PANTHER Gene Information

Gene Symbol(s):

Ak3

Organism:

Rattus norvegicus

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Gene Name:

GTP:AMP phosphotransferase AK3, mitochondrial

Gene ID:

619885

Protein ID:

P29411

Persistent Id:

PTN000599959

Alternate Ids:

450312(GI)	AK 3 {ECO:0000255\|HAMAP-Rule:MF_03169}(Synonym)
BAA02379(EMBL-CDS)	2.7.4.10 {ECO:0000255\|HAMAP-Rule:MF_03169}(EC)
CHEMBL4799(ChEMBL)	Ak3(Symbol)
NP_037350(refSeq)	619885(RGD)
D13062(EMBL)	KAD3_RAT(UniProtKB-ID)
26956(GeneID)
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PANTHER Classification

PANTHER Family:	NUCLEOTIDE KINASE (PTHR23359)
PANTHER Subfamily:	GTP:AMP PHOSPHOTRANSFERASE AK3, MITOCHONDRIAL (PTHR23359:SF68)
PANTHER GO-slim Molecular Function:	kinase activity phosphotransferase activity, phosphate group as acceptor
PANTHER GO-slim Biological Process:	purine ribonucleoside monophosphate metabolic process purine ribonucleotide metabolic process nucleoside triphosphate biosynthetic process
PANTHER GO-slim Cellular Component:	mitochondrial matrix
PANTHER protein class:	nucleotide kinase

Pathway Categories:

De novo purine biosynthesis

Adenylate kinase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	GTP binding, adenylate kinase activity, ATP binding, identical protein binding, nucleoside diphosphate kinase activity, nucleoside triphosphate adenylate kinase activity
GO BP Complete:	cerebellum development, ADP biosynthetic process, nucleoside triphosphate biosynthetic process, response to starvation, GTP metabolic process, nucleoside monophosphate phosphorylation, olfactory bulb development, muscle organ development, AMP phosphorylation, UTP metabolic process, ITP metabolic process, liver development, AMP metabolic process, dATP metabolic process
GO CC Complete:	cytoplasm, mitochondrial matrix, mitochondrion

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Factors involved in megakaryocyte development and platelet production, Hemostasis

Orthologs

ID	Organism	Type
HUMAN\|HGNC=17376\|UniProtKB=Q9UIJ7	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000020742.6\|UniProtKB=K7DFL9	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000028122.2\|UniProtKB=G3S5H3	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000000143.4\|UniProtKB=H9FV35	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1860835\|UniProtKB=Q9WTP7	Mus musculus	LDO
BOVIN\|Ensembl=ENSBTAG00000017147\|UniProtKB=P08760	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000023595.4\|UniProtKB=A0A4X1W814	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000011235.4\|UniProtKB=A0A5F5PR03	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000030675.4\|UniProtKB=A0A2I2UEP0	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845011485.1\|UniProtKB=A0A8I3RYK2	Canis lupus familiaris	O
FELCA\|Ensembl=ENSFCAG00000028063.4\|UniProtKB=M3X611	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845015368.1\|UniProtKB=A0A8I3S1F8	Canis lupus familiaris	LDO
CANLF\|Ensembl=ENSCAFG00845020841.1\|UniProtKB=A0A8I3PJ23	Canis lupus familiaris	O
CANLF\|Ensembl=ENSCAFG00845015368.1\|UniProtKB=A0A8I3S1F8	Canis lupus familiaris	O
CANLF\|Ensembl=ENSCAFG00845009134.1\|UniProtKB=A0A8I3NAJ9	Canis lupus familiaris	O
CANLF\|Ensembl=ENSCAFG00845024370.1\|UniProtKB=A0A8I3PHW7	Canis lupus familiaris	LDO
CANLF\|Ensembl=ENSCAFG00845015626.1\|UniProtKB=A0A8I3NX81	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000042741.1\|UniProtKB=A0A5F8HGD5	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000001505.3\|UniProtKB=F7DCB5	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010011143.1\|UniProtKB=A0A8V0Y9V8	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000003605.4\|UniProtKB=G1KC24	Anolis carolinensis	LDO
XENLA\|Gene=ak3.L\|UniProtKB=Q4V864	Xenopus laevis	O
XENLA\|Gene=ak3.S\|UniProtKB=Q6NTU0	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-977028\|UniProtKB=A0A8J0S7N1	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000010417.2\|UniProtKB=H2M3P6	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-040426-2142\|UniProtKB=F1R4S7	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000011239.1\|UniProtKB=W5MZK4	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000004751.3\|UniProtKB=F6PR96	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118431882\|UniProtKB=A0A9J7MDD2	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC583479\|UniProtKB=A0A7M6USS0	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00009543\|UniProtKB=Q86D11	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG21667\|UniProtKB=A8Y0S6	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00014058\|UniProtKB=Q09629	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00026035\|UniProtKB=A8WSS5	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00280954\|UniProtKB=A0A2A6BWI5	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0042094\|UniProtKB=Q9VGU6	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP009660\|UniProtKB=A0A1S4H1P5	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC009374\|UniProtKB=D6WR14	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_206791\|UniProtKB=E9FWU3	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW020183\|UniProtKB=B7Q3A0	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG114439\|UniProtKB=T1EG17	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g184404\|UniProtKB=A7S170	Nematostella vectensis	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_21342\|UniProtKB=A9UVJ8	Monosiga brevicollis	LDO
YEAST\|SGD=S000000972\|UniProtKB=P26364	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_AGR115C\|UniProtKB=Q74ZT3	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000185135\|UniProtKB=A0A1D8PQH7	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_F26521g\|UniProtKB=Q6C0A1	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_00259\|UniProtKB=Q5BGS1	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_1G03420\|UniProtKB=Q4WK78	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU03216\|UniProtKB=Q7SGV3	Neurospora crassa	LDO
SCLS1\|EnsemblGenome=SS1G_06024\|UniProtKB=A7EL27	Sclerotinia sclerotiorum	LDO
PHANO\|Gene_ORFName=SNOG_07673\|UniProtKB=Q0UKP1	Phaeosphaeria nodorum	O
PHANO\|EnsemblGenome=SNOG_04669\|UniProtKB=Q0UU95	Phaeosphaeria nodorum	LDO
CRYNJ\|EnsemblGenome=CND00160\|UniProtKB=Q5KJ94	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_05924\|UniProtKB=A0A0D1CGU1	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_01078\|UniProtKB=E3JUM2	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_87801\|UniProtKB=F4P0A1	Batrachochytrium dendrobatidis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_29990\|UniProtKB=F4P268	Batrachochytrium dendrobatidis	LDO
DICDI\|dictyBase=DDB_G0292730\|UniProtKB=Q54CT8	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_40956\|UniProtKB=F0ZZ46	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_13_1350\|UniProtKB=Q4QG19	Leishmania major	O
LEIMA\|EnsemblGenome=LMJF_27_1950\|UniProtKB=E9ADH5	Leishmania major	O
PHYRM\|Gene=H3H479_PHYRM\|UniProtKB=H3H479	Phytophthora ramorum	O
LEIMA\|EnsemblGenome=LMJF_25_2370\|UniProtKB=Q4Q9J9	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb11.02.0990\|UniProtKB=Q386G1	Trypanosoma brucei	LDO
GIAIC\|EnsemblGenome=GL50803_4849\|UniProtKB=A8BTN6	Giardia intestinalis	LDO
PLAF7\|EnsemblGenome=PF3D7_0931900\|UniProtKB=C0H582	Plasmodium falciparum	LDO
PARTE\|EnsemblGenome=GSPATT00028631001\|UniProtKB=A0BGC9	Paramecium tetraurelia	LDO
PARTE\|EnsemblGenome=GSPATT00026987001\|UniProtKB=A0EH72	Paramecium tetraurelia	O
KORCO\|EnsemblGenome=Kcr_1559\|UniProtKB=B1L775	Korarchaeum cryptofilum	O
HALSA\|EnsemblGenome=VNG_1724G\|UniProtKB=Q9HPA7	Halobacterium salinarum	O
THEKO\|EnsemblGenome=TK0812\|UniProtKB=Q5JH68	Thermococcus kodakaraensis	O
CHLAA\|EnsemblGenome=Caur_2957\|UniProtKB=A9WG02	Chloroflexus aurantiacus	O
CHLAA\|EnsemblGenome=Caur_2390\|UniProtKB=A9WH87	Chloroflexus aurantiacus	O
STRCO\|Gene_OrderedLocusName=SCO4723\|UniProtKB=P43414	Streptomyces coelicolor	O
MYCTU\|Gene_OrderedLocusName=Rv0733\|UniProtKB=P9WKF5	Mycobacterium tuberculosis	O
CLOBH\|Gene_OrderedLocusName=CBO3460\|UniProtKB=A5I7I5	Clostridium botulinum	O
STRR6\|EnsemblGenome=spr0210\|UniProtKB=Q8DRD4	Streptococcus pneumoniae	O
STAA8\|EnsemblGenome=SAOUHSC_02490\|UniProtKB=Q2FW27	Staphylococcus aureus	O
LISMO\|EnsemblGenome=CAD00689\|UniProtKB=Q8Y449	Listeria monocytogenes	O
BACSU\|EnsemblGenome=BSU_01370\|UniProtKB=P16304	Bacillus subtilis	O
BACCR\|EnsemblGenome=BC_0152\|UniProtKB=Q81J22	Bacillus cereus	O
THEMA\|EnsemblGenome=TM_1479\|UniProtKB=Q9X1I8	Thermotoga maritima	O
GLOVI\|EnsemblGenome=BAC89333\|UniProtKB=Q7NKT5	Gloeobacter violaceus	O
SYNY3\|EnsemblGenome=BAA16643\|UniProtKB=P72641	Synechocystis	O
SYNY3\|EnsemblGenome=BAA17330\|UniProtKB=P73302	Synechocystis	O
LEPIN\|EnsemblGenome=LA_0760\|UniProtKB=Q9XD15	Leptospira interrogans	O
BACTN\|EnsemblGenome=BT_4387\|UniProtKB=Q89ZJ0	Bacteroides thetaiotaomicron	O
CHLTR\|EnsemblGenome=CT_128\|UniProtKB=O84130	Chlamydia trachomatis	O
RHOBA\|EnsemblGenome=RB7867\|UniProtKB=Q7UN00	Rhodopirellula baltica	O
AQUAE\|EnsemblGenome=aq_078\|UniProtKB=O66490	Aquifex aeolicus	O
THEYD\|EnsemblGenome=THEYE_A1836\|UniProtKB=B5YHP1	Thermodesulfovibrio yellowstonii	O
DICTD\|EnsemblGenome=Dtur_1001\|UniProtKB=B8E1F3	Dictyoglomus turgidum	O
FUSNN\|EnsemblGenome=FN1298\|UniProtKB=Q8RE31	Fusobacterium nucleatum	O
HELPY\|EnsemblGenome=HP_0618\|UniProtKB=P56104	Helicobacter pylori	O
NEIMB\|EnsemblGenome=NMB0823\|UniProtKB=P0A0U7	Neisseria meningitidis serogroup b	O
GEOSL\|EnsemblGenome=GSU2836\|UniProtKB=Q749A8	Geobacter sulfurreducens	O
BRADU\|Gene=adk\|UniProtKB=Q89JA5	Bradyrhizobium diazoefficiens	O
COXBU\|EnsemblGenome=CBU_0454\|UniProtKB=Q83E75	Coxiella burnetii	O
HAEIN\|EnsemblGenome=HI_0349\|UniProtKB=P24323	Haemophilus influenzae	O
SHEON\|Gene_OrderedLocusName=SO_2018\|UniProtKB=Q8EFF5	Shewanella oneidensis	O
VIBCH\|EnsemblGenome=VC_0986\|UniProtKB=Q9KTB7	Vibrio cholerae	O
PSEAE\|EnsemblGenome=PA3686\|UniProtKB=Q9HXV4	Pseudomonas aeruginosa	O
SALTY\|EnsemblGenome=STM0488\|UniProtKB=P0A1V4	Salmonella typhimurium	O
YERPE\|EnsemblGenome=YP_0812\|UniProtKB=O69172	Yersinia pestis	O
ECOLI\|EnsemblGenome=BAE76253\|UniProtKB=P69441	Escherichia coli	O