PANTHER Gene Information

Gene Symbol(s):

Cacna2d2

Organism:

Rattus norvegicus

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Gene Name:

Voltage-dependent calcium channel subunit alpha-2_delta-2

Gene ID:

631360

Protein ID:

Q8CFG6

Persistent Id:

PTN000018381

Alternate Ids:

28212250(GI)	NM_175592(refSeq)
AF486277(EMBL)	AAO14653(EMBL-CDS)
Voltage-gated calcium channel subunit alpha-2/delta-2(Synonym)	Cacna2d2(Symbol)
631360(RGD)	CHEMBL3988639(ChEMBL)
CA2D2_RAT(UniProtKB-ID)	300992(GeneID)
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PANTHER Classification

PANTHER Family:	VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED (PTHR10166)
PANTHER Subfamily:	VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-2 (PTHR10166:SF7)
PANTHER GO-slim Molecular Function:	voltage-gated calcium channel activity
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:	voltage-gated calcium channel complex
PANTHER protein class:	voltage-gated ion channel

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	metal ion binding, calcium channel activity, calcium channel regulator activity, voltage-gated calcium channel activity
GO BP Complete:	neuromuscular junction development, regulation of neurotransmitter receptor localization to postsynaptic specialization membrane, organ growth, regulation of multicellular organism growth, rhythmic synaptic transmission, calcium ion transport, muscle cell development, positive regulation of organ growth, calcium ion transmembrane transport
GO CC Complete:	GABA-ergic synapse, voltage-gated calcium channel complex, presynaptic active zone membrane, monoatomic ion channel complex

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Metabolism, Muscle contraction, Integration of energy metabolism, Regulation of insulin secretion, Presynaptic depolarization and calcium channel opening, Phase 2 - plateau phase, Neuronal System, Transmission across Chemical Synapses, Cardiac conduction, Phase 0 - rapid depolarisation

Orthologs

ID	Organism	Type
HUMAN\|HGNC=1400\|UniProtKB=Q9NY47	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000014964.7\|UniProtKB=A0A2I3TKQ2	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000007132.3\|UniProtKB=G3QW42	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000007022.4\|UniProtKB=F7F5S9	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1929813\|UniProtKB=Q6PHS9	Mus musculus	LDO
BOVIN\|Ensembl=ENSBTAG00000009489.7\|UniProtKB=F1MX37	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000011412.5\|UniProtKB=A0A8W4FF87	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000001156.4\|UniProtKB=F6YBW2	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000007016.6\|UniProtKB=A0A5F5XWB4	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845020679.1\|UniProtKB=A0A8I3P8U8	Canis lupus familiaris	LDO
ORNAN\|Ensembl=ENSOANG00000010417.3\|UniProtKB=A0A6I8NHK2	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010028132.1\|UniProtKB=A0A8V1AHM4	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000007030.4\|UniProtKB=A0A803SXI2	Anolis carolinensis	LDO
XENLA\|Gene=cacna2d2.S\|UniProtKB=A0A8J1KJY9	Xenopus laevis	LDO
XENLA\|Gene=cacna2d2.L\|UniProtKB=A0A8J1MZM5	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-854937\|UniProtKB=A0A6I8S0M4	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000002164.2\|UniProtKB=A0A3B3H3P5	Oryzias latipes	O
DANRE\|Gene=cacna2d2b\|UniProtKB=A0A8M3AUK1	Danio rerio	O
ORYLA\|Ensembl=ENSORLG00000003682.2\|UniProtKB=A0A3B3HK21	Oryzias latipes	LDO
DANRE\|Gene=cacna2d2a\|UniProtKB=A0A8M3B0S8	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000014252.1\|UniProtKB=W5NAA0	lepisosteus oculatus	LDO
BRAFL\|Gene=LOC118416228\|UniProtKB=A0A9J7L7X3	Branchiostoma floridae	O
BRAFL\|Gene=LOC118416201\|UniProtKB=A0A9J7L7V5	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC105441547\|UniProtKB=A0A7M7MZD9	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00007041\|UniProtKB=G5EG74	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG02926\|UniProtKB=A8WT73	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00278310\|UniProtKB=A0A2A6BZ90	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00006772\|UniProtKB=P34374	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG16666\|UniProtKB=A8XP97	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00096769\|UniProtKB=A0A2A6CBK0	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0028863\|UniProtKB=X2J9Z3	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP009598\|UniProtKB=A0A903XHE3	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC001887\|UniProtKB=A0A139WP66	Tribolium castaneum	O
DROME\|FlyBase=FBgn0261999\|UniProtKB=Q8IP22	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP009579\|UniProtKB=A0A1S4H1J5	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC004591\|UniProtKB=D6W834	Tribolium castaneum	O
DROME\|FlyBase=FBgn0261041\|UniProtKB=A0A0B4K866	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP005490\|UniProtKB=A0A1S4GQ08	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC008265\|UniProtKB=D2A0T3	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC034736\|UniProtKB=A0A139WGS5	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_324542\|UniProtKB=E9H214	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_317041\|UniProtKB=E9GER3	Daphnia pulex	O
HELRO\|EnsemblGenome=HelroG174990\|UniProtKB=T1F8P7	helobdella robusta	O
TRIAD\|EnsemblGenome=TriadG56910\|UniProtKB=B3RWW7	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG56917\|UniProtKB=B3RWX4	Trichoplax adhaerens	O
EMENI\|EnsemblGenome=ANIA_05167\|UniProtKB=Q5B2R3	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_6G06990\|UniProtKB=Q4WNB0	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU07565\|UniProtKB=Q7S1Y8	Neurospora crassa	O
SELML\|EnsemblGenome=SELMODRAFT_423100\|UniProtKB=D8SKK3	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_402207\|UniProtKB=D8QPX5	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_423098\|UniProtKB=D8SKK1	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_402199\|UniProtKB=D8QPW7	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_423092\|UniProtKB=D8SKJ4	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_402200\|UniProtKB=D8QPW8	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_402202\|UniProtKB=D8QPX0	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c1_25930\|UniProtKB=A0A2K1L9Q7	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c10_3200\|UniProtKB=A0A2K1JXH6	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c2_5170\|UniProtKB=A0A2K1L0A2	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c7_20720\|UniProtKB=A0A2K1KCD4	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c7_19620\|UniProtKB=A0A2K1KC88	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c20_5240\|UniProtKB=A0A2K1IU47	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c22_5320\|UniProtKB=A0A2K1IMC0	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c17_14540\|UniProtKB=A0A7I4B6P4	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0123s0041\|UniProtKB=A0A2R6W9N0	Marchantia polymorpha	O
MARPO\|EnsemblGenome=MARPO_0009s0226\|UniProtKB=A0A2R6XM14	Marchantia polymorpha	O
MARPO\|EnsemblGenome=MARPO_0110s0042\|UniProtKB=A0A2R6WCH7	Marchantia polymorpha	O
MARPO\|EnsemblGenome=MARPO_0123s0042\|UniProtKB=A0A2R6W9N1	Marchantia polymorpha	O
MARPO\|EnsemblGenome=MARPO_0009s0220\|UniProtKB=A0A2R6XM18	Marchantia polymorpha	O
MARPO\|EnsemblGenome=MARPO_0200s0010\|UniProtKB=A0A2R6W0N0	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_006550030\|UniProtKB=A0A1Y1IIM7	Klebsormidium nitens	O
KLENI\|Gene_ORFName=KFL_006550020\|UniProtKB=A0A1Y1IKA2	Klebsormidium nitens	O
STRCO\|Gene_OrderedLocusName=SCO2721\|UniProtKB=Q9L1J5	Streptomyces coelicolor	O
CLOBH\|Gene_OrderedLocusName=CBO3213\|UniProtKB=A5I6U2	Clostridium botulinum	O
CLOBH\|Gene_OrderedLocusName=CBO0552\|UniProtKB=A5HZ97	Clostridium botulinum	O
BACTN\|EnsemblGenome=BT_4465\|UniProtKB=Q89ZB2	Bacteroides thetaiotaomicron	O
RHOBA\|EnsemblGenome=RB7099\|UniProtKB=Q7UP85	Rhodopirellula baltica	O
SHEON\|Gene_OrderedLocusName=SO_3552\|UniProtKB=Q8EBG6	Shewanella oneidensis	O
XANCP\|EnsemblGenome=XCC2915\|UniProtKB=Q8P6Q2	Xanthomonas campestris	O
SALTY\|EnsemblGenome=STM2315\|UniProtKB=Q8ZNE5	Salmonella typhimurium	O
ECOLI\|EnsemblGenome=BAE76678\|UniProtKB=P76481	Escherichia coli	O