PANTHER Gene Information   
Gene Symbol(s): PRKN
Organism: Sus scrofa
View Gene in Tree
Tree
Tree
Gene Name: E3 ubiquitin-protein ligase parkin
Gene ID: ENSSSCG00000004032.5
Protein ID: Q1WDP3
Persistent Id: PTN002580849
Alternate Ids:
ENSSSCP00000061874(Ensembl_PRO) ENSSSCT00000070113(Ensembl_TRS)
Q1WDP3_PIG(UniProtKB-ID) 733673(GeneID)
NM_001044603(refSeq) 85718640(GI)
DQ359724(EMBL) ENSSSCG00000004032(Ensembl)
Q1WDP3(Synonym) ABC75246(EMBL-CDS)
Show All

PANTHER Classification
PANTHER Family: UBIQUILIN (PTHR10677)
PANTHER Subfamily: UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN (PTHR10677:SF40)  
PANTHER GO-slim Molecular Function: polyubiquitin modification-dependent protein binding
PANTHER GO-slim Biological Process: ubiquitin-dependent protein catabolic process
PANTHER GO-slim Cellular Component: cytosol
PANTHER protein class: scaffold/adaptor protein
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: tubulin binding, protein kinase binding, zinc ion binding, identical protein binding, ubiquitin protein ligase activity, histone deacetylase binding, polyubiquitin modification-dependent protein binding, beta-catenin binding, ubiquitin-specific protease binding, protein-containing complex binding, G protein-coupled receptor binding, ubiquitin conjugating enzyme binding, ubiquitin protein ligase binding, F-box domain binding, actin binding, ubiquitin binding, transcription corepressor activity, phospholipase binding, PDZ domain binding, cullin family protein binding, Hsp70 protein binding
GO BP Complete: norepinephrine metabolic process, dopamine metabolic process, mitochondrion to lysosome vesicle-mediated transport, adult locomotory behavior, learning, type 2 mitophagy, regulation of cellular response to oxidative stress, regulation of mitochondrial membrane potential, aggresome assembly, negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, positive regulation of protein localization to membrane, negative regulation of gene expression, proteasome-mediated ubiquitin-dependent protein catabolic process, positive regulation of gene expression, negative regulation of actin filament bundle assembly, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, response to endoplasmic reticulum stress, negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway, positive regulation of protein linear polyubiquitination, negative regulation of exosomal secretion, positive regulation of dendrite extension, positive regulation of tumor necrosis factor-mediated signaling pathway, negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of intralumenal vesicle formation, positive regulation of canonical NF-kappaB signal transduction, negative regulation of insulin secretion, positive regulation of transcription by RNA polymerase II, negative regulation of transcription by RNA polymerase II, startle response, dopamine uptake involved in synaptic transmission, positive regulation of mitochondrial fusion, protein localization to mitochondrion, positive regulation of neurotransmitter uptake, free ubiquitin chain polymerization, protein autoubiquitination, negative regulation of reactive oxygen species metabolic process, protein K11-linked ubiquitination, protein K48-linked ubiquitination, regulation protein catabolic process at presynapse, negative regulation of release of cytochrome c from mitochondria, negative regulation of spontaneous neurotransmitter secretion, negative regulation by host of viral genome replication, regulation of synaptic vesicle endocytosis, protein monoubiquitination, ubiquitin-dependent protein catabolic process, protein destabilization, negative regulation of canonical Wnt signaling pathway, regulation of dopamine metabolic process, cellular response to toxic substance, protein K63-linked ubiquitination, positive regulation of type 2 mitophagy, protein stabilization, protein K6-linked ubiquitination, synaptic transmission, glutamatergic
GO CC Complete: Parkin-FBXW7-Cul1 ubiquitin ligase complex, presynapse, perinuclear region of cytoplasm, nuclear speck, mitochondrion, mitochondrion-derived vesicle, cytosol, endoplasmic reticulum, Golgi apparatus, aggresome, neuron projection, dopaminergic synapse
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: -

Orthologs