PANTHER Gene Information   
Gene Symbol(s): Ptgs2
Organism: Rattus norvegicus
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Gene Name: Prostaglandin G_H synthase 2
Gene ID: 620349
Protein ID: P35355
Persistent Id: PTN000224654
Alternate Ids:
Cox-2(Synonym) 548484(GI)
ENSRNOT00000003567(Ensembl_TRS) Ptgs2(Symbol)
AAA16477(EMBL-CDS) U03389(EMBL)
CHEMBL2977(ChEMBL) ENSRNOG00000002525(Ensembl)
ENSRNOP00000003567(Ensembl_PRO) 620349(RGD)
1.14.99.1(EC) 29527(GeneID)
Q925V4(AltAccession) NM_017232(refSeq)
PGH2_RAT(UniProtKB-ID)
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PANTHER Classification
PANTHER Family: PROSTAGLANDIN G/H SYNTHASE (PTHR11903)
PANTHER Subfamily: PROSTAGLANDIN G_H SYNTHASE 2 (PTHR11903:SF8)  
PANTHER GO-slim Molecular Function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
PANTHER GO-slim Biological Process: long-chain fatty acid metabolic process
unsaturated fatty acid biosynthetic process
icosanoid biosynthetic process
prostaglandin metabolic process
PANTHER GO-slim Cellular Component: neuron projection
cytoplasm
PANTHER protein class: oxygenase
Pathway Categories: CCKR signaling map
   COX2
Inflammation mediated by chemokine and cytokine signaling pathway
   Cyclooxygenase
CCKR signaling map
   COX2
Toll receptor signaling pathway
   Gene trancription
CCKR signaling map
   COX2
Endothelin signaling pathway
   cyclooxygenase-2
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: peroxidase activity, prostaglandin-endoperoxide synthase activity, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, protein binding, protein homodimerization activity, metal ion binding, enzyme binding, heme binding
GO BP Complete: positive regulation of brown fat cell differentiation, response to fructose, decidualization, learning, positive regulation of cell migration involved in sprouting angiogenesis, memory, brown fat cell differentiation, cellular response to fluid shear stress, positive regulation of synaptic plasticity, negative regulation of calcium ion transport, positive regulation of synaptic transmission, glutamatergic, cellular response to hypoxia, maintenance of blood-brain barrier, positive regulation of vascular endothelial growth factor production, positive regulation of peptidyl-serine phosphorylation, positive regulation of protein import into nucleus, positive regulation of prostaglandin biosynthetic process, cellular response to lead ion, response to angiotensin, prostaglandin biosynthetic process, response to estradiol, cellular oxidant detoxification, response to selenium ion, prostaglandin secretion, positive regulation of fever generation, response to tumor necrosis factor, response to manganese ion, response to cytokine, positive regulation of nitric oxide biosynthetic process, response to vitamin D, negative regulation of cell population proliferation, positive regulation of cell population proliferation, positive regulation of vasoconstriction, negative regulation of cell cycle, response to xenobiotic stimulus, negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress, positive regulation of fibroblast growth factor production, hair cycle, negative regulation of smooth muscle contraction, positive regulation of smooth muscle contraction, positive regulation of smooth muscle cell proliferation, cellular response to non-ionic osmotic stress, response to oxidative stress, cellular response to heat, angiogenesis, response to glucocorticoid, response to fatty acid, negative regulation of synaptic transmission, dopaminergic, cellular response to ATP, positive regulation of transforming growth factor beta production, cellular response to homocysteine, bone mineralization, positive regulation of platelet-derived growth factor production, regulation of neuroinflammatory response, regulation of blood pressure, embryo implantation, response to nematode, regulation of cell population proliferation, cyclooxygenase pathway, cellular response to mechanical stimulus, cellular response to lipopolysaccharide, negative regulation of apoptotic process, positive regulation of apoptotic process, response to lipopolysaccharide
GO CC Complete: endoplasmic reticulum membrane, nuclear inner membrane, caveola, cytoplasm, nuclear outer membrane, endoplasmic reticulum, protein-containing complex, neuron projection
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Biosynthesis of DPA-derived SPMs, Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives, Fatty acid metabolism, Metabolism of water-soluble vitamins and cofactors, Synthesis of Prostaglandins (PG) and Thromboxanes (TX), Synthesis of 15-eicosatetraenoic acid derivatives, Nicotinate metabolism, Biosynthesis of DPAn-3 SPMs, Metabolism, Arachidonic acid metabolism, Metabolism of lipids, Metabolism of vitamins and cofactors, Biosynthesis of EPA-derived SPMs, Biosynthesis of specialized proresolving mediators (SPMs), Nicotinamide salvaging, Biosynthesis of DHA-derived SPMs

Orthologs