PANTHER Gene Information

Gene Symbol(s):

101759990

Organism:

Setaria italica

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Gene Name:

Folylpolyglutamate synthase

Gene ID:

SETIT_034828mg

Protein ID:

K4A7H2

Persistent Id:

PTN004235759

Alternate Ids:

514815874(GI)	AGNK02005543(EMBL)
K4A7H2(Synonym)	XM_004982628(refSeq)
SETIT_034828mg(Ensembl)	K4A7H2_SETIT(UniProtKB-ID)
101759990(GeneID)	RCV42243(EMBL-CDS)
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PANTHER Classification

PANTHER Family:	FOLYLPOLYGLUTAMATE SYNTHASE-RELATED (PTHR11136)
PANTHER Subfamily:	FOLYLPOLYGLUTAMATE SYNTHASE (PTHR11136:SF6)
PANTHER GO-slim Molecular Function:	ligase activity
PANTHER GO-slim Biological Process:	organonitrogen compound biosynthetic process organic cyclic compound biosynthetic process cellular nitrogen compound biosynthetic process aromatic compound biosynthetic process heterocycle biosynthetic process folic acid-containing compound metabolic process
PANTHER GO-slim Cellular Component:	cytosol mitochondrion
PANTHER protein class:	ligase

Pathway Categories:

Tetrahydrofolate biosynthesis

Dihydrofolate synthase

Formyltetrahydrofolate biosynthesis

Dihydrofolate synthase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	tetrahydrofolylpolyglutamate synthase activity, ATP binding, metal ion binding, acid-amino acid ligase activity, ligase activity
GO BP Complete:	folic acid-containing compound biosynthetic process, tetrahydrofolylpolyglutamate biosynthetic process, one-carbon metabolic process
GO CC Complete:	cytoplasm, mitochondrion, cytosol

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=3824\|UniProtKB=Q05932	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000021399.5\|UniProtKB=K7BAH4	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000000943.3\|UniProtKB=G3QF64	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000018506.4\|UniProtKB=A0A1D5R296	Macaca mulatta	O
MOUSE\|MGI=MGI=95576\|UniProtKB=P48760	Mus musculus	O
RAT\|RGD=1587713\|UniProtKB=M0R401	Rattus norvegicus	O
BOVIN\|Gene=FPGS\|UniProtKB=A6H751	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000008994.6\|UniProtKB=F1MWN5	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000005626.5\|UniProtKB=F1RS02	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000013074.4\|UniProtKB=A0A5F5PQA7	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000001488.5\|UniProtKB=A0A337ST19	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845005346.1\|UniProtKB=A0A8I3MXH3	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000005594.3\|UniProtKB=F7DJU5	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000008391.4\|UniProtKB=F6XLU7	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010028091.1\|UniProtKB=A0A8V1AJ93	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000015606.3\|UniProtKB=A0A803TCN2	Anolis carolinensis	O
XENLA\|Gene=fpgs.S\|UniProtKB=A0A1L8F1L6	Xenopus laevis	O
XENLA\|Gene=fpgs.L\|UniProtKB=A0A8J1LI43	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-1003162\|UniProtKB=A4IIL7	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000018278.2\|UniProtKB=H2MVP5	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-040426-2781\|UniProtKB=F1Q7N0	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000005327.1\|UniProtKB=W5MDF7	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000004096.3\|UniProtKB=F6YHL8	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000002123.3\|UniProtKB=F6WRV9	Ciona intestinalis	O
BRAFL\|Gene=LOC118421641\|UniProtKB=A0A9J7LLU4	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC105445392\|UniProtKB=A0A7M7MYJ5	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC584857\|UniProtKB=A0A7M7RCW9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100890414\|UniProtKB=A0A7M7SSU5	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115929174\|UniProtKB=A0A7M7PM37	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC588460\|UniProtKB=A0A7M7TGZ3	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC592205\|UniProtKB=A0A7M7HNC2	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00017777\|UniProtKB=Q09509	Caenorhabditis elegans	O
PRIPA\|EnsemblGenome=WBGene00304270\|UniProtKB=A0A8R1V1Z3	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0051773\|UniProtKB=Q9VQW0	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0030407\|UniProtKB=Q9VYL1	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP004679\|UniProtKB=Q5TSB4	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC000540\|UniProtKB=D6W9Q8	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_205741\|UniProtKB=E9FT03	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW006911\|UniProtKB=B7PVJ7	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG64438\|UniProtKB=T1FXU9	helobdella robusta	O
TRIAD\|EnsemblGenome=TriadG53217\|UniProtKB=B3RNM4	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_28582\|UniProtKB=A9V8L2	Monosiga brevicollis	O
YEAST\|SGD=S000005767\|UniProtKB=Q08645	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_ACR134W\|UniProtKB=Q75BY6	Eremothecium gossypii	O
CANAL\|CGD=CAL0000187593\|UniProtKB=A0A1D8PH56	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_E24497g\|UniProtKB=Q6C4Q7	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_03840\|UniProtKB=Q5B6J0	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_6G09440\|UniProtKB=Q4WML8	Neosartorya fumigata	O
ASPFU\|EnsemblGenome=AFUA_8G04160\|UniProtKB=Q4WCJ9	Neosartorya fumigata	O
ASPFU\|EnsemblGenome=AFUA_4G08060\|UniProtKB=Q4WP52	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU00893\|UniProtKB=Q7SFD9	Neurospora crassa	O
NEUCR\|EnsemblGenome=NCU00892\|UniProtKB=O13492	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_04298\|UniProtKB=A7EG57	Sclerotinia sclerotiorum	O
SCLS1\|EnsemblGenome=SS1G_07273\|UniProtKB=A7EPM4	Sclerotinia sclerotiorum	O
SCLS1\|EnsemblGenome=SS1G_04299\|UniProtKB=A7EG58	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_00842\|UniProtKB=Q0V572	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPBC1709.17\|UniProtKB=O74742	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_03224\|UniProtKB=B6K3N4	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CNC04840\|UniProtKB=Q5KJZ3	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_03772\|UniProtKB=A0A0D1CNF1	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_17179\|UniProtKB=E3L2Y2	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_9940\|UniProtKB=F4NXV7	Batrachochytrium dendrobatidis	O
DICDI\|dictyBase=DDB_G0292632\|UniProtKB=Q54CY5	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_77507\|UniProtKB=F0ZGT5	Dictyostelium purpureum	O
LEIMA\|EnsemblGenome=LMJF_36_2610\|UniProtKB=Q4Q1G0	Leishmania major	O
TRYB2\|Gene_ORFName=Tb10.6k15.3140\|UniProtKB=Q38AL2	Trypanosoma brucei	O
TRIV3\|Gene_ORFName=TVAG_229870\|UniProtKB=A2G107	Trichomonas vaginalis	O
THAPS\|EnsemblGenome=THAPSDRAFT_bd460\|UniProtKB=B8LEL5	Thalassiosira pseudonana	O
PHYRM\|Gene=H3GHG7_PHYRM\|UniProtKB=H3GHG7	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_05g239100v5\|UniProtKB=A0A2K3DT30	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_05g239067v5\|UniProtKB=A0A2K3DT28	Chlamydomonas reinhardtii	O
AMBTC\|EnsemblGenome=AMTR_s00012p00264440\|UniProtKB=W1PJ91	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_129G00040\|UniProtKB=A0A0K9Q1K0	Zostera marina	O
ZOSMR\|Gene_ORFName=ZOSMA_162G00210\|UniProtKB=A0A0K9PU49	Zostera marina	O
MUSAM\|EnsemblGenome=Ma06_g35910\|UniProtKB=A0A804JP74	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma09_g03530\|UniProtKB=A0A804KFJ3	Musa acuminata subsp. malaccensis	O
SORBI\|EnsemblGenome=SORBI_3001G201900\|UniProtKB=C5WWE5	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb044170\|UniProtKB=A0A804LXU2	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os10g0503200\|UniProtKB=Q337F3	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_3g30210v3\|UniProtKB=A0A0Q3LYL7	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.1HG0048070\|UniProtKB=A0A8I6WPN3	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS1A02G173700\|UniProtKB=A0A3B5XZ14	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1B02G190700\|UniProtKB=A0A3B5YW76	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1D02G165100\|UniProtKB=A0A3B5ZUF6	Triticum aestivum	LDO
NELNU\|Gene_ORFName=HUJ06_028014\|UniProtKB=A0A1U7ZWX3	Nelumbo nucifera	O
SPIOL\|Gene=LOC110785484\|UniProtKB=A0A9R0JSM4	Spinacia oleracea	O
HELAN\|Gene_ORFName=HannXRQ_Chr08g0221221\|UniProtKB=A0A251U4J3	Helianthus annuus	O
HELAN\|Gene_ORFName=HanXRQr2_Chr08g0333571\|UniProtKB=A0A9K3IDV6	Helianthus annuus	O
HELAN\|Gene_ORFName=HanXRQr2_Chr09g0381751\|UniProtKB=A0A9K3I4V7	Helianthus annuus	O
HELAN\|Gene_ORFName=HanXRQr2_Chr04g0171261\|UniProtKB=A0A9K3J850	Helianthus annuus	O
HELAN\|Gene_ORFName=HannXRQ_Chr09g0247031\|UniProtKB=A0A251TSX0	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C900482610\|UniProtKB=A0A9R1WV21	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a003647mg\|UniProtKB=A0A022R8Q0	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_27565\|UniProtKB=A0A2G2YEB2	Capsicum annuum	O
CAPAN\|EnsemblGenome=T459_15184\|UniProtKB=A0A2G2ZJJ0	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400027193\|UniProtKB=M1CLE8	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc05g052920.3\|UniProtKB=A0A3Q7GP62	Solanum lycopersicum	O
TOBAC\|Gene=LOC107783423\|UniProtKB=A0A1S3Z650	Nicotiana tabacum	O
TOBAC\|Gene=LOC107779364\|UniProtKB=A0A1S3YT05	Nicotiana tabacum	O
VITVI\|Gene_OrderedLocusName=VIT_13s0019g02390\|UniProtKB=F6HNT5	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_J02122\|UniProtKB=A0A059AGA2	Eucalyptus grandis	O
BRANA\|Gene_ORFName=GSBRNA2T00069395001\|UniProtKB=A0A078HU15	Brassica napus	O
BRANA\|Gene_ORFName=GSBRNA2T00072610001\|UniProtKB=A0A078HRI2	Brassica napus	O
ARATH\|TAIR=locus=2078936\|UniProtKB=Q8W035	Arabidopsis thaliana	O
BRANA\|Gene_ORFName=GSBRNA2T00049390001\|UniProtKB=A0A078FEG9	Brassica napus	O
BRANA\|Gene_ORFName=GSBRNA2T00078636001\|UniProtKB=A0A078FMD3	Brassica napus	O
BRACM\|EnsemblGenome=Bra009156\|UniProtKB=M4CY59	Brassica campestris	O
BRACM\|EnsemblGenome=Bra028746\|UniProtKB=M4EIY1	Brassica campestris	O
ARATH\|TAIR=locus=2153639\|UniProtKB=F4K2A1	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107900459\|UniProtKB=A0A1U8ITW2	Gossypium hirsutum	O
GOSHI\|Gene=LOC107900458\|UniProtKB=A0A1U8IYW0	Gossypium hirsutum	O
GOSHI\|Gene=LOC107962034\|UniProtKB=A0A1U8PRE5	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_042683\|UniProtKB=A0A061FL03	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g048728mg\|UniProtKB=A0A067G0J8	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_008G060600v3\|UniProtKB=A0A2K1ZCM6	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_010G197800v3\|UniProtKB=A0A2K1YX21	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_10G023400\|UniProtKB=A0A2C9V3U5	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_1482420\|UniProtKB=B9SE17	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_18G034200\|UniProtKB=K7MPN5	Glycine max	O
MEDTR\|EnsemblGenome=MTR_3g069160\|UniProtKB=A0A072V9A4	Medicago truncatula	O
MEDTR\|EnsemblGenome=MTR_3g069180\|UniProtKB=G7J9Z6	Medicago truncatula	O
SOYBN\|EnsemblGenome=GLYMA_14G065400\|UniProtKB=K7M5A2	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_02G251400\|UniProtKB=K7KAN4	Glycine max	O
MEDTR\|EnsemblGenome=MTR_5g081250\|UniProtKB=G7K218	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr12_23730\|UniProtKB=A0A6P9E8C0	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_5G630860\|UniProtKB=A0A0A0KTX7	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_2G241100\|UniProtKB=A0A251QLZ2	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_229276\|UniProtKB=D8SVL1	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_75567\|UniProtKB=D8QMQ9	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_402687\|UniProtKB=D8QMQ8	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_234236\|UniProtKB=D8SJ46	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_86713\|UniProtKB=D8R7G7	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_32076\|UniProtKB=D8RVZ6	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c23_670\|UniProtKB=A0A2K1IHQ1	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c24_9100\|UniProtKB=A9TAU6	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0010s0086\|UniProtKB=A0A2R6XKP2	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_001580250\|UniProtKB=A0A1Y1I3F7	Klebsormidium nitens	O
CHLAA\|EnsemblGenome=Caur_0436\|UniProtKB=A9WDT0	Chloroflexus aurantiacus	O
STRCO\|Gene_OrderedLocusName=SCO2614\|UniProtKB=Q9L1G4	Streptomyces coelicolor	O
MYCTU\|Gene_OrderedLocusName=LH57_13380\|UniProtKB=I6Y0R5	Mycobacterium tuberculosis	O
CLOBH\|Gene_OrderedLocusName=CBO3163\|UniProtKB=A5I6P2	Clostridium botulinum	O
STRR6\|EnsemblGenome=spr0267\|UniProtKB=Q8DR92	Streptococcus pneumoniae	O
STRR6\|EnsemblGenome=spr0178\|UniProtKB=Q8DRE0	Streptococcus pneumoniae	O
STAA8\|EnsemblGenome=SAOUHSC_01766\|UniProtKB=Q2FXR9	Staphylococcus aureus	O
LISMO\|Gene=folC\|UniProtKB=Q8Y6Y0	Listeria monocytogenes	O
BACSU\|EnsemblGenome=BSU_28080\|UniProtKB=Q05865	Bacillus subtilis	O
BACCR\|EnsemblGenome=BC_4464\|UniProtKB=Q817R7	Bacillus cereus	O
THEMA\|EnsemblGenome=TM_0166\|UniProtKB=Q9WY13	Thermotoga maritima	O
DEIRA\|EnsemblGenome=DR_0340\|UniProtKB=Q9RXH3	Deinococcus radiodurans	O
GLOVI\|Gene=folC\|UniProtKB=Q7NLP7	Gloeobacter violaceus	O
SYNY3\|Gene=folC\|UniProtKB=P73842	Synechocystis	O
LEPIN\|EnsemblGenome=LA_0637\|UniProtKB=Q8F8C1	Leptospira interrogans	O
BACTN\|EnsemblGenome=BT_1335\|UniProtKB=Q8A839	Bacteroides thetaiotaomicron	O
RHOBA\|EnsemblGenome=RB6237\|UniProtKB=Q7UQM1	Rhodopirellula baltica	O
AQUAE\|EnsemblGenome=aq_2045\|UniProtKB=O67833	Aquifex aeolicus	O
THEYD\|EnsemblGenome=THEYE_A0558\|UniProtKB=B5YJI6	Thermodesulfovibrio yellowstonii	O
DICTD\|EnsemblGenome=Dtur_0758\|UniProtKB=B8DZV7	Dictyoglomus turgidum	O
FUSNN\|EnsemblGenome=FN1014\|UniProtKB=Q8RES8	Fusobacterium nucleatum	O
HELPY\|EnsemblGenome=HP_1545\|UniProtKB=O26070	Helicobacter pylori	O
NEIMB\|EnsemblGenome=NMB0693\|UniProtKB=Q9K0C1	Neisseria meningitidis serogroup b	O
GEOSL\|EnsemblGenome=GSU2368\|UniProtKB=Q74AI6	Geobacter sulfurreducens	O
BRADU\|Gene=folC\|UniProtKB=Q89WE2	Bradyrhizobium diazoefficiens	O
COXBU\|EnsemblGenome=CBU_0894\|UniProtKB=Q83D50	Coxiella burnetii	O
HAEIN\|EnsemblGenome=HI_1261\|UniProtKB=P43775	Haemophilus influenzae	O
SHEON\|Gene_OrderedLocusName=SO_3067\|UniProtKB=Q8ECR5	Shewanella oneidensis	O
VIBCH\|EnsemblGenome=VC_1001\|UniProtKB=Q9KTA2	Vibrio cholerae	O
XANCP\|EnsemblGenome=XCC0950\|UniProtKB=Q8PC05	Xanthomonas campestris	O
PSEAE\|EnsemblGenome=PA3111\|UniProtKB=Q9HZA8	Pseudomonas aeruginosa	O
SALTY\|EnsemblGenome=STM2365\|UniProtKB=Q8ZNC0	Salmonella typhimurium	O
YERPE\|Gene_OrderedLocusName=YPO2769\|UniProtKB=A0A5P8YIK0	Yersinia pestis	O
ECOLI\|EnsemblGenome=BAA16164\|UniProtKB=P08192	Escherichia coli	O