PANTHER Gene Information

Gene Symbol(s):

PIK3C2A

Organism:

Pan troglodytes

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Gene Name:

Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha

Gene ID:

ENSPTRG00000003399.5

Protein ID:

H2Q383

Persistent Id:

PTN000005689

Alternate Ids:

ENSPTRG00000003399(Ensembl)	JAA18035(EMBL-CDS)
XP_001172532(refSeq)	694943581(GI)
ENSPTRT00000006426(Ensembl_TRS)	GABF01004110(EMBL)
ENSPTRP00000005931(Ensembl_PRO)	H2Q383_PANTR(UniProtKB-ID)
H2Q383(Synonym)	451052(GeneID)
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PANTHER Classification

PANTHER Family:	PHOSPHATIDYLINOSITOL KINASE (PTHR10048)
PANTHER Subfamily:	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA (PTHR10048:SF28)
PANTHER GO-slim Molecular Function:	lipid kinase activity phosphotransferase activity, alcohol group as acceptor
PANTHER GO-slim Biological Process:	cell migration phosphatidylinositol phosphate biosynthetic process phosphatidylinositol 3-kinase/protein kinase B signal transduction
PANTHER GO-slim Cellular Component:	phosphatidylinositol 3-kinase complex plasma membrane cytoplasm
PANTHER protein class:	kinase

Pathway Categories:

VEGF signaling pathway

Phosphatidylinositol 3-kinase

Hypoxia response via HIF activation

Phosphatidylinositol 3-kinase

Insulin/IGF pathway-protein kinase B signaling cascade

Phosphatidylinositol 3-kinase

FGF signaling pathway

Phosphatidylinositol 3-kinase

Angiogenesis

Phosphatidylinositol 3-kinase

EGF receptor signaling pathway

Phosphatidylinositol 3-kinase

Integrin signalling pathway

Phosphatidylinositol 3-kinase

Axon guidance mediated by netrin

Phosphatidylinositol 3-kinase

Endothelin signaling pathway

Phosphatidylinositol 3-kinase

p53 pathway feedback loops 2

Phosphatidylinositol 3-kinase

p53 pathway

Phosphatidylinositol 3-kinase

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	ATP binding, phosphatidylinositol binding, clathrin binding, 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity, kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, 1-phosphatidylinositol-3-kinase activity
GO BP Complete:	positive regulation of autophagy, phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol-mediated signaling, lipid metabolic process, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol phosphate biosynthetic process, endocytosis, positive regulation of cell migration involved in sprouting angiogenesis, cell migration
GO CC Complete:	trans-Golgi network, cytoplasm, intracellular membrane-bounded organelle, cytosol, vesicle, clathrin-coated vesicle, plasma membrane, nucleoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=8971\|UniProtKB=O00443	Homo sapiens	LDO
GORGO\|Ensembl=ENSGGOG00000011040.3\|UniProtKB=G3RRS8	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000022548.4\|UniProtKB=F6Y9J9	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1203729\|UniProtKB=Q61194	Mus musculus	LDO
RAT\|RGD=1310389\|UniProtKB=D3ZTF6	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000004901.6\|UniProtKB=E1BE68	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000025406.3\|UniProtKB=I3LLX2	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000014963.4\|UniProtKB=F6U9E2	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000023161.4\|UniProtKB=A0A2I2UT47	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845027085.1\|UniProtKB=A0A8I3SAR3	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000007062.5\|UniProtKB=F6PV08	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000007685.3\|UniProtKB=F6VDD2	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010023209.1\|UniProtKB=A0A8V0ZLS9	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000000045.4\|UniProtKB=G1K875	Anolis carolinensis	LDO
XENLA\|Gene=pik3c2a.S\|UniProtKB=A0A1L8GEH2	Xenopus laevis	O
XENLA\|Gene=pik3c2a.L\|UniProtKB=A0A1L8GIB5	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-484563\|UniProtKB=F6SUB4	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000001292.2\|UniProtKB=A0A3B3IHY8	Oryzias latipes	LDO
DANRE\|Gene=pik3c2a\|UniProtKB=A0A8M2B5U1	Danio rerio	LDO
DANRE\|Ensembl=ENSDARG00000109612.1\|UniProtKB=A0A2R8QSP1	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000002963.1\|UniProtKB=W5M537	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000023383.1\|UniProtKB=H2Y1I5	Ciona intestinalis	O
BRAFL\|Gene=LOC118414477\|UniProtKB=A0A9J7L1K4	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC586734\|UniProtKB=A0A7M7P313	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00009552\|UniProtKB=G5EDY0	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG07670\|UniProtKB=A8X4B6	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00095713\|UniProtKB=A0A2A6BJJ3	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0015278\|UniProtKB=Q7K3H0	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP011036\|UniProtKB=A0A1S4H5J3	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC034925\|UniProtKB=A0A139WAA5	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_303261\|UniProtKB=E9FU84	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW004026\|UniProtKB=B7PIF4	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW022811\|UniProtKB=B7QET6	Ixodes scapularis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g90881\|UniProtKB=A7RRA6	Nematostella vectensis	O
MONBE\|EnsemblGenome=MONBRDRAFT_28086\|UniProtKB=A9V757	Monosiga brevicollis	O
ENTH1\|EnsemblGenome=EHI_188970\|UniProtKB=C4M2W4	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_006130\|UniProtKB=C4M2P7	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_095130\|UniProtKB=C4M4S6	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_040690\|UniProtKB=C4M5P0	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_009890\|UniProtKB=C4M0Q4	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_013980\|UniProtKB=C4LXN9	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0268548\|UniProtKB=Q55FX5	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_38568\|UniProtKB=F0ZUR5	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0291093\|UniProtKB=Q54F55	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_96754\|UniProtKB=F0ZAX6	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0283081\|UniProtKB=P54674	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_52203\|UniProtKB=F0Z7E7	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0282625\|UniProtKB=Q54S78	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_35373\|UniProtKB=F0ZP96	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0275011\|UniProtKB=P54675	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_149892\|UniProtKB=F0ZEX7	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0278727\|UniProtKB=P54673	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_58194\|UniProtKB=F0ZZM8	Dictyostelium purpureum	O
GIAIC\|EnsemblGenome=GL50803_14855\|UniProtKB=A8B5J3	Giardia intestinalis	O
TRIV3\|Gene_ORFName=TVAG_393100\|UniProtKB=A2DYA6	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_344900\|UniProtKB=A2F0T8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_083340\|UniProtKB=A2DM61	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_284350\|UniProtKB=A2EN93	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_101460\|UniProtKB=A2DJM8	Trichomonas vaginalis	O
PARTE\|EnsemblGenome=GSPATT00018694001\|UniProtKB=A0DN72	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00019938001\|UniProtKB=A0DT78	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00012877001\|UniProtKB=A0D2V1	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00027505001\|UniProtKB=A0EIN5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00039649001\|UniProtKB=A0DLV0	Paramecium tetraurelia	O
PHYRM\|Gene=H3GL97_PHYRM\|UniProtKB=H3GL97	Phytophthora ramorum	O
PHYRM\|Gene=H3GLA1_PHYRM\|UniProtKB=H3GLA1	Phytophthora ramorum	O
KLENI\|Gene_ORFName=KFL_003910060\|UniProtKB=A0A1Y1IAN1	Klebsormidium nitens	O