PANTHER Gene Information   
Gene Symbol(s): Mmp8
Organism: Rattus norvegicus
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Gene Name: Neutrophil collagenase
Gene ID: 631408
Protein ID: O88766
Persistent Id: PTN000024166
Alternate Ids:
AJ007288(EMBL) 63849(GeneID)
Matrix metalloproteinase-8(Synonym) CAA07432(EMBL-CDS)
631408(RGD) Mmp8(Symbol)
3242321(GI) CHEMBL2312(ChEMBL)
NM_022221(refSeq) 3.4.24.34(EC)
MMP8_RAT(UniProtKB-ID)
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PANTHER Classification
PANTHER Family: MATRIX METALLOPROTEINASE (PTHR10201)
PANTHER Subfamily: NEUTROPHIL COLLAGENASE (PTHR10201:SF137)  
PANTHER GO-slim Molecular Function: metalloendopeptidase activity
PANTHER GO-slim Biological Process: catabolic process
extracellular matrix organization
PANTHER GO-slim Cellular Component:
PANTHER protein class: metalloprotease
Pathway Categories: Alzheimer disease-presenilin pathway
   Matrix metalloprotease
Plasminogen activating cascade
   pro-matrix metalloprotease 13
Plasminogen activating cascade
   Matrix metalloprotease 13

GO MF Complete: zinc ion binding, calcium ion binding, tumor necrosis factor binding, endopeptidase activity, serine-type endopeptidase activity, peptidase activity, metalloendopeptidase activity, metallopeptidase activity
GO BP Complete: cellular response to lipopolysaccharide, ossification, protein catabolic process, positive regulation of tumor necrosis factor-mediated signaling pathway, positive regulation of microglial cell activation, proteolysis, extracellular matrix organization, endodermal cell differentiation, positive regulation of neuroinflammatory response, collagen catabolic process, positive regulation of tumor necrosis factor production
GO CC Complete: extracellular space, extracellular matrix
Reactome Pathways: Degradation of the extracellular matrix, Activation of Matrix Metalloproteinases, Neutrophil degranulation, Immune System, Innate Immune System, Collagen degradation, Extracellular matrix organization