PANTHER Gene Information

Gene Symbol(s):

PIK3CA

Organism:

Ornithorhynchus anatinus

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Gene Name:

phosphatidylinositol-4,5-bisphosphate 3-kinase

Gene ID:

ENSOANG00000013922.3

Protein ID:

F7DUD6

Persistent Id:

PTN000005772

Alternate Ids:

F7DUD6(Synonym)	100073788(GeneID)
149632470(GI)	ENSOANG00000013922(Ensembl)
XP_007664598(refSeq)	F7DUD6_ORNAN(UniProtKB-ID)
ENSOANP00000021943(Ensembl_PRO)	ENSOANT00000021947(Ensembl_TRS)
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PANTHER Classification

PANTHER Family:	PHOSPHATIDYLINOSITOL KINASE (PTHR10048)
PANTHER Subfamily:	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (PTHR10048:SF107)
PANTHER GO-slim Molecular Function:	lipid kinase activity phosphotransferase activity, alcohol group as acceptor
PANTHER GO-slim Biological Process:	cell migration phosphatidylinositol phosphate biosynthetic process phosphatidylinositol 3-kinase/protein kinase B signal transduction
PANTHER GO-slim Cellular Component:	phosphatidylinositol 3-kinase complex plasma membrane cytoplasm
PANTHER protein class:	kinase

Pathway Categories:

PI3 kinase pathway

p110

T cell activation

Phosphatidylinositol 3-kinase

p53 pathway

p110alpha

PI3 kinase pathway

Activated p110

Ras Pathway

Phosphatidylinositol 3-kinase

p53 pathway feedback loops 2

P110alpha

Insulin/IGF pathway-protein kinase B signaling cascade

Phosphatidylinositol 3-kinase

Inflammation mediated by chemokine and cytokine signaling pathway

Phosphatidylinositol 3-kinase

Endothelin signaling pathway

Phosphatidylinositol 3-kinase

p53 pathway feedback loops 2

Phosphatidylinositol 3-kinase

Insulin/IGF pathway-protein kinase B signaling cascade

p110alpha

Insulin/IGF pathway-protein kinase B signaling cascade

P110alpha

p53 pathway

Phosphatidylinositol 3-kinase

Interleukin signaling pathway

Phosphatidylinositol 3-kinase

VEGF signaling pathway

Phosphatidylinositol 3-kinase

Hypoxia response via HIF activation

Phosphatidylinositol 3-kinase

FGF signaling pathway

Phosphatidylinositol 3-kinase

p53 pathway

Phosphatidylinositol 3-kinase, catalytic subunit, alpha

Angiogenesis

Phosphatidylinositol 3-kinase

EGF receptor signaling pathway

Phosphatidylinositol 3-kinase

Integrin signalling pathway

Phosphatidylinositol 3-kinase

p53 pathway feedback loops 2

P110ALPHA

Axon guidance mediated by netrin

Phosphatidylinositol 3-kinase

PDGF signaling pathway

Phosphatidylinositol 3-kinase

Apoptosis signaling pathway

Phosphatidylinositol 3-kinase

B cell activation

Phosphatidylinositol 3-kinase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	ATP binding, protein kinase activator activity, insulin receptor substrate binding, 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity, kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, 1-phosphatidylinositol-3-kinase activity
GO BP Complete:	regulation of multicellular organism growth, insulin receptor signaling pathway, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol phosphate biosynthetic process, glucose metabolic process, regulation of actin filament organization, negative regulation of neuron apoptotic process, cellular response to insulin stimulus, phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of anoikis, cellular response to glucose stimulus, liver development, energy homeostasis, response to muscle stretch, cell migration, autosome genomic imprinting, negative regulation of fibroblast apoptotic process, cardiac muscle cell contraction, positive regulation of protein localization to membrane, vascular endothelial growth factor signaling pathway, insulin-like growth factor receptor signaling pathway, regulation of cellular respiration, adipose tissue development, negative regulation of actin filament depolymerization, cellular response to hydrostatic pressure, phosphatidylinositol-mediated signaling, regulation of gene expression, actin cytoskeleton organization, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, relaxation of cardiac muscle
GO CC Complete:	phosphatidylinositol 3-kinase complex, class IA, phosphatidylinositol 3-kinase complex, phosphatidylinositol 3-kinase complex, class IB, cytoplasm, intercalated disc, plasma membrane, lamellipodium

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=8975\|UniProtKB=P42336	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000015642.4\|UniProtKB=A0A2I3T7A8	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000009365.3\|UniProtKB=G3R1S6	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000005188.4\|UniProtKB=H9FVU5	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1206581\|UniProtKB=P42337	Mus musculus	LDO
RAT\|RGD=620916\|UniProtKB=A0A0G2K344	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000009232\|UniProtKB=P32871	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000030413.4\|UniProtKB=A0A5K1UB41	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000015019.4\|UniProtKB=F6VFI8	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000018737.5\|UniProtKB=A0A2I2UYM7	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845015587.1\|UniProtKB=A0A5F4C2B1	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000021305.5\|UniProtKB=F7G3I5	Monodelphis domestica	LDO
CHICK\|Ensembl=ENSGALG00010018296.1\|UniProtKB=O42391	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000004872.4\|UniProtKB=G1KDE7	Anolis carolinensis	LDO
XENLA\|Gene=pik3ca.L\|UniProtKB=A0A8J1KR78	Xenopus laevis	O
XENLA\|Gene=pik3ca.S\|UniProtKB=A0A1L8G3Z7	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-998106\|UniProtKB=B0BLW6	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000011644.2\|UniProtKB=H2LYJ3	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000008938.2\|UniProtKB=H2LYJ4	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-130409-1\|UniProtKB=F1QAD7	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000001119.1\|UniProtKB=W5LYS0	lepisosteus oculatus	LDO
BRAFL\|Gene=LOC118430400\|UniProtKB=A0A9J7MA80	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC754280\|UniProtKB=A0A7M7SZL6	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00000090\|UniProtKB=Q94125	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG02868\|UniProtKB=P0C5E7	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00108058\|UniProtKB=A0A2A6CZC4	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00277220\|UniProtKB=A0A2A6CYZ1	Pristionchus pacificus	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_333863\|UniProtKB=E9HU18	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_300912\|UniProtKB=E9HFD3	Daphnia pulex	LDO
HELRO\|EnsemblGenome=HelroG155850\|UniProtKB=T1ELN4	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g242402\|UniProtKB=A7S2J3	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG26293\|UniProtKB=B3RZJ1	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_7145\|UniProtKB=A9UW25	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_18656\|UniProtKB=A9UWS0	Monosiga brevicollis	O
ENTH1\|EnsemblGenome=EHI_188970\|UniProtKB=C4M2W4	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_006130\|UniProtKB=C4M2P7	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_095130\|UniProtKB=C4M4S6	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_040690\|UniProtKB=C4M5P0	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_009890\|UniProtKB=C4M0Q4	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_013980\|UniProtKB=C4LXN9	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0268548\|UniProtKB=Q55FX5	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_38568\|UniProtKB=F0ZUR5	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0291093\|UniProtKB=Q54F55	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_96754\|UniProtKB=F0ZAX6	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0283081\|UniProtKB=P54674	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_52203\|UniProtKB=F0Z7E7	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0282625\|UniProtKB=Q54S78	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_35373\|UniProtKB=F0ZP96	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0275011\|UniProtKB=P54675	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_149892\|UniProtKB=F0ZEX7	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0278727\|UniProtKB=P54673	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_58194\|UniProtKB=F0ZZM8	Dictyostelium purpureum	O
GIAIC\|EnsemblGenome=GL50803_14855\|UniProtKB=A8B5J3	Giardia intestinalis	O
TRIV3\|Gene_ORFName=TVAG_393100\|UniProtKB=A2DYA6	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_344900\|UniProtKB=A2F0T8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_083340\|UniProtKB=A2DM61	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_284350\|UniProtKB=A2EN93	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_101460\|UniProtKB=A2DJM8	Trichomonas vaginalis	O
PARTE\|EnsemblGenome=GSPATT00018694001\|UniProtKB=A0DN72	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00019938001\|UniProtKB=A0DT78	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00012877001\|UniProtKB=A0D2V1	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00027505001\|UniProtKB=A0EIN5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00039649001\|UniProtKB=A0DLV0	Paramecium tetraurelia	O
PHYRM\|Gene=H3GL97_PHYRM\|UniProtKB=H3GL97	Phytophthora ramorum	O
PHYRM\|Gene=H3GLA1_PHYRM\|UniProtKB=H3GLA1	Phytophthora ramorum	O
KLENI\|Gene_ORFName=KFL_003910060\|UniProtKB=A0A1Y1IAN1	Klebsormidium nitens	O