PANTHER Gene Information

Gene Symbol(s):

Slc24a2

Organism:

Rattus norvegicus

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Gene Name:

Sodium_potassium_calcium exchanger 2

Gene ID:

628650

Protein ID:

O54701

Persistent Id:

PTN000091132

Alternate Ids:

O54706(AltAccession)	AAC19405(EMBL-CDS)
13994179(GI)	AF027506(EMBL)
NCKX2_RAT(UniProtKB-ID)	ENSRNOG00000008169(Ensembl)
Slc24a2(Symbol)	84550(GeneID)
Na(+)/K(+)/Ca(2+)-exchange protein 2(Synonym)	628650(RGD)
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PANTHER Classification

PANTHER Family:	SODIUM/POTASSIUM/CALCIUM EXCHANGER (PTHR10846)
PANTHER Subfamily:	SODIUM_POTASSIUM_CALCIUM EXCHANGER 2 (PTHR10846:SF41)
PANTHER GO-slim Molecular Function:	calcium channel activity potassium ion transmembrane transporter activity sodium ion transmembrane transporter activity antiporter activity active monoatomic ion transmembrane transporter activity
PANTHER GO-slim Biological Process:	intracellular calcium ion homeostasis calcium ion transmembrane transport negative regulation of cell communication positive regulation of synaptic transmission regulation of synaptic plasticity negative regulation of signaling
PANTHER GO-slim Cellular Component:	plasma membrane
PANTHER protein class:	secondary carrier transporter

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	calcium channel activity, calcium, potassium:sodium antiporter activity, symporter activity
GO BP Complete:	calcium ion import, potassium ion transmembrane transport, protein-containing complex assembly, monoatomic ion transmembrane transport, learning, memory, intracellular calcium ion homeostasis, neuron cellular homeostasis, calcium ion transport, calcium ion transmembrane transport, sodium ion transmembrane transport, long-term synaptic potentiation, establishment of localization in cell, long-term synaptic depression, calcium ion import across plasma membrane
GO CC Complete:	presynapse, postsynapse, membrane, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Transport of small molecules, Sodium/Calcium exchangers, SLC-mediated transmembrane transport, Transport of inorganic cations/anions and amino acids/oligopeptides

Orthologs

ID	Organism	Type
HUMAN\|HGNC=10976\|UniProtKB=Q9UI40	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000020806.4\|UniProtKB=H2QX18	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000016544.3\|UniProtKB=G3RK82	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000020651.4\|UniProtKB=H9FSI4	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1923626\|UniProtKB=Q8BUN9	Mus musculus	LDO
BOVIN\|Ensembl=ENSBTAG00000043972.3\|UniProtKB=E1BM98	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000005167.5\|UniProtKB=F1SNG2	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000020101.3\|UniProtKB=F7E0G7	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000010086.6\|UniProtKB=A0A5F5XJB0	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845014662.1\|UniProtKB=A0A8I3NPM6	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000003525.4\|UniProtKB=A0A5F8GD32	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000012398.2\|UniProtKB=A0A6I8N4S2	Ornithorhynchus anatinus	LDO
CHICK\|Gene=SLC24A2\|UniProtKB=Q9IAL7	Gallus gallus	LDO
CHICK\|Ensembl=ENSGALG00010016336.1\|UniProtKB=A0A1L1RQA3	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000017625.4\|UniProtKB=G1KU78	Anolis carolinensis	LDO
XENLA\|Gene=LOC108706932\|UniProtKB=A0A8J1M2U2	Xenopus laevis	O
XENLA\|Gene=LOC108695376\|UniProtKB=A0A1L8HY64	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-483618\|UniProtKB=F6Z301	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000020813.2\|UniProtKB=H2N2T3	Oryzias latipes	LDO
ORYLA\|Ensembl=ENSORLG00000004872.2\|UniProtKB=A0A3B3HZ44	Oryzias latipes	O
DANRE\|Gene=slc24a2\|UniProtKB=A0A8M6YXT0	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000011046.1\|UniProtKB=W5MYV6	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000024440.1\|UniProtKB=H2Y2I8	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118409798\|UniProtKB=A0A9J7KMZ3	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC582498\|UniProtKB=A0A7M7RFU6	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00003570\|UniProtKB=G5EC02	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00031160\|UniProtKB=A8X8P8	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00103652\|UniProtKB=A0A2A6CS23	Pristionchus pacificus	LDO
CAEEL\|WormBase=WBGene00003569\|UniProtKB=P90858	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG03868\|UniProtKB=A8WWY5	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00096083\|UniProtKB=A0A8R1YAY5	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0028704\|UniProtKB=Q9U6A0	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP029241\|UniProtKB=A0A3F2YYY2	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC010208\|UniProtKB=D6WTN1	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_10542\|UniProtKB=E9HDA8	Daphnia pulex	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g206699\|UniProtKB=A7S4I7	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG63252\|UniProtKB=B3RSG1	Trichoplax adhaerens	LDO
ENTH1\|EnsemblGenome=CL6EHI_018640\|UniProtKB=C4MA70	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=EHI_049410\|UniProtKB=C4LUE3	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_049310\|UniProtKB=C4LUD3	Entamoeba histolytica	O
PARTE\|EnsemblGenome=GSPATT00007604001\|UniProtKB=A0CH97	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00014844001\|UniProtKB=A0DA70	Paramecium tetraurelia	O
THAPS\|EnsemblGenome=THAPSDRAFT_4973\|UniProtKB=B8C1L5	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_10292\|UniProtKB=B8CDR0	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_bd1662\|UniProtKB=B8LEG5	Thalassiosira pseudonana	O
NITMS\|EnsemblGenome=Nmar_0590\|UniProtKB=A9A357	Nitrosopumilus maritimus	O
SACS2\|EnsemblGenome=SSO1174\|UniProtKB=Q97YX8	Sulfolobus solfataricus	O
SACS2\|EnsemblGenome=SSO3192\|UniProtKB=Q97U31	Sulfolobus solfataricus	O
METAC\|EnsemblGenome=MA_2817\|UniProtKB=Q8TM51	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_3021\|UniProtKB=Q8TLL5	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_2008\|UniProtKB=Q8TPA6	Methanosarcina acetivorans	O
METJA\|EnsemblGenome=MJ_0091\|UniProtKB=Q57556	Methanocaldococcus jannaschii	O
HALSA\|EnsemblGenome=VNG_2257G\|UniProtKB=Q9HN44	Halobacterium salinarum	O
HALSA\|EnsemblGenome=VNG_0380G\|UniProtKB=Q9HS69	Halobacterium salinarum	O
THEKO\|EnsemblGenome=TK0867\|UniProtKB=Q5JI20	Thermococcus kodakaraensis	O
CHLAA\|EnsemblGenome=Caur_1857\|UniProtKB=A9WDA7	Chloroflexus aurantiacus	O
CHLAA\|EnsemblGenome=Caur_2211\|UniProtKB=A9WFS0	Chloroflexus aurantiacus	O
THEMA\|EnsemblGenome=TM_0724\|UniProtKB=Q9WZI3	Thermotoga maritima	O
SYNY3\|Gene=P72945_SYNY3\|UniProtKB=P72945	Synechocystis	O
BACTN\|EnsemblGenome=BT_3019\|UniProtKB=Q8A3D5	Bacteroides thetaiotaomicron	O
RHOBA\|EnsemblGenome=RB1641\|UniProtKB=Q7UX07	Rhodopirellula baltica	O
AQUAE\|EnsemblGenome=aq_066\|UniProtKB=O66480	Aquifex aeolicus	O
THEYD\|EnsemblGenome=THEYE_A0130\|UniProtKB=B5YHF9	Thermodesulfovibrio yellowstonii	O
COXBU\|EnsemblGenome=CBU_0095\|UniProtKB=Q83F54	Coxiella burnetii	O
SHEON\|Gene_OrderedLocusName=SO_0354\|UniProtKB=Q8EJV2	Shewanella oneidensis	O
VIBCH\|EnsemblGenome=VC_2522\|UniProtKB=Q9KP54	Vibrio cholerae	O
SALTY\|EnsemblGenome=STM3314\|UniProtKB=Q8ZLS2	Salmonella typhimurium	O
YERPE\|Gene_OrderedLocusName=YPO3576\|UniProtKB=A0A2U2H2F5	Yersinia pestis	O
ECOLI\|EnsemblGenome=BAE77240\|UniProtKB=P45394	Escherichia coli	O