PANTHER Gene Information

Gene Symbol(s):

EPRS1

Organism:

Macaca mulatta

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Gene Name:

Glutamyl-prolyl-tRNA synthetase 1

Gene ID:

ENSMMUG00000008722.4

Protein ID:

A0A1D5QB56

Persistent Id:

PTN000012575

Alternate Ids:

706899(GeneID)	XM_015116029(refSeq)
A0A1D5QB56(Synonym)	A0A1D5QB56_MACMU(UniProtKB-ID)
ENSMMUT00000075821(Ensembl_TRS)	ENSMMUG00000008722(Ensembl)
966921804(GI)	ENSMMUP00000045274(Ensembl_PRO)
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PANTHER Classification

PANTHER Family:	PROLYL-TRNA SYNTHETASE (PTHR43382)
PANTHER Subfamily:	BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE (PTHR43382:SF2)
PANTHER GO-slim Molecular Function:	catalytic activity, acting on RNA ligase activity
PANTHER GO-slim Biological Process:	amino acid metabolic process translation tRNA metabolic process
PANTHER GO-slim Cellular Component:	catalytic complex intracellular protein-containing complex cytoplasm
PANTHER protein class:	aminoacyl-tRNA synthetase

Pathway Categories:

Heme biosynthesis

Glutamyl-tRNA-synthetase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	ATP binding, aminoacyl-tRNA ligase activity, zinc ion binding, identical protein binding, protein homodimerization activity, proline-tRNA ligase activity, GTPase binding, glutamate-tRNA ligase activity, RNA stem-loop binding
GO BP Complete:	cellular response to insulin stimulus, tRNA aminoacylation for protein translation, regulation of long-chain fatty acid import into cell, cellular response to type II interferon, glutamyl-tRNA aminoacylation, negative regulation of translation, prolyl-tRNA aminoacylation, translation
GO CC Complete:	GAIT complex, cytoplasm, cytosol, aminoacyl-tRNA synthetase multienzyme complex, ribonucleoprotein complex, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=3418\|UniProtKB=P07814	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000001995.5\|UniProtKB=H2Q156	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000012404.3\|UniProtKB=G3S6M5	Gorilla gorilla gorilla	LDO
MOUSE\|MGI=MGI=97838\|UniProtKB=Q8CGC7	Mus musculus	LDO
RAT\|RGD=1310952\|UniProtKB=A0A8I6GJ92	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000006898.6\|UniProtKB=G3X6L9	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000010821.5\|UniProtKB=F1S9K5	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000000700.4\|UniProtKB=A0A3Q2LSB2	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000002590.6\|UniProtKB=M3VYT1	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845028538.1\|UniProtKB=A0A8I3SBI9	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000004398.5\|UniProtKB=A0A5F8GSL4	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000001424.4\|UniProtKB=A0A6I8P1G0	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010016118.1\|UniProtKB=A0A3Q2TSP8	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000001213.4\|UniProtKB=A0A803TLQ5	Anolis carolinensis	LDO
XENLA\|Gene=eprs1.S\|UniProtKB=A0A8J1KR56	Xenopus laevis	O
XENLA\|Gene=eprs1.L\|UniProtKB=A0A8J1KP01	Xenopus laevis	LDO
XENTR\|Gene=eprs1\|UniProtKB=A0A8J1JM70	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000014819.2\|UniProtKB=A0A3B3H833	Oryzias latipes	LDO
DANRE\|Gene=eprs\|UniProtKB=A0A8M3ARK1	Danio rerio	LDO
CIOIN\|Ensembl=ENSCING00000007544.3\|UniProtKB=F6T8P3	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118419906\|UniProtKB=A0A9J7LGP4	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC581596\|UniProtKB=A0A7M7LTG2	Strongylocentrotus purpuratus	LDO
STRPU\|EnsemblGenome=LOC115929473\|UniProtKB=A0A7M7T508	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00004189\|UniProtKB=Q22620	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00042330\|UniProtKB=A8WK34	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00281812\|UniProtKB=A0A2A6BUB6	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00098841\|UniProtKB=A0A8R1U9L3	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00304743\|UniProtKB=A0A8R1V558	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0005674\|UniProtKB=P28668	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP002945\|UniProtKB=Q7PRA2	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC033635\|UniProtKB=A0A139WFQ4	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_227683\|UniProtKB=E9H862	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW018719\|UniProtKB=B7PKR5	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG78758\|UniProtKB=T1G3F3	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG103731\|UniProtKB=T1EDH0	helobdella robusta	LDO
TRIAD\|EnsemblGenome=TriadG54976\|UniProtKB=B3RQG2	Trichoplax adhaerens	LDO
YEAST\|SGD=S000001062\|UniProtKB=P38708	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_AEL021C\|UniProtKB=Q757N3	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000176548\|UniProtKB=Q59R20	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_E05027g\|UniProtKB=Q6C6Z6	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_02150\|UniProtKB=Q5BBD0	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_2G16010\|UniProtKB=Q4WZR7	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU04449\|UniProtKB=Q7RWB7	Neurospora crassa	LDO
SCLS1\|EnsemblGenome=SS1G_08648\|UniProtKB=A7ETJ2	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_14060\|UniProtKB=Q0U2H3	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPBC19C7.06\|UniProtKB=O60155	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_01259\|UniProtKB=B6K068	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNB05640\|UniProtKB=Q5KLD7	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_00855\|UniProtKB=A0A0D1E965	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_18362\|UniProtKB=E3L752	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_15636\|UniProtKB=F4NSZ0	Batrachochytrium dendrobatidis	LDO
ENTH1\|EnsemblGenome=CL6EHI_040400\|UniProtKB=C4M2G9	Entamoeba histolytica	LDO
DICDI\|dictyBase=DDB_G0284197\|UniProtKB=Q54Q07	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_45022\|UniProtKB=F0Z8H2	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_18_1210\|UniProtKB=Q4QDS1	Leishmania major	LDO
LEIMA\|EnsemblGenome=LMJF_18_1220\|UniProtKB=Q4QDS0	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb10.389.0630\|UniProtKB=Q388V7	Trypanosoma brucei	LDO
PLAF7\|EnsemblGenome=PF3D7_1213800\|UniProtKB=Q8I5R7	Plasmodium falciparum	LDO
PARTE\|EnsemblGenome=GSPATT00000999001\|UniProtKB=A0CKG8	Paramecium tetraurelia	LDO
PARTE\|EnsemblGenome=GSPATT00000079001\|UniProtKB=Q6BFG9	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00008815001\|UniProtKB=A0CNK6	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00003434001\|UniProtKB=A0E5K6	Paramecium tetraurelia	O
THAPS\|EnsemblGenome=THAPSDRAFT_264365\|UniProtKB=B8LCI1	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3GKZ2_PHYRM\|UniProtKB=H3GKZ2	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_07g351300v5\|UniProtKB=A0A2K3DLB8	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_10g429100v5\|UniProtKB=A0A2K3D9Q8	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00058p00127050\|UniProtKB=W1PFT0	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_112G00560\|UniProtKB=A0A0K9Q5C3	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma04_g09380\|UniProtKB=A0A804IMU0	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_015090mg\|UniProtKB=K3YLG6	Setaria italica	O
SETIT\|EnsemblGenome=SETIT_021775mg\|UniProtKB=K3Z5F7	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3009G175300\|UniProtKB=C5YZU3	Sorghum bicolor	O
SORBI\|EnsemblGenome=SORBI_3007G180100\|UniProtKB=C5YH58	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb073240\|UniProtKB=A0A804MBI7	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb202580\|UniProtKB=K7UDG5	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os12g0443700\|UniProtKB=Q2QS11	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_4g07854v3\|UniProtKB=I1IIK4	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.7HG0669220\|UniProtKB=A0A8I6Y6W4	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS7B02G107300\|UniProtKB=A0A3B6SED2	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS7D02G203800\|UniProtKB=A0A3B6TGM1	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS7A02G200500\|UniProtKB=A0A3B6RCP8	Triticum aestivum	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0309270\|UniProtKB=A0A8I6XCG6	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS3A02G419600\|UniProtKB=A0A3B6EQF4	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G455000\|UniProtKB=A0A077RYX7	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1B02G342200\|UniProtKB=A0A3B5Z1S9	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3D02G415200\|UniProtKB=A0A3B6GZ62	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1D02G210600\|UniProtKB=A0A3B5ZUA0	Triticum aestivum	LDO
NELNU\|Gene=LOC104593391\|UniProtKB=A0A1U8Q189	Nelumbo nucifera	O
NELNU\|Gene=LOC104612218\|UniProtKB=A0A1U8BKV2	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110798449\|UniProtKB=A0A9R0K5K3	Spinacia oleracea	LDO
HELAN\|Gene_ORFName=HanXRQr2_Chr15g0694481\|UniProtKB=A0A9K3E267	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C900493460\|UniProtKB=A0A9R1UCP1	Lactuca sativa	O
LACSA\|Gene_ORFName=LSAT_V11C800430380\|UniProtKB=A0A9R1URR5	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a004835mg\|UniProtKB=A0A022QDE7	Erythranthe guttata	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a004863mg\|UniProtKB=A0A022R6H7	Erythranthe guttata	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400014136\|UniProtKB=M1B3Z4	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc03g117330.3\|UniProtKB=A0A3Q7FRV5	Solanum lycopersicum	O
TOBAC\|Gene=LOC107825813\|UniProtKB=A0A1S4D4E3	Nicotiana tabacum	O
TOBAC\|Gene=LOC107809645\|UniProtKB=A0A1S4BML9	Nicotiana tabacum	O
CAPAN\|EnsemblGenome=T459_17522\|UniProtKB=A0A1U8HBG0	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400028502\|UniProtKB=M1CRV0	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc06g068320.3\|UniProtKB=A0A3Q7HT73	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107765319\|UniProtKB=A0A1S3XHM8	Nicotiana tabacum	O
TOBAC\|Gene=LOC107795811\|UniProtKB=A0A1S4ABM4	Nicotiana tabacum	O
TOBAC\|Gene=LOC107795810\|UniProtKB=A0A1S4ABF8	Nicotiana tabacum	O
TOBAC\|Gene=LOC107829030\|UniProtKB=A0A1S4DEQ0	Nicotiana tabacum	LDO
VITVI\|EnsemblGenome=Vitvi07g00529\|UniProtKB=D7U2U2	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_K00563\|UniProtKB=A0A059A097	Eucalyptus grandis	O
EUCGR\|EnsemblGenome=EUGRSUZ_J00690\|UniProtKB=A0A059AB74	Eucalyptus grandis	LDO
BRANA\|Gene_ORFName=GSBRNA2T00028951001\|UniProtKB=A0A078GIU2	Brassica napus	O
BRACM\|EnsemblGenome=Bra003487\|UniProtKB=M4CH04	Brassica campestris	O
BRANA\|Gene_ORFName=GSBRNA2T00028950001\|UniProtKB=A0A078GIA6	Brassica napus	O
BRACM\|EnsemblGenome=Bra003486\|UniProtKB=M4CH03	Brassica campestris	O
BRANA\|Gene_ORFName=GSBRNA2T00049468001\|UniProtKB=A0A078FEM2	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra029197\|UniProtKB=M4EK80	Brassica campestris	O
BRACM\|EnsemblGenome=Bra028248\|UniProtKB=M4EHI3	Brassica campestris	O
BRACM\|EnsemblGenome=Bra007663\|UniProtKB=A0A397Y298	Brassica campestris	LDO
ARATH\|TAIR=locus=2098053\|UniProtKB=Q9M1R2	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107960196\|UniProtKB=A0A1U8PLA6	Gossypium hirsutum	LDO
GOSHI\|Gene=LOC107922884\|UniProtKB=A0A1U8L1N5	Gossypium hirsutum	O
GOSHI\|Gene=LOC107945987\|UniProtKB=A0A1U8N968	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_004945\|UniProtKB=A0A061DRL1	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g010398mg\|UniProtKB=A0A067H4L9	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_002G187000v3\|UniProtKB=A0A2K2BKY7	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_014G112400v3\|UniProtKB=A9PFZ9	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_01G235100\|UniProtKB=A0A2C9WQW1	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_1343320\|UniProtKB=B9RN41	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_03G224500\|UniProtKB=I1JQX3	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_19G221400\|UniProtKB=I1NBI4	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_3g048190\|UniProtKB=G7IXY9	Medicago truncatula	O
MEDTR\|EnsemblGenome=MTR_3g114570\|UniProtKB=G7J5V4	Medicago truncatula	O
MEDTR\|EnsemblGenome=MTR_7g110660\|UniProtKB=G7KUM3	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr08_10540\|UniProtKB=A0A2I4FMR5	Juglans regia	O
JUGRE\|EnsemblGenome=Jr11_17090\|UniProtKB=A0A2I4GGY8	Juglans regia	LDO
JUGRE\|EnsemblGenome=Jr08_10560\|UniProtKB=A0A2I4FMN0	Juglans regia	O
JUGRE\|EnsemblGenome=Jr08_10550\|UniProtKB=A0A6P9F1W1	Juglans regia	O
JUGRE\|EnsemblGenome=Jr11_17100\|UniProtKB=A0A2I4GGZ2	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_4G015750\|UniProtKB=A0A0A0KTZ1	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_1G103500\|UniProtKB=A0A251QV87	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_74713\|UniProtKB=D8QP68	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_118068\|UniProtKB=D8SIV6	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c2_3850\|UniProtKB=A0A2K1L033	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0025s0131\|UniProtKB=A0A2R6XBG2	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_000390420\|UniProtKB=A0A1Y1HP82	Klebsormidium nitens	LDO
NITMS\|EnsemblGenome=Nmar_0658\|UniProtKB=A9A3C5	Nitrosopumilus maritimus	LDO
HALSA\|EnsemblGenome=VNG_0403G\|UniProtKB=Q9HS52	Halobacterium salinarum	LDO
CHLAA\|EnsemblGenome=Caur_1310\|UniProtKB=A9W9Q2	Chloroflexus aurantiacus	LDO
MYCGE\|EnsemblGenome=MG_283\|UniProtKB=P47525	mycoplasma genitalium	LDO
BACCR\|EnsemblGenome=BC_0439\|UniProtKB=Q81IE9	Bacillus cereus	LDO
DEIRA\|EnsemblGenome=DR_1266\|UniProtKB=Q9RUW4	Deinococcus radiodurans	LDO
BACTN\|EnsemblGenome=BT_0929\|UniProtKB=Q8A988	Bacteroides thetaiotaomicron	LDO
RHOBA\|EnsemblGenome=RB5178\|UniProtKB=Q7UGJ7	Rhodopirellula baltica	LDO
DICTD\|EnsemblGenome=Dtur_0830\|UniProtKB=B8E028	Dictyoglomus turgidum	LDO