PANTHER Gene Information

Gene Symbol(s):

MARK3

Organism:

Sus scrofa

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Gene Name:

non-specific serine_threonine protein kinase

Gene ID:

ENSSSCG00000021669.4

Protein ID:

A0A286ZWW3

Persistent Id:

PTN001552541

Alternate Ids:

A0A286ZWW3(Synonym)	ENSSSCG00000021669(Ensembl)
A0A286ZWW3_PIG(UniProtKB-ID)	ENSSSCT00000056626(Ensembl_TRS)
ENSSSCP00000036113(Ensembl_PRO)
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PANTHER Classification

PANTHER Family:	MAP/MICROTUBULE AFFINITY-REGULATING KINASE (PTHR24346)
PANTHER Subfamily:	MAP_MICROTUBULE AFFINITY-REGULATING KINASE 3 (PTHR24346:SF1)
PANTHER GO-slim Molecular Function:	protein serine/threonine kinase activity
PANTHER GO-slim Biological Process:	microtubule cytoskeleton organization intracellular signal transduction
PANTHER GO-slim Cellular Component:	cytoplasm plasma membrane
PANTHER protein class:	non-receptor serine/threonine protein kinase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	histone H3S10 kinase activity, histone H2BS14 kinase activity, histone H2AS1 kinase activity, eukaryotic translation initiation factor 2alpha kinase activity, protein serine/threonine kinase activity, 3-phosphoinositide-dependent protein kinase activity, ribosomal protein S6 kinase activity, tau-protein kinase activity, DNA-dependent protein kinase activity, ATP binding, histone H2AT120 kinase activity, AMP-activated protein kinase activity, histone H2AS121 kinase activity, histone H3S57 kinase activity, histone H4S1 kinase activity, histone H3T3 kinase activity, histone H2BS36 kinase activity, histone H3S28 kinase activity, histone H3T45 kinase activity, histone H2AXS139 kinase activity, Rho-dependent protein serine/threonine kinase activity, histone H3T11 kinase activity, protein serine kinase activity, histone H3T6 kinase activity
GO BP Complete:	negative regulation of hippo signaling, negative regulation of protein localization to nucleus, chromatin remodeling, microtubule cytoskeleton organization, intracellular signal transduction
GO CC Complete:	dendrite, cytoplasm, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

MAPK family signaling cascades, MAP2K and MAPK activation, MAPK1/MAPK3 signaling, Negative regulation of MAPK pathway, Signal Transduction, RAF activation, RAF/MAP kinase cascade

Orthologs

ID	Organism	Type
HUMAN\|HGNC=6897\|UniProtKB=P27448	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000006754.6\|UniProtKB=H2R138	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000007387.3\|UniProtKB=G3RNJ5	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000003641.4\|UniProtKB=A0A1D5Q0S2	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1341865\|UniProtKB=Q03141	Mus musculus	LDO
RAT\|RGD=619883\|UniProtKB=Q8VHF0	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000013410.6\|UniProtKB=A0A3Q1LWF1	Bos taurus	LDO
HORSE\|Ensembl=ENSECAG00000016955.4\|UniProtKB=A0A9L0TBW9	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000007949.6\|UniProtKB=A0A5F5XL17	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845018426.1\|UniProtKB=A0A8I3PDX9	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000013489.4\|UniProtKB=F7F8R2	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000000773.4\|UniProtKB=F6RDT7	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010015792.1\|UniProtKB=A0A8V0YLV1	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000000652.4\|UniProtKB=H9G460	Anolis carolinensis	LDO
XENLA\|Gene=mark3.L\|UniProtKB=A0A8J1LED8	Xenopus laevis	LDO
ORYLA\|Ensembl=ENSORLG00000017921.2\|UniProtKB=A0A3B3I9T7	Oryzias latipes	O
DANRE\|Gene=mark3a\|UniProtKB=A0A8M9PXN3	Danio rerio	O
DANRE\|Gene=mark3b\|UniProtKB=A0A8M3AL25	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000009889.1\|UniProtKB=W5MUP2	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000008201.3\|UniProtKB=F6PJL4	Ciona intestinalis	O
BRAFL\|Gene=LOC118411561\|UniProtKB=A0A9J7MJW1	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC100890266\|UniProtKB=A0A7M7SYA1	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100889556\|UniProtKB=A0A7M7P9P4	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC592325\|UniProtKB=A0A7M7HGN9	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00003916\|UniProtKB=Q9TW45	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG04756\|UniProtKB=A8WYE4	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00277629\|UniProtKB=A0A2A6BEG1	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00102456\|UniProtKB=A0A2A6BZY9	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00280367\|UniProtKB=A0A2A6C102	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0026064\|UniProtKB=Q9VGP9	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0026063\|UniProtKB=Q9VGQ0	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0260934\|UniProtKB=A1ZBL9	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP010341\|UniProtKB=A0A1S4H3R9	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP029469\|UniProtKB=A0A453YZQ5	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC032576\|UniProtKB=A0A139WKC9	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_313175\|UniProtKB=E9G331	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW014579\|UniProtKB=B7QKV7	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG192553\|UniProtKB=T1FU26	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG62924\|UniProtKB=T1FX78	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG84170\|UniProtKB=T1G5F9	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG71411\|UniProtKB=T1G0L1	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG66187\|UniProtKB=T1FYI3	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG86903\|UniProtKB=T1G6J0	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG83409\|UniProtKB=T1G552	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g139527\|UniProtKB=A7SZV3	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG27001\|UniProtKB=B3S0C9	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_34468\|UniProtKB=A9VBY4	Monosiga brevicollis	O
CANAL\|CGD=CAL0000177153\|UniProtKB=A0A1D8PRN8	Candida albicans	O
ASPFU\|EnsemblGenome=AFUA_1G11080\|UniProtKB=Q4WSZ7	Neosartorya fumigata	O
SCHJY\|EnsemblGenome=SJAG_02838\|UniProtKB=B6K1B3	Schizosaccharomyces japonicus	O
ASPFU\|EnsemblGenome=AFUA_1G11930\|UniProtKB=E9RDZ3	Neosartorya fumigata	O
SCHJY\|EnsemblGenome=SJAG_04469\|UniProtKB=B6K6W9	Schizosaccharomyces japonicus	O
SCHJY\|EnsemblGenome=SJAG_03602\|UniProtKB=B6K4P0	Schizosaccharomyces japonicus	O
BATDJ\|Gene_ORFName=BATDEDRAFT_10042\|UniProtKB=F4NZ62	Batrachochytrium dendrobatidis	O
ENTH1\|EnsemblGenome=CL6EHI_073490\|UniProtKB=C4LXL3	Entamoeba histolytica	O
ENTH1\|Gene_ORFName=EHI_025300\|UniProtKB=A0A8U0WP54	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0280133\|UniProtKB=Q54VU4	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_151676\|UniProtKB=F0ZJH1	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0292304\|UniProtKB=Q54DF2	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_51418\|UniProtKB=F1A3P4	Dictyostelium purpureum	O
GIAIC\|EnsemblGenome=GL50803_9487\|UniProtKB=A8B530	Giardia intestinalis	O
PLAF7\|EnsemblGenome=PF3D7_1441300\|UniProtKB=Q8IL57	Plasmodium falciparum	O
PARTE\|EnsemblGenome=GSPATT00031618001\|UniProtKB=A0BS70	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00002297001\|UniProtKB=A0DGK1	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00020040001\|UniProtKB=A0DTJ2	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00018964001\|UniProtKB=A0DP01	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00030300001\|UniProtKB=A0BM97	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00004376001\|UniProtKB=A0BCL5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00018952001\|UniProtKB=A0DNY9	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00026401001\|UniProtKB=A0EFI7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00024498001\|UniProtKB=A0E900	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00024481001\|UniProtKB=A0E8Y3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00017966001\|UniProtKB=A0DKR9	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00028068001\|UniProtKB=A0BER8	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00022278001\|UniProtKB=A0E1E2	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00009964001\|UniProtKB=A0CSC5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00025088001\|UniProtKB=A0EAN7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00029968001\|UniProtKB=A0BLB9	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00014139001\|UniProtKB=A0D805	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00019068001\|UniProtKB=A0DPB9	Paramecium tetraurelia	O
PHYRM\|Gene=H3H0P0_PHYRM\|UniProtKB=H3H0P0	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_07g329850v5\|UniProtKB=A0A2K3DJR9	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_09g403850v5\|UniProtKB=A0A2K3DCM7	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_13g568050v5\|UniProtKB=A0A2K3CZG1	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_16g685389v5\|UniProtKB=A0A2K3CW32	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_02g076000v5\|UniProtKB=A0A2K3E058	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_01g036000v5\|UniProtKB=A0A2K3E716	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_06g251050v5\|UniProtKB=A0A2K3DLY4	Chlamydomonas reinhardtii	O
HELAN\|Gene_ORFName=HanXRQr2_Chr05g0231561\|UniProtKB=A0A9K3J1W2	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C500236580\|UniProtKB=A0A9R1XB86	Lactuca sativa	O
KLENI\|Gene_ORFName=KFL_000330150\|UniProtKB=A0A1Y1HQV7	Klebsormidium nitens	O
LACSA\|Gene_ORFName=LSAT_V11C400212270\|UniProtKB=A0A9R1XHY6	Lactuca sativa	O
KLENI\|Gene_ORFName=KFL_000980330\|UniProtKB=A0A0U9HJG2	Klebsormidium nitens	O
KLENI\|Gene_ORFName=KFL_007820030\|UniProtKB=A0A1Y1IQA2	Klebsormidium nitens	O
KLENI\|Gene_ORFName=KFL_001250250\|UniProtKB=A0A1Y1I3Z9	Klebsormidium nitens	O
KLENI\|Gene_ORFName=KFL_000970360\|UniProtKB=A0A0U9HJE6	Klebsormidium nitens	O
MUSAM\|EnsemblGenome=Ma01_g02460\|UniProtKB=A0A804HPI0	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma00_g00400\|UniProtKB=A0A804HLY2	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma10_g08280\|UniProtKB=A0A804KTZ1	Musa acuminata subsp. malaccensis	O
MAIZE\|EnsemblGenome=Zm00001eb013270\|UniProtKB=Q6RXY1	Zea mays	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0320770\|UniProtKB=A0A8I7BB45	Hordeum vulgare subsp. vulgare	O
SETIT\|EnsemblGenome=SETIT_019716mg\|UniProtKB=K3YZK6	Setaria italica	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.1HG0060110\|UniProtKB=A0A8I6X3U9	Hordeum vulgare subsp. vulgare	O
MAIZE\|EnsemblGenome=Zm00001eb293240\|UniProtKB=A0A804Q4X7	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb353700\|UniProtKB=A0A804QSJ7	Zea mays	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0286490\|UniProtKB=A0A8I6XFN7	Hordeum vulgare subsp. vulgare	O
SPIOL\|Gene=LOC110800356\|UniProtKB=A0A9R0J5M8	Spinacia oleracea	O
HELAN\|Gene_ORFName=HanXRQr2_Chr07g0308661\|UniProtKB=A0A9K3ING8	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C900467660\|UniProtKB=A0A9R1UGU9	Lactuca sativa	O
PHYPA\|EnsemblGenome=Pp3c3_5570\|UniProtKB=A0A7I4DGQ5	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0038s0082\|UniProtKB=A0A2R6X3U9	Marchantia polymorpha	O
MARPO\|EnsemblGenome=MARPO_0160s0010\|UniProtKB=A0A2R6W3Y3	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_008220030\|UniProtKB=A0A1Y1INE1	Klebsormidium nitens	O
STRCO\|Gene_OrderedLocusName=SCO4820\|UniProtKB=Q9K3K0	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO4817\|UniProtKB=Q9K3K3	Streptomyces coelicolor	O
DEIRA\|EnsemblGenome=DR_1213\|UniProtKB=Q9RV17	Deinococcus radiodurans	O
RHOBA\|EnsemblGenome=RB12694\|UniProtKB=Q7UI82	Rhodopirellula baltica	O
AQUAE\|EnsemblGenome=aq_576\|UniProtKB=O66844	Aquifex aeolicus	O