PANTHER Gene Information

Gene Symbol(s):

Mbd1

Organism:

Rattus norvegicus

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Gene Name:

Methyl-CpG binding domain protein 1

Gene ID:

1305980

Protein ID:

A0A8I6A3W5

Persistent Id:

PTN000273849

Alternate Ids:

564393955(GI)	XP_006254973(refSeq)
A0A8I6A3W5(Synonym)	ENSRNOG00000024104(Ensembl)
1305980(RGD)	ENSRNOT00000111311(Ensembl_TRS)
291439(GeneID)	ENSRNOP00000086562(Ensembl_PRO)
A0A8I6A3W5_RAT(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	METHYL-CPG BINDING PROTEIN, MBD (PTHR12396)
PANTHER Subfamily:	METHYL-CPG-BINDING DOMAIN PROTEIN 1 (PTHR12396:SF57)
PANTHER GO-slim Molecular Function:	nucleotide binding sequence-specific DNA binding
PANTHER GO-slim Biological Process:	negative regulation of transcription by RNA polymerase II DNA methylation-dependent heterochromatin formation
PANTHER GO-slim Cellular Component:	nucleus
PANTHER protein class:	chromatin/chromatin-binding, or -regulatory protein

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	DNA binding, zinc ion binding, double-stranded methylated DNA binding, unmethylated CpG binding, chromatin binding, methyl-CpG binding
GO BP Complete:	negative regulation of transcription by RNA polymerase II, negative regulation of gene expression, ventricular cardiac muscle tissue development, neuron differentiation, response to estradiol, response to cocaine, negative regulation of astrocyte differentiation, response to xenobiotic stimulus, response to organic cyclic compound, response to nutrient levels, epigenetic regulation of gene expression, DNA methylation-dependent constitutive heterochromatin formation
GO CC Complete:	heterochromatin, nucleus, cytoplasm, nuclear speck, intracellular membrane-bounded organelle, nuclear matrix, chromatin, nucleoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

SUMO E3 ligases SUMOylate target proteins, SUMOylation of transcription cofactors, SUMOylation, Metabolism of proteins, Post-translational protein modification

Orthologs

ID	Organism	Type
HUMAN\|HGNC=6916\|UniProtKB=Q9UIS9	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000010021.7\|UniProtKB=K7CVL7	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000016966.3\|UniProtKB=G3RU66	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000009050.4\|UniProtKB=F7FBN7	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1333811\|UniProtKB=Q9Z2E2	Mus musculus	LDO
PIG\|Ensembl=ENSSSCG00000004516.5\|UniProtKB=F1RPP4	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000011497.4\|UniProtKB=F7BF66	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000015730.6\|UniProtKB=A0A2I2UQ58	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845005631.1\|UniProtKB=A0A8I3RUB6	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000042737.1\|UniProtKB=A0A5F8HDE4	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000042027.1\|UniProtKB=A0A6I8PAD0	Ornithorhynchus anatinus	LDO
ORYLA\|Ensembl=ENSORLG00000029390.1\|UniProtKB=A0A3B3HF07	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-030131-6318\|UniProtKB=Q7SZX5	Danio rerio	LDO
BRAFL\|Gene_ORFName=BRAFLDRAFT_126023\|UniProtKB=C3Y1X1	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC587853\|UniProtKB=A0A7M7HI36	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00023409\|UniProtKB=G5ECR1	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00039281\|UniProtKB=Q4U5R6	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00099236\|UniProtKB=Q5MK08	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0027950\|UniProtKB=A0A0B4KGZ0	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP003982\|UniProtKB=F5HM38	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC003775\|UniProtKB=D6WEM7	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_310291\|UniProtKB=E9FT46	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_195138\|UniProtKB=E9GAX3	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW010143\|UniProtKB=B7Q0K4	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG185546\|UniProtKB=T1FMY9	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g125309\|UniProtKB=A7SNU1	Nematostella vectensis	O