PANTHER Gene Information

Gene Symbol(s):

PIK3CG

Organism:

Pan troglodytes

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Gene Name:

phosphatidylinositol-4,5-bisphosphate 3-kinase

Gene ID:

ENSPTRG00000019573.6

Protein ID:

A0A2J8QY32

Persistent Id:

PTN000005817

Alternate Ids:

A0A2J8QY32_PANTR(UniProtKB-ID)	ENSPTRT00000043957(Ensembl_TRS)
XM_519303(refSeq)	AC188593(EMBL)
ENSPTRP00000044953(Ensembl_PRO)	A0A2J8QY32(Synonym)
114615370(GI)	463649(GeneID)
ENSPTRG00000019573(Ensembl)
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PANTHER Classification

PANTHER Family:	PHOSPHATIDYLINOSITOL KINASE (PTHR10048)
PANTHER Subfamily:	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM (PTHR10048:SF34)
PANTHER GO-slim Molecular Function:	lipid kinase activity phosphotransferase activity, alcohol group as acceptor
PANTHER GO-slim Biological Process:	cell migration phosphatidylinositol phosphate biosynthetic process phosphatidylinositol 3-kinase/protein kinase B signal transduction
PANTHER GO-slim Cellular Component:	phosphatidylinositol 3-kinase complex plasma membrane cytoplasm
PANTHER protein class:	kinase

Pathway Categories:

T cell activation

Phosphatidylinositol 3-kinase

Ras Pathway

Phosphatidylinositol 3-kinase

Insulin/IGF pathway-protein kinase B signaling cascade

Phosphatidylinositol 3-kinase

Inflammation mediated by chemokine and cytokine signaling pathway

Phosphatidylinositol 3-kinase

Endothelin signaling pathway

Phosphatidylinositol 3-kinase

p53 pathway feedback loops 2

Phosphatidylinositol 3-kinase

p53 pathway

Phosphatidylinositol 3-kinase

VEGF signaling pathway

Phosphatidylinositol 3-kinase

Hypoxia response via HIF activation

Phosphatidylinositol 3-kinase

FGF signaling pathway

Phosphatidylinositol 3-kinase

EGF receptor signaling pathway

Phosphatidylinositol 3-kinase

Angiogenesis

Phosphatidylinositol 3-kinase

Integrin signalling pathway

Phosphatidylinositol 3-kinase

Axon guidance mediated by netrin

Phosphatidylinositol 3-kinase

PDGF signaling pathway

Phosphatidylinositol 3-kinase

B cell activation

Phosphatidylinositol 3-kinase

Apoptosis signaling pathway

Phosphatidylinositol 3-kinase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	ATP binding, identical protein binding, ephrin receptor binding, 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity, kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, protein serine kinase activity, 1-phosphatidylinositol-3-kinase activity
GO BP Complete:	positive regulation of Rac protein signal transduction, negative regulation of fibroblast apoptotic process, G protein-coupled receptor signaling pathway, regulation of calcium ion transmembrane transport, phosphatidylinositol-3-phosphate biosynthetic process, regulation of angiogenesis, phosphatidylinositol phosphate biosynthetic process, sphingosine-1-phosphate receptor signaling pathway, phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol-mediated signaling, lipid metabolic process, cellular response to cAMP, positive regulation of endothelial cell migration, cell migration, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO CC Complete:	phosphatidylinositol 3-kinase complex, class IA, phosphatidylinositol 3-kinase complex, class IB, cytoplasm, membrane, cytosol, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=8978\|UniProtKB=P48736	Homo sapiens	LDO
GORGO\|Ensembl=ENSGGOG00000014735.3\|UniProtKB=G3S7D1	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000011385.3\|UniProtKB=F6W7C8	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1353576\|UniProtKB=Q9JHG7	Mus musculus	LDO
RAT\|RGD=1306468\|UniProtKB=D3ZFJ0	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000020848.6\|UniProtKB=A0A3Q1M2L5	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000027272.3\|UniProtKB=I3LJB7	Sus scrofa	O
PIG\|Gene=PIK3CG\|UniProtKB=O02697	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000019708.4\|UniProtKB=F7DD93	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000004554.6\|UniProtKB=M3W2E5	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845026701.1\|UniProtKB=A0A8I3S601	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000016386.4\|UniProtKB=F7E9G2	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000049478.1\|UniProtKB=A0A6I8PK17	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010009050.1\|UniProtKB=A0A8V0XVL2	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000014783.3\|UniProtKB=G1KQF3	Anolis carolinensis	LDO
XENLA\|Gene=LOC108711184\|UniProtKB=A0A8J1MN31	Xenopus laevis	O
XENLA\|Gene=pik3cg.S\|UniProtKB=A0A1L8GTX9	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-1011009\|UniProtKB=A0A8J0S934	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000001750.2\|UniProtKB=H2L8L2	Oryzias latipes	O
DANRE\|Gene=si=rp71-17i16.5\|UniProtKB=A0A8M9Q3P0	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000013171.1\|UniProtKB=W5N6H2	lepisosteus oculatus	O
ORYLA\|Ensembl=ENSORLG00000009458.2\|UniProtKB=H2M0C9	Oryzias latipes	LDO
DANRE\|Gene=pik3cg\|UniProtKB=A0A8M9Q5U7	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000015829.1\|UniProtKB=W5NFS7	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000006921.3\|UniProtKB=F6VP00	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118430400\|UniProtKB=A0A9J7MA80	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC754280\|UniProtKB=A0A7M7SZL6	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00000090\|UniProtKB=Q94125	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG02868\|UniProtKB=P0C5E7	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00108058\|UniProtKB=A0A2A6CZC4	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00277220\|UniProtKB=A0A2A6CYZ1	Pristionchus pacificus	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_333863\|UniProtKB=E9HU18	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_300912\|UniProtKB=E9HFD3	Daphnia pulex	O
HELRO\|EnsemblGenome=HelroG155850\|UniProtKB=T1ELN4	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g242402\|UniProtKB=A7S2J3	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG26293\|UniProtKB=B3RZJ1	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_7145\|UniProtKB=A9UW25	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_18656\|UniProtKB=A9UWS0	Monosiga brevicollis	O
ENTH1\|EnsemblGenome=EHI_188970\|UniProtKB=C4M2W4	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_006130\|UniProtKB=C4M2P7	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_095130\|UniProtKB=C4M4S6	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_040690\|UniProtKB=C4M5P0	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_009890\|UniProtKB=C4M0Q4	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_013980\|UniProtKB=C4LXN9	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0268548\|UniProtKB=Q55FX5	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_38568\|UniProtKB=F0ZUR5	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0291093\|UniProtKB=Q54F55	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_96754\|UniProtKB=F0ZAX6	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0283081\|UniProtKB=P54674	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_52203\|UniProtKB=F0Z7E7	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0282625\|UniProtKB=Q54S78	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_35373\|UniProtKB=F0ZP96	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0275011\|UniProtKB=P54675	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_149892\|UniProtKB=F0ZEX7	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0278727\|UniProtKB=P54673	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_58194\|UniProtKB=F0ZZM8	Dictyostelium purpureum	O
GIAIC\|EnsemblGenome=GL50803_14855\|UniProtKB=A8B5J3	Giardia intestinalis	O
TRIV3\|Gene_ORFName=TVAG_393100\|UniProtKB=A2DYA6	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_344900\|UniProtKB=A2F0T8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_083340\|UniProtKB=A2DM61	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_284350\|UniProtKB=A2EN93	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_101460\|UniProtKB=A2DJM8	Trichomonas vaginalis	O
PARTE\|EnsemblGenome=GSPATT00018694001\|UniProtKB=A0DN72	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00019938001\|UniProtKB=A0DT78	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00012877001\|UniProtKB=A0D2V1	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00027505001\|UniProtKB=A0EIN5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00039649001\|UniProtKB=A0DLV0	Paramecium tetraurelia	O
PHYRM\|Gene=H3GL97_PHYRM\|UniProtKB=H3GL97	Phytophthora ramorum	O
PHYRM\|Gene=H3GLA1_PHYRM\|UniProtKB=H3GLA1	Phytophthora ramorum	O
KLENI\|Gene_ORFName=KFL_003910060\|UniProtKB=A0A1Y1IAN1	Klebsormidium nitens	O