PANTHER Gene Information

Gene Symbol(s):

VIT_10s0003g01620

Organism:

Vitis vinifera

View Gene in Tree

Tree

Gene Name:

Ras-related protein RABA1d

Gene ID:

VIT_10s0003g01620

Protein ID:

A5AUV6

Persistent Id:

PTN002375285

Alternate Ids:

CCB55703(EMBL-CDS)	AM436451(EMBL)
A5AUV6_VITVI(UniProtKB-ID)	147772737(GI)
A5AUV6(Synonym)
Show All

PANTHER Classification

PANTHER Family:	DRAB11-RELATED (PTHR47979)
PANTHER Subfamily:	RAS-RELATED PROTEIN RABA1A (PTHR47979:SF65)
PANTHER GO-slim Molecular Function:	carbohydrate derivative binding nucleotide binding GTPase activity anion binding
PANTHER GO-slim Biological Process:	vesicle-mediated transport
PANTHER GO-slim Cellular Component:	endosome
PANTHER protein class:	small GTPase

Pathway Categories:

Huntington disease

Rab8

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	GTP binding, GTPase activity
GO BP Complete:	-
GO CC Complete:	-

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=9760\|UniProtKB=P62491	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000044358.1\|UniProtKB=H2Q9M8	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000014252.3\|UniProtKB=G3REC0	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000008006.4\|UniProtKB=H9ZET8	Macaca mulatta	O
MOUSE\|MGI=MGI=1858202\|UniProtKB=P62492	Mus musculus	O
RAT\|RGD=619762\|UniProtKB=P62494	Rattus norvegicus	O
BOVIN\|Gene=RAB11A\|UniProtKB=Q2TA29	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000048711.1\|UniProtKB=A0A3Q1M6P5	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000018959.4\|UniProtKB=F2Z4D5	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000032312\|UniProtKB=Q52NJ1	Sus scrofa	O
FELCA\|Ensembl=ENSFCAG00000030174.4\|UniProtKB=A0A5F5XXR7	Felis catus	O
CANLF\|Ensembl=ENSCAFG00000055546\|UniProtKB=P62490	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000009810.4\|UniProtKB=F6SG28	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000038794.1\|UniProtKB=A0A6I8N7S5	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010017870.1\|UniProtKB=A0A8V0Z564	Gallus gallus	O
CHICK\|Gene_ORFName=RCJMB04_16p4\|UniProtKB=Q5ZJN2	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000004479.3\|UniProtKB=H9G954	Anolis carolinensis	O
XENLA\|Gene=rab11a.L\|UniProtKB=Q642Q5	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-489346\|UniProtKB=Q28HH1	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000016126.2\|UniProtKB=A0A3B3IFR1	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-031118-188\|UniProtKB=Q7SY35	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000008865.1\|UniProtKB=W5MQZ1	lepisosteus oculatus	O
ORYLA\|Ensembl=ENSORLG00000018331.2\|UniProtKB=H2MKD7	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-041114-53\|UniProtKB=Q5U3E1	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000013835.1\|UniProtKB=W5N8V1	lepisosteus oculatus	O
HUMAN\|HGNC=18238\|UniProtKB=P57735	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000001446.6\|UniProtKB=H2R0X3	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000006821.3\|UniProtKB=G3QVB1	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000022306.4\|UniProtKB=F6XEC1	Macaca mulatta	O
MOUSE\|MGI=MGI=1858203\|UniProtKB=Q9WTL2	Mus musculus	O
RAT\|RGD=1308447\|UniProtKB=B5DEP2	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000018914\|UniProtKB=Q58DW6	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000039186.2\|UniProtKB=A0A287BR95	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000023191.3\|UniProtKB=F6V2P8	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000011775.5\|UniProtKB=M3WFQ9	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845010319.1\|UniProtKB=A0A8I3NFM4	Canis lupus familiaris	O
CANLF\|Ensembl=ENSCAFG00040021172\|UniProtKB=E2RQ15	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000048622.1\|UniProtKB=A0A5F8HCQ2	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000036213.1\|UniProtKB=A0A6I8P679	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010028075.1\|UniProtKB=A0A8V1AHB6	Gallus gallus	O
XENLA\|Gene=rab25.S\|UniProtKB=Q32NL6	Xenopus laevis	O
XENLA\|Gene=rab25.L\|UniProtKB=Q6GLV5	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-494256\|UniProtKB=Q66KL6	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000012158.2\|UniProtKB=H2M9L7	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-041212-69\|UniProtKB=Q1LVA5	Danio rerio	O
ORYLA\|Ensembl=ENSORLG00000016135.2\|UniProtKB=A0A3B3HY70	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-050706-113\|UniProtKB=F1Q9W8	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000008881.1\|UniProtKB=W5MR01	lepisosteus oculatus	O
HUMAN\|HGNC=9761\|UniProtKB=Q15907	Homo sapiens	O
MACMU\|Ensembl=ENSMMUG00000010225.4\|UniProtKB=H9ZFC3	Macaca mulatta	O
MOUSE\|MGI=MGI=99425\|UniProtKB=P46638	Mus musculus	O
RAT\|RGD=68369\|UniProtKB=O35509	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000002475\|UniProtKB=Q3MHP2	Bos taurus	O
PIG\|Ensembl=ENSSSCG00005045785.1\|UniProtKB=F2Z5J9	Sus scrofa	O
FELCA\|Ensembl=ENSFCAG00000015216.5\|UniProtKB=M3WM66	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845006072.1\|UniProtKB=A0A8I3N1Q2	Canis lupus familiaris	O
CANLF\|Ensembl=ENSCAFG00845006072.1\|UniProtKB=A0A8I3N1Q2	Canis lupus familiaris	O
ORNAN\|Ensembl=ENSOANG00000045493.1\|UniProtKB=A0A6I8PQ59	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010028072.1\|UniProtKB=A0A8V1AHB3	Gallus gallus	O
CHICK\|Ensembl=ENSGALG00010027741.1\|UniProtKB=Q5F3R8	Gallus gallus	O
XENLA\|Gene=rab11b.2.L\|UniProtKB=Q5M991	Xenopus laevis	O
XENLA\|Gene=rab11b.2.S\|UniProtKB=A0A1L8HNE7	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-5963250\|UniProtKB=Q6DJB4	Xenopus tropicalis	O
XENLA\|Gene=rab11b.1.S\|UniProtKB=Q8AVV4	Xenopus laevis	O
XENLA\|Gene=rab11b.1.L\|UniProtKB=Q641B7	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-491174\|UniProtKB=Q5XH99	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000013938.2\|UniProtKB=A0A3B3HTY1	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000015284.2\|UniProtKB=H2MKD4	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000015307.2\|UniProtKB=H2MKF6	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-040426-2860\|UniProtKB=Q802D1	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-040718-293\|UniProtKB=Q6DGU2	Danio rerio	O
CIOIN\|Ensembl=ENSCING00000002864.3\|UniProtKB=F6TMB6	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000005409.3\|UniProtKB=F6Z9S5	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000009526.3\|UniProtKB=F6XCQ7	Ciona intestinalis	O
BRAFL\|Gene=LOC118415211\|UniProtKB=A0A9J7MQ61	Branchiostoma floridae	O
BRAFL\|Gene_ORFName=BRAFLDRAFT_266781\|UniProtKB=C3YDX8	Branchiostoma floridae	O
STRPU\|EnsemblGenome=GeneID_373420\|UniProtKB=A0A7M6UL15	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00004275\|UniProtKB=Q1ZXR4	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00004274\|UniProtKB=O01803	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG23562\|UniProtKB=H8WH16	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00037954\|UniProtKB=A8XTK7	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00026667\|UniProtKB=A8WVQ0	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00094747\|UniProtKB=A0A2A6BUK0	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0015790\|UniProtKB=O18335	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP004559\|UniProtKB=A7UT37	Anopheles gambiae	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_304112\|UniProtKB=E9GJA1	Daphnia pulex	O
HELRO\|EnsemblGenome=HelroG104797\|UniProtKB=T1EDN7	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG154551\|UniProtKB=T1ELF1	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG185511\|UniProtKB=T1FMX0	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g174073\|UniProtKB=A7ST94	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g193205\|UniProtKB=A7ST02	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG63185\|UniProtKB=B3RM76	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_35328\|UniProtKB=A9VCQ0	Monosiga brevicollis	O
YEAST\|SGD=S000000833\|UniProtKB=P38555	Saccharomyces cerevisiae	O
YEAST\|SGD=S000003178\|UniProtKB=P51996	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_AER434C\|UniProtKB=Q755T4	Eremothecium gossypii	O
CANAL\|CGD=CAL0000190363\|UniProtKB=A0A1D8PTI2	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_C14168g\|UniProtKB=Q6CBZ3	Yarrowia lipolytica	O
YARLI\|EnsemblGenome=YALI0_D14630g\|UniProtKB=Q6C932	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_00347\|UniProtKB=C8VTZ0	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_1G02190\|UniProtKB=Q4WKK1	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU01523\|UniProtKB=F5H8U4	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_02097\|UniProtKB=A7E9W7	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_01620\|UniProtKB=Q0V2Z4	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPAC18G6.03\|UniProtKB=P17610	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_03915\|UniProtKB=B6K5E1	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CNE01820\|UniProtKB=Q5KGZ4	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_01651\|UniProtKB=A0A0D1E427	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_05920\|UniProtKB=E3K628	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_85182\|UniProtKB=F4NV58	Batrachochytrium dendrobatidis	O
ENTH1\|Gene_ORFName=EHI_056100\|UniProtKB=A0A8U0WNX4	Entamoeba histolytica	O
ENTH1\|Gene_ORFName=EHI_107250\|UniProtKB=A0A8U0WPZ4	Entamoeba histolytica	O
ENTH1\|Gene_ORFName=EHI_005460\|UniProtKB=A0A8U0WP83	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0269238\|UniProtKB=P36412	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_91321\|UniProtKB=F0ZAM9	Dictyostelium purpureum	O
LEIMA\|EnsemblGenome=LMJF_10_1170\|UniProtKB=Q4QH97	Leishmania major	O
TRYB2\|Gene_ORFName=Tb927.8.4620\|UniProtKB=D6XLJ7	Trypanosoma brucei	O
GIAIC\|EnsemblGenome=GL50803_1695\|UniProtKB=E2RU48	Giardia intestinalis	O
TRIV3\|Gene_ORFName=TVAG_134510\|UniProtKB=A0A8U0WP14	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_358310\|UniProtKB=A2ELD9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_069950\|UniProtKB=A2ESN6	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_169740\|UniProtKB=A0A8U0WQ38	Trichomonas vaginalis	O
PLAF7\|EnsemblGenome=PF3D7_1340700\|UniProtKB=C0H5G2	Plasmodium falciparum	O
PARTE\|EnsemblGenome=GSPATT00000100001\|UniProtKB=A0BAU8	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00003449001\|UniProtKB=A0E5M1	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00028595001\|UniProtKB=A0BG93	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00018826001\|UniProtKB=A0DNL3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00010511001\|UniProtKB=A0CU45	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00029131001\|UniProtKB=Q3SDH5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00026605001\|UniProtKB=A0EG41	Paramecium tetraurelia	O
PARTE\|Gene_ORFName=PTMB.389\|UniProtKB=Q6BFI4	Paramecium tetraurelia	O
PLAF7\|EnsemblGenome=PF3D7_1320600\|UniProtKB=Q76NM4	Plasmodium falciparum	O
PARTE\|EnsemblGenome=GSPATT00021744001\|UniProtKB=Q3SD71	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00031953001\|UniProtKB=A0BT54	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00017121001\|UniProtKB=A0DI83	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00027877001\|UniProtKB=A0BE78	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00016098001\|UniProtKB=Q3SD03	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00003870001\|UniProtKB=Q3SD30	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00034349001\|UniProtKB=Q3SD39	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00035216001\|UniProtKB=A0C5M0	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00000573001\|UniProtKB=Q3SDP9	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00009876001\|UniProtKB=Q3SCZ6	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00031772001\|UniProtKB=Q3SCX1	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00015032001\|UniProtKB=Q3SD28	Paramecium tetraurelia	O
THAPS\|EnsemblGenome=THAPS_23528\|UniProtKB=B5YND5	Thalassiosira pseudonana	O
PHYRM\|Gene=H3G5K5_PHYRM\|UniProtKB=H3G5K5	Phytophthora ramorum	O
PHYRM\|Gene=H3GM54_PHYRM\|UniProtKB=H3GM54	Phytophthora ramorum	O
PHYRM\|Gene=H3GTY6_PHYRM\|UniProtKB=H3GTY6	Phytophthora ramorum	O
PHYRM\|Gene=H3G8U7_PHYRM\|UniProtKB=H3G8U7	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_03g189250v5\|UniProtKB=A8IRT2	Chlamydomonas reinhardtii	O
AMBTC\|EnsemblGenome=AMTR_s00108p00135260\|UniProtKB=W1NXE7	Amborella trichopoda	O
MUSAM\|EnsemblGenome=Ma08_g28370\|UniProtKB=A0A804KBQ7	Musa acuminata subsp. malaccensis	LDO
MUSAM\|EnsemblGenome=Ma09_g05450\|UniProtKB=A0A804KGA3	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma03_g17060\|UniProtKB=A0A804ID07	Musa acuminata subsp. malaccensis	LDO
MUSAM\|EnsemblGenome=Ma06_g33480\|UniProtKB=A0A804JN94	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma08_g28370\|UniProtKB=A0A804KBQ7	Musa acuminata subsp. malaccensis	O
SORBI\|EnsemblGenome=SORBI_3003G351150\|UniProtKB=A0A1W0W0D8	Sorghum bicolor	LDO
NELNU\|Gene=LOC104591257\|UniProtKB=A0A1U7ZJ84	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110783739\|UniProtKB=A0A9R0I787	Spinacia oleracea	LDO
HELAN\|Gene_ORFName=HannXRQ_Chr04g0116921\|UniProtKB=A0A251V018	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C100043480\|UniProtKB=A0A9R1XTM7	Lactuca sativa	LDO
CAPAN\|EnsemblGenome=T459_20259\|UniProtKB=A0A2G2Z3Y6	Capsicum annuum	LDO
SOLLC\|EnsemblGenome=Solyc07g055290.3\|UniProtKB=A0A3Q7HG43	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107821622\|UniProtKB=A0A1S4CQL5	Nicotiana tabacum	O
TOBAC\|Gene=LOC107821633\|UniProtKB=A0A1S4CR16	Nicotiana tabacum	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_K01566\|UniProtKB=A0A059A210	Eucalyptus grandis	O
EUCGR\|EnsemblGenome=EUGRSUZ_K01169\|UniProtKB=A0A058ZZN3	Eucalyptus grandis	LDO
BRANA\|Gene_ORFName=DARMORV10_C08P51270.1\|UniProtKB=A0A078F9C4	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra032424\|UniProtKB=A0A3P5YSQ7	Brassica campestris	LDO
ARATH\|TAIR=locus=2202280\|UniProtKB=P28185	Arabidopsis thaliana	LDO
THECC\|EnsemblGenome=TCM_008954\|UniProtKB=A0A061E5L9	Theobroma cacao	LDO
POPTR\|Gene_ORFName=POPTR_011G070200\|UniProtKB=A0A3N7FVC3	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_16G043200\|UniProtKB=A0A2C9U8P1	Manihot esculenta	LDO
SOYBN\|EnsemblGenome=GLYMA_12G212400\|UniProtKB=Q8LJR5	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_13G289300\|UniProtKB=I1M3K1	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_2g083860\|UniProtKB=G7IM71	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr01_23540\|UniProtKB=A0A2I4HLT4	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_7G049180\|UniProtKB=A0A0A0K737	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_3G113200\|UniProtKB=M5WTH3	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_158820\|UniProtKB=D8SVZ0	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_135992\|UniProtKB=D8TB47	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_146310\|UniProtKB=D8RE14	Selaginella moellendorffii	O
MARPO\|EnsemblGenome=MARPO_YA0041\|UniProtKB=A0A2R6VX48	Marchantia polymorpha	O
MARPO\|EnsemblGenome=MARPO_0018s0008\|UniProtKB=A0A2R6XFC9	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_001600170\|UniProtKB=A0A1Y1I4U9	Klebsormidium nitens	O