PANTHER Gene Information

Gene Symbol(s):

panB

Organism:

Mycobacterium tuberculosis

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Gene Name:

3-methyl-2-oxobutanoate hydroxymethyltransferase

Gene ID:

Rv2225

Protein ID:

P9WIL7

Persistent Id:

PTN002325036

Alternate Ids:

2.1.2.11(EC)	15609362(GI)
PANB(Synonym)	WP_003411489(refSeq)
PANB_MYCTU(UniProtKB-ID)	panB(Symbol)
887440(GeneID)	Q10505(AltAccession)
CCP45003(EMBL-CDS)	AL123456(EMBL)
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PANTHER Classification

PANTHER Family:	3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (PTHR20881)
PANTHER Subfamily:	3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (PTHR20881:SF0)
PANTHER GO-slim Molecular Function:	magnesium ion binding transferase activity, transferring one-carbon groups
PANTHER GO-slim Biological Process:	amide biosynthetic process cellular modified amino acid metabolic process organonitrogen compound biosynthetic process monocarboxylic acid biosynthetic process
PANTHER GO-slim Cellular Component:
PANTHER protein class:	methyltransferase

Pathway Categories:

Pantothenate biosynthesis

3-methyl-2-oxobutanoate hydroxymethyltransferase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	magnesium ion binding, 3-methyl-2-oxobutanoate hydroxymethyltransferase activity, metal ion binding, transferase activity
GO BP Complete:	pantothenate biosynthetic process
GO CC Complete:	cytoplasm, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
MONBE\|EnsemblGenome=MONBRDRAFT_1298\|UniProtKB=A9UP51	Monosiga brevicollis	LDO
YEAST\|SGD=S000000380\|UniProtKB=P38122	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_ABR186W\|UniProtKB=Q75D37	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000175867\|UniProtKB=Q5ABB3	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_B18898g\|UniProtKB=Q6CE35	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_01778\|UniProtKB=Q9Y7B6	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_6G09170\|UniProtKB=Q4WMP7	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU10048\|UniProtKB=Q7S084	Neurospora crassa	LDO
SCLS1\|EnsemblGenome=SS1G_02278\|UniProtKB=A7EAE6	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_06641\|UniProtKB=Q0UNM3	Phaeosphaeria nodorum	LDO
SCHJY\|EnsemblGenome=SJAG_05200\|UniProtKB=B6JWN4	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNJ00390\|UniProtKB=Q5KAV0	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_04420\|UniProtKB=A0A0D1DSK3	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_09130\|UniProtKB=E3KG81	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_14009\|UniProtKB=F4PBH9	Batrachochytrium dendrobatidis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_20812\|UniProtKB=F4PBS0	Batrachochytrium dendrobatidis	LDO
DICDI\|dictyBase=DDB_G0286637\|UniProtKB=Q54LH3	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_153349\|UniProtKB=F0ZNN8	Dictyostelium purpureum	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_3959\|UniProtKB=B8BWG2	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3GZV2_PHYRM\|UniProtKB=H3GZV2	Phytophthora ramorum	O
PHYRM\|Gene=H3H8G4_PHYRM\|UniProtKB=H3H8G4	Phytophthora ramorum	O
PHYRM\|Gene=H3H2Q7_PHYRM\|UniProtKB=H3H2Q7	Phytophthora ramorum	O
PHYRM\|Gene=H3H8S2_PHYRM\|UniProtKB=H3H8S2	Phytophthora ramorum	O
PHYRM\|Gene=H3GTL7_PHYRM\|UniProtKB=H3GTL7	Phytophthora ramorum	O
PHYRM\|Gene=H3GUY0_PHYRM\|UniProtKB=H3GUY0	Phytophthora ramorum	O
PHYRM\|Gene=H3GTL4_PHYRM\|UniProtKB=H3GTL4	Phytophthora ramorum	O
PHYRM\|Gene=H3G552_PHYRM\|UniProtKB=H3G552	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_12g508550v5\|UniProtKB=A0A2K3D2Q6	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00061p00199330\|UniProtKB=U5D9Q5	Amborella trichopoda	LDO
AMBTC\|EnsemblGenome=AMTR_s00061p00198380\|UniProtKB=U5DCS9	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_5G00430\|UniProtKB=A0A0K9NTS4	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma10_g14820\|UniProtKB=A0A804KW91	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_002048mg\|UniProtKB=K3XJH5	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3003G011600\|UniProtKB=C5XKA7	Sorghum bicolor	O
SORBI\|EnsemblGenome=SORBI_3003G011700\|UniProtKB=C5XKA8	Sorghum bicolor	O
SORBI\|EnsemblGenome=SORBI_3003G011800\|UniProtKB=C5XKA9	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb339000\|UniProtKB=B4FTG2	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os01g0225500\|UniProtKB=Q9AWZ7	Oryza sativa	O
ORYSJ\|Gene_OrderedLocusName=LOC_Os01g12560\|UniProtKB=Q9AWZ8	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_2g07470v3\|UniProtKB=I1HDG1	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0248130\|UniProtKB=A0A8I6X4I2	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS3A02G150600\|UniProtKB=A0A3B6EH81	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G177600\|UniProtKB=A0A077S100	Triticum aestivum	LDO
NELNU\|Gene_ORFName=HUJ06_020514\|UniProtKB=A0A1U8A4R3	Nelumbo nucifera	O
NELNU\|Gene=LOC104590826\|UniProtKB=A0A1U7Z3W2	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110790076\|UniProtKB=A0A9R0ILV3	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr17g0820321\|UniProtKB=A0A251RX25	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C400170640\|UniProtKB=A0A9R1VXE7	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a009002mg\|UniProtKB=A0A022QX45	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_28445\|UniProtKB=A0A2G2YGS7	Capsicum annuum	O
CAPAN\|EnsemblGenome=T459_28446\|UniProtKB=A0A1U8EKI6	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400002011\|UniProtKB=M0ZPF9	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc09g007130.3\|UniProtKB=A0A3Q7HVQ3	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107805656\|UniProtKB=A0A1S4B8L3	Nicotiana tabacum	O
TOBAC\|Gene=LOC107781389\|UniProtKB=A0A1S3YZE7	Nicotiana tabacum	LDO
VITVI\|EnsemblGenome=Vitvi15g01089\|UniProtKB=F6I650	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_B01984\|UniProtKB=A0A059D3Y7	Eucalyptus grandis	O
EUCGR\|EnsemblGenome=EUGRSUZ_B01986\|UniProtKB=A0A059D3H4	Eucalyptus grandis	O
EUCGR\|EnsemblGenome=EUGRSUZ_B01988\|UniProtKB=A0A059D4K5	Eucalyptus grandis	LDO
BRANA\|Gene_ORFName=DARMORV10_A07P25550.1\|UniProtKB=A0A078IS78	Brassica napus	LDO
BRANA\|Gene_ORFName=DARMORV10_C06P27540.1\|UniProtKB=A0A078IRF2	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra007612\|UniProtKB=M4CTR8	Brassica campestris	O
BRACM\|EnsemblGenome=Bra003453\|UniProtKB=A0A397YMH8	Brassica campestris	LDO
ARATH\|TAIR=locus=2062969\|UniProtKB=O82357	Arabidopsis thaliana	O
ARATH\|TAIR=locus=2082847\|UniProtKB=Q9M315	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107930502\|UniProtKB=A0A1U8LSU8	Gossypium hirsutum	O
GOSHI\|Gene=LOC107921292\|UniProtKB=A0A1U8KW52	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_005259\|UniProtKB=A0A061DST8	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g016682mg\|UniProtKB=A0A067HEP1	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_002G164600v3\|UniProtKB=A0A2K2BJV1	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_014G090500v3\|UniProtKB=B9I8Q3	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_05G029300\|UniProtKB=A0A2C9VSS3	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_1616690\|UniProtKB=B9RDY4	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_09G254700\|UniProtKB=I1L6F5	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_18G238300\|UniProtKB=K7MUD8	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_07G064600\|UniProtKB=A0A0R0J726	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_4g037305\|UniProtKB=A0A072UK84	Medicago truncatula	O
MEDTR\|EnsemblGenome=MTR_8g028555\|UniProtKB=A0A072TNM1	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr12_04420\|UniProtKB=A0A6P9DXC6	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_7G338120\|UniProtKB=A0A0A0K8B2	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_2G177600\|UniProtKB=M5X1Q5	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_104329\|UniProtKB=D8RYD4	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_81343\|UniProtKB=D8QZ83	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_66137\|UniProtKB=D8RB99	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_180289\|UniProtKB=D8SJQ2	Selaginella moellendorffii	LDO
SELML\|EnsemblGenome=SELMODRAFT_173629\|UniProtKB=D8RRV3	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c7_220\|UniProtKB=A0A7I4FTF4	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0035s0043\|UniProtKB=A0A2R6X566	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_000210230\|UniProtKB=A0A1Y1HQU6	Klebsormidium nitens	LDO
NITMS\|EnsemblGenome=Nmar_1720\|UniProtKB=A9A2T9	Nitrosopumilus maritimus	LDO
SACS2\|EnsemblGenome=SSO2400\|UniProtKB=Q97W44	Sulfolobus solfataricus	LDO
PYRAE\|EnsemblGenome=PAE3410\|UniProtKB=Q8ZT69	Pyrobaculum aerophilum	LDO
HALSA\|EnsemblGenome=VNG_1478G\|UniProtKB=Q9HPT6	Halobacterium salinarum	LDO
THEKO\|EnsemblGenome=TK0363\|UniProtKB=Q5JCY6	Thermococcus kodakaraensis	LDO
CHLAA\|EnsemblGenome=Caur_2208\|UniProtKB=A9WFR7	Chloroflexus aurantiacus	LDO
STRCO\|Gene_OrderedLocusName=SCO2256\|UniProtKB=Q9RKS2	Streptomyces coelicolor	LDO
CLOBH\|Gene_OrderedLocusName=CBO0425\|UniProtKB=A5HYW9	Clostridium botulinum	LDO
STAA8\|EnsemblGenome=SAOUHSC_02919\|UniProtKB=Q2FV21	Staphylococcus aureus	LDO
LISMO\|EnsemblGenome=CAC99980\|UniProtKB=Q8Y601	Listeria monocytogenes	LDO
BACSU\|EnsemblGenome=BSU_22430\|UniProtKB=P52996	Bacillus subtilis	LDO
BACCR\|EnsemblGenome=BC_1540\|UniProtKB=Q81FN7	Bacillus cereus	LDO
THEMA\|EnsemblGenome=TM_1728\|UniProtKB=Q9X251	Thermotoga maritima	LDO
DEIRA\|EnsemblGenome=DR_2615\|UniProtKB=Q9RR81	Deinococcus radiodurans	LDO
GLOVI\|EnsemblGenome=BAC88703\|UniProtKB=Q7NMK3	Gloeobacter violaceus	LDO
SYNY3\|EnsemblGenome=BAA10813\|UniProtKB=P52997	Synechocystis	LDO
LEPIN\|EnsemblGenome=LA_3958\|UniProtKB=Q8EZ98	Leptospira interrogans	LDO
BACTN\|EnsemblGenome=BT_0698\|UniProtKB=Q8A9W7	Bacteroides thetaiotaomicron	LDO
RHOBA\|EnsemblGenome=RB9090\|UniProtKB=Q7UM39	Rhodopirellula baltica	LDO
AQUAE\|EnsemblGenome=aq_1973\|UniProtKB=O67783	Aquifex aeolicus	LDO
THEYD\|EnsemblGenome=THEYE_A0277\|UniProtKB=B5YIG6	Thermodesulfovibrio yellowstonii	LDO
HELPY\|EnsemblGenome=HP_1058\|UniProtKB=O25698	Helicobacter pylori	LDO
NEIMB\|EnsemblGenome=NMB0870\|UniProtKB=Q9JZW6	Neisseria meningitidis serogroup b	LDO
GEOSL\|EnsemblGenome=GSU1705\|UniProtKB=Q74CG8	Geobacter sulfurreducens	LDO
BRADU\|EnsemblGenome=BAC49313\|UniProtKB=Q89MZ4	Bradyrhizobium diazoefficiens	O
BRADU\|EnsemblGenome=BAC46891\|UniProtKB=Q89TZ6	Bradyrhizobium diazoefficiens	O
BRADU\|EnsemblGenome=BAC47366\|UniProtKB=Q9AMS0	Bradyrhizobium diazoefficiens	LDO
COXBU\|EnsemblGenome=CBU_0424\|UniProtKB=Q83EA2	Coxiella burnetii	LDO
SHEON\|Gene_OrderedLocusName=SO_0870\|UniProtKB=Q8EIG9	Shewanella oneidensis	LDO
VIBCH\|EnsemblGenome=VC_0592\|UniProtKB=Q9KUD0	Vibrio cholerae	LDO
XANCP\|EnsemblGenome=XCC1768\|UniProtKB=Q8P9T0	Xanthomonas campestris	LDO
PSEAE\|EnsemblGenome=PA1598\|UniProtKB=Q9I3C3	Pseudomonas aeruginosa	O
PSEAE\|EnsemblGenome=PA4729\|UniProtKB=Q9HV70	Pseudomonas aeruginosa	LDO
SALTY\|EnsemblGenome=STM0182\|UniProtKB=Q8ZRR0	Salmonella typhimurium	LDO
YERPE\|EnsemblGenome=YP_0284\|UniProtKB=Q8ZBK8	Yersinia pestis	LDO
ECOLI\|EnsemblGenome=BAB96711\|UniProtKB=P31057	Escherichia coli	LDO