PANTHER Gene Information

Gene Symbol(s):

PIK3C3

Organism:

Macaca mulatta

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Gene Name:

Phosphatidylinositol 3-kinase catalytic subunit type 3

Gene ID:

ENSMMUG00000014553.4

Protein ID:

H9ENP3

Persistent Id:

PTN000005971

Alternate Ids:

693918(GeneID)	ENSMMUP00000019111(Ensembl_PRO)
H9ENP3(Synonym)	ENSMMUT00000020418(Ensembl_TRS)
H9ENP3_MACMU(UniProtKB-ID)	AFH27474(EMBL-CDS)
JU320246(EMBL)	XM_001082892(refSeq)
ENSMMUG00000014553(Ensembl)	967489136(GI)
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PANTHER Classification

PANTHER Family:	PHOSPHATIDYLINOSITOL KINASE (PTHR10048)
PANTHER Subfamily:	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3 (PTHR10048:SF7)
PANTHER GO-slim Molecular Function:	lipid kinase activity phosphotransferase activity, alcohol group as acceptor
PANTHER GO-slim Biological Process:	autophagosome assembly phosphatidylinositol phosphate biosynthetic process endocytosis intracellular signal transduction
PANTHER GO-slim Cellular Component:	phosphatidylinositol 3-kinase complex, class III peroxisome endosome phagophore assembly site
PANTHER protein class:	kinase

Pathway Categories:

VEGF signaling pathway

Phosphatidylinositol 3-kinase

T cell activation

Phosphatidylinositol 3-kinase

Ras Pathway

Phosphatidylinositol 3-kinase

Hypoxia response via HIF activation

Phosphatidylinositol 3-kinase

Insulin/IGF pathway-protein kinase B signaling cascade

Phosphatidylinositol 3-kinase

FGF signaling pathway

Phosphatidylinositol 3-kinase

Angiogenesis

Phosphatidylinositol 3-kinase

EGF receptor signaling pathway

Phosphatidylinositol 3-kinase

Integrin signalling pathway

Phosphatidylinositol 3-kinase

Endothelin signaling pathway

Phosphatidylinositol 3-kinase

PDGF signaling pathway

Phosphatidylinositol 3-kinase

p53 pathway feedback loops 2

Phosphatidylinositol 3-kinase

p53 pathway

Phosphatidylinositol 3-kinase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	phosphatidylinositol kinase activity, ATP binding, protein kinase activity, kinase activity, 1-phosphatidylinositol-3-kinase activity
GO BP Complete:	protein localization to phagophore assembly site, positive regulation by host of viral genome replication, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol phosphate biosynthetic process, pexophagy, cellular response to starvation, endocytosis, cellular response to glucose starvation, autophagosome assembly, autophagosome maturation, phosphatidylinositol-mediated signaling, synaptic vesicle endocytosis, autophagy, lipid metabolic process, regulation of autophagy, early endosome to late endosome transport, regulation of macroautophagy, regulation of cytokinesis, macroautophagy
GO CC Complete:	phosphatidylinositol 3-kinase complex, class III, type II, phosphatidylinositol 3-kinase complex, class III, type I, phagophore assembly site, phosphatidylinositol 3-kinase complex, class III, late endosome, phagocytic vesicle, autolysosome, GABA-ergic synapse, peroxisome, endosome, postsynapse, cytoplasm, presynaptic endosome, membrane, postsynaptic endosome, midbody, glutamatergic synapse

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=8974\|UniProtKB=Q8NEB9	Homo sapiens	LDO
MOUSE\|MGI=MGI=2445019\|UniProtKB=Q6PF93	Mus musculus	LDO
RAT\|RGD=620899\|UniProtKB=O88763	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000026290.5\|UniProtKB=F1MTL5	Bos taurus	LDO
PIG\|Gene=PIK3C3\|UniProtKB=Q5D891	Sus scrofa	O
PIG\|Ensembl=ENSSSCG00000003749.5\|UniProtKB=F1SAI0	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000010657.4\|UniProtKB=A0A3Q2KR82	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000022869.4\|UniProtKB=M3XFX9	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845003885.1\|UniProtKB=A0A8I3MWD3	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000000219.4\|UniProtKB=A0A5F8GF03	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000003359.3\|UniProtKB=A0A6I8N9B8	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010009548.1\|UniProtKB=A0A3Q2UDQ7	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000013961.4\|UniProtKB=A0A803TMD1	Anolis carolinensis	LDO
XENLA\|Gene=pik3c3.L\|UniProtKB=A0A8J0U6Q4	Xenopus laevis	LDO
XENLA\|Gene=pik3c3.S\|UniProtKB=A0A8J1M5J9	Xenopus laevis	O
XENLA\|Gene=pik3c3\|UniProtKB=Q6AZN6	Xenopus laevis	LDO
XENTR\|Gene=pik3c3\|UniProtKB=A0A8J1J1B5	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000007721.2\|UniProtKB=A0A3B3HSF3	Oryzias latipes	LDO
DANRE\|Gene=pik3c3\|UniProtKB=A0A8M9QGZ6	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000009397.1\|UniProtKB=W5MSW9	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000003389.4\|UniProtKB=H2XJF2	Ciona intestinalis	LDO
BRAFL\|Gene_ORFName=BRAFLDRAFT_280369\|UniProtKB=C3Y1V6	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC591736\|UniProtKB=A0A7M7N8P2	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00006932\|UniProtKB=Q9TXI7	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00040729\|UniProtKB=A8Y1J0	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00306039\|UniProtKB=A0A8R1ZAI4	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0015277\|UniProtKB=Q9W1M7	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP010273\|UniProtKB=A0A1S4H3K1	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC000620\|UniProtKB=D6W9A3	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_188071\|UniProtKB=E9GGF7	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW008679\|UniProtKB=B7Q1P7	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG113006\|UniProtKB=T1EFP5	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g91901\|UniProtKB=A7RSD9	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG22684\|UniProtKB=B3RSP8	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_21897\|UniProtKB=A9UNY0	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_30053\|UniProtKB=A9VCW1	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_34747\|UniProtKB=A9VDS0	Monosiga brevicollis	LDO
YEAST\|SGD=S000004230\|UniProtKB=P22543	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_AGL113C\|UniProtKB=Q750Q5	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000195103\|UniProtKB=A0A1D8PDV7	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_F09559g\|UniProtKB=Q6C299	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_04709\|UniProtKB=Q5B421	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_5G08670\|UniProtKB=Q4WUJ4	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU00656\|UniProtKB=Q7SHZ6	Neurospora crassa	LDO
SCLS1\|Gene_ORFName=SS1G_11324\|UniProtKB=A7F154	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_12889\|UniProtKB=Q0U5S5	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPAC458.05\|UniProtKB=P50520	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_00114\|UniProtKB=B6JXH5	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNB03120\|UniProtKB=Q5KM37	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_00453\|UniProtKB=A0A0D1E9M7	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_16800\|UniProtKB=E3L2M3	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_36168\|UniProtKB=F4PCU9	Batrachochytrium dendrobatidis	LDO
ENTH1\|EnsemblGenome=EHI_184240\|UniProtKB=C4M9Z9	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_091940\|UniProtKB=C4LUX1	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_193070\|UniProtKB=C4M9A9	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=EHI_096560\|UniProtKB=C4LWG8	Entamoeba histolytica	LDO
DICDI\|dictyBase=DDB_G0280813\|UniProtKB=Q54UU9	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_153093\|UniProtKB=F0ZN15	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0289601\|UniProtKB=P54676	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_155819\|UniProtKB=F0ZUZ3	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_30_1850\|UniProtKB=Q4Q7B0	Leishmania major	O
LEIMA\|EnsemblGenome=LMJF_24_2010\|UniProtKB=Q4QAC9	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb11.01.6980\|UniProtKB=Q381Q2	Trypanosoma brucei	O
TRYB2\|Gene_ORFName=Tb927.8.6210\|UniProtKB=Q57YM2	Trypanosoma brucei	LDO
GIAIC\|EnsemblGenome=GL50803_17406\|UniProtKB=A8B8M9	Giardia intestinalis	LDO
TRIV3\|Gene_ORFName=TVAG_006610\|UniProtKB=A2FTE2	Trichomonas vaginalis	LDO
TRIV3\|Gene_ORFName=TVAG_332500\|UniProtKB=A2FAC3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_046650\|UniProtKB=A2EAP0	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_045170\|UniProtKB=A2E8G5	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_247270\|UniProtKB=A2DKR5	Trichomonas vaginalis	O
PLAF7\|EnsemblGenome=PF3D7_0515300\|UniProtKB=Q8I3V5	Plasmodium falciparum	LDO
PARTE\|EnsemblGenome=GSPATT00022039001\|UniProtKB=A0E0Q4	Paramecium tetraurelia	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_36937\|UniProtKB=B8CAM6	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3GKJ2_PHYRM\|UniProtKB=H3GKJ2	Phytophthora ramorum	O
PHYRM\|Gene=H3H3A8_PHYRM\|UniProtKB=H3H3A8	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_01g035500v5\|UniProtKB=A0A2K3E706	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00028p00234070\|UniProtKB=W1PSL1	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_400G00090\|UniProtKB=A0A0K9P3A4	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma01_g14450\|UniProtKB=A0A804HU26	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_013269mg\|UniProtKB=K3YGA1	Setaria italica	LDO
MAIZE\|EnsemblGenome=Zm00001eb178330\|UniProtKB=K7UUC4	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os08g0307400\|UniProtKB=Q6UUD9	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_3g20220v3\|UniProtKB=A0A2K2CYH4	Brachypodium distachyon	O
ORYSJ\|EnsemblGenome=Os05g0180600\|UniProtKB=Q5KQK1	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_2g40030v3\|UniProtKB=A0A0Q3KB61	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.5HG0432290\|UniProtKB=A0A8I6XNN0	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS5B02G062000\|UniProtKB=A0A3B6LEX8	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS5D02G065700\|UniProtKB=A0A3B6ML65	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS5A02G054400\|UniProtKB=A0A3B6KBM5	Triticum aestivum	LDO
NELNU\|Gene=LOC104606043\|UniProtKB=A0A1U8AP65	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110782962\|UniProtKB=A0A9R0I597	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr17g0787051\|UniProtKB=A0A251RLR1	Helianthus annuus	O
HELAN\|Gene_ORFName=HanXRQr2_Chr06g0253031\|UniProtKB=A0A9K3ITQ4	Helianthus annuus	LDO
HELAN\|Gene_ORFName=HannXRQ_Chr14g0446801\|UniProtKB=A0A251SI74	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C300112320\|UniProtKB=A0A9R1XMQ1	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a001464mg\|UniProtKB=A0A022RS20	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_34843\|UniProtKB=A0A1U8GT76	Capsicum annuum	LDO
SOLLC\|EnsemblGenome=Solyc04g015350.3\|UniProtKB=A0A3Q7GS54	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107795370\|UniProtKB=A0A1S4AA19	Nicotiana tabacum	O
TOBAC\|Gene=LOC107788462\|UniProtKB=A0A1S3ZM66	Nicotiana tabacum	LDO
VITVI\|EnsemblGenome=Vitvi01g00712\|UniProtKB=D7TDH7	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_B01668\|UniProtKB=A0A059D3R6	Eucalyptus grandis	O
EUCGR\|EnsemblGenome=EUGRSUZ_H02571\|UniProtKB=A0A059B1Q8	Eucalyptus grandis	LDO
BRANA\|Gene_ORFName=DARMORV10_C09P21800.1\|UniProtKB=A0A078I8I2	Brassica napus	O
BRANA\|Gene_ORFName=DARMORV10_A09P17490.1\|UniProtKB=A0A078IUF8	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra027152\|UniProtKB=M4EEE0	Brassica campestris	LDO
ARATH\|TAIR=locus=2036546\|UniProtKB=P42339	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107922365\|UniProtKB=A0A1U8KZP3	Gossypium hirsutum	LDO
GOSHI\|Gene=LOC107916519\|UniProtKB=A0A1U8KJX9	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_010393\|UniProtKB=A0A061E791	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g003462mg\|UniProtKB=A0A067GRY2	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_012G075100v3\|UniProtKB=A0A2K1YAC9	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_12G027200\|UniProtKB=A0A2C9UT43	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_0528000\|UniProtKB=B9SH94	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_06G096300\|UniProtKB=I1K9Q4	Glycine max	O
SOYBN\|Gene=PI3K1_SOYBN\|UniProtKB=P42347	Glycine max	LDO
SOYBN\|Gene=PI3K2_SOYBN\|UniProtKB=P42348	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_04G094500\|UniProtKB=I1JV67	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_5g034120\|UniProtKB=Q8GUA6	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr16_09970\|UniProtKB=A0A2I4E6Q2	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_2G348290\|UniProtKB=A0A0A0LQK5	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_1G251400\|UniProtKB=M5Y2N0	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_129115\|UniProtKB=D8T0H3	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_97360\|UniProtKB=D8RMQ9	Selaginella moellendorffii	LDO
SELML\|EnsemblGenome=SELMODRAFT_118849\|UniProtKB=D8SKG0	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_268853\|UniProtKB=D8SLT8	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c10_8910\|UniProtKB=A0A2K1JYB4	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0003s0185\|UniProtKB=A0A2R6XT93	Marchantia polymorpha	LDO