PANTHER Gene Information

Gene Symbol(s):

PIK3R2

Organism:

Macaca mulatta

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Gene Name:

Phosphatidylinositol 3-kinase regulatory subunit beta

Gene ID:

ENSMMUG00000003162.4

Protein ID:

F7EP57

Persistent Id:

PTN000016403

Alternate Ids:

ENSMMUG00000003162(Ensembl)	384475632(GI)
F7EP57_MACMU(UniProtKB-ID)	JU476014(EMBL)
719367(GeneID)	NM_001258052(refSeq)
ENSMMUT00000004480(Ensembl_TRS)	ENSMMUP00000004228(Ensembl_PRO)
AFH32818(EMBL-CDS)	F7EP57(Synonym)
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PANTHER Classification

PANTHER Family:	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT (PTHR10155)
PANTHER Subfamily:	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA (PTHR10155:SF1)
PANTHER GO-slim Molecular Function:	kinase regulator activity
PANTHER GO-slim Biological Process:	phosphatidylinositol phosphate biosynthetic process insulin receptor signaling pathway
PANTHER GO-slim Cellular Component:	phosphatidylinositol 3-kinase complex
PANTHER protein class:	kinase modulator

Pathway Categories:

VEGF signaling pathway

Phosphatidylinositol 3-kinase

PI3 kinase pathway

p85

T cell activation

Phosphatidylinositol 3-kinase

Hypoxia response via HIF activation

Phosphatidylinositol 3-kinase

Insulin/IGF pathway-protein kinase B signaling cascade

Phosphatidylinositol 3-kinase

Angiogenesis

Phosphatidylinositol 3-kinase

Integrin signalling pathway

Phosphatidylinositol 3-kinase

Axon guidance mediated by netrin

Phosphatidylinositol 3-kinase

Endothelin signaling pathway

Phosphatidylinositol 3-kinase

PDGF signaling pathway

Phosphatidylinositol 3-kinase

p53 pathway feedback loops 2

Phosphatidylinositol 3-kinase

p53 pathway

Phosphatidylinositol 3-kinase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	phosphotyrosine residue binding, protein phosphatase binding, phosphatidylinositol 3-kinase regulatory subunit binding, protein heterodimerization activity, kinase activity, receptor tyrosine kinase binding, 1-phosphatidylinositol-3-kinase regulator activity
GO BP Complete:	regulation of protein localization to plasma membrane, positive regulation of protein import into nucleus, signal transduction, insulin receptor signaling pathway, negative regulation of MAPK cascade, regulation of stress fiber assembly, positive regulation of cell adhesion, positive regulation of transcription by RNA polymerase II, regulation of actin filament polymerization, cellular response to insulin stimulus, phosphatidylinositol 3-kinase/protein kinase B signal transduction, intracellular glucose homeostasis, regulation of autophagy, response to endoplasmic reticulum stress
GO CC Complete:	phosphatidylinositol 3-kinase complex, class IA, nucleus, focal adhesion, cytosol

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=8980\|UniProtKB=O00459	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000010694.5\|UniProtKB=H2QFS6	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000016197.3\|UniProtKB=A0A2I2Y5U1	Gorilla gorilla gorilla	LDO
MOUSE\|MGI=MGI=1098772\|UniProtKB=O08908	Mus musculus	LDO
RAT\|RGD=68341\|UniProtKB=Q63788	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000002350\|UniProtKB=P23726	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000013900.5\|UniProtKB=F1S916	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000009499.4\|UniProtKB=A0A3Q2KJF6	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000026883.4\|UniProtKB=A0A337SCA8	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845023471.1\|UniProtKB=A0A8I3S3N2	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000001734.4\|UniProtKB=A0A5F8HJC4	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000001300.4\|UniProtKB=A0A6I8NZ71	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010027324.1\|UniProtKB=E1C2C5	Gallus gallus	LDO
XENLA\|Gene=pik3r2.L\|UniProtKB=A0A1L8HWT4	Xenopus laevis	O
XENLA\|Gene=pik3r2.S\|UniProtKB=A0A1L8HNI8	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-6077418\|UniProtKB=A0A6I8Q186	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000024065.1\|UniProtKB=A0A3B3H4F5	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-040309-1\|UniProtKB=B3DHG9	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000001519.1\|UniProtKB=W5M050	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000023616.1\|UniProtKB=F7BLX7	Ciona intestinalis	O
BRAFL\|Gene=LOC118432571\|UniProtKB=A0A9J7MFS2	Branchiostoma floridae	O
CAEEL\|WormBase=WBGene00000001\|UniProtKB=G5EDP9	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00032086\|UniProtKB=A8XBV2	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00117228\|UniProtKB=A0A2A6BTE0	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0020622\|UniProtKB=Q7KTZ2	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP005583\|UniProtKB=A0A1S4GQF6	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC030884\|UniProtKB=A0A139WP68	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_43714\|UniProtKB=E9G0D1	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_111818\|UniProtKB=E9HA70	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW011707\|UniProtKB=B7Q548	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG76166\|UniProtKB=T1G2G0	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g84479\|UniProtKB=A7RK55	Nematostella vectensis	O
MONBE\|EnsemblGenome=MONBRDRAFT_33139\|UniProtKB=A9V3X4	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_33736\|UniProtKB=A9V765	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_10565\|UniProtKB=A9V6R6	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_24251\|UniProtKB=A9UVV0	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_9122\|UniProtKB=A9V255	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_33646\|UniProtKB=A9V6S8	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_10537\|UniProtKB=A9V6N4	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_12142\|UniProtKB=A9VBC5	Monosiga brevicollis	O
PHYRM\|Gene=H3GME9_PHYRM\|UniProtKB=H3GME9	Phytophthora ramorum	O