PANTHER Gene Information   
Gene Symbol(s): PIK3CA
Organism: Canis lupus familiaris
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Gene Name: phosphatidylinositol-4,5-bisphosphate 3-kinase
Gene ID: ENSCAFG00845015587.1
Protein ID: A0A5F4C2B1
Persistent Id: PTN000005768
Alternate Ids:
XP_545208(refSeq) A0A5F4C2B1_CANLF(UniProtKB-ID)
BCU05156(EMBL-CDS) ENSCAFG00845015587(Ensembl)
ENSCAFT00845027831(Ensembl_TRS) A0A5F4C2B1(Synonym)
488084(GeneID) ENSCAFP00845021905(Ensembl_PRO)
74003159(GI) LC625864(EMBL)
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PANTHER Classification
PANTHER Family: PHOSPHATIDYLINOSITOL KINASE (PTHR10048)
PANTHER Subfamily: PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (PTHR10048:SF107)  
PANTHER GO-slim Molecular Function: lipid kinase activity
phosphotransferase activity, alcohol group as acceptor
PANTHER GO-slim Biological Process: cell migration
phosphatidylinositol phosphate biosynthetic process
phosphatidylinositol 3-kinase/protein kinase B signal transduction
PANTHER GO-slim Cellular Component: phosphatidylinositol 3-kinase complex
plasma membrane
cytoplasm
PANTHER protein class: kinase
Pathway Categories: PI3 kinase pathway
   p110
T cell activation
   Phosphatidylinositol 3-kinase
p53 pathway
   p110alpha
PI3 kinase pathway
   Activated p110
Ras Pathway
   Phosphatidylinositol 3-kinase
p53 pathway feedback loops 2
   P110alpha
Insulin/IGF pathway-protein kinase B signaling cascade
   Phosphatidylinositol 3-kinase
Inflammation mediated by chemokine and cytokine signaling pathway
   Phosphatidylinositol 3-kinase
Endothelin signaling pathway
   Phosphatidylinositol 3-kinase
p53 pathway feedback loops 2
   Phosphatidylinositol 3-kinase
Insulin/IGF pathway-protein kinase B signaling cascade
   p110alpha
Insulin/IGF pathway-protein kinase B signaling cascade
   P110alpha
p53 pathway
   Phosphatidylinositol 3-kinase
Interleukin signaling pathway
   Phosphatidylinositol 3-kinase
VEGF signaling pathway
   Phosphatidylinositol 3-kinase
Hypoxia response via HIF activation
   Phosphatidylinositol 3-kinase
FGF signaling pathway
   Phosphatidylinositol 3-kinase
p53 pathway
   Phosphatidylinositol 3-kinase, catalytic subunit, alpha
Angiogenesis
   Phosphatidylinositol 3-kinase
EGF receptor signaling pathway
   Phosphatidylinositol 3-kinase
Integrin signalling pathway
   Phosphatidylinositol 3-kinase
p53 pathway feedback loops 2
   P110ALPHA
Axon guidance mediated by netrin
   Phosphatidylinositol 3-kinase
PDGF signaling pathway
   Phosphatidylinositol 3-kinase
Apoptosis signaling pathway
   Phosphatidylinositol 3-kinase
B cell activation
   Phosphatidylinositol 3-kinase

GO MF Complete: ATP binding, 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, 1-phosphatidylinositol-3-kinase activity
GO BP Complete: phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol-mediated signaling, phosphatidylinositol-3-phosphate biosynthetic process, cell migration
GO CC Complete: phosphatidylinositol 3-kinase complex, class IA, phosphatidylinositol 3-kinase complex, class IB, cytoplasm, plasma membrane
Reactome Pathways: Signaling by FGFR3, PI3K Cascade, Interleukin-3, Interleukin-5 and GM-CSF signaling, Signaling by Interleukins, Signaling by FGFR4, Insulin receptor signalling cascade, IRS-related events triggered by IGF1R, Signaling by Insulin receptor, IGF1R signaling cascade, CD28 dependent PI3K/Akt signaling, CD28 co-stimulation, Signaling by VEGF, Signaling by NTRK1 (TRKA), Interleukin receptor SHC signaling, Synthesis of PIPs at the plasma membrane, PI3K events in ERBB4 signaling, RAC2 GTPase cycle, Signaling by GPCR, MAPK1/MAPK3 signaling, RHO GTPase cycle, Role of LAT2/NTAL/LAB on calcium mobilization, Developmental Biology, DAP12 signaling, IRS-mediated signalling, Downstream signaling of activated FGFR3, Extra-nuclear estrogen signaling, Signaling by SCF-KIT, Signaling by ERBB4, PI-3K cascade:FGFR2, Downstream signaling of activated FGFR2, Tie2 Signaling, VEGFA-VEGFR2 Pathway, Axon guidance, Metabolism of lipids, Fcgamma receptor (FCGR) dependent phagocytosis, Downstream TCR signaling, Signal Transduction, Innate Immune System, PIP3 activates AKT signaling, Signaling by MET, Intracellular signaling by second messengers, Signaling by FGFR2, Regulation of signaling by CBL, Metabolism, Signaling by FGFR1, PI Metabolism, Phospholipid metabolism, Downstream signaling of activated FGFR1, PI-3K cascade:FGFR4, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, PI-3K cascade:FGFR1, Costimulation by the CD28 family, Nervous system development, Signaling by Erythropoietin, RAF/MAP kinase cascade, Role of phospholipids in phagocytosis, Signaling by Nuclear Receptors, G alpha (q) signalling events, Cell surface interactions at the vascular wall, Signaling by Rho GTPases, Signaling by ERBB2, Signaling by FGFR, Signaling by Receptor Tyrosine Kinases, Immune System, Interleukin-2 family signaling, Downstream signal transduction, DAP12 interactions, PI3K events in ERBB2 signaling, RAC1 GTPase cycle, MET activates PI3K/AKT signaling, ESR-mediated signaling, GPCR downstream signalling, Fc epsilon receptor (FCERI) signaling, GPVI-mediated activation cascade, PI3K/AKT activation, PI-3K cascade:FGFR3, Signaling by PDGF, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, Platelet activation, signaling and aggregation, Adaptive Immune System, Signaling by NTRKs, TCR signaling, RET signaling, Cytokine Signaling in Immune system, Signaling by EGFR, Hemostasis, Erythropoietin activates Phosphoinositide-3-kinase (PI3K), Signaling by ALK, Downstream signaling of activated FGFR4, GAB1 signalosome, Negative regulation of the PI3K/AKT network, FLT3 Signaling, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), MAPK family signaling cascades