PANTHER Gene Information

Gene Symbol(s):

Pkn2

Organism:

Rattus norvegicus

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Gene Name:

Serine_threonine-protein kinase N2

Gene ID:

620146

Protein ID:

O08874

Persistent Id:

PTN000684021

Alternate Ids:

AAB53364(EMBL-CDS)	AABR03012657(EMBL)
2.7.11.13(EC)	2062375(GI)
PKN gamma(Synonym)	PKN2_RAT(UniProtKB-ID)
Pkn2(Symbol)	620146(RGD)
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PANTHER Classification

PANTHER Family:	SERINE/THREONINE-PROTEIN KINASE (PTHR24356)
PANTHER Subfamily:	SERINE_THREONINE-PROTEIN KINASE N2 (PTHR24356:SF322)
PANTHER GO-slim Molecular Function:	protein serine/threonine kinase activity
PANTHER GO-slim Biological Process:	peptidyl-serine phosphorylation intracellular signal transduction
PANTHER GO-slim Cellular Component:
PANTHER protein class:	non-receptor serine/threonine protein kinase

Pathway Categories:

PDGF signaling pathway

Protein kinase C

Alzheimer disease-amyloid secretase pathway

Protein kinase C

Muscarinic acetylcholine receptor 1 and 3 signaling pathway

Protein kinase C

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	RNA polymerase binding, diacylglycerol-dependent, calcium-independent serine/threonine kinase activity, ATP binding, histone deacetylase binding, small GTPase binding, protein serine/threonine kinase activity, kinase activity, calcium,diacylglycerol-dependent serine/threonine kinase activity, protein serine kinase activity
GO BP Complete:	signal transduction, cell projection organization, cell adhesion, protein phosphorylation, positive regulation of mitotic cell cycle, cell division, apical junction assembly, apoptotic process, regulation of cell motility, positive regulation of viral genome replication, epithelial cell migration, positive regulation of cytokinesis, intracellular signal transduction
GO CC Complete:	nuclear body, cleavage furrow, plasma membrane, nucleoplasm, nucleus, centrosome, cytoskeleton, perinuclear region of cytoplasm, intermediate filament cytoskeleton, cytoplasm, membrane, apical junction complex, cytosol, protein-containing complex, midbody, lamellipodium

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

RHO GTPase cycle, RHOA GTPase cycle, RHO GTPase Effectors, RAC1 GTPase cycle, Signaling by Rho GTPases, RHO GTPases activate PKNs, Signal Transduction, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, RHOB GTPase cycle

Orthologs

ID	Organism	Type
HUMAN\|HGNC=9406\|UniProtKB=Q16513	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000000931.7\|UniProtKB=H2PZC4	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000008937.3\|UniProtKB=A0A2I2Z7U9	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000020588.4\|UniProtKB=A0A1D5QYM8	Macaca mulatta	LDO
MOUSE\|MGI=MGI=109211\|UniProtKB=Q8BWW9	Mus musculus	LDO
BOVIN\|Ensembl=ENSBTAG00000021900.6\|UniProtKB=F1MFK1	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000006927.5\|UniProtKB=A0A286ZLF6	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000024916.4\|UniProtKB=F6S2E6	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000024813.4\|UniProtKB=M3X0Q3	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845018917.1\|UniProtKB=A0A8I3PD08	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000012423.4\|UniProtKB=A0A5F8G616	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000009127.4\|UniProtKB=F7F108	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010022983.1\|UniProtKB=E1BYS6	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000001417.4\|UniProtKB=A0A803TFE9	Anolis carolinensis	LDO
XENLA\|Gene=LOC108713564\|UniProtKB=A0A8J0UYT9	Xenopus laevis	O
XENTR\|Gene=LOC105946627\|UniProtKB=A0A8J1J3Q9	Xenopus tropicalis	O
XENTR\|Gene=LOC116408592\|UniProtKB=A0A8J1J2I2	Xenopus tropicalis	O
XENTR\|Gene=LOC101733758\|UniProtKB=A0A8J0T253	Xenopus tropicalis	O
XENTR\|Gene=LOC101731553\|UniProtKB=A0A8J1JHJ6	Xenopus tropicalis	O
XENTR\|Gene=LOC101731784\|UniProtKB=A0A8J1JF29	Xenopus tropicalis	O
XENTR\|Gene=LOC100493742\|UniProtKB=A0A8J1JF52	Xenopus tropicalis	O
XENLA\|Gene=LOC121402807\|UniProtKB=A0A8J1MVC9	Xenopus laevis	O
XENTR\|Gene=LOC101732451\|UniProtKB=A0A8J1ISU4	Xenopus tropicalis	O
XENTR\|Gene=LOC101734329\|UniProtKB=A0A8J0T5X3	Xenopus tropicalis	O
XENTR\|Gene=LOC101732266\|UniProtKB=A0A8J1IV66	Xenopus tropicalis	O
XENTR\|Gene=LOC116407505\|UniProtKB=A0A8J1ISV0	Xenopus tropicalis	O
XENTR\|Gene=LOC105948372\|UniProtKB=A0A8J1ISU9	Xenopus tropicalis	O
XENTR\|Gene=LOC116410995\|UniProtKB=A0A8J1JPS4	Xenopus tropicalis	O
XENTR\|Gene=LOC101734648\|UniProtKB=A0A8J1IW12	Xenopus tropicalis	O
XENTR\|Gene=LOC101732209\|UniProtKB=A0A8J1IV70	Xenopus tropicalis	O
XENTR\|Gene=LOC116407608\|UniProtKB=A0A8J1ITU0	Xenopus tropicalis	O
XENLA\|Gene=pkn2.L\|UniProtKB=A0A1L8GMX6	Xenopus laevis	O
XENLA\|Gene=pkn2.S\|UniProtKB=A0A1L8GGA4	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-995298\|UniProtKB=F7CM85	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000012736.2\|UniProtKB=H2MBN0	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-030131-1902\|UniProtKB=E7F7I3	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000006047.1\|UniProtKB=W5MG04	lepisosteus oculatus	O
ORYLA\|Ensembl=ENSORLG00000004877.2\|UniProtKB=H2LJF4	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-061207-42\|UniProtKB=A0A0R4IJZ0	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-061013-393\|UniProtKB=A7MBL8	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000005077.1\|UniProtKB=W5MCL1	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000009071.3\|UniProtKB=F6QIR4	Ciona intestinalis	O
BRAFL\|Gene=LOC118420649\|UniProtKB=A0A9J7LI73	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC582022\|UniProtKB=A0A7M7PM13	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00016980\|UniProtKB=G4S4W1	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG19698\|UniProtKB=A8XW82	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00009793\|UniProtKB=A0A4V0ILM7	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG17230\|UniProtKB=A8XQI7	Caenorhabditis briggsae	O
DROME\|FlyBase=FBgn0020621\|UniProtKB=A1Z7T0	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP007587\|UniProtKB=A0A1S4GVK5	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC032431\|UniProtKB=A0A139WL43	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_305605\|UniProtKB=E9FWM9	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_305606\|UniProtKB=E9FWN0	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW011060\|UniProtKB=B7Q8L8	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG89736\|UniProtKB=T1G7G9	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g98367\|UniProtKB=A7RYZ0	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG20881\|UniProtKB=B3RNW1	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_31267\|UniProtKB=A9USR5	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_10752\|UniProtKB=A9V750	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_21555\|UniProtKB=A9V1T6	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_34036\|UniProtKB=A9V9H6	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_39232\|UniProtKB=A9VD19	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_20766\|UniProtKB=A9UXQ2	Monosiga brevicollis	O
YEAST\|SGD=S000000201\|UniProtKB=P24583	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_ACR191C\|UniProtKB=Q75BT0	Eremothecium gossypii	O
CANAL\|CGD=CAL0000201435\|UniProtKB=Q5ANK2	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_F09746g\|UniProtKB=Q6C292	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_00106\|UniProtKB=C8VQM0	Emericella nidulans	O
NEUCR\|EnsemblGenome=NCU06544\|UniProtKB=P87253	Neurospora crassa	O
PHANO\|EnsemblGenome=SNOG_07073\|UniProtKB=Q0UME1	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPAC17G8.14c\|UniProtKB=P36582	Schizosaccharomyces pombe	O
SCHPO\|PomBase=SPBC12D12.04c\|UniProtKB=P36583	Schizosaccharomyces pombe	O
CRYNJ\|EnsemblGenome=CNE01630\|UniProtKB=Q5KH12	Cryptococcus neoformans	O
CRYNJ\|EnsemblGenome=CNC03300\|UniProtKB=Q5KKE3	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_15023\|UniProtKB=A0A0D1DRE2	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_12641\|UniProtKB=E3KRH5	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_15370\|UniProtKB=F4NTP5	Batrachochytrium dendrobatidis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_19449\|UniProtKB=F4P170	Batrachochytrium dendrobatidis	O
ENTH1\|EnsemblGenome=CL6EHI_125820\|UniProtKB=C4LVW8	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_097620\|UniProtKB=C4M933	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_188930\|UniProtKB=C4M2W0	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_044470\|UniProtKB=B1N2G7	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_042150\|UniProtKB=C4M4G9	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_053040\|UniProtKB=C4M3C2	Entamoeba histolytica	O
ENTH1\|Gene_ORFName=EHI_138540\|UniProtKB=A0A8U0WPI4	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0288795\|UniProtKB=Q54IF2	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_149347\|UniProtKB=F0ZDG7	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0268620\|UniProtKB=P54644	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_152431\|UniProtKB=F0ZLC3	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_38849\|UniProtKB=F0ZVB0	Dictyostelium purpureum	O
LEIMA\|EnsemblGenome=LMJF_30_0800\|UniProtKB=Q4Q7M5	Leishmania major	O
TRYB2\|Gene_ORFName=Tb11.01.2290\|UniProtKB=Q383M7	Trypanosoma brucei	O
TRYB2\|Gene_ORFName=Tb927.3.2690\|UniProtKB=Q582Y1	Trypanosoma brucei	O
GIAIC\|EnsemblGenome=GL50803_11364\|UniProtKB=E2RTY0	Giardia intestinalis	O
TRIV3\|Gene_ORFName=TVAG_195270\|UniProtKB=A2FLX7	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_324020\|UniProtKB=A2F4A4	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_430560\|UniProtKB=A2E382	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_316050\|UniProtKB=A2FAW3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_447920\|UniProtKB=A2DS63	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_047250\|UniProtKB=A2FHJ2	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_267830\|UniProtKB=A2DLD2	Trichomonas vaginalis	O
SACS2\|EnsemblGenome=SSO3207\|UniProtKB=Q97U18	Sulfolobus solfataricus	O