PANTHER Gene Information   
Gene Symbol(s): PIK3CD
Organism: Homo sapiens
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Gene Name: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Gene ID: HGNC:8977
Protein ID: O00329
Enhancers: View enhancers for HUMAN|HGNC=8977|UniProtKB=O00329
Genetic Variant Annotation: Annoq
Persistent Id: PTN002467582
Alternate Ids:
PK3CD_HUMAN(UniProtKB-ID) AAI32922(EMBL-CDS)
MetaCyc:ENSG00000171608-MON(BioCyc) Q5SR49(AltAccession)
156564405(GI) 2.7.1.153 {ECO:0000269|PubMed:15135396}(EC)
JN190435(EMBL) ENSG00000171608(Ensembl)
PK3CD(Synonym) PIK3CD(Symbol)
602839(MIM) CHEMBL3130(ChEMBL)
5293(GeneID) HGNC:8977(HGNC)
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PANTHER Classification
PANTHER Family: PHOSPHATIDYLINOSITOL KINASE (PTHR10048)
PANTHER Subfamily: PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (PTHR10048:SF35)  
PANTHER GO-slim Molecular Function: phosphotransferase activity, alcohol group as acceptor
lipid kinase activity
PANTHER GO-slim Biological Process: phosphatidylinositol 3-kinase/protein kinase B signal transduction
cell migration
phosphatidylinositol phosphate biosynthetic process
PANTHER GO-slim Cellular Component: cytoplasm
plasma membrane
phosphatidylinositol 3-kinase complex
PANTHER protein class: kinase
Pathway Categories: T cell activation
   Phosphatidylinositol 3-kinase
Ras Pathway
   Phosphatidylinositol 3-kinase
Insulin/IGF pathway-protein kinase B signaling cascade
   Phosphatidylinositol 3-kinase
Inflammation mediated by chemokine and cytokine signaling pathway
   Phosphatidylinositol 3-kinase
Endothelin signaling pathway
   Phosphatidylinositol 3-kinase
p53 pathway feedback loops 2
   Phosphatidylinositol 3-kinase
p53 pathway
   Phosphatidylinositol 3-kinase
VEGF signaling pathway
   Phosphatidylinositol 3-kinase
Hypoxia response via HIF activation
   Phosphatidylinositol 3-kinase
FGF signaling pathway
   Phosphatidylinositol 3-kinase
EGF receptor signaling pathway
   Phosphatidylinositol 3-kinase
Angiogenesis
   Phosphatidylinositol 3-kinase
Integrin signalling pathway
   Phosphatidylinositol 3-kinase
Axon guidance mediated by netrin
   Phosphatidylinositol 3-kinase
PDGF signaling pathway
   Phosphatidylinositol 3-kinase
B cell activation
   Phosphatidylinositol 3-kinase
Apoptosis signaling pathway
   Phosphatidylinositol 3-kinase
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: ATP binding, protein binding, 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, 1-phosphatidylinositol-3-kinase activity
GO BP Complete: phosphatidylinositol-3-phosphate biosynthetic process, T cell activation, B cell activation, protein phosphorylation, mast cell degranulation, positive regulation of angiogenesis, inflammatory response, phosphatidylinositol 3-kinase/protein kinase B signal transduction, immune response, T cell chemotaxis, respiratory burst involved in defense response, natural killer cell activation, positive regulation of endothelial cell migration, cell migration, B cell chemotaxis, T cell receptor signaling pathway, B cell receptor signaling pathway, mast cell differentiation, B cell differentiation, signal transduction, positive regulation of neutrophil apoptotic process, positive regulation of epithelial tube formation, vascular endothelial growth factor signaling pathway, adaptive immune response, mast cell chemotaxis, T cell differentiation, phosphatidylinositol-mediated signaling, natural killer cell differentiation, positive regulation of gene expression, innate immune response, neutrophil extravasation, neutrophil chemotaxis, natural killer cell chemotaxis, positive regulation of endothelial cell proliferation, positive regulation of cytokine production, positive regulation of cell migration
GO CC Complete: phosphatidylinositol 3-kinase complex, class IA, phosphatidylinositol 3-kinase complex, cytoplasm, cytosol, plasma membrane
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: PI3K/AKT Signaling in Cancer, PI Metabolism, Interleukin-3, Interleukin-5 and GM-CSF signaling, Signaling by Interleukins, Phospholipid metabolism, Regulation of signaling by CBL, Erythropoietin activates Phosphoinositide-3-kinase (PI3K), Diseases of signal transduction by growth factor receptors and second messengers, Signal Transduction, PIP3 activates AKT signaling, Signaling by Erythropoietin, Developmental Biology, Constitutive Signaling by Aberrant PI3K in Cancer, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, Disease, Synthesis of PIPs at the plasma membrane, Negative regulation of the PI3K/AKT network, Metabolism, RET signaling, Signaling by the B Cell Receptor (BCR), Cytokine Signaling in Immune system, Interleukin receptor SHC signaling, Interleukin-2 family signaling, Immune System, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, Adaptive Immune System, Metabolism of lipids, Axon guidance, Nervous system development, Intracellular signaling by second messengers

Orthologs