PANTHER Gene Information

Gene Symbol(s):

NOTCH4

Organism:

Pan troglodytes

View Gene in Tree

Tree

Gene Name:

Notch receptor 4

Gene ID:

ENSPTRG00000034379.3

Protein ID:

H2RDK4

Persistent Id:

PTN000621246

Alternate Ids:

ENSPTRT00000067434(Ensembl_TRS)	H2RDK4_PANTR(UniProtKB-ID)
AC190421(EMBL)	H2RDK4(Synonym)
462587(GeneID)	ENSPTRG00000034379(Ensembl)
1034174680(GI)	ENSPTRP00000059022(Ensembl_PRO)
XM_009450982(refSeq)
Show All

PANTHER Classification

PANTHER Family:	NOTCH LIGAND FAMILY MEMBER (PTHR24044)
PANTHER Subfamily:	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4 (PTHR24044:SF489)
PANTHER GO-slim Molecular Function:	signaling receptor binding
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:
PANTHER protein class:	intercellular signal molecule

Pathway Categories:

Alzheimer disease-presenilin pathway

Notch extracellular fragment

Notch signaling pathway

Notch intracellular tethered fragment

Alzheimer disease-presenilin pathway

Notch N-terminal fragment

Alzheimer disease-presenilin pathway

Notch transmembrane fragment

Alzheimer disease-presenilin pathway

Notch fragment

Alzheimer disease-presenilin pathway

Notch C-terminal fragment

Notch signaling pathway

Notch intracellular soluble fragment

Alzheimer disease-presenilin pathway

Notch

Angiogenesis

Notch Receptor

Notch signaling pathway

Notch

Notch signaling pathway

Notch transmembrane domain fragment

Alzheimer disease-presenilin pathway

Notch intracellular domain

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	metal ion binding, calcium ion binding, signaling receptor activity, cis-regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, Notch binding
GO BP Complete:	negative regulation of transcription by RNA polymerase II, mammary gland development, regulation of developmental process, negative regulation of cell adhesion molecule production, Notch signaling pathway, positive regulation of smooth muscle cell differentiation, cell differentiation, epithelial to mesenchymal transition, regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, negative regulation of cell-cell adhesion mediated by cadherin
GO CC Complete:	nucleus, membrane, plasma membrane, cell surface

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=7884\|UniProtKB=Q99466	Homo sapiens	LDO
MACMU\|Ensembl=ENSMMUG00000018461.4\|UniProtKB=F7HCR6	Macaca mulatta	LDO
MOUSE\|MGI=MGI=107471\|UniProtKB=P31695	Mus musculus	LDO
RAT\|RGD=1303282\|UniProtKB=Q6MG89	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000025424.5\|UniProtKB=G3X812	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000001440.5\|UniProtKB=F6PXC7	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000012302.4\|UniProtKB=F6SVF8	Equus caballus	LDO
MONDO\|Ensembl=ENSMODG00000014864.5\|UniProtKB=F6SDD3	Monodelphis domestica	LDO
XENTR\|Gene=notch4\|UniProtKB=A0A8J1INF6	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000010198.2\|UniProtKB=H2M2Y9	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-141222-10\|UniProtKB=A0A0R4IN59	Danio rerio	LDO
CIOIN\|Ensembl=ENSCING00000018084.1\|UniProtKB=H2XVL3	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000022886.1\|UniProtKB=H2XLF7	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000015059.2\|UniProtKB=F6S801	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118417562\|UniProtKB=A0A9J7LBQ9	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC115920620\|UniProtKB=A0A7M7SUM9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105440436\|UniProtKB=A0A7M7P3J5	Strongylocentrotus purpuratus	LDO
STRPU\|EnsemblGenome=LOC105442995\|UniProtKB=A0A7M7PFG9	Strongylocentrotus purpuratus	O
DROME\|FlyBase=FBgn0259685\|UniProtKB=P10040	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP003873\|UniProtKB=A0A1S4GJZ2	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC004424\|UniProtKB=D6WD05	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_301952\|UniProtKB=E9GB00	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW000169\|UniProtKB=B7P5N2	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW015131\|UniProtKB=B7QN02	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG72662\|UniProtKB=T1G135	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG109730\|UniProtKB=T1EEW1	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG66198\|UniProtKB=T1FYI4	helobdella robusta	LDO
HELRO\|EnsemblGenome=HelroG75352\|UniProtKB=T1G240	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g139161\|UniProtKB=A7SZH7	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g61395\|UniProtKB=A7RR01	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g148151\|UniProtKB=A7T6R5	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g120454\|UniProtKB=A7SJC2	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g87929\|UniProtKB=A7RNQ6	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g142783\|UniProtKB=A7T268	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g84684\|UniProtKB=A7RKD7	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g125015\|UniProtKB=A7SNM7	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g84597\|UniProtKB=A7RKD3	Nematostella vectensis	O
NEMVE\|Gene_ORFName=NEMVEDRAFT_v1g141385\|UniProtKB=A7T161	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g84176\|UniProtKB=A7RKD4	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g64340\|UniProtKB=A7RP66	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG22292\|UniProtKB=B3RR34	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_38707\|UniProtKB=A9V9N1	Monosiga brevicollis	O
GIAIC\|EnsemblGenome=GL50803_24512\|UniProtKB=A8B4D5	Giardia intestinalis	O
CHLRE\|EnsemblGenome=CHLRE_16g690095v5\|UniProtKB=A0A2K3CW78	Chlamydomonas reinhardtii	O