PANTHER Gene Information   
Gene Symbol(s): Zfp36
Organism: Rattus norvegicus
View Gene in Tree
Tree Reduced Tree  
Tree Reduced Tree
Gene Name: mRNA decay activator protein ZFP36
Gene ID: 620722
Protein ID: P47973
Persistent Id: PTN000284308
Alternate Ids:
TTP_RAT(UniProtKB-ID) TTP(Synonym)
NM_133290(refSeq) Q54AH1(AltAccession)
BAB12432(EMBL-CDS) 57759(GI)
Zfp36{ECO:0000312|RGD:620722}(Symbol) X63369(EMBL)
79426(GeneID) 620722(RGD)
Show All

PANTHER Classification
PANTHER Family: CCCH ZINC FINGER/TIS11-RELATED (PTHR12547)
PANTHER Subfamily: MRNA DECAY ACTIVATOR PROTEIN ZFP36 (PTHR12547:SF58)  
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:
PANTHER protein class: RNA metabolism protein
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: C-C chemokine binding, RNA polymerase binding, DNA binding, protein kinase binding, heat shock protein binding, mRNA 3'-UTR AU-rich region binding, metal ion binding, mRNA binding, mRNA 3'-UTR binding, enzyme binding, protein-containing complex binding, 14-3-3 protein binding
GO BP Complete: positive regulation of mRNA catabolic process, regulation of keratinocyte apoptotic process, 3'-UTR-mediated mRNA destabilization, nuclear-transcribed mRNA catabolic process, deadenylation-independent decay, positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, response to wounding, response to starvation, positive regulation of fat cell differentiation, regulation of mRNA stability, negative regulation of hematopoietic stem cell differentiation, mRNA catabolic process, negative regulation of erythrocyte differentiation, negative regulation of transcription by RNA polymerase II, MAPK cascade, negative regulation of interleukin-2 production, regulation of keratinocyte proliferation, positive regulation of miRNA-mediated gene silencing, RNA destabilization, cellular response to tumor necrosis factor, intracellular signal transduction, mRNA transport, regulation of keratinocyte differentiation, negative regulation of myeloid cell differentiation, 3'-UTR-mediated mRNA stabilization, positive regulation of intracellular mRNA localization, miRNA-mediated gene silencing by inhibition of translation, p38MAPK cascade, negative regulation of polynucleotide adenylyltransferase activity, negative regulation of inflammatory response, regulation of tumor necrosis factor production, cellular response to fibroblast growth factor stimulus, hematopoietic stem cell differentiation, positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, nuclear-transcribed mRNA poly(A) tail shortening, positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, regulation of transcription by RNA polymerase II, cellular response to granulocyte macrophage colony-stimulating factor stimulus, cellular response to lipopolysaccharide, cellular response to glucocorticoid stimulus, cellular response to epidermal growth factor stimulus, myeloid cell differentiation, negative regulation of viral transcription
GO CC Complete: nucleus, cytoplasmic stress granule, cytoplasm, P-body, cytosol, ribonucleoprotein complex, CCR4-NOT complex, exosome (RNase complex)
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, Regulation of mRNA stability by proteins that bind AU-rich elements, Metabolism of RNA

Orthologs