PANTHER Gene Information   
Gene Symbol(s): Hspb1
Organism: Rattus norvegicus
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Gene Name: Heat shock protein beta-1
Gene ID: 61306
Protein ID: P42930
Persistent Id: PTN000163179
Alternate Ids:
HSPB1_RAT(UniProtKB-ID) Heat shock 27 kDa protein(Synonym)
204665(GI) Q9QWA8(AltAccession)
AAB29536(EMBL-CDS) S67755(EMBL)
61306(RGD) Hspb1(Symbol)
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PANTHER Classification
PANTHER Family: HEAT SHOCK PROTEIN HSP-12.2-RELATED (PTHR45640)
PANTHER Subfamily: HEAT SHOCK PROTEIN BETA-1 (PTHR45640:SF7)  
PANTHER GO-slim Molecular Function: unfolded protein binding
PANTHER GO-slim Biological Process: protein folding
negative regulation of apoptotic process
response to heat
PANTHER GO-slim Cellular Component: nucleus
cytoplasm
PANTHER protein class: chaperone
Pathway Categories: CCKR signaling map
   HSP27
p38 MAPK pathway
   heat shock protein 27kD
Angiogenesis
   Heat-Shock Protein 27
VEGF signaling pathway
   Heat-Shock Protein 27
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: protein kinase C binding, protein kinase binding, identical protein binding, protein binding, protein homodimerization activity, protein folding chaperone, ubiquitin binding, RNA polymerase II-specific DNA-binding transcription factor binding, unfolded protein binding, protein kinase C inhibitor activity
GO BP Complete: negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, chaperone-mediated protein folding, regulation of canonical NF-kappaB signal transduction, cellular response to butyrate, response to virus, negative regulation of protein kinase activity, positive regulation of angiogenesis, response to heat, response to ischemia, negative regulation of regulatory T cell differentiation, anterograde axonal protein transport, negative regulation of cellular response to oxidative stress, positive regulation of endothelial cell chemotaxis, positive regulation of neuron projection development, positive regulation of tumor necrosis factor production, cellular response to hydrogen peroxide, response to muscle stretch, platelet aggregation, intracellular signal transduction, female pregnancy, protein refolding, positive regulation of blood vessel endothelial cell migration, vascular endothelial growth factor receptor signaling pathway, regulation of protein phosphorylation, response to angiotensin, negative regulation of apoptotic process, cellular response to interleukin-11, cellular response to vascular endothelial growth factor stimulus, positive regulation of interleukin-1 beta production, negative regulation of apoptotic signaling pathway
GO CC Complete: axon cytoplasm, proteasome complex, perikaryon, plasma membrane, nucleus, Z disc, dendrite, cornified envelope, contractile muscle fiber, cytoplasm, cardiac myofibril, spindle, I band, M band, axon, postsynaptic density membrane
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Regulation of mRNA stability by proteins that bind AU-rich elements, Signaling by Nuclear Receptors, VEGFA-VEGFR2 Pathway, MAPK family signaling cascades, MAPK6/MAPK4 signaling, ESR-mediated signaling, Signaling by VEGF, Extra-nuclear estrogen signaling, Signaling by Receptor Tyrosine Kinases, Metabolism of RNA, Signal Transduction, AUF1 (hnRNP D0) binds and destabilizes mRNA

Orthologs