PANTHER Gene Information

Gene Symbol(s):

mcm8

Organism:

Xenopus tropicalis

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Gene Name:

DNA helicase MCM8

Gene ID:

XB-GENE-961372

Protein ID:

Q0V9Q6

Persistent Id:

PTN000179884

Alternate Ids:

AAI21434(EMBL-CDS)	AAMC01063807(EMBL)
118403475(GI)	MCM8_XENTR(UniProtKB-ID)
Minichromosome maintenance 8(Synonym)	779797(GeneID)
NP_001072344(refSeq)	mcm8(Symbol)
3.6.4.12(EC)
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PANTHER Classification

PANTHER Family:	DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER (PTHR11630)
PANTHER Subfamily:	DNA HELICASE MCM8 (PTHR11630:SF47)
PANTHER GO-slim Molecular Function:	single-stranded DNA binding single-stranded DNA helicase activity
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:	MCM complex nucleus
PANTHER protein class:	DNA metabolism protein

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	ATP hydrolysis activity, double-stranded DNA helicase activity, helicase activity, four-way junction helicase activity, forked DNA-dependent helicase activity, cohesin loader activity, single-stranded DNA binding, DNA binding, ATP binding, DNA clamp loader activity, ATP-dependent H2AZ histone chaperone activity, ATP-dependent H3-H4 histone complex chaperone activity, single-stranded 3'-5' DNA helicase activity, single-stranded DNA helicase activity, chromatin extrusion motor activity, hydrolase activity
GO BP Complete:	DNA repair, DNA replication, regulation of DNA-templated DNA replication initiation, DNA duplex unwinding, double-strand break repair via homologous recombination, DNA recombination, DNA damage response
GO CC Complete:	nucleus, MCM complex, MCM8-MCM9 complex

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Cell Cycle, Orc1 removal from chromatin, Assembly of the pre-replicative complex, DNA Replication, CDC6 association with the ORC:origin complex, G1/S Transition, Synthesis of DNA, Activation of the pre-replicative complex, Cell Cycle, Mitotic, Mitotic G1 phase and G1/S transition, DNA Replication Pre-Initiation, S Phase, Switching of origins to a post-replicative state

Orthologs

ID	Organism	Type
HUMAN\|HGNC=16147\|UniProtKB=Q9UJA3	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000013233.7\|UniProtKB=A0A2I3RCL0	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000008602.3\|UniProtKB=G3S967	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000013740.4\|UniProtKB=F6RN32	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1913884\|UniProtKB=Q9CWV1	Mus musculus	LDO
RAT\|RGD=1305218\|UniProtKB=D3ZVK1	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000014623\|UniProtKB=E1BPX4	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000007047.4\|UniProtKB=F1SBM1	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000015452.4\|UniProtKB=A0A9L0RQP1	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000011524.6\|UniProtKB=M3WF93	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845027289.1\|UniProtKB=A0A8I3SAR8	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000003865.4\|UniProtKB=F7DTQ6	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000008405.3\|UniProtKB=F6WQ16	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010017462.1\|UniProtKB=A0A8V0Z2M8	Gallus gallus	O
CHICK\|Ensembl=ENSGALG00015006795\|UniProtKB=I0IUP3	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000000664.3\|UniProtKB=G1K8S6	Anolis carolinensis	LDO
XENLA\|Gene=mcm8\|UniProtKB=Q5F310	Xenopus laevis	LDO
XENLA\|Gene=mcm8.L\|UniProtKB=A0A8J1KLP5	Xenopus laevis	LDO
ORYLA\|Ensembl=ENSORLG00000001413.2\|UniProtKB=A0A3B3HZ94	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-120927-1\|UniProtKB=E7F643	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000016449.1\|UniProtKB=W5NI58	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000004980.3\|UniProtKB=F6WMK2	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118412140\|UniProtKB=A0A9J7MKS1	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC593200\|UniProtKB=A0A7M7PR06	Strongylocentrotus purpuratus	LDO
DROME\|FlyBase=FBgn0003227\|UniProtKB=Q9VF30	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP002581\|UniProtKB=A0A1S4GFC0	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP002580\|UniProtKB=Q7QCD9	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC009331\|UniProtKB=D6WRH7	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_62337\|UniProtKB=E9HG19	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW013018\|UniProtKB=B7QBZ6	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG111248\|UniProtKB=T1EF98	helobdella robusta	LDO
TRIAD\|EnsemblGenome=TriadG59235\|UniProtKB=B3S586	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_9453\|UniProtKB=A9V374	Monosiga brevicollis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_21770\|UniProtKB=F4NV73	Batrachochytrium dendrobatidis	LDO
ENTH1\|EnsemblGenome=CL6EHI_140670\|UniProtKB=C4M3N9	Entamoeba histolytica	LDO
DICDI\|dictyBase=DDB_G0283009\|UniProtKB=Q54RN8	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_146993\|UniProtKB=F0Z7D8	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_05_0330\|UniProtKB=Q4QJG9	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb10.406.0500\|UniProtKB=Q389T6	Trypanosoma brucei	LDO
TRIV3\|Gene_ORFName=TVAG_476710\|UniProtKB=A2DA94	Trichomonas vaginalis	LDO
PLAF7\|EnsemblGenome=PF3D7_1211300\|UniProtKB=Q8I5T7	Plasmodium falciparum	LDO
PARTE\|EnsemblGenome=GSPATT00029613001\|UniProtKB=A0BKB5	Paramecium tetraurelia	LDO
PHYRM\|Gene=H3G6Z8_PHYRM\|UniProtKB=H3G6Z8	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_16g665950v5\|UniProtKB=A0A2K3CTV1	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00080p00032690\|UniProtKB=W1PB14	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_75G00390\|UniProtKB=A0A0K9NPE7	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma11_g08040\|UniProtKB=A0A804L5I4	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_021273mg\|UniProtKB=K3Z405	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3009G166400\|UniProtKB=A0A1B6P920	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb351640\|UniProtKB=A0A804UGL5	Zea mays	LDO
ORYSJ\|Gene_OrderedLocusName=LOC_Os05g38850\|UniProtKB=B9FKM7	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_2g22907v3\|UniProtKB=I1HIL9	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.1HG0072870\|UniProtKB=A0A8I6WHT7	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS1A02G288700\|UniProtKB=A0A3B5Y3S0	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1D02G287700\|UniProtKB=A0A3B5ZX19	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1B02G298100\|UniProtKB=A0A3B5Z1E5	Triticum aestivum	LDO
NELNU\|Gene=LOC104594747\|UniProtKB=A0A1U7ZI19	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110803912\|UniProtKB=A0A9R0JDI6	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr13g0584311\|UniProtKB=A0A251SR73	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C600310670\|UniProtKB=A0A9R1X8V4	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a026728mg\|UniProtKB=A0A022RNR8	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_22757\|UniProtKB=A0A2G2YQE3	Capsicum annuum	LDO
SOLLC\|EnsemblGenome=Solyc09g007330.3\|UniProtKB=A0A3Q7HY35	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107821960\|UniProtKB=A0A1S4CRP2	Nicotiana tabacum	O
TOBAC\|Gene=LOC107788161\|UniProtKB=A0A1S3ZL86	Nicotiana tabacum	LDO
VITVI\|Gene_OrderedLocusName=VIT_08s0040g03290\|UniProtKB=F6HQU8	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_A01177\|UniProtKB=A0A059DF31	Eucalyptus grandis	LDO
BRANA\|Gene_ORFName=DARMORV10_C05P58430.1\|UniProtKB=A0A078HW41	Brassica napus	O
BRANA\|Gene_ORFName=DARMORV10_A05P39400.1\|UniProtKB=A0A078I6H9	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra029782\|UniProtKB=M4ELW2	Brassica campestris	LDO
ARATH\|TAIR=locus=2074934\|UniProtKB=Q9SF37	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107905290\|UniProtKB=A0A1U8JAR7	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_022086\|UniProtKB=A0A061ESY8	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g040742mg\|UniProtKB=A0A067EN25	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_006G131900v3\|UniProtKB=A0A2K2A1K1	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_08G003200\|UniProtKB=A0A2C9VC38	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_0819630\|UniProtKB=B9SGR4	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_19G178600\|UniProtKB=A0A0R0F0P6	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_7g100680\|UniProtKB=G7L1Q5	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr03_22190\|UniProtKB=A0A2I4HM42	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_3G736810\|UniProtKB=A0A0A0LDE1	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_6G241500\|UniProtKB=A0A251NV32	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_427437\|UniProtKB=D8SZM1	Selaginella moellendorffii	LDO
SELML\|EnsemblGenome=SELMODRAFT_405992\|UniProtKB=D8R0B2	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c24_12060\|UniProtKB=A0A2K1IGG1	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0006s0301\|UniProtKB=A0A2R6XQC2	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_000740040\|UniProtKB=A0A1Y1HSW1	Klebsormidium nitens	LDO
NITMS\|EnsemblGenome=Nmar_0242\|UniProtKB=A9A310	Nitrosopumilus maritimus	O
KORCO\|EnsemblGenome=Kcr_1352\|UniProtKB=B1L6L9	Korarchaeum cryptofilum	O
SACS2\|EnsemblGenome=SSO0774\|UniProtKB=Q9UXG1	Sulfolobus solfataricus	O
PYRAE\|EnsemblGenome=PAE0901\|UniProtKB=Q8ZY88	Pyrobaculum aerophilum	O
METAC\|EnsemblGenome=MA_3829\|UniProtKB=Q8TJF6	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_0681\|UniProtKB=Q8TSW4	Methanosarcina acetivorans	O
METJA\|EnsemblGenome=MJ_ECL13\|UniProtKB=Q60275	Methanocaldococcus jannaschii	O
METJA\|EnsemblGenome=MJ_1489\|UniProtKB=Q58884	Methanocaldococcus jannaschii	O
METJA\|EnsemblGenome=MJ_0363\|UniProtKB=Q57809	Methanocaldococcus jannaschii	O
METJA\|EnsemblGenome=MJ_0961\|UniProtKB=Q58371	Methanocaldococcus jannaschii	O
HALSA\|EnsemblGenome=VNG_2181G\|UniProtKB=Q9HNA5	Halobacterium salinarum	O
THEKO\|EnsemblGenome=TK1361\|UniProtKB=Q5JGW1	Thermococcus kodakaraensis	O
THEKO\|EnsemblGenome=TK0096\|UniProtKB=Q5JEJ0	Thermococcus kodakaraensis	O
THEKO\|EnsemblGenome=TK1620\|UniProtKB=Q5JIT1	Thermococcus kodakaraensis	O