PANTHER Gene Information

Gene Symbol(s):

CSF1R

Organism:

Ornithorhynchus anatinus

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Gene Name:

receptor protein-tyrosine kinase

Gene ID:

ENSOANG00000002293.4

Protein ID:

A0A6I8N2V4

Persistent Id:

PTN000699155

Alternate Ids:

ENSOANG00000002293(Ensembl)	ENSOANT00000059233(Ensembl_TRS)
A0A6I8N2V4_ORNAN(UniProtKB-ID)	ENSOANP00000035273(Ensembl_PRO)
A0A6I8N2V4(Synonym)
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PANTHER Classification

PANTHER Family:	TYROSINE-PROTEIN KINASE RECEPTOR (PTHR24416)
PANTHER Subfamily:	MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR (PTHR24416:SF47)
PANTHER GO-slim Molecular Function:	growth factor binding transmembrane receptor protein tyrosine kinase activity
PANTHER GO-slim Biological Process:	transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of kinase activity osteoclast differentiation positive regulation of cell migration multicellular organism development regulation of MAPK cascade
PANTHER GO-slim Cellular Component:	receptor complex plasma membrane
PANTHER protein class:	transmembrane signal receptor

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	placental growth factor receptor activity, growth factor binding, protein phosphatase binding, protein homodimerization activity, stem cell factor receptor activity, brain-derived neurotrophic factor receptor activity, macrophage colony-stimulating factor receptor activity, protein tyrosine kinase collagen receptor activity, insulin-like growth factor receptor activity, vascular endothelial growth factor receptor activity, boss receptor activity, GPI-linked ephrin receptor activity, epidermal growth factor receptor activity, transmembrane-ephrin receptor activity, hepatocyte growth factor receptor activity, platelet-derived growth factor beta-receptor activity, fibroblast growth factor receptor activity, platelet-derived growth factor alpha-receptor activity, ATP binding, protein tyrosine kinase activity, insulin receptor activity, transmembrane receptor protein tyrosine kinase activity, metal ion binding, cytokine binding
GO BP Complete:	cell population proliferation, regulation of cell shape, regulation of MAPK cascade, multicellular organism development, insulin receptor signaling pathway, forebrain neuron differentiation, epidermal growth factor receptor signaling pathway, negative regulation of cell population proliferation, hemopoiesis, regulation of macrophage migration, positive regulation of cell population proliferation, axon guidance, fibroblast growth factor receptor signaling pathway, positive regulation by host of viral process, microglial cell proliferation, olfactory bulb development, response to ischemia, cytokine-mediated signaling pathway, positive regulation of macrophage chemotaxis, positive regulation of chemokine production, positive regulation of macrophage proliferation, cellular response to macrophage colony-stimulating factor stimulus, Kit signaling pathway, vascular endothelial growth factor receptor-1 signaling pathway, platelet-derived growth factor receptor-alpha signaling pathway, macrophage colony-stimulating factor signaling pathway, platelet-derived growth factor receptor-beta signaling pathway, vascular endothelial growth factor signaling pathway, insulin-like growth factor receptor signaling pathway, cell surface receptor protein tyrosine kinase signaling pathway, collagen-activated tyrosine kinase receptor signaling pathway, cell-cell junction maintenance, osteoclast differentiation, hepatocyte growth factor receptor signaling pathway, brain-derived neurotrophic factor receptor signaling pathway, regulation of actin cytoskeleton organization, ruffle organization, negative regulation of apoptotic process, ephrin receptor signaling pathway, positive regulation of ERK1 and ERK2 cascade, cellular response to cytokine stimulus, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of cell migration, positive regulation of cell motility
GO CC Complete:	intracellular membrane-bounded organelle, membrane, receptor complex, plasma membrane, nucleoplasm, cell surface, CSF1-CSF1R complex

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=2433\|UniProtKB=P07333	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000017409.6\|UniProtKB=A0A2I3SWC5	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000008936.3\|UniProtKB=G3RMC9	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000011556.4\|UniProtKB=A0A1D5QZE0	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1339758\|UniProtKB=P09581	Mus musculus	LDO
RAT\|RGD=2425\|UniProtKB=Q00495	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000012771.6\|UniProtKB=A7Z067	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000014441.5\|UniProtKB=A0A5G2QIU0	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000000860.4\|UniProtKB=A0A9L0S2G1	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000003633.6\|UniProtKB=M3W0P5	Felis catus	LDO
FELCA\|Gene=CSF1R\|UniProtKB=P13369	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845008395.1\|UniProtKB=A0A8I3MXT5	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000009759.4\|UniProtKB=F6WT52	Monodelphis domestica	LDO
CHICK\|Ensembl=ENSGALG00010016804.1\|UniProtKB=A0A8V0YXM5	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000015531.4\|UniProtKB=G1KRD5	Anolis carolinensis	LDO
XENLA\|Gene=LOC101243554\|UniProtKB=A0A8J1MUC7	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-6257851\|UniProtKB=Q640T5	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000012809.2\|UniProtKB=H2MBW3	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000004849.2\|UniProtKB=A0A3B3I1Y4	Oryzias latipes	LDO
DANRE\|Gene=csf1rb\|UniProtKB=A0A8M3AX73	Danio rerio	O
DANRE\|Gene=csf1ra\|UniProtKB=A0A8M9QKN6	Danio rerio	LDO
DANRE\|ZFIN=ZDB-GENE-001205-1\|UniProtKB=Q9I8N6	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000011078.1\|UniProtKB=W5MZ16	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000003493.3\|UniProtKB=F6TLX0	Ciona intestinalis	O
BRAFL\|Gene=LOC118418363\|UniProtKB=A0A9J7MV71	Branchiostoma floridae	O
BRAFL\|Gene=LOC118403946\|UniProtKB=A0A9J7HIK2	Branchiostoma floridae	O
BRAFL\|Gene=LOC118419709\|UniProtKB=A0A9J7LFS0	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC105444281\|UniProtKB=A0A7M7NBJ5	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105438002\|UniProtKB=A0A7M7NGH8	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC579430\|UniProtKB=A0A7M7NBH9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105437797\|UniProtKB=A0A7M7P5W9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115918442\|UniProtKB=A0A7M7NFV5	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC575248\|UniProtKB=A0A7M7NGI9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105443986\|UniProtKB=A0A7M7NDD9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC593142\|UniProtKB=A0A7M7PJZ3	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105445932\|UniProtKB=A0A7M7NC15	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105444011\|UniProtKB=A0A7M7NDZ4	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105443826\|UniProtKB=A0A7M7NBR9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105439256\|UniProtKB=A0A7M7NFB8	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100892684\|UniProtKB=A0A7M7NF85	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115921149\|UniProtKB=A0A7M7NC60	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105444275\|UniProtKB=A0A7M7ND25	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC590825\|UniProtKB=A0A7M7NBI9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100888196\|UniProtKB=A0A7M7LL81	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100888329\|UniProtKB=A0A7M7P467	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC579837\|UniProtKB=A0A7M7RCU0	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00017310\|UniProtKB=A0A2C9C3B4	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG19102\|UniProtKB=A8XUS9	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00103469\|UniProtKB=A0A2A6CRG6	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00008599\|UniProtKB=Q19238	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG05239\|UniProtKB=A8WZG4	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00107078\|UniProtKB=A0A2A6CZ19	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00002195\|UniProtKB=F3NWW5	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG22767\|UniProtKB=A8Y2V0	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00276578\|UniProtKB=A0A2A6B4J7	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00015087\|UniProtKB=Q10915	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG11187\|UniProtKB=A8XCN3	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00304683\|UniProtKB=A0A8R1Z946	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00011169\|UniProtKB=Q21868	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00002199\|UniProtKB=P34891	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00011339\|UniProtKB=O18008	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00002200\|UniProtKB=P34892	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG04906\|UniProtKB=A8WYS1	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG13386\|UniProtKB=A8XHW0	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG13385\|UniProtKB=A8XHW1	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00020678\|UniProtKB=A0A1I6CMA1	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG01733\|UniProtKB=A8WQZ3	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00021745\|UniProtKB=Q9N4T2	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00003862\|UniProtKB=Q17833	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00002211\|UniProtKB=O17955	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00003863\|UniProtKB=Q23677	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00011168\|UniProtKB=Q21867	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00012270\|UniProtKB=Q95ZK1	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00027499\|UniProtKB=A8WYS2	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG04913\|UniProtKB=A8WYS8	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00027448\|UniProtKB=A8WYM1	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00027500\|UniProtKB=A8WYS3	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00006897\|UniProtKB=Q21041	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00006894\|UniProtKB=G5ED65	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00006896\|UniProtKB=Q21038	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG17535\|UniProtKB=A8XR68	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG17536\|UniProtKB=A8XR69	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG17534\|UniProtKB=A8XR67	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00278186\|UniProtKB=A0A2A6B1V3	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00278185\|UniProtKB=A0A2A6B2E3	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0032006\|UniProtKB=E1JHB7	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP008813\|UniProtKB=A0A1S4GZA9	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC007584\|UniProtKB=A0A139WIY2	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_58385\|UniProtKB=E9H5T6	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_305264\|UniProtKB=E9GQ40	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_48616\|UniProtKB=E9GD08	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_4284\|UniProtKB=E9GD15	Daphnia pulex	O
DAPPU\|Gene_ORFName=DAPPUDRAFT_44144\|UniProtKB=E9FZB6	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_43719\|UniProtKB=E9FZF2	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_308023\|UniProtKB=E9H5G0	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_114299\|UniProtKB=E9HHQ5	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_130278\|UniProtKB=E9HM17	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_110024\|UniProtKB=E9H4Z3	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_325477\|UniProtKB=E9H4U6	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_331276\|UniProtKB=E9HLZ6	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_110251\|UniProtKB=E9H5G3	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_61463\|UniProtKB=E9HD20	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_119760\|UniProtKB=E9HZE7	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_302458\|UniProtKB=E9HNF0	Daphnia pulex	O
DAPPU\|Gene_ORFName=DAPPUDRAFT_48631\|UniProtKB=E9GCS3	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_108386\|UniProtKB=E9H018	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_53509\|UniProtKB=E9GQD0	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_308030\|UniProtKB=E9H5J0	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_253800\|UniProtKB=E9H5G1	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_58353\|UniProtKB=E9H5T9	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_64428\|UniProtKB=E9HNF3	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_302459\|UniProtKB=E9HNF4	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_130102\|UniProtKB=E9HGU7	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW005359\|UniProtKB=B7PKS1	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG133386\|UniProtKB=T1EI07	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG170959\|UniProtKB=T1F3M5	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG75629\|UniProtKB=T1G278	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG141355\|UniProtKB=T1EJ33	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG89500\|UniProtKB=T1G7D9	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g94990\|UniProtKB=A7RVU0	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g115371\|UniProtKB=A7SEI8	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g94997\|UniProtKB=A7RVT8	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g87486\|UniProtKB=A7RN88	Nematostella vectensis	O
NEMVE\|Gene_ORFName=NEMVEDRAFT_v1g87445\|UniProtKB=A7RN91	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG50752\|UniProtKB=B3S5N3	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG25090\|UniProtKB=B3RWV1	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_30176\|UniProtKB=A9VD80	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_2692\|UniProtKB=A9UPY9	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_27311\|UniProtKB=A9V4X6	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_34526\|UniProtKB=A9VCA3	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_33842\|UniProtKB=A9V7V7	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_33860\|UniProtKB=A9V7Z4	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_44299\|UniProtKB=A9V2D0	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_44298\|UniProtKB=A9UWK2	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_27155\|UniProtKB=A9V4G9	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_16001\|UniProtKB=A9UW70	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_27552\|UniProtKB=A9V5L8	Monosiga brevicollis	O