PANTHER Gene Information   
Gene Symbol(s): aurkb
Organism: Xenopus tropicalis
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Gene Name: Aurora kinase B
Gene ID: XB-GENE-1019626
Protein ID: A4IGM9
Persistent Id: PTN001967782
Alternate Ids:
2.7.11.1(EC) 134254246(GI)
549613(GeneID) AIRK2(Synonym)
AURKB_XENTR(UniProtKB-ID) XP_012809282(refSeq)
BC135173(EMBL) aurkb{ECO:0000312|EMBL:AAI35174.1}(Symbol)
AAI35174(EMBL-CDS)
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PANTHER Classification
PANTHER Family: SERINE/THREONINE-PROTEIN KINASE IAL-RELATED (PTHR24350)
PANTHER Subfamily: AURORA KINASE B (PTHR24350:SF4)  
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process: regulation of cytokinesis
mitotic spindle organization
PANTHER GO-slim Cellular Component: spindle midzone
microtubule associated complex
spindle microtubule
nucleus
midbody
kinetochore
centrosome
spindle pole
PANTHER protein class: non-receptor serine/threonine protein kinase
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: histone H3S10 kinase activity, histone H2BS14 kinase activity, histone H2AS1 kinase activity, protein kinase activity, eukaryotic translation initiation factor 2alpha kinase activity, protein serine/threonine kinase activity, 3-phosphoinositide-dependent protein kinase activity, ribosomal protein S6 kinase activity, DNA-dependent protein kinase activity, ATP binding, histone H2AT120 kinase activity, AMP-activated protein kinase activity, histone H2AS121 kinase activity, histone H3S57 kinase activity, histone H4S1 kinase activity, histone H3T3 kinase activity, histone H2BS36 kinase activity, histone H3S28 kinase activity, histone H3T45 kinase activity, histone H2AXS139 kinase activity, Rho-dependent protein serine/threonine kinase activity, histone H3T11 kinase activity, protein serine kinase activity, histone H3T6 kinase activity
GO BP Complete: cleavage furrow formation, repair of mitotic kinetochore microtubule attachment defect, mitotic spindle organization, positive regulation of mitotic sister chromatid segregation, chromosome segregation, post-translational protein modification, midbody abscission, mitotic cytokinesis checkpoint signaling, negative regulation of transcription by RNA polymerase II, cell division, spindle assembly, mitotic spindle midzone assembly, negative regulation of B cell apoptotic process, regulation of cytokinesis, protein localization to kinetochore, cellular response to UV, negative regulation of cytokinesis, mitotic sister chromatid biorientation, positive regulation of cytokinesis
GO CC Complete: spindle pole, kinetochore, chromosome, chromosome, centromeric region, chromatin, nucleus, spindle microtubule, centrosome, spindle midzone, cytoskeleton, cytoplasm, spindle, chromosome passenger complex, midbody
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Signal Transduction, Signaling by Rho GTPases, SUMOylation of DNA replication proteins, Cell Cycle, Gene expression (Transcription), EML4 and NUDC in mitotic spindle formation, Mitotic Prometaphase, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Amplification of signal from the kinetochores, Mitotic Metaphase and Anaphase, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Cell Cycle, Mitotic, Mitotic Anaphase, Metabolism of proteins, Regulation of mitotic cell cycle, Generic Transcription Pathway, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, RHO GTPase Effectors, Regulation of TP53 Activity through Phosphorylation, Mitotic Spindle Checkpoint, RHO GTPases Activate Formins, Separation of Sister Chromatids, M Phase, Cell Cycle Checkpoints, Resolution of Sister Chromatid Cohesion, SUMOylation, APC/C-mediated degradation of cell cycle proteins, RNA Polymerase II Transcription, Transcriptional Regulation by TP53, Regulation of TP53 Activity

Orthologs