PANTHER Gene Information

Gene Symbol(s):

trxB

Organism:

Mycobacterium tuberculosis

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Gene Name:

Thioredoxin reductase

Gene ID:

Rv3913

Protein ID:

P9WHH1

Persistent Id:

PTN002450793

Alternate Ids:

TRXB(Synonym)	P52214(AltAccession)
AL123456(EMBL)	trxB(Symbol)
444897476(GI)	CAA65070(EMBL-CDS)
NZ_NVQJ01000005(refSeq)	1.8.1.9 {ECO:0000269\|PubMed:16301794}(EC)
45427913(GeneID)	TRXB_MYCTU(UniProtKB-ID)
CHEMBL2390811(ChEMBL)
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PANTHER Classification

PANTHER Family:	THIOREDOXIN REDUCTASE 1-RELATED-RELATED (PTHR48105)
PANTHER Subfamily:	THIOREDOXIN REDUCTASE 1-RELATED (PTHR48105:SF16)
PANTHER GO-slim Molecular Function:	antioxidant activity protein-disulfide reductase activity
PANTHER GO-slim Biological Process:	cellular homeostasis
PANTHER GO-slim Cellular Component:
PANTHER protein class:	reductase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	protein binding, protein-disulfide reductase activity, oxidoreductase activity, flavin adenine dinucleotide binding, thioredoxin-disulfide reductase (NADPH) activity, NADPH binding
GO BP Complete:	response to hypoxia, removal of superoxide radicals, cell redox homeostasis
GO CC Complete:	cytoplasm, cytosol

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Bacterial Infection Pathways, Latent infection - Other responses of Mtb to phagocytosis, Infection with Mycobacterium tuberculosis, Disease, Cell redox homeostasis, Infectious disease

Orthologs

ID	Organism	Type
GIAIC\|EnsemblGenome=GL50803_9827\|UniProtKB=E2RU27	Giardia intestinalis	LDO
TRIV3\|Gene_ORFName=TVAG_125360\|UniProtKB=A2F9L1	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_240530\|UniProtKB=A2EJA0	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_348010\|UniProtKB=A2DSU2	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_281360\|UniProtKB=A2F960	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_474980\|UniProtKB=A0A8U0WQ27	Trichomonas vaginalis	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_270256\|UniProtKB=B8C176	Thalassiosira pseudonana	LDO
NITMS\|EnsemblGenome=Nmar_0672\|UniProtKB=A9A479	Nitrosopumilus maritimus	LDO
KORCO\|EnsemblGenome=Kcr_1054\|UniProtKB=B1L5S1	Korarchaeum cryptofilum	LDO
SACS2\|EnsemblGenome=SSO2765\|UniProtKB=Q97V69	Sulfolobus solfataricus	O
PYRAE\|EnsemblGenome=PAE1725\|UniProtKB=Q8ZWL7	Pyrobaculum aerophilum	O
SACS2\|EnsemblGenome=SSO2416\|UniProtKB=Q97W27	Sulfolobus solfataricus	LDO
PYRAE\|EnsemblGenome=PAE2744\|UniProtKB=Q8ZUK0	Pyrobaculum aerophilum	LDO
METAC\|EnsemblGenome=MA_1368\|UniProtKB=Q8TR16	Methanosarcina acetivorans	LDO
METJA\|EnsemblGenome=MJ_1536\|UniProtKB=Q58931	Methanocaldococcus jannaschii	LDO
HALSA\|EnsemblGenome=VNG_2301G\|UniProtKB=Q9HN08	Halobacterium salinarum	O
HALSA\|EnsemblGenome=VNG_1259G\|UniProtKB=P82854	Halobacterium salinarum	LDO
THEKO\|EnsemblGenome=TK2100\|UniProtKB=Q5JIK4	Thermococcus kodakaraensis	LDO
CHLAA\|EnsemblGenome=Caur_2066\|UniProtKB=A9WEL6	Chloroflexus aurantiacus	LDO
STRCO\|Gene_OrderedLocusName=SCO6834\|UniProtKB=Q7AKE3	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO3890\|UniProtKB=P52215	Streptomyces coelicolor	LDO
MYCGE\|EnsemblGenome=MG_102\|UniProtKB=P47348	mycoplasma genitalium	LDO
CLOBH\|Gene_OrderedLocusName=CBO1254\|UniProtKB=A5I194	Clostridium botulinum	O
CLOBH\|Gene_OrderedLocusName=CBO3433\|UniProtKB=A5I7F8	Clostridium botulinum	O
CLOBH\|Gene_OrderedLocusName=CBO1259\|UniProtKB=A5I198	Clostridium botulinum	LDO
STRR6\|EnsemblGenome=spr1312\|UniProtKB=Q8DP78	Streptococcus pneumoniae	LDO
STAA8\|EnsemblGenome=SAOUHSC_00785\|UniProtKB=Q2G041	Staphylococcus aureus	LDO
LISMO\|EnsemblGenome=CAD00556\|UniProtKB=O32823	Listeria monocytogenes	LDO
BACSU\|EnsemblGenome=BSU_34790\|UniProtKB=P80880	Bacillus subtilis	LDO
BACCR\|EnsemblGenome=BC_5159\|UniProtKB=Q815J1	Bacillus cereus	LDO
THEMA\|EnsemblGenome=TM_0134\|UniProtKB=Q9WXY7	Thermotoga maritima	O
THEMA\|EnsemblGenome=TM_0869\|UniProtKB=Q9WZX3	Thermotoga maritima	LDO
DEIRA\|EnsemblGenome=DR_1982\|UniProtKB=Q9RSY7	Deinococcus radiodurans	LDO
GLOVI\|Gene=Q7NCP4_GLOVI\|UniProtKB=Q7NCP4	Gloeobacter violaceus	O
SYNY3\|Gene=P74746_SYNY3\|UniProtKB=P74746	Synechocystis	O
GLOVI\|Gene=Q7NMP6_GLOVI\|UniProtKB=Q7NMP6	Gloeobacter violaceus	LDO
LEPIN\|EnsemblGenome=LA_2494\|UniProtKB=Q8F3B3	Leptospira interrogans	LDO
BACTN\|EnsemblGenome=BT_4336\|UniProtKB=Q89ZP0	Bacteroides thetaiotaomicron	LDO
CHLTR\|EnsemblGenome=CT_099\|UniProtKB=O84101	Chlamydia trachomatis	LDO
RHOBA\|EnsemblGenome=RB7223\|UniProtKB=Q7UP13	Rhodopirellula baltica	LDO
AQUAE\|EnsemblGenome=aq_500\|UniProtKB=O66790	Aquifex aeolicus	LDO
THEYD\|EnsemblGenome=THEYE_A1747\|UniProtKB=B5YH48	Thermodesulfovibrio yellowstonii	LDO
DICTD\|EnsemblGenome=Dtur_0760\|UniProtKB=B8DZV9	Dictyoglomus turgidum	LDO
FUSNN\|EnsemblGenome=FN1163\|UniProtKB=Q8REE4	Fusobacterium nucleatum	O
FUSNN\|EnsemblGenome=FN1984\|UniProtKB=Q8RHN0	Fusobacterium nucleatum	LDO
HELPY\|EnsemblGenome=HP_0825\|UniProtKB=P56431	Helicobacter pylori	LDO
NEIMB\|EnsemblGenome=NMB1324\|UniProtKB=Q9JZ28	Neisseria meningitidis serogroup b	LDO
GEOSL\|EnsemblGenome=GSU0488\|UniProtKB=Q74FW4	Geobacter sulfurreducens	LDO
BRADU\|Gene=trxB\|UniProtKB=Q89DQ9	Bradyrhizobium diazoefficiens	LDO
COXBU\|EnsemblGenome=CBU_1193\|UniProtKB=P39916	Coxiella burnetii	LDO
HAEIN\|EnsemblGenome=HI_1158\|UniProtKB=P43788	Haemophilus influenzae	LDO
SHEON\|Gene_OrderedLocusName=SO_2303\|UniProtKB=Q8EER5	Shewanella oneidensis	LDO
VIBCH\|EnsemblGenome=VC_1182\|UniProtKB=Q9KSS4	Vibrio cholerae	LDO
XANCP\|EnsemblGenome=XCC1971\|UniProtKB=Q8P994	Xanthomonas campestris	LDO
PSEAE\|EnsemblGenome=PA0849\|UniProtKB=Q9I592	Pseudomonas aeruginosa	O
PSEAE\|EnsemblGenome=PA2616\|UniProtKB=Q9I0M2	Pseudomonas aeruginosa	LDO
SALTY\|EnsemblGenome=STM0958\|UniProtKB=Q7CQU5	Salmonella typhimurium	LDO
YERPE\|Gene_OrderedLocusName=YPO1374\|UniProtKB=A0A5P8YGL8	Yersinia pestis	LDO
ECOLI\|EnsemblGenome=BAA35613\|UniProtKB=P0A9P4	Escherichia coli	LDO