UniProtKB=Q9ZBJ9	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO0984\|UniProtKB=Q93J60	Streptomyces coelicolor	LDO
CLOBH\|Gene_OrderedLocusName=CBO3201\|UniProtKB=A5I6T0	Clostridium botulinum	O
DEIRA\|EnsemblGenome=DR_1068\|UniProtKB=Q9RVG1	Deinococcus radiodurans	O
RHOBA\|EnsemblGenome=RB1092\|UniProtKB=Q7UXV2	Rhodopirellula baltica	O
FUSNN\|EnsemblGenome=FN1019\|UniProtKB=Q8RES5	Fusobacterium nucleatum	O
BRADU\|Gene=Q89SH2_BRADU\|UniProtKB=Q89SH2	Bradyrhizobium diazoefficiens	O
COXBU\|EnsemblGenome=CBU_0576\|UniProtKB=Q83DW6	Coxiella burnetii	O
PSEAE\|EnsemblGenome=PA1628\|UniProtKB=Q9I394	Pseudomonas aeruginosa	O
PSEAE\|EnsemblGenome=PA3590\|UniProtKB=Q9HY36	Pseudomonas aeruginosa	O
ECOLI\|EnsemblGenome=BAA15001\|UniProtKB=P76083	Escherichia coli	O